A study of 55,000 Canadian patients with COVID-19 found that vaccination significantly reduced severe outcomes and burden on healthcare systems. The research also highlights the importance of vaccination in reducing mortality rates associated with COVID-19.
Scientists at Tokyo University of Science created a fracture-resistant alloy through heat-treatment, exhibiting improved elastocaloric properties and resistance to cyclical loads. The Cu-Zn-Al alloy showed significant increases in grain size, leading to enhanced cooling capabilities and paving the way for innovative refrigeration systems.
A new study reveals that climate zones in Kenya are shifting towards hotter and drier conditions, leading to declines in ecological diversity and threatening terrestrial ecosystems. The research highlights the urgent need for adaptation strategies to mitigate the impact of climate change on food security and ecosystem management.
A new MYC inhibitor, Omomyc, has shown promising preclinical results in reducing melanoma tumor growth and metastatic capacity by halting the transcription of genes implicated in cell growth and proliferation. The study demonstrates a good prognostic gene signature in melanoma patients with this approach.
Researchers uncover the critical link between cellular energy levels and mitochondrial damage through protein FNIP1. The study reveals that FNIP1 enables communication between AMPK and TFEB, instructing genes to remove damaged mitochondria and create new ones.
Astronomers have developed a more accurate method to measure the composition of galaxies using data from telescopes on Earth and in space. By correcting for temperature fluctuations, researchers found that the result from collisionally excited infrared lines is still 50% less than that from recombination line method.
Researchers create patch that uses ultrasound to deliver drugs directly to the site of need, reducing systemic toxicity and improving local drug delivery. The device shows promise for treating a range of skin conditions and could also be adapted for hormone delivery and cancer treatment.
Researchers have identified a possible way to help break the cycle between sleep disturbances and Alzheimer's disease. A small study found that people who took a sleeping aid experienced a drop in key Alzheimer's proteins.
Conclusive evidence of chicken breeding in the Yayoi period of Japan has been discovered at the Karako-Kagi site. The study found that chickens were bred in the area during the middle Yayoi period, around 381-204 BCE, providing clear evidence that breeding occurred on the Japanese archipelago.
Signs of common infections in middle-aged and older adults were associated with poorer performance on a test of global cognitive function. Elevated antibodies to herpes simplex virus type 1 or cytomegalovirus were individually linked to worse performance, with more positive tests related to multiple infections showing stronger effects.
A new neural network, CD-GAN, uses common sense knowledge to enhance text descriptions and generate images of birds at three resolution levels. The system achieved competitive scores against other image generation methods, producing vivid and natural-looking images.
Research by Professor Mila Vulchanova reveals associations between language development and cognitive skills in children. Non-verbal tests show that severity of language difficulties can be predicted based on cognitive markers, supporting the importance of measuring both verbal and non-verbal skills.
Jefferson Lab achieves gold-level GreenBuy Award for fiscal year 2022, attaining superior recognition for its sixth consecutive year. The lab prioritizes environmental sustainability through initiatives such as electric vehicle charging stations and reusable water fountains.
Researchers at Gladstone Institutes have made a groundbreaking discovery about how neurons consume and metabolize glucose, a process crucial for maintaining normal energy levels. The study found that neurons rely on glycolysis to break down glucose, and its disruption can lead to severe learning and memory problems in mice.
A research team developed an AI approach to automate crop head counting, using synthetic annotated datasets to train deep learning models. The technique demonstrates improved accuracy and can be applied to other applications with dense repeating patterns.
Researchers identify critical drought thresholds that impact vegetation growth and nonlinear responses to soil moisture stress. The study reveals two distinct phases of vegetation response, with a well-defined threshold beyond which vegetation becomes vulnerable to drought intensification.
Horodyskia, a fossil with uniform size and spacing, is among the oldest multicellular macroorganisms. Its fossils suggest coenocytism and simple clonal coloniality, challenging previous interpretations.
A recent study identified over 182,000 small seismic events in South Korea, with 135,000 related to mining explosions. The researchers used machine learning techniques to analyze data from 421 seismic stations and found distinct patterns that allowed them to distinguish between microseismic events and earthquakes.
A team of researchers has created a new map of candidate extracellular RNA binding proteins and their associated RNAs in various bodily fluids. This resource was developed using computational analyses and validated experimentally, providing a foundation for understanding exRNA biology and its potential use in liquid biopsies.
A Brazilian study found that pediatric ICU workers experienced high levels of burnout, anxiety, depression, and post-traumatic stress disorder during the COVID-19 pandemic. Despite high job satisfaction, organizational support can help mitigate psychological distress.
A new review paper highlights the potential of fungal biotechnology to advance various industries. By manipulating fungal genomes, researchers can develop bioinformatic tools and create sustainable biomaterials, such as machine learning algorithms for predicting mycological patterns or fungal batteries.
Researchers from University of Warsaw and Utrecht University observed the Brazil nut effect in a mixture of charged colloidal particles without external energy. The phenomenon involves heavier particles rising to the top due to repulsion forces, with potential applications in geology, soft matter physics, and industry.
The Florida Atlantic University (FAU) WAVES program aims to address the shortage of mental health service providers in high-need schools. With a five-year, $6 million grant from the US Department of Education, FAU will train 119 school counselors to reduce barriers to degree completion and improve student outcomes.
Researchers have found a new target and drug combination that appears to stop the destruction of vision in premature newborns. By blocking ACAT1, an enzyme that converts cholesterol into smaller pieces, scientists can prevent the formation of leaky blood vessels and inflammation in the retina.
Researchers developed a gene signature called CisSig to predict cancer patients' response to cisplatin. The approach aims to overcome the obstacle of interpreting gene signatures in the human body and has been validated in muscle-invasive bladder cancer patients.
A study published in Communications Biology suggests that gut bacteria's digestion of fucose sugar may be behind weaker immune responses to the COVID-19 mRNA vaccine. Individuals with lower T-cell responses had higher expression of genes FOS and ATF3, which are part of a larger group controlling T-cell survival and activity.
Researchers discovered how yeast cells transform their cytoplasmic biophysical properties to return to vegetative growth. The study sheds light on the mechanisms behind spore dormancy and its exit.
A new study at Stanford University found a previously unknown cellular pathway for clearing misfolded proteins from the nucleus. This pathway could be a target for therapies of age-related diseases like Alzheimer's, Parkinson's, and Huntington's. Cells use this pathway to manage misfolded proteins in both the cytoplasm and nucleus.
A new study found that individuals who experienced childhood adversity, such as poverty, illness, or death in the family, are at higher risk of developing type 2 diabetes in early adulthood. The study, conducted on a large population-based cohort, reveals that these adverse experiences can lead to increased inflammation, insulin resist...
A recent study published in JAMA Oncology reveals that disparities in cancer care are linked to differences between clinicians' and patients' identities. Younger, lower-income minorities were disproportionately affected by delayed care due to these identity differences.
The study of nematodes' body size can inform scientists' understanding of cellular growth, with the goal of discovering novel genes that control cell size and potential targets for cancer treatment. Nematodes are a model species for biological studies due to their quick growth rate and ability to produce hundreds of eggs.
Researchers at Chalmers University have successfully used a quantum computer to calculate the intrinsic energy of small molecules, demonstrating a new method called Reference-State Error Mitigation. This breakthrough has the potential to advance the boundaries of chemical calculations and simulate complex chemical processes.
A new drug, atogepant, has shown promise in preventing migraines for people who have had no success with other preventive drugs. In a preliminary study, participants taking the drug experienced fewer days with migraine compared to those taking a placebo.
Researchers found that an extra copy of a gene controlling synapse formation causes excessive inhibitory signaling in the brain of mice with Down syndrome. This may contribute to conditions such as autism, epilepsy, and bipolar disorder.
Researchers have developed a new method using co-thermal in-situ reduction of inorganic carbonates to produce high-purity CO with a selectivity of 95.8%, reducing carbon-dioxide emission and offering potential for green hydrogen production.
A team of researchers has identified a peptide that disrupts the interaction between alpha-synuclein and a protein subunit of cellular machinery, reducing its levels and promoting cell clearance. The study suggests a new therapeutic avenue for Parkinson's disease and other neurodegenerative conditions.
A novel model, TGFS, simulates the response of fruit growth and quality to environmental factors and cultivation practices. The study found that reducing nitrogen and water input can increase tomato fresh weight by 27.8-36.4% while increasing soluble sugar concentration up to 10%. This provides a promising tool for optimizing N and wat...
A new PANDA-project aims to develop and test an ear-EEG device that can screen patients for Alzheimer's and Parkinson's diseases. The technology measures brain electrical activity and sleep patterns, with the goal of identifying early signs of the diseases and enabling earlier diagnosis.
The rate of suspected suicide attempts by poisoning among children and adolescents ages 10-19 increased 30% during the COVID-19 pandemic compared to 2019. The most common substances involved were acetaminophen and ibuprofen, highlighting the need for comprehensive approach to suicide prevention.
Andrew Lupini, a scientist at Oak Ridge National Laboratory, has been elected Fellow of the Microscopy Society of America. He made significant contributions to aberration correction in scanning transmission electron microscopy, improving resolution and advancing the field.
Scientists have created a method to produce synthetic spider silk with eightfold higher yields than previous methods, making it a promising material for sustainable clothing production. The new silk fibers retain the desirable properties of enhanced strength and toughness while being lightweight.
Researchers have found that the subfornical organ senses circulating parathyroid hormone (PTH) and modulates its peripheral level. PTH then alters bone metabolism and remodeling, highlighting a critical role of the brain-parathyroid-bone axis in maintaining bone homeostasis.
Researchers at Moffitt Cancer Center have identified a critical pathway in the development of MYC-driven lymphoma, involving the chemical modification of eIF5A with hypusine. Inhibiting this process prevents lymphoma development and progression in mouse models, offering new therapeutic strategies.
A study by University of Cologne researchers found that 25-35% of permafrost's organic carbon is bound to mineral particles, making it harder for microorganisms to utilize. This complex binding process affects the release of greenhouse gases from thawing permafrost.
A new PSMA PET scoring system, the tumor-to-salivary gland ratio (PSG score), can predict patient response to <sup> 177 </sup> Lu-PSMA therapy. Patients with high PSG scores had longer PSA progression-free survival and overall survival rates.
A study by researchers at the University of Michigan found that an extra copy of the DSCAM gene in mice with Down syndrome causes improper neuron development and excessive inhibition. This discovery suggests modulation of DSCAM expression levels could be a viable therapeutic strategy for repairing synaptic deficits seen in Down syndrome.
Cedars-Sinai investigators have discovered a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using human induced pluripotent stem cells. The new approach uses cells derived from iPSCs that are renewable, scalable, and can delay disease progression in rodents.
A recent study from Aarhus University found that music used for studying and sleeping share similar characteristics, such as slow tempo and repetitive patterns. The study suggests that these similarities can be attributed to the calming effects of the music on the brain, creating a conducive environment for both tasks.
A four-year field experiment in Estonia reveals that recycling phosphorus-rich lake sediments can sustain grass biomass yield and provide essential nutrients. However, the study also highlights potential environmental risks associated with sediment application methods.
A new study finds that economic growth is insufficient to eliminate dog-mediated rabies, highlighting the need for targeted interventions such as improved pet ownership and education in vulnerable communities. The research uses data from over 100 countries to show a strong association between poverty and higher death rates from rabies.
Researchers study how choice of network framework affects synchronization, finding that hypergraphs promote easier synchronization than simplicial complexes. The choice of representation can influence the outcome, suggesting structural heterogeneity is key to understanding collective dynamics.
A new study on nematode worms reveals that they react to cannabinoids in the same way as humans, increasing hunger for favorite foods and decreasing hunger for non-favored foods. The discovery emphasizes the commonality of cannabinoid effects across species.
A new study by Columbia University Mailman School of Public Health finds that water arsenic levels are associated with higher urinary arsenic among the U.S. population, especially in public water supplies in the West and South regions. The researchers found that private well users and those in public water systems have higher urinary a...
Researchers developed a method to heal and recycle garnet electrolytes with Li dendrite penetration through heat treatment, increasing ionic conductivity and relative density. The recycled pellets showed improved densification and suppressed Li dendrite penetration, enabling higher critical current density.
Researchers at POSTECH have successfully developed perovskite solar cells using novel additives, achieving high power conversion efficiency and fill factor. The use of alkylammonium formats enables the elimination of surface defects, leading to more stable and efficient solar cells.
The SuperBIT telescope has begun capturing high-resolution images of the Universe on its first research flight. It is investigating the mystery of dark matter, which is thought to be made up of particles that can bounce off each other during galaxy collisions.
The team successfully entangled two qudits with unprecedented performance, enabling faster and more robust quantum computing. This breakthrough could lead to significant advancements in fields like chemistry and physics.
The study found associations between prenatal maternal stress life events and adverse neurodevelopmental outcomes in offspring. DNA methylation likely plays a role in these associations. The research provides new insights into how the fetal environment influences neurodevelopment, metabolism and immunologic functions.
A preclinical study suggests that abnormal immune activity in astrocytes is sufficient to cause cognitive deficits in dementia. Astrocytes produce excessive immune messengers, activating neurons and leading to hyperactivity.
TRIO Pharmaceuticals is developing a proprietary platform of dual-action tumor immunity-enhancing drugs aimed at treating cancers with high unmet medical needs. The company's innovative approach selectively eliminates immunosuppressive cells, enhancing antitumor activity.