Researchers identified the structure of a special type of amyloid beta plaque protein associated with Alzheimer's disease progression. Lecanemab, an approved AD treatment, can bind and neutralize these small aggregates, potentially slowing cognitive decline in patients with early AD.
The Society for Cardiovascular Angiography & Interventions is launching a program to introduce future physicians to interventional cardiology. The Ready to Launch - Careers in Cardiology program will host medical students from the Phoenix area and provide them with impactful conversations, training paths, and hands-on demonstrations.
A novel HIV restriction factor, Schlafen 12, has been identified as a key player in latent virus survival. This finding opens the possibility of designing new therapeutic strategies against HIV by blocking its antiviral functions.
Researchers discovered a link between MCEMP1 protein on mast cells and severe asthma. Inhibiting this protein could provide relief for patients with severe asthma by reducing inflammation in the airway and lungs. The study provides critical information for developing new therapies for long-term lung conditions.
The Texas A&M Institute for Advancing Health Through Agriculture is partnering with the Chicago Council on Global Affairs to develop a National Roadmap for Responsive Agriculture Solutions. The study aims to set priorities for supporting health through food and agriculture, focusing on reducing diet-related chronic diseases.
A new study found that overweight boys tend to have lower testicular volume, putting them at risk for infertility in adulthood. The research suggests that weight loss could help patients avoid infertility later in life.
A USC researcher and international team identified consistent DNA base pairs across 240 mammals, including humans, that play a key role in human disease. These 'constrained' base pairs remained generally consistent over millions of years of evolution and are significantly linked to genetic variation.
The study presents a novel, deployable electrode array for minimally invasive craniosurgery, featuring spiraled arms that unfold over sensitive brain tissue. The device's eversion mechanism allows for arbitrary size deployment with minimal compression on the brain.
A randomized clinical trial found that providing palliative care at the time of cancer surgery did not improve patient outcomes, including quality of life and survival. The study suggests that surgeons should not be reluctant to call for palliative care consultations based on fear of upsetting patients.
A new study reveals that crops such as corn, sorghum, and millet have evolved by swapping genetic modules between cells to adapt to environmental changes. Researchers identified trends of gene module trading among the species, which may help scientists pinpoint genes controlling drought tolerance.
Trials of Pfizer's maternal RSV vaccine suggest a possible increase in preterm births, prompting experts to call for further analysis and post-approval monitoring. The vaccine aims to protect infants from severe RSV illness, but its safety concerns have raised eyebrows.
A study by University of California, Riverside found that older adults are less likely to ignore distractors in their surroundings while engaging in a cognitive task and an effortful physical task. This decline is greater when simultaneously performing a physical task, such as driving or carrying grocery bags.
Researchers found that humpback whales have a unique response to wind noise, singing louder in noisy conditions. In contrast, they do not exhibit an increased reaction to vessel noise from boats. This finding has implications for understanding whale behavior and potential consequences for breeding practices.
Researchers have discovered a new phase of liquid magnetism in layered helical magnets, where magnetic dipoles behave like 'flattened puddles' with varying alignment between layers. This phenomenon, predicted by a computational model, may explain the unusual electronic behavior observed in these materials.
New research found that area-level deprivation is strongly associated with the risk of long COVID, with females having a higher risk. People working in healthcare and education sectors had the highest risk of long COVID compared to those in manufacturing and construction sectors.
Researchers from Cima University of Navarra have found that inhaling menthol improves cognitive ability in animal models of Alzheimer's disease by modulating the immune system and reducing interleukin-1-beta levels. This study opens doors to developing therapies based on stimulating and training the olfactory system.
Researchers have developed a simplified surface design that enables liquid directional steering on the same surface as conventional designs. The new surface topography features dual reentrant curvatures and microgrooves, which regulate liquids' spreading dynamics. This innovation simplifies fabrication and opens up practical applications.
Researchers have created a 19-core optical fiber with a standard cladding diameter, achieving a record transmission capacity of 1.7 petabits per second over 63.5 km. This design uses randomly coupled multi-core fibers and MIMO digital signal processing to minimize power consumption.
A study found that fatigued law enforcement officers have difficulty collecting information that could bring justice to victims. Researchers linked sleep deprivation to increased resistance from interviewees, decreased ability to establish rapport, and difficulties in managing emotions.
Researchers developed an AI algorithm called CathEF to estimate left ventricular ejection fraction (LVEF) from standard angiogram videos, providing real-time information for clinical decision-making. The tool was trained on a large dataset and demonstrated strong correlations with echocardiographic LVEF measurements.
A 16-week remote exercise program improved cardiorespiratory fitness, lung function, and functional capacity in severe COVID-19 survivors. The study found significant benefits in health-related quality of life and reduced persistent symptoms.
Soil microbiology research increasingly relies on big data, with experiments moving from labs to fields. Discrepancies between lab and field studies impact policies due to inconsistent results. Bridging the gap requires interdisciplinary collaboration to improve upscaling of soil microbiology research.
A study from Dartmouth College found that athletes' physique is adapted to shedding or retaining heat in certain climates, affecting their performance in Ironman events. Taller, leaner runners excel in warm climates, while stockier builds fare better in colder climates.
Bird and bat deaths at US wind turbines surge during seasonal migrations, with most species affected in the prairies and plains. The study's findings suggest adjusting curtailment requirements to protect sensitive bird and bat species.
Scientists discovered that the diversification of life at 500 million years ago led to a drastic change in the chemistry of Earth's crust, with phosphorus levels tripling in crustal rocks. This increase supported the continued expansion of life on Earth.
A novel protein nanoparticle vaccine candidate using adjuvants has been developed to boost effectiveness against viral infections. The study found that the vaccine provided complete protection against influenza viral challenges.
Researchers develop bio-inspired microphones that detect specific signals without consuming a lot of energy or requiring supervision. These miniature sensors are ideal for hazardous or hard-to-reach applications.
A new study suggests that catastrophic Australian bushfires in 2019-2020 contributed to a rare, three-year La Niña event. The research found that wildfire emissions brightened cloud decks across the Southern Hemisphere, cooling the Tropical Pacific ocean and ultimately shifting climate conditions.
The Human Pangenome Reference Consortium expands and updates the human genome project with nearly full genomic data from 47 people of diverse ancestry. Researchers at UW Medicine made significant contributions to drafting the pangenome reference and studying variation within repetitive DNA, which could improve equity in human genome re...
Researchers found that washing with certain soaps changed the human body odor profile, making some people more attractive and others repellent to mosquitoes. The team identified specific chemicals associated with mosquito attraction and repulsion, offering insights into how soap use can impact mosquito preference.
Researchers found that certain soaps increased mosquito attractiveness while others decreased it, with coconut scented soap being the repellant. The study's findings have implications for disease prevention and could be expanded upon with further research.
A new study by Harvard T.H. Chan School of Public Health found significant racial inequalities in treatment for opioid use disorder, with White patients receiving medication up to 80% more frequently than Black and Hispanic patients. Despite similar numbers of healthcare visits, disparities persist.
A new human pangenome reference has been created, capturing significantly more human diversity than the previous single reference. The reference includes genome sequences of 47 people and aims to increase that number to 350 by mid-2024.
A new model for disease transmission takes into account the effects of social dynamics and social norms on behaviors such as mask-wearing. The study found that small changes in certain factors can lead to large changes in disease spread rates, creating distinct infection waves. Social conformity creates a 'stickiness' where individuals...
Anionic Pt(0) complexes, highly reactive and unstable, have been stabilized by electron-accepting boron compounds. This breakthrough enables researchers to elucidate their molecular structures for the first time. The findings provide new guidelines for creating these active chemical species.
Researchers identified two crucial drivers of brand extension success: parent brand equity and extension fit. The study suggests five groups of moderators to improve brand extension strategies.
Engineers at the University of New South Wales have created a solution for overcrowded circuitry in quantum computer chips by developing jellybean quantum dots in silicon. The device allows for spaced-out qubits that can interact with each other, enabling more efficient quantum computing.
A study published in Nature Communications reveals a small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility. The research team discovered that mice lacking NICOL were sterile, indicating its importance for the sperm-maturation pathway.
Researchers aim to understand how neurons receive signals for taste and touch sensations, exploring potential emotional correlations. The study will investigate the organization of brain circuits supporting these intersections, with implications for health and disease.
Researchers at the Lewis Katz School of Medicine found that calcium sensor MICU1 regulates mitochondrial ultrastructure, governing inner and outer mitochondrial membrane structure. This discovery provides a framework for understanding cellular energetics and cell death, with implications for diseases such as cardiovascular disease.
Overweight and obesity in early adulthood are associated with increased risks of colorectal cancer and non-colorectal gastrointestinal cancers. The study highlights the need for further exploration into the mechanisms driving these associations.
A study published by the European Respiratory Society found that around 20.2% of French adults are likely to have obstructive sleep apnoea (OSA), with only 3.5% being treated for the condition. OSA is more common in men, older adults, and those with cardiovascular disease.
A recent study found that workplace accidents are most likely to occur in moderately dangerous environments due to inadequate safety behaviors. Workers tend to underestimate the need for safety measures and allocate insufficient time and effort to work safely in these conditions.
Researchers developed a review to improve cloud microphysics modeling, addressing challenges such as turbulence and parameterization. The model aims to enhance short- and long-term weather forecasting and optimize solar energy capture.
A team of researchers used a capsule to collect data on digestion and microorganisms in the upper intestine, revealing nearly 2,000 metabolites and associations between diet and metabolite levels. The study provides new insights into human gut metabolism and microbiome interactions.
A research team at Hokkaido University has developed a system to deliver antioxidants to mitochondria in the liver, reducing oxidative stress and damaging caused by ROS. The system, called CoQ10-MITO-Porter, was found to be more effective when downsized particles were used.
A recent study published in PLOS ONE found that pregnant and lactating dogs share similarities in certain blood metabolites with human pregnancy, including glucose and fatty acid concentrations. The research analyzed 27 dogs from 21 breeds and discovered intriguing correlations between canine metabolism and human physiological processes.
Researchers characterize 106 dim blazars to test the blazar sequence theory, exploring black hole growth and general relativity. The study reveals that lower-energy peaks for dim blazars peak in blue, higher-energy light, extending current knowledge of the pattern.
Research analysis over 200,000 working-age adults reveals a strong association between area-level deprivation and long COVID risk. Females from least deprived areas had comparable long COVID risk to males from most deprived areas. The study highlights the need for targeted public health interventions to address health inequalities.
A new study found that hysterectomy, oophorectomy, and tubal ligation are associated with an increased risk of cardiovascular disease. The strongest association was seen among women who underwent surgery before age 50.
The human pangenome reference combines genetic material from 47 individuals, enabling a deeper and more accurate understanding of worldwide genomic diversity. This improves the detection of variants in the human genome, particularly structural variants that can have important health implications.
Acoustic artist Colin Malloy transforms ocean data into captivating percussion songs, raising awareness about the impact of oil production on oceans. His music aims to encourage listeners to reflect on the issues surrounding oceans, leveraging the power of art to digest information on an emotional level.
Researchers at the University of Illinois have developed a new procedure, SCRIBE, that enables precise printing of microdevices into existing materials. The technique uses multiphoton lithography to selectively modify regions of the material's interior and manufacture custom small-scale optical devices.
MIT chemists develop rapid test to determine whether individuals have neutralizing antibodies against Covid-19, offering protection against future infections. The technique uses a fingerprint of sugar molecules to identify neutralizing antibodies in blood samples.
A recent study in Columbus reveals striking disparities in accessibility for wheelchair users traveling by public bus. Manual wheelchair users have access to only 1% of the city, while powered wheelchair users can reach about 25%. The main obstacle is infrastructure, particularly sidewalks, which are damaged or missing in many areas.
Researchers have released a high-quality collection of reference human genome sequences capturing substantially more human diversity. The new pangenome includes genome sequences of 47 people, with the goal of increasing that number to 350 by mid-2024.
A targeted kinase inhibitor added to a two-drug immunotherapy combination slowed the progression of advanced kidney cancer, with patients experiencing significantly improved progression-free survival. The median PFS was 11.3 months for those on nivolumab and ipilimumab alone, compared to not yet reached in the three-drug group.
Researchers found that highly work-relevant personal information from an AI agent elicits greater empathy in users, while less or no disclosure leads to suppressed empathy. This study suggests self-disclosure could be used to improve people's acceptance of AI technologies.
Researchers have created a new pangenome that fills in missing sequencing gaps from the original Human Genome Project, expanding diversity of genomes represented. The achievement improves analysis for disease diagnosis, drug discovery, and genome-guided precision medicine.
A new laser-based breathalyzer using artificial intelligence can detect COVID-19 in real-time with excellent accuracy. The technology, powered by frequency comb spectroscopy and machine learning, analyzes the unique chemical fingerprint of each breath sample to identify specific health conditions.