The UTHSC team will investigate how mitochondria affect the aging process and age-related diseases, including Alzheimer's. The five-year project will explore gene variants, diet, sex, age, and mitochondrial copy number to better understand these relationships.
Researchers at Helmholtz Munich have discovered that slowing down DNA replication speed improves reprogramming efficiency of cells into totipotent cells. This breakthrough could be a major advancement for stem cell therapy and regenerative medicine approaches.
A study led by Kyoto University researchers found that modulating hormone levels can improve meibomian gland disorder, a common cause of dry eyes. Topical administration of nicotinamide mononucleotide (NMN) boosted NAD levels and rebooted 3-HSD activity in mutant mice, alleviating dryness.
A new study from Cincinnati Children's Hospital Medical Center found that medical-legal partnerships, which connect pediatric patients with advocates from Legal Aid Society, significantly reduce hospital admissions for children. The program, launched in 2008, has resulted in a 38% reduction in hospitalizations among referred cases.
Researchers at HKUMed found that intramuscular olanzapine is a cost-effective and safer alternative to traditional sedatives like haloperidol. IM olanzapine was shown to be more benign on the cardiovascular system and had fewer movement disorders compared to haloperidol.
A retrospective analysis found that socioeconomically disadvantaged older adults are at a higher risk of decline in function and cognition after an intensive care unit hospitalization. The study highlights the need to prioritize low-income seniors in rehabilitation and recovery efforts after critical illness.
Researchers have identified a novel enzyme that catalyzes the formation of glycosidic bonds in complex sugar moieties. The discovery provides fresh insights into carbohydrate metabolism and offers a breakthrough for the synthesis of sugar chains, which play key roles in various biological processes.
A recent study reveals that Megalodon's body size was influenced by water temperature, with individuals growing larger in cooler waters. The research suggests that Bergmann's rule may have played a role in the shark's gigantism.
Researchers from NUS's Department of Chemical and Biomolecular Engineering have demonstrated the stability of CO2 hydrates in oceanic sediments, a potential technology for storing large volumes of carbon emissions. The team found that CO2 hydrates can remain stable for up to 30 days under pressurized conditions.
A multidisciplinary team at Northern Arizona University is using $1.3 million in funding to reduce racial disparities in STEM graduate programs. The team will create a cohort-based bridge program between NAU and tribal colleges, providing recruitment, training, and placement support for historically excluded groups.
Researchers at Tokyo Metropolitan University developed a simple synthesis method for iron-based single-atom catalysts that activate peroxymonosulfate to break down difficult-to-degrade pollutants. The team discovered two distinct chemical pathways involving 'high-spin' state iron sites, which interact with peroxymonosulfate to create r...
Researchers at Aalto University developed a simple, low-cost wireless charging system that provides efficient charging regardless of device position or orientation. The new design uses a cylindrical power coil to create a donut-shaped charging field, increasing convenience and reliability for consumer devices.
Researchers successfully used composite tissue transfer techniques from face transplant surgery for 'autotransplantation' of avulsed facial tissues. The technique involves re reconnecting the patient's own blood vessels to restore circulation, allowing for successful replantation without postoperative complications.
Researchers at the University of Washington developed an AI-designed protein that can awaken individual dormant genes by disabling chemical 'off switches'. This approach allows for safe upregulation of specific genes to affect cell activity without permanently changing the genome.
Researchers discovered two novel contractile injection systems (CISs) in cyanobacteria and a marine bacterium, revealing unique features and anchoring mechanisms. These systems provide insights into the evolutionary differences between various injection system classes.
Higher elevation mountain forests are using more water on average during droughts, reducing water availability downstream for cities and wildlife. Researchers found that these forests tend to be located above 3,280 feet and have increased water use due to rising temperatures and changes in tree species composition.
A new study reveals that individuals use covert online signals to convey their political identity, especially in mixed groups. This allows them to communicate without risking negative reactions from those who disagree. The research found that people prefer overt signals in homogeneous groups.
A new study by Bar-Ilan University researchers found that choosing to be with others is more consequential to well-being than choosing to be alone. Participants reported higher satisfaction and happiness when with others, but also experienced lower well-being in situations not chosen by themselves.
Scientists create novel germplasm by introgressing B. rapa genome into B. juncea and demonstrate increased genetic diversity and phenotypic variation among the introgression lines. This strategy provides a new method to expand genetic variation in Brassica species.
A new study using a dataset of over 36,000 adults found that light-to-moderate alcohol consumption was associated with reductions in overall brain volume. The association grew stronger with increasing levels of alcohol consumption, comparable to aging two and three years, respectively.
A new study by Columbia University researchers has identified key differences in immune cells and responses between MIS-C patients and other febrile infection patients. These findings may lead to faster diagnosis and better treatment of MIS-C.
Scientists from Carleton College and the University of Colorado Boulder present discussions and activities on DEI as a fundamental part of physics training. Instructors can design their own lessons using individual reflection activities or lead class discussions.
The Korea Institute of Science and Technology has developed a process technology that removes toxic hydrogen sulfide during the production of ethylene from biogas. This allows for the direct production of ethylene from biogas with reduced energy consumption, enabling domestic chemical companies to achieve carbon neutrality.
A new fluorescent DNA label has been developed to visualize disrupted DNA architecture in cancer cells, with promising results for improved cancer diagnoses and risk stratification. The study showed that the label can distinguish normal tissue from precancerous and cancerous lesions.
Researchers used submersibles to explore deep reefs, increasing the recorded number of deep-reef fishes by 9-fold. The study found that reef-fish faunas extend below the mesophotic zone and revealed a previously unknown reef ocean zone, the rariphotic.
A team of UTSA researchers has developed an innovative inhibitor that blocks the effects of cytochrome P450 8B1, a key enzyme linked to cholesterol absorption and obesity. The treatment shows promise in reducing glucose levels without affecting body weight, offering potential relief from obesity-associated metabolic disorders.
Researchers at the University of Seville conducted a study on deficit irrigation for Sunchocola tomatoes, finding no significant changes in commercial quality but increased carotenoids and phenolic compounds. The results have significant nutritional importance and potential for global irrigation water savings.
Researchers improve solar cell performance predictions by analyzing terahertz and microwave spectroscopy data, enabling more accurate assessments of material quality. This advancement can quickly test new semiconducting materials for their potential suitability.
Researchers found that patients with stage III melanoma who received immunotherapy alone had better rates of distant metastasis-free survival compared to those who underwent completion lymph node dissection. The study suggests that de-escalation of unnecessary therapies, such as CLND, may improve patient outcomes and reduce complications.
Scientists have created a supramolecular template using dendron-assembled structures to synthesize quasi-sub-nanoparticles with controlled atomicity. This approach offers a cost-effective and versatile method for producing a variety of nanostructures.
The World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases (WCO-IOF-ESCEO) 2022 will discuss secondary fracture prevention. Global experts will provide clinical guidance and information on post-fracture care through various sessions.
Researchers warn that deforestation and climate change are exacerbating drought conditions in Brazil's agricultural frontier, threatening soybean yields. The study analyzed changes in hydrology and weather patterns over four decades, highlighting a rise in temperatures, dry days, and decreased precipitation.
Recent review on auxin and GA signaling pathways reveals molecular mechanisms regulating fruit growth. Auxin promotes GA biosynthesis, while DELLA proteins regulate GA signaling, promoting fruit development.
CLABSIs contribute significantly to infant morbidity and mortality in the NICU, leading to prolonged hospitalization and increased healthcare costs. The Society for Healthcare Epidemiology of America provides practical guidance on preventing CLABSI through implementation of specific strategies.
Researchers developed a microneedle treatment that increased desensitization rates to peanut allergy in mice, outperforming existing immunotherapy methods. The novel approach achieved significant results using lower doses of allergen, offering new hope for millions suffering from peanut allergy.
Researchers have developed a peptide hydrogel, SupraGel, that efficiently produces cell spheroids with maintained stemness. The hydrogel's biocompatibility and scalability make it an ideal platform for studying cellular complexities and screening drugs.
Researchers found that a community-based approach to reporting APOL1 genetic test results resulted in lower blood pressure readings among hypertensive patients. This trial suggests that involving communities in genetic testing could be beneficial for reducing the risks of chronic kidney disease.
Researchers use artificial intelligence to predict algae's potential as a reliable, economic source for biofuel, overcoming challenges of low yield and high harvesting cost. The project aims to transform the bioeconomy by reducing petroleum dependency and alleviating climate change.
Researchers will use virtual reality to simulate crimes and evaluate eyewitness accuracy and confidence. The pristine condition hypothesis suggests that high-confidence witness identifications are likely to be accurate when procedures are optimal.
A new study by Harvard Pilgrim Health Care Institute examines cost-related experiences of families with non-group health insurance plans. Despite lower out-of-pocket spending among subsidy-eligible enrollees, negative cost-related experiences persist, highlighting the need for expanded subsidies to address affordability challenges.
Researchers at Universitat Politècnica de València are working on improving the safety of lithium-ion batteries in electric vehicles. They aim to reduce thermal instability and prevent fires, with potential benefits for the automotive sector and beyond.
Research finds that individuals with a migration background in Turkey and former Soviet Union exhibit similar levels of health literacy as the general German population. However, they face unique challenges such as limited access to multilingual health information and difficulties communicating with doctors. The study emphasizes the ne...
The employment-to-population ratio for working-age people with disabilities decreased from 33.8% in January to 33.1% in February 2022, while labor force participation rates also declined. Despite the decline, employment numbers remain above historic levels.
A recent study found that younger age at the time of menarche is associated with chronic pain in adulthood. Women who experienced their first menstrual period earlier reported higher rates of chronic pain and longer duration of pain. The study suggests that increased estrogen levels may contribute to this association.
A new study published in JAMA Network Open finds that a combination treatment of nicotine replacement therapy and varenicline is more effective for smoking cessation in heavy drinkers, resulting in 44.3% abstinence rate. Participants also showed significant reductions in drinking rates, with 25% decrease in weekly drinking days.
A recent study published in Frontiers in Marine Science found that 31% of pet food products from Singapore contained shark DNA, highlighting the prevalence of ingredient mislabeling. The researchers suggest implementing global standards for pet food labels to avoid overexploitation of endangered sharks.
Researchers at the University of New Hampshire have mapped magnetic fields in three dimensions, enabling improved diagnostic imaging and enhanced storage capacity for devices. The breakthrough has implications for medical imaging technologies like CT scans and magnetic memory devices.
A randomized clinical trial found that low-cost letters encouraging individuals to complete the enrollment process resulted in a significant increase in health insurance enrollment. The study suggests that such letters could be an effective tool for promoting health insurance coverage, particularly among underserved populations.
Researchers explored geological reconstructions using soil and air temperatures, petrogenesis of silicic magmas, and spatial skills for sequence stratigraphic interpretation. New data provide insights into homogeneous melt production and evolution of voluminous SMO magmas.
Researchers have discovered a common thread between multiple neurodegenerative diseases, including Alzheimer's, dementia with Lewy bodies, and frontotemporal lobar degeneration. A protein called TMEM106B forms fibrils in diseased brain tissue, potentially hobbling cells.
Researchers at Imperial College London developed a bendy robotic arm that can twist and turn in all directions, allowing for customizable shapes. The team created an augmented reality system to enhance user-friendliness, enabling users to easily configure the robot using motion tracking cameras and smartglasses.
A study published in Nature Communications reveals the precise molecular structure of siponimod, a multiple sclerosis drug, and its interactions with S1P receptors. This knowledge may lead to the development of more targeted therapies that reduce side effects.
Researchers studied China-Tibet dynamics and the Hiawatha impact crater in a new GSA Bulletin article. Meanwhile, another study focused on the distribution of groundwater arsenic in the transboundary Ganges River aquifer system between India and Bangladesh.
This study demonstrates a wafer-scale Si subulate array substrate for RRAM devices, improving cycle-to-cycle and device-to-device uniformity. The smallest curvature radius achieved is controlled by adjusting etching time, resulting in enhanced resistive window, retention characteristics, and switching voltage uniformity.
Researchers at Bielefeld University have identified five key characteristics of mitosis in the microalga Volvox carteri, including a porous nuclear envelope and crucial centrosome function. They used confocal laser scanning microscopy to capture high-resolution images of live cell division and gain insights into the complex process.
The new laboratory will use microfluidics, AI, and machine learning to conduct thousands of parallel experiments on single-cell eukaryotic yeast and other microbes. This will simplify the study of biology and provide a pathbreaking 'robot scientist' for fundamental research.
A new study reveals that liquid fructose intake, even in high-fat diets, can accelerate liver fat accumulation and hypertriglyceridemia. The study found that fructose induces an increase in the synthesis of fatty acids in the liver and inhibits lipid oxidation, leading to the emergence of non-alcoholic fatty liver disease (NAFLD).
Researchers examined spatial and racial disparities in COVID-19 mortality rates during the pandemic. County-level data revealed notable differences in mortality rates among different racial groups.
Researchers at UC San Diego have designed a flexible protein system that selectively binds to non-copper metals, overcoming universal restrictions on metal selectivity. This breakthrough paves the way for the design of novel functional proteins and metal sequestration agents with potential applications in environmental remediation and ...
A longitudinal study confirmed that adults' religious styles change over a person's lifetime, with most participants moving to a higher style. Factors such as openness to experience and low agreement with their own religion supported this progression, while regression was also observed in a significant number of cases.