Researchers found that statins can rescue ganglion cells in mice with reduced ABCA1 gene expression, suggesting a potential treatment for POAG. The study also revealed decreased HDL formation and ABCA1 deficiency in patients with open-angle glaucoma.
A group of researchers from Osaka Metropolitan University found that administering parathyroid hormone to rat Achilles tendons increased the production of cartilaginous matrix and promoted chondrogenic differentiation. This breakthrough discovery may lead to improved outcomes for meniscal reconstruction surgery, protecting knee cartila...
A study of over 80,000 adults from nine countries found that siblings have a surprisingly small impact on personality in adulthood. The research refutes the idea that growing up with brothers or sisters causes certain personality traits to develop in the long term.
A team of researchers from Kyoto University and Cameroon used camera trap surveys to predict the total biomass of large rodents and duikers in southeast Cameroon. They developed six candidate indicators, including the ratio of red duikers to blue duikers, which showed positive linear correlations with total bushmeat biomass.
A new study found that school-aged children can successfully use a nasal swab to obtain their own COVID-19 test specimen, providing data for recommendations on self-swabbing in schools and other settings. The study showed that children as young as 4 years old can follow instructions and collect their own samples with high accuracy.
Researchers identified 15 instances of mucinization, where new mucins emerged from non-mucin proteins by adding repeating sequences. This process transformed the proteins into mucins with gooey consistency, contributing to their various biological functions.
Gut epithelial cells control mutualism between host immune system and gut microbiome by regulating SFB and Th17 cell levels. Lack of IκBζ gene impairs defense mechanisms against pathogens, leading to inflammatory diseases.
Researchers experimentally verified the generalized eigenstate thermalization hypothesis (GETH) using a quantum-walk platform. They demonstrated that any superposition state within a small energy-momentum window relaxes to the same reduced state, independent of the initial state.
Researchers are investigating whether COVID-19 contributes to the development of cognitive decline that may lead to dementia. The study will analyze data from over 500 participants, including those with Parkinson's disease and related disorders, to determine if there is a connection between COVID-19 infection and neurocognitive decline.
Researchers at the University of Oldenburg and Fraunhofer IWES collaborate on a new project to develop more accurate wind flow simulations using artificial intelligence. The goal is to reduce computing times and enhance precision, ultimately accelerating innovation in wind turbine design.
Scientists at Caltech have developed a framework for designing new materials inspired by the fundamental rules of termite nests. The 'virtual growth program' simulates natural growth patterns and generates disordered geometries with unique mechanical properties.
The study found that the probability of surviving cardiac arrest outside hospital has more than doubled in 30 years, from approximately 5% to 11%. The improvement is attributed to increased CPR training and better healthcare resources. However, ambulance delays and an increase in difficult-to-treat cases are hindering further progress.
A Singapore study analyzed 2.4 million adults, finding higher risk of severe COVID-19 among those without boosters, yet vaccine effectiveness remained high, even after 2 years since last dose.
Researchers develop new scheme to measure tunneling time without theoretical calculation, finding ionization times decrease with increasing electron energy. The technique provides insight into fundamental dynamics of laser-matter interaction and potential retrieval of geometrical information.
Researchers have combined tesaglitazar and GLP-1 in a new hormone combination for type 2 diabetes treatment, improving glucose metabolism with minimal doses. The new drug has shown promise in animal studies, reducing kidney damage and increasing insulin sensitivity.
A Chinese research group found that China's natural climate solutions (NCS) can counterbalance 11-12% of industrial CO2 emissions by 2030. The study quantified NCS pathways, including conservation, restoration, and improved forest management, and estimated their contribution to climate change mitigation.
A new study published in Scientific Reports shows that selectively planting vegetation between roads and playgrounds can cut toxic air pollution reaching school children. Western red cedar tredges were found to be most effective at capturing particulate matter, with almost half of black carbon and 46% of fine particles eliminated.
A combination of immunotherapy and virotherapy using myxoma virus provides new hope for patients with treatment resistant cancers. The approach boosts the immune capacity to effectively target and destroy cancer cells, inducing a form of cell death called autosis.
A study at MedUni Vienna identified a glycerol-3-phosphate shuttle system as an essential back-up in neurons, ensuring sufficient energy supply even when one regulatory system fails. The system follows a hierarchy, with deployment triggered by the failure of other two mechanisms to function adequately.
Researchers gauged small-scale fishers' willingness to use vessel tracking systems, finding that safety functionality and ownership of data were key factors. In a survey of 211 fishers, 67% were willing to pay for the technology, while those citing corruption as their main problem were more likely to participate if paid.
A new titanium-based photocatalyst overcomes production inefficiencies in polyethylene furandicarboxylate (PEF), a biobased plastic replacement for PET. The catalyst increases efficiency by shifting light absorption to the visible range, reducing unwanted byproducts and requiring less UV light.
A new durable coating developed by University of Michigan engineers can kill 99.9% of microbes, including SARS-CoV-2, E. coli, and MRSA, for months on end. The coating combines tea tree and cinnamon oils with polyurethane to create a long-lasting antimicrobial surface.
Researchers have discovered the oldest clinical case of Klinefelter Syndrome in a 1,000-year-old skeleton from Portugal, providing new insights into the prevalence of the condition throughout human history. The study used a combination of genetic, statistical, and anthropological analysis to confirm the diagnosis.
Researchers developed a novel approach to generate high-speed random numbers using self-chaotic microcavity lasers. The study achieved physical random numbers at 10 Gb/s, paving the way for small and robust random signal sources.
A University of Michigan study finds that an all-electric mail-delivery fleet would reduce lifetime greenhouse gas emissions by 14.7-21.4 million metric tons compared to gasoline-powered vehicles, up to 63% lower than previously estimated. The study highlights flaws in the USPS environmental analysis.
Researchers have developed a new treatment principle that combines DNA-based and protein-based vaccines to stimulate the immune system against both hepatitis B and D viruses. The treatment has been shown to protect cultured cells against HBV and HDV infection, producing high levels of neutralizing antibodies and T-cells.
A study by Kumamoto University researchers found that a defective isoform of the SIGIRR gene activates an inflammatory pathway associated with cystic fibrosis. This defect leads to decreased expression and function of anti-inflammatory molecules, resulting in severe inflammation.
A recent study by pediatric cardiologists has found that certain maternal health conditions can partially explain the racial disparities in congenital heart disease outcomes. The research assessed over 8,000 infant and mother records from diverse populations and identified placental and metabolic syndromes as contributing factors.
A new study reveals two preserved slabs in the upper mantle beneath Myanmar, strongly supporting the double subduction model. The findings provide convincing geoscientific evidence to consolidate this model, which explains anomalously fast India-Asian convergence.
A study by University of Eastern Finland explores the role of self-disclosure in forging long-term B2B customer relationships. Sales professionals disclose personal and company information, leading to deeper relationships with increased trust, communication, and shared goals.
Researchers developed a single-molecule technique to investigate how bacterial proteins form pores in mammalian cells. They tracked the assembly of perfringolysin O protein and found that it forms pores even before complete ring formation is completed.
A three-year project aims to research novel pest management tools for cotton production by modifying terpene biosynthesis in cotton using a transgene-free CRISPR/CAS9 approach. The goal is to silence genes that produce monoterpenes, reducing infestations and pesticide use.
A new map of brain stem circuits controlling eating behavior could lead to better obesity treatments. The atlas, built from recent discoveries in mice and human studies, identifies two food intake-suppressing circuits in the brain stem, one causing nausea and another not.
Researchers outline a five-step approach to increase racial representation in cancer clinical trials through DRIVE: Diversity officer, Ranking of clinical studies, Individual diversity plan, Verification, and Training. This can lead to more inclusive and individualized treatment for diverse patient populations.
Researchers found a strong association between ultra-processed food consumption and adverse mental health symptoms, including depression, anxiety, and mentally unhealthy days. The study suggests that the high sugar, salt, and saturated fat content of ultra-processed foods may contribute to these negative effects.
A new study predicts that record-breaking heat waves will become more frequent in places like North America and Europe by 2100. The research suggests that even if countries meet the Paris Agreement goal of limiting warming to 2°C, dangerous heat stress could double by 2100 in the tropics.
A University of the Basque Country team has successfully produced starch-based pharmaceutical tablets using 3D printing technology. The tablets display varying release properties depending on the type of starch used, offering promising solutions for personalized medicine and tailored drug delivery.
A Japanese study found that a single ill healthcare worker caused respiratory infections among 17 patients, resulting in $12,324 in medical costs. The findings highlight the importance of addressing presenteeism and its impact on patient safety.
Recent studies in Journal of Pharmaceutical Analysis highlight innovative nanosensors for efficient biomolecular detection, including rutin, paracetamol, and hypochlorite. These advancements enable high sensitivity and reliability in clinical samples, paving the way for improved patient care.
Researchers confirm significant increase in freshwater entering the Arctic Ocean via the Bering Strait, leading to a decrease in saltiness and potential impacts on sea ice formation and regional ecosystems. This change could also affect climate-sensitive processes, such as deep water mixing in the North Atlantic.
Scientists discovered a mechanism to generate asymmetric temperature profiles without dynamic modulation, allowing for the imitated advection of heat. This phenomenon enables thermal trapping like that observed in black holes, with potential applications in waste heat recovery and thermal funneling.
A new study found patterns of fetal abdominal growth associated with maternal lipid metabolites that track newborn growth, adiposity, and development into childhood. The study monitored over 3,500 babies from birth to 2 years of age, providing insights into the complex interaction between maternal and fetal nutrition early in pregnancy.
Researchers at Rice University have created a new optical tool called homo-FRET that allows them to observe the real-time activity of two-component systems in bacteria. This breakthrough enables scientists to study the behavior of deadly pathogens and antibiotic-resistant bacteria, shedding light on their mechanisms and potential targe...
The COVID-19 pandemic had a devastating impact on Mayotte, with over 4,000 laboratory-confirmed cases causing interruptions in work and healthcare services. The island's unique socioeconomic vulnerability and communication challenges affected the surveillance and monitoring of the outbreak.
Researchers from TU Delft discovered a CRISPR-Cas system that cuts proteins instead of DNA, opening doors to sensing RNA molecules in pathogens. The cutting protein has an on-off switch that only activates when recognizing viral RNA, causing dormancy and preventing virus multiplication.
New research reveals that tau protein can self-assemble to form an envelope around microtubules, compacting them and affecting how other proteins attach. This novel behavior may play a regulatory role in healthy brain tissue, bringing us closer to understanding its connection to disease.
Researchers at Imperial College London have developed a new material, sodium bismuth sulfide (NaBiS2), that can absorb comparable levels of sunlight as conventional silicon solar cells but with 10,000 times lower thickness. The material has potential for making lightweight solar cells suitable for aerospace applications.
A new type of filter capacitor is developed using structurally integrated carbon tube grids, achieving high frequency response performance and volumetric capacitance. The capacitors are expected to be used in electronic circuits for AC line-filtering, providing a solution to the limitations of traditional aluminum electrolytic capacitors.
A new UCL-led study found that most British adults support stricter tobacco regulations, including banning sales near schools and raising the legal age to 21. The survey of over 1,700 adults in England and Scotland showed strong majority support for these policies.
Researchers have developed a new nanophotonic coating that can effectively manage body temperature without the need for external energy sources. The coating, which is transparent to visible light and infrared radiation, has been shown to provide a 15°C higher heating effect than commercial clothing.
A recent study found that a single high-performing cover crop can effectively suppress weeds, even surpassing the benefits of mixtures containing multiple species. The research demonstrated that monoculture cover crops, such as buckwheat and oat, outperformed average mixtures in terms of productivity and weed suppression.
The Perseverance rover has collected the first Martian rock samples that could be returned to Earth, shedding light on whether Mars ever hosted life. The rock samples come from the Jezero crater floor, where scientists believe a watery past may have supported life.
A study published in Scientific Reports found that Australian bushfires contributed to the highest recorded temperature in the lower stratosphere since the early 1990s. The smoke aerosols emitted by the fires led to a significant increase in stratospheric temperatures, with a modelled temperature spike of around 0.65 degrees Celsius.
A team of scientists developed RASTMIN, a method that achieves equivalent resolution to MINFLUX but can be implemented in standard confocal microscopes. RASTMIN enables nanometre resolution and can be used with existing laser-scanning microscopes.
A University of Colorado Anschutz Medical Campus faculty member has received a DOD grant to study noninvasive biomarkers for vascularized composite allograft rejection. The goal is to develop a simple saliva test to monitor patients for signs of graft rejection, reducing the need for frequent biopsies.
A new paper from Concordia University's Next-Generation Cities Institute outlines the challenges and realities of sustainable real estate development. The study identifies key stakeholders and building life-cycle processes to reduce carbon footprint. Cities can use municipal policies and incentives, such as fast-track zoning and densit...
Researchers at Gladstone Institutes and UCSF have developed a new approach to introduce long DNA sequences into cells with remarkable efficiency. The technology, which uses single-stranded DNA templates, overcomes the limitations of traditional viral vectors and has the potential to make cell therapies faster, better, and less expensive.
The Perseverance rover has revealed a crater floor composed of igneous rocks altered by water, with core samples stored for potential return to Earth. The rover's radar scans also suggest a layered structure beneath the surface, indicating history of igneous activity and repeated exposure to liquid water.
Researchers have identified Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) as a key regulator in the development and progression of nonalcoholic steatohepatitis. IGF2BP2 overexpression was found to induce liver steatosis, inflammation, and injury in healthy mice, while knockdown improved NASH pathogenesis.
Researchers discovered a significant difference in saliva bacteria between college students who reported recent suicidal thoughts and those without. Students with recent suicidal ideation had higher levels of bacteria associated with inflammatory health conditions and lower levels of Alloprevotella rava, which promotes brain health.