Fentanyl-related pediatric deaths increased substantially from 2013 to 2021, with the COVID-19 pandemic exacerbating this public health crisis. Annual deaths peaked in 2020 and 2021, indicating a more than 6-fold increase among children under 5 years.
Researchers have found an advanced immunotherapy treatment, called CAR T therapy, to be effective in targeting Diffuse Intrinsic Pontine Glioma (DIPG) tumours. The treatment involves isolating a patient's immune cells and re-infusing them into the patient to fight their cancer.
The Southwest Rural Health Research Center's survey highlights mental health and addiction as rising concerns in rural areas, while access to quality healthcare remains a significant issue. Economic stability is also a key priority, reflecting the impact of poverty on healthcare access.
Researchers at Oregon State University are part of a $5 million NSF effort to accelerate robotics research by providing standardized humanoid robots. The project will build on an earlier success that designed and tested 10 prototype Quori robots, incorporating lessons learned to improve the robot's design and distribution.
Researchers found that ragweed and ryegrass emit more subpollen particles than previously thought, which can boost cloud formation and contribute to climate change. Whole pollen grains also facilitate cloud growth, but SPPs are poor ice-nucleating sites.
Researchers developed a method to investigate surfactant arrangement at the liquid-vapor interface using X-ray photoelectron spectroscopy. They achieved Ångstrom-depth resolution and distinguished between hydrophilic and hydrophobic ends of perfluorinated pentanoic acid molecules.
The study examines the impact of surface type on Arctic amplification, finding that ice-retreat regions experience the strongest warming and largest seasonal contrast. The seasonal energy transfer mechanism and changes in effective thermal inertia also contribute to the seasonality of AA.
A new glycosidic-bond-based mass-spectrometry-cleavable cross-linker has been developed to improve data analysis throughput and identification accuracy of cross-linking information. This technique enables in-vivo cross-linking of protein complexes in live cells, achieving large-scale and precise analysis of 1,453 proteins.
Researchers at UC Irvine have developed a DNA enzyme that can target specific RNA mutations in cancer cells while leaving healthy strands intact. This breakthrough technology could revolutionize disease treatments with precise, targeted therapies.
A sharp increase in colchicine's price led to a 17% drop in its use and worsened disease control in gout patients. Patients turned to alternative medications with potentially different side effects, resulting in increased emergency department visits and specialist consultations.
Human brain organoids, grown in labs from stem cells, raise questions about personhood. Researchers propose a legal framework to understand their potential personhood and uses.
Hospitals affected by ransomware may see increased patient loads and resource strain, impacting time-sensitive care for acute stroke patients. Targeted cyberattacks can have regional disaster implications on healthcare delivery.
A new study found that an online belonging exercise increased the rate of full-time college completion among students, especially at institutions with strong support strategies in place. The intervention showed significant effects on students' persistence, course taking, and sense of belonging.
The telescope has imaged three nested belts extending up to 14 billion miles from the star, with inner belts revealed for the first time. The discovery provides insights into the structure of exoplanetary systems and the formation of planets.
Researchers created organoids from patient tissues to test chemotherapy drugs and identified genetic signatures that predict treatment response, offering high accuracy in personalized drug screening. This breakthrough may help select effective drugs for individual patients, reducing trial and error.
A POSTECH research team has successfully mass-produced metalenses for visible light, overcoming previous limitations in fabrication and efficiency. By combining photolithography and nanoimprint lithography, the team achieved high-speed production of high-performance lenses with improved efficiency up to 90%.
A new study analyzes over 86,000 bird specimens to reveal that smaller bird species are declining faster in body size while increasing their wing length. The research suggests that climate change may be driving this shift, with smaller birds potentially adapting more quickly to evolutionary pressures.
Dr Germain Honvo, a young investigator, receives the prestigious award for his international contributions to osteoarthritis research and publications on guideline development. He is recognized as a future thought leader in the musculoskeletal field.
KNT-127 exhibits anti-stressing and anti-depressant effects in mice, improving social interaction and reducing stress-induced hormone levels. The agent suppresses neuronal inflammation and newborn death without affecting neurogenesis.
Dr. Miaomiao Zhang's research aims to automate late mechanical activation detection from cardiac magnetic resonance images using machine learning and AI techniques. This could lead to more accurate placement of CRT electrodes and improved patient outcomes.
Researchers at Macquarie University identified rare genetic defects in MND and FTD patients that also cause other neurodegenerative diseases. These short tandem repeat expansions are found in over 20 diseases and may contribute to neuron death.
Researchers at Florida State University have developed organic-inorganic hybrid materials that can improve image quality in X-ray machines, CT scans, and other radiation detection technologies. The new materials emit light within nanoseconds, allowing for better imaging and higher resolution and contrast in images.
Researchers found that T cells can self-activate by puckering their cell membrane, boosting function and slowing tumor growth in a mouse model. This discovery could inspire new anti-tumor therapeutics and provide insights into treating autoimmune diseases.
A University of Gothenburg study shows that increased physical activity, with four hours of weekly exercise, doubles the chances of recovering well by six months after a stroke. Men and people with normal cognition tend to maintain an active lifestyle more often, leading to better recovery outcomes.
A recent clinical trial showed that cemiplimab plus platinum chemotherapy can prolong survival in patients with advanced lung cancer, improving their quality of life. The treatment also reduced symptoms such as pain and cough, and delayed clinically meaningful deterioration.
Researchers developed a glycan identification method based on nanopore single-molecule sensing through derivatization strategy. The method identified different glycan isomers, varying lengths, and branched simple glycans. It revealed cation-π interactions contributing to sensing and paving the way for glycan sequencing
An AI tool has identified people at highest risk for pancreatic cancer, suggesting population screening could expedite diagnosis and improve outcomes. The model predicted disease occurrence with accuracy comparable to genetic sequencing tests, targeting those at elevated risk without relying on family history or genetic mutations.
A new video anomaly detection algorithm (COVAD) uses content-based attention to focus on objects in frames, improving performance over baseline models. The algorithm also refines the memory module for normal behavioral patterns.
A study of over 6.5 million individuals found that those in their 20s and 30s with mental disorders have up to three-fold increased risk of heart attack or stroke. Regular health checks and medication may help prevent these conditions.
A new study recommends routine genetic testing of adults aged 40 and under for three genetic conditions: hereditary breast and ovarian cancer syndrome, Lynch syndrome, and familial hypercholesterolemia. The analysis shows that screening would be cost-effective, with a significant price tag but long-term benefits worth the investment.
Researchers have identified a standard for gallbladder cancer surgery, highlighting its impact on short- and long-term postoperative outcomes. The benchmark group showed significantly better overall survival rates compared to non-benchmark groups.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
A new study led by Mass General Brigham researchers found that 88% of rare disease experts agree on the benefits of genomic sequencing in newborn screening. The experts recommended screening for over 600 genetic conditions, including those associated with hemophilia and retinoblastoma.
A study by Bocconi University researchers found that terrorist attacks and perceived threats from ethnic minorities shifted German Twitter users' language towards the far-right AfD party. Voters rewarded the party at the 2017 election, with no traditional explanatory variable playing a role in the effect.
A new COVID-19 vaccine developed at Rutgers University may provide more durable protection against SARS-CoV-2 and its emerging variants than existing vaccines. The vaccine, dubbed MT-001, uses a unique section of the spike protein as its immunogen, which could potentially elicit broadly neutralizing antibodies.
A sustainable, insoluble, and chiral photonic cellulose nanocrystal patch enables calcium ion (Ca2+) sensing in sweat. The researchers developed a simple method to fabricate CNC-based hydrogels, which exhibit freeze resistance, strong adhesion, good biocompatibility, and high sensitivity to Ca2+.
A study examines how viral infections may alter microbial processes and ecosystem functioning in response to climate change. The research reveals potential gaps in understanding the connections between viruses, warming, and ecosystem functioning.
Scientists at Columbia University create a new class of integrated photonic devices that can convert light from an optical waveguide to an arbitrary optical pattern in free space. The devices simultaneously control all four optical degrees of freedom, paving the way for applications in quantum optics, optogenetics, and holographic disp...
Eight low-cost interventions can prevent an estimated 566,000 stillbirths and 5.2 million babies born preterm or small for gestational age each year. Implementing these interventions in 81 low- and middle-income countries could save the lives of millions of babies and improve long-term health outcomes.
Researchers from TIFR Hyderabad create molecular strainers that can filter particles as small as hydrogen molecules, offering a new basis for designing more efficient filtration processes. The study's findings provide insights into the movement of molecules through sieves and open up avenues for further exploration in industries.
A new study has shown that women are underrepresented in late-breaking cardiovascular clinical trials (LBCT) presented at national meetings. LBCT can have an impact on novel drug and device approvals, intervention indications, and patient management.
Researchers identified a novel high RS gene, SSIIIb, which when combined with the loss-of-function SSIIIa gene, increased RS content in cooked rice. This breakthrough provides genetic resources for breeding high-RS rice varieties, potentially reducing obesity and related health issues.
A retrospective cohort study of U.S. veterans found that adding a GLP1 receptor agonist to diabetes treatment reduced the risk of major adverse cardiovascular events and heart failure hospitalization by about 20% compared to DPP4 inhibitors. The study's findings will aid clinicians in choosing a diabetes drug regimen for older patients.
A new study by University of Waterloo researchers found that Canadian electronic waste (e-waste) has more than tripled in the last two decades, generating close to a million tons in 2020. E-waste generation per person has increased from 8.3 kg to 25.3 kg between 2000 and 2020.
Research highlights unique effects of Asian American subgroups on heart disease and Type 2 diabetes risk. Variations in cardiovascular risk among Asian Americans indicate the need for individual subgroup data to better understand health risks.
A team led by Taylor Hughes and Gaurav Bahl has experimentally realized a theoretical extension of chirality in two dimensions. They constructed a topological circuit network to explore new behaviors predicted by this extended chirality, which manifests as locking between a particle's flow direction and an arrow carried along with it.
Researchers estimate that plugging 14,000 inactive offshore wells could cost up to $30 billion, with over 90% in shallow areas. The majority of costs would come from deeper water wells, but these pose less environmental risk compared to those closer to shore.
Researchers found that many cryptocurrencies take months or years to fix severe security vulnerabilities, with some taking over three years. Bitcoin fixed a vulnerability in just seven days, while others like Litecoin and Dogecoin took 114 days and 185 days respectively.
Recent cluster analyses identify novel risk stratification concepts to better implement precision medicine in clinical practice. Metabolically unhealthy individuals, regardless of weight, face a higher CVD risk compared to obese, metabolically healthy peers.
Researchers have observed stabilization of the Beaufort Gyre in the Arctic Ocean, which could lead to a massive freshwater release. This change could impact the Atlantic Meridional Overturning Circulation (AMOC), potentially disrupting global climate patterns.
Researchers at the University of Minnesota have developed a new diagnostic technique called Nano-QuIC, which significantly improves protein-misfolding detection methods. The method reduces detection times from 14 hours to just four hours and increases sensitivity by a factor of ten.
The study shows that zolbetuximab delays tumor progression and improves overall survival by 25% compared to chemotherapy alone. Patients with CLDN18.2-positive tumors responded well to the treatment, indicating a new clinically relevant biomarker for gastric cancer.
Researchers at Mount Sinai have discovered a previously unknown way in which the brain and immune system interact in multiple sclerosis. They found that the inflammatory protein interleukin-3 (IL-3) coordinates this communication, inciting the recruitment of immune cells to the brain and exacerbating brain inflammation.
Researchers at the University of Gothenburg found that advanced AI systems can lead to excessive suspicion and damage relationships due to uncertainty about conversational partner's intentions. The study highlights the need for transparent AI design, with well-functioning voices that clearly indicate they are synthetic.
Researchers develop a new online learning algorithm that enables the training of larger spiking neural networks with six million neurons. This allows for faster and more efficient processing of tasks such as speech recognition and object detection.
A devastating fungal disease, Fusarium wilt of banana (FWB), caused by Tropical Race 4 (TR4) is spreading in Mozambique, jeopardizing banana production. The Cavendish banana variety is highly susceptible to the disease, and lack of access to on-farm data hinders effective containment.
A specialized weight loss program for Deaf people, designed and led by Deaf individuals, resulted in significant weight loss among participants. The Deaf Weight Wise program focused on lifestyle changes, social support, and cultural relevance, leading to a higher retention rate and better outcomes compared to mainstream programs.
The LY6 gene family has been found to be overexpressed in uterine corpus endometrial carcinoma (UCEC), leading to poor patient survival. Several LY6 genes have been identified as potential tumor-associated antigens and biomarkers for UCEC detection and prognosis.
West Virginia University is leading a $20 million project to elevate neuroscience research, diversify the workforce, and enhance education. The initiative aims to study synaptic plasticity, expand data science education, and promote participation from underrepresented groups.
A new interactive online Fragility Fracture Decision Aid can help clinicians and patients visualize their individual risk of fracture. The Canadian Task Force on Preventive Health Care recommends a "risk assessment–first" screening process for women 65 years and older, centered around shared decision-making with primary care providers.