Researchers at IRB Barcelona have developed new p38 inhibitors that selectively impair one of the activation pathways of the protein, allowing it to perform many of its normal functions. The inhibitors show therapeutic potential for heart diseases such as cardiac cell death and cardiotoxicity.
Researchers developed a technique to enhance the stability of perovskite solar cells by using fluorinated aniliniums, avoiding progressive ligand intercalation. This approach achieved a certified quasi-steady-state power-conversion efficiency of 24.09% for inverted-structure PSCs.
Researchers investigated whether people rate women's and men's soccer differently based on player gender. They found that biased perceptions of female athletes' talent and toughness exist, affecting how we perceive their performance quality. The study suggests that women's soccer hasn't yet reached its full economic potential.
The Save Our Seas Foundation's World of Sharks website now features interactive 3D models of white sharks and manta rays, enabling users to explore shark physiology and evolution in an engaging way. The 3D models are open-access and free to view and download for non-profit use.
A team from the University of Tokyo combines economic theory with biology to understand how natural systems respond to change. They use the Slutsky equation to discover that different metabolic systems share previously unknown universal properties, which can be understood using tools from other academic fields.
Researchers have developed a new class of systems that exploit interference to create quadrature nonreciprocity, allowing for unidirectional signal transmission without breaking time-reversal symmetry. This enables the creation of dual carriageways for signals, with potential applications in quantum information processing and sensing.
A new species of ancient alligator, Alligator munensis, is described from a fossilized skull in Thailand. The species is closely related to the Chinese alligator and has unique features such as a broad snout and large tooth sockets, suggesting it ate hard-shelled prey.
Researchers have discovered that adding the tropical alga Asparagopsis taxiformis, also known as red sea plume, to cow feces significantly reduces methane production by 44%. The study suggests that this approach could be a promising natural method for reducing greenhouse gas emissions from manure.
Researchers at Weizmann Institute of Science have discovered quantum vortices in strongly interacting photons. These vortices exhibit unique properties that can be used to study the behavior of photons and their interactions with matter.
A study published in the Journal of Hospital Infection reveals that pharmacist-led multi-faceted interventions can optimize antimicrobial prescriptions in dental clinics, reducing the incidence of serious infectious diseases. The intervention increased penicillin usage and decreased the use of broad-spectrum antimicrobials.
Researchers at Drexel University have developed a photocatalytic titanium oxide nanofilament material that can harness sunlight to unlock the potential of hydrogen as a fuel source. The material outperforms current methods and is stable for months, offering a sustainable and affordable path to creating hydrogen fuel.
A recent study led by Professor Simona Stäger identified a molecular imprint that predisposes memory CD4+ T lymphocytes to cell death in people living with HIV. The discovery could have implications for other chronic infectious diseases and may lead to the development of new therapeutic approaches.
Lero is recruiting 16 top international post-doctoral researchers for a €2.9 million fellowship program focusing on privacy, trust, inclusion and fairness in software expertise. The program will provide discipline-specific skills training and enhance career development.
Researchers at the University of Texas at Dallas have discovered a previously unknown self-renewal mechanism in kidney cells that allows them to rejuvenate themselves and remain healthy. This process is fundamentally different from other regenerative processes, such as cell division, and enables kidneys to function normally for life.
A new theoretical study provides a framework for understanding nonlocality in quantum networks, which are essential for performing operations inaccessible to standard technology. The researchers determined the conditions necessary for creating systems with strong, quantum correlations.
A new study by the University of Portsmouth highlights the challenges faced by women in achieving career success in policing. The 'Macho culture' of police work discourages hostile behaviors and affects women's progression.
CRISPR editing improves wood properties by increasing the carbohydrate-to-lignin ratio up to 228% in poplar trees, enabling more efficient fiber pulping. This breakthrough could bring unprecedented bioeconomic opportunities and environmental benefits to sustainable wood fibers production.
A new app called START has been shown to accurately identify autistic children in India, with a success rate of 86% for neurodevelopmental disorders and 78% for autism. The low-cost tablet screening tool uses simple games and questions to measure social preference, sensory interests, and motor skills.
Researchers developed MemTrax, a continuous recognition test for advanced cognitive impairment screening. The test quickly and accurately quantifies memory processing, storage, and retrieval, providing precise assessments of severity and rate of change over time.
Massachusetts General researchers discover that macrophages and their proteins contribute to AFib's irregular heartbeat patterns. Inhibiting macrophage recruitment reduces AFib, suggesting a promising strategy for treatment.
Scientists have successfully visualized the topology of electrons in topological quantum materials using '3D glasses,' a technique that uses circularly polarized X-ray light. This breakthrough enables the characterization of quantum materials topologically, paving the way for energy-saving electronics and high-tech advancements.
A study found that pediatric hospitalizations for RSV in high-risk children spiked during off-seasons due to delayed prophylactic availability. The researchers emphasize the need for a more fluid policy to protect these vulnerable kids.
Researchers have successfully visualized the three-dimensional structure of human tRNA splicing endonuclease TSEN, a crucial enzyme in tRNA maturation. The study reveals how TSEN recognizes and excises introns from precursor tRNAs, shedding light on its role in neurodegenerative disorders like pontocerebellar hypoplasia.
Researchers develop new method to visualize glass transformation into supercooled liquid, confirming unusual separation between liquid domains. The technique allows for direct comparison between computational models and physical reality, shedding light on the glass transition process.
Researchers emphasize the importance of clear causal assumptions and sensitivity analysis to evaluate results' robustness. They advocate for adopting transparent practices in conducting and reporting causal analyses, leading to better understanding of causal relationships and evidence-based decision-making.
Research by Monika Ardelt and Bhavna Sharma found that wise organizations prioritize supervisor support, autonomy, competence, and relatedness to foster employee connection, job fulfillment, and overall well-being. This approach enables businesses to thrive in the long term while making a positive impact on their communities.
A randomized clinical trial found that low-dose atropine eye drops did not slow myopia progression or axial elongation in US school-age children. The results suggest that atropine, 0.01%, eye drops are not effective for controlling myopia in this population.
The Multicultural Psychology Consultation Team (MPCT) fosters a network of clinicians and leaders interested in increasing access for people with rising identities. The team's efforts focus on building cultural humility, multiculturally responsive clinical care, and supporting providers delivering care.
Recent AI advancements in healthcare and animal behavior pose unique ethical concerns and policy challenges. Meanwhile, generative AI technologies raise questions about copyright and training data, while task automation via AI innovations could reduce income inequality. These pieces explore the benefits and risks of machine intelligence.
Catherine Royer's research aims to understand how enzymes function under high pressure and thrive in extreme temperatures. The project could lead to the development of new biotechnological applications.
Researchers at North Carolina State University used CRISPR gene-editing to breed poplar trees with reduced lignin levels, while improving their wood properties. This breakthrough could make fiber production for paper, diapers, and other products more sustainable, efficient, and cost-effective.
Scientists found that cooling or warming the striatum region slows down or speeds up activity patterns, which correlates with rats' timing judgements. This provides evidence for the 'population clock hypothesis', suggesting that brains use decentralized and flexible sense of time.
Research investigates how porosity affects piezoelectric properties of PVDF films, a material suitable for biomedical applications. High porosity improves piezoelectric performance, enabling more sensitive pressure sensors for hemodynamic monitoring.
In a groundbreaking procedure, Adriana Rodriguez received a dual-organ transplant, with her healthy liver transplanted into another patient to mitigate rejection risk. This innovative approach, known as HALT-D, demonstrates the potential for immunoprotection and has implications for highly sensitized patients requiring multiple organs.
A new study found that 21.3% of respondents used skin lightening agents, often for conditions like acne or hyperpigmentation, but most users were unaware of potential toxic ingredients and risks. The study highlights the need for cultural mindfulness in dermatology care to ensure safe and effective treatment across all communities.
Researchers found that plastic debris on coral reefs increases with depth, largely stemming from fishing activities, and is correlated with proximity to marine protected areas. The study, which surveyed over 1,200 reefs across 14 countries, highlights the need for increased protections to address this growing threat.
A mathematical model of UK cat populations suggests that neutering of owned cats affects not only their own population but also those of feral, stray, and shelter subpopulations. The model shows that lower rates of neutering of female owned cats lead to population booms within the other subpopulations, especially for stray cats.
Researchers have identified a unique role for certain immune receptors in leprosy infections, which could lead to new treatments. The study found that targeting a specific glycolipid and its interaction with an immune receptor may offer an alternative approach to current antibiotic-heavy treatment.
A Duke University team has found that retrotransposons use the cell's DNA repair function to create a ring-like shape and then produce a matching double strand. This discovery challenges long-held theories about retrotransposons being byproducts of bad gene copying.
Researchers at UCLA Jonsson Comprehensive Cancer Center confirmed genetic variants of unknown significance are verified mutations that increase the risk of kidney cancer. The findings could lead to new treatment options for people with hereditary leiomyomatosis and renal cell cancer (HLRCC).
An international team of scientists used nondestructive chemical analysis to uncover subtle changes in ancient Egyptian funerary paintings, including reworked motifs and pigments. The discovery sheds new light on the creative process and intellectual identities of pharaonic artists, revealing a more dynamic and complex artistic tradition.
Researchers at CiQUS developed biomimetic nanocarriers that fuse with host cell membranes to release drugs into cytosol. This approach enhances therapeutic efficacy and bioavailability by increasing selectivity and safety.
Mass General Brigham researchers have made key improvements to Parkinson's disease cell therapies by using regulatory T cells to supplement neuronal cell therapy. The study shows that co-transplanting regulatory T cells with dopaminergic neurons increases survival and improves behavior recovery in rodent models.
EPFL researchers have created a novel biosensor, ImmunoSEIRA, to detect misfolded protein biomarkers linked to Parkinson's and Alzheimer's diseases. The sensor employs AI-powered neural networks for disease stage quantification and features gold nanorod arrays with antibodies for specific protein detection.
Researchers have developed a novel approach to generate highly directional single photons using a quantum emitter in a one-dimensional waveguide. This design improves extraction efficiency and reduces emission time uncertainty by exploiting the Purcell effect, offering a promising solution for quantum technologies.
Researchers detected Orientia bacteria in chiggers at high frequency in North Carolina recreational parks. The bacterium causes a disease similar to Rocky Mountain spotted fever, which can be fatal if left untreated.
Sylvester Comprehensive Cancer Center researchers developed a first-of-its-kind orally administered drug Platin-L to disrupt prostate cancer cells' metabolism and deliver cisplatin directly into treatment-resistant cancer cells. The study showed that Platin-L is safe and effective in shrinking treatment-resistant cancers.
Researchers discovered that combining honey and vinegar can effectively kill bacteria in biofilms, making it a potential treatment for persistent infections. The study found that using both honey and acetic acid was more effective than using either substance alone.
A new talking therapy called Augmented Depression Therapy (ADepT) has shown encouraging early signs of being more effective and cheaper to deliver than current Cognitive Behavioural Therapy (CBT). ADePT targets building wellbeing alongside reducing depressive symptoms, with promising results in a pilot trial.
The team led by Jan J. Weigand developed an innovative method for producing phosphorus-based chemicals, reducing environmental impacts and enabling a more sustainable access to platform chemicals. Phosphorus recycling through electrochemical methods is also being explored, aiming to reduce waste and conserve natural resources.
Researchers identified six distinct blood pressure trajectories in the first half of pregnancy that accurately predicted preeclampsia and gestational hypertension. These early predictions worked equally well across different racial groups, with three patterns identifying 74% of patients at risk.
Researchers at Mass General Cancer Center treated 16 patients with a BRAF/MEK inhibitor, resulting in a 91% reduction in tumor size and complete response in all patients who received one or more cycles of therapy. The treatment showed unprecedented success in targeting brain tumors using precision medicine approaches.
A new study published in Developmental Cell reveals that a signal produced by neurons is essential for the proper formation of the blood-brain barrier during embryonic development and helps maintain its integrity throughout adulthood. The findings could lead to more effective ways of delivering cancer or psychiatric medicines into the ...
A new UNF study highlights the critical yet understudied factor of salinity changes in ocean and coastlines caused by climate change. Changes in salinity can have potentially devastating impacts on vital coastal and estuarine ecosystems, threatening the health and economy of local communities.
A new study by Yale University reveals that combining pembrolizumab with other treatments reduces tumor size and improves response rates for patients with advanced NSCLC. The treatment regimens resulted in higher survival outcomes, particularly in patients with specific biomarker-defined subgroups.
Researchers at Michigan State University have discovered a way to utilize vibrations in quantum computing to prevent information loss. By tuning the vibrations experienced by qubits and understanding their impact on fidelity, the team can create more stable quantum states.
A study led by the University of Konstanz warns that human-induced salinity changes could have devastating impacts on marine organisms and ecosystems. Salinity is a critical factor in many metabolic processes, and its effects are often underestimated due to its complex interactions with other physical and chemical properties.
Researchers found evidence of 2.9 billion-year-old glaciers in South Africa using relative oxygen isotope concentrations and physical proof. The discovery suggests the presence of continental ice caps at that time or a previously unknown 'snowball Earth' period.
A new mRNA derivative, comb-structured RNA, has been developed to enhance anti-cancer activities by activating immune cells and demonstrating high tumor effects in mice models. The study shows the potential of this novel cancer mRNA vaccine as a safe and effective treatment.
A team of Swiss robots, including legged ANYmal and wheeled robots, is sent to explore a challenging terrain, showcasing the benefits of redundancy and specialization. The robots work together to detect minerals and identify rocks, with semi-autonomous capabilities for direct task assignment.