Research published in Science Translational Medicine found that gum disease may trigger an immune response in patients with rheumatoid arthritis. Breaches in damaged gums allow oral bacteria to seep into the bloodstream, activating an immune response that targets the body's own proteins and causes flare-ups.
Researchers at Tokyo Medical and Dental University have found that a specific lipid, alpha-tocopherol, increases the uptake of antisense oligonucleotides in the stroke-lesioned brain. This delivery method has potential for targeted protein expression after a stroke.
Deep-sea scientists have discovered extensive, ancient coral reefs within the Galápagos Marine Reserve, supporting a diverse array of marine life. The reefs are pristine and teeming with life, offering insights into global significance and potential as 'canaries in the mine' for other reefs.
Researchers at Tokyo Institute of Technology developed a simple sol-gel method to synthesize highly pure bifunctional solid acid-base catalysts with desirable properties. The new method produces SrTiO3 nanoparticles with high surface area, showing 10 times higher catalytic activity than commercially available titanates.
Researchers develop 'Human Appropriation of Net Primary Production' (HANNP) metric to accurately estimate human impacts on the earth's systems. This new approach starts at the source, measuring the total biomass produced through photosynthesis and comparing it to what humans have appropriated for their own use.
A new machine learning study found that habit formation varies in time for different behaviors, such as gym-going and hand-washing. The study analyzed data from over 30,000 gymgoers and 3,000 hospital workers, revealing factors like past behavior and time since last visit played significant roles.
A new study published in Proceedings of the National Academy of Sciences documents the dynamic nature of student discipline during an academic year. Schools with high racial disparity see discipline rates for Black students increase faster as the semester continues.
A new study evaluated the effect of hybrid-closed loop Control-IQ technology on time-in-range, mean glucose, hyperglycemia metrics, and HbA1c levels. The technology showed significant improvements, particularly in participants with poor baseline glycemic control.
The ESMO Breast Cancer Congress 2023 will feature presentations on the latest clinical data on breast cancer treatments, including new drugs and technologies such as antibody drug conjugates and checkpoint inhibitors. The congress will also explore personalized therapeutic approaches for better outcomes in triple-negative breast cancer.
A new Twitter analysis reveals that medical dramas like New Amsterdam, Chicago Med, and Grey's Anatomy influenced hundreds of people's thoughts on vaping dangers. The study found that nearly half the tweets commented on the realism of the storylines, with some even expressing intention to quit vaping.
Researchers at Duke University have successfully improved the resolution of Magnetic Resonance Imaging (MRI), capturing images of a mouse brain with unprecedented sharpness. The breakthrough allows for the visualization of microscopic details within the brain, enabling new insights into neurodegenerative diseases such as Alzheimer's an...
A team of UCF College of Medicine researchers created a digital topographical map of the cardiac sympathetic neural network, controlling heart rate and 'fight-or-flight' response. The map will guide treatments like neuromodulation therapy for hypertension, sleep apnea, and heart failure.
Researchers at The Mount Sinai Hospital have created versatile disease models of acute myeloid leukemia (AML), allowing for accurate study of the cancer's progression and response to drugs. These models, derived from induced pluripotent stem cells, can mimic different stages of AML and are nearly identical to those found in patients.
A phase 3 clinical trial shows that motixafortide combined with standard therapy increases the number of stem cells that can be harvested in over 92% of patients. The combination also enhances the collection of primitive stem cells, which have greater potential for reconstituting blood cell types.
Researchers are studying the impact of climate change on basement pathogens, moisture, and air quality in urban environments, focusing on Black Americans in Pittsburgh. The study aims to document conditions and understand the link between weather events and cumulative health impacts for residents across the adult lifespan.
A new study at Umeå University reveals that tick-borne encephalitis virus infects distinct brain cell types and regions depending on the immune system's activation status. The researchers mapped the virus's behavior in the brain, identifying specific areas and cells infected by TBE virus.
A personalized mRNA-based cancer vaccine, mRNA-4157/V940, improves recurrence-free survival in patients with high-risk melanoma when combined with pembrolizumab. The clinical benefit is observed regardless of tumor mutational burden status.
A recent study found that the COVID-19 pandemic significantly increased mortality rates among people with intellectual disabilities, with a disparity of five times higher than in the general population. This increase was not limited to COVID-19-related deaths but also affected other conditions such as cancer and mental health disorders.
A recent study found that immunotherapy alone resulted in a 89% favorable treatment response rate for patients with desmoplastic melanoma. This suggests that combination therapies may not be necessary for these patients, reducing the risk of toxicity.
Researchers use 3D imaging technology to study Tully monsters and reject vertebrate hypothesis, but uncertainty remains about its exact classification as an invertebrate chordate or protostome. The study sheds light on the challenges of piecing together Earth's evolutionary history and highlights the importance of Mazon Creek fossils.
Researchers found that crowdsourced listeners can accurately assess voice quality for people with Parkinson's disease, supporting the use of crowdsourcing to evaluate speech samples. The study replicated a previous finding that intensive voice and articulation therapies improve voice quality.
A recent Italian study has shed light on how the gut microbiota evolves in infants from birth to three months. The research found that the diversity of gut bacteria increases rapidly in the first few months, with some bacterial families exhibiting marked changes in abundance over time.
Rapid metagenomics can provide accurate results within just 6 hours of knowing bacteria are growing in a blood sample, allowing for effective treatment 18-42 hours earlier than conventional laboratory tests. Metagenomic sequencing has the potential to save lives and better manage the use of antibiotics by rapidly identifying antimicrob...
Researchers developed a new imaging technique that visualizes the interaction between reactive astrocytes and neurons in the brain, revealing a potential breakthrough in Alzheimer's disease diagnosis and treatment. The study found that acetate promotes reactive astrogliosis, leading to dementia, and offers a new target for AD treatment.
A new tool has been developed to measure customer aggression in the retail sector, which can lead to emotional exhaustion and job stress among employees. The scale identifies four types of aggressive behaviors, including being ignored or having fake negative reviews posted online.
A recent clinical trial found that nearly 90% of patients with unresectable desmoplastic melanoma responded to treatment with pembrolizumab. The immunotherapy drug showed impressive results in both treatable and inoperable cases, suggesting a promising treatment option for this rare form of skin cancer.
A novel technique of three-dimensional (3D) slice-to-volume (SVR) MRI allows for precise delineation and measurement of the fetal optic pathway (FOP). The study found that FOP was visualized in 9 cases in unprocessed fetal MRIs, compared to 55 cases in 3D SVR images.
A new target for drug-resistant ovarian cancer has been identified through a preclinical study led by researchers at Penn Medicine. An antibody-drug conjugate targeting B7-H4 showed significant anti-tumor activity and sustained response in treatment-resistant models.
A recent study published in Nature Communications reports finding Poly-Chlorinated Biphenyls (PCBs) at the bottom of the Atacama Trench in the Pacific Ocean. The discovery highlights the persistence of PCBs, a toxic substance banned globally since the 1970s, in deep-sea environments.
A study published in Brain found that disconnecting nerve pathways in the brain can lead to improved seizure freedom in patients with frontal lobe epilepsy. The research, involving 47 patients, revealed that cutting these connections resulted in 88% of patients being seizure-free after three years.
A new CLEM approach uses small gold nanoparticles as single probes visible in both LM and EM with high contrast and photostability. This method detects individual nanoparticles with nanometric precision, enabling accurate correlative microscopy workflows without the need for unstable fluorophores or additional fiducial markers.
A region-wide study of over 50,000 patients with atrial fibrillation found that statin users had a significantly lower risk of stroke and transient ischemic attack compared to non-users. Long-term statin use was associated with greater protection against stroke than short-term use.
A new study found that long COVID's impact on public health systems is likely due to the volume of those infected with SARS-CoV-2, rather than the severity of symptoms. In a highly vaccinated population, adults with Omicron had similar ongoing symptoms and functional limitations as those with influenza.
New research shows that COVID-19 vaccines have directly saved at least 1,004,927 lives across Europe between December 2020 and March 2023. The majority of these lives were saved in people aged 60 years and older, with the first booster accounting for almost two-thirds of lives saved.
A new vaccine type, mRNA-4157/V940, added to immunotherapy significantly reduced melanoma recurrence and death rates. The combination was found to be effective in 22.4% of patients compared to 40% without the vaccine.
Dr. Erik K. Paulson, MD, chair of Duke University's radiology department, has been elected as the 123rd President of ARRS for a one-year term starting April 2023. He succeeds Gary J. Whitman, who served from 2022 to 2023.
Researchers found that high-dose VE303 prevented recurrent C. difficile infection compared to placebo, suggesting a potential new treatment approach. A larger phase 3 study is needed to confirm these findings.
Denmark has seen a significant surge in strep A infections, particularly among the elderly, since late 2022. The new M1 subvariant is responsible for 30% of cases and may be contributing to the outbreak's severity.
Researchers at Shinshu University developed a microfluidic device using acoustic focusing to collect microplastics from water. The device achieved a 105-fold enrichment of MPs, making it an efficient solution for removing microplastics from laundry and industrial wastewater.
Researchers found that remnants of ancient retroviruses in the human genome can be targeted by antibodies to improve lung cancer treatment. The study suggests that boosting antibody responses could help predict patient response to immunotherapy and lead to improved outcomes.
The European Society of Cardiology has published a detailed guidance on the natural pacemaker method, which mimics the heart's normal function. This method can benefit approximately half of the 1.4 million patients who will receive a pacemaker in 2023, particularly those with atrioventricular block or left bundle branch block.
Infections caused by Group A Streptococcus (GAS) decreased by 80% as COVID-19 lockdown took effect and remained low until March 2022, when they increased 18% a month to surpass pre-COVID levels.
A major UK study has discovered that disturbed sleep patterns in patients hospitalised with COVID-19 were likely a driver of breathlessness. The study found that 62% of participants experienced sleep disruption, which persisted for at least 12 months and was associated with anxiety and muscle weakness.
The highest incidence of invasive Group A Streptococcus (GAS) disease has shifted from the most deprived groups to the second most affluent group in the UK, according to new research. The emm1 strain, which causes severe disease, was more common in 2022 than previous years.
Researchers identified protective drugs that shield two abundant gut bacterial species without compromising antibiotic effectiveness against disease-causing bacteria. The study found a novel combination of antibiotics with antidote drugs, such as dicumarol and tolfenamic acid, which protected the gut microbiome and maintained antibioti...
A study of matched counties found that those reopening with in-person instruction experienced higher COVID-19 case incidence six and eight weeks later. County-level COVID-19 incidence increased at these time points compared to virtual instructional models.
Researchers found that individuals within two Xiongnu elite cemeteries exhibited extremely high genetic diversity, confirming the empire as a multiethnic entity. High status individuals showed lower genetic diversity, while those of lower status had higher heterogeneity, suggesting a diverse origin pool.
Researchers have identified hundreds of genes with significant stroke-driven changes and likely relevance in human strokes. The study found alterations in sphingolipid production, which are involved in regulating blood vessels, and pinpointed several molecular pathways that can be targeted for stroke treatment.
EACVI 2023 is a patient-focused, multimodality imaging event that showcases the latest advancements in echocardiography, CMR, nuclear cardiology, and cardiac CT. The congress highlights novel treatments for long COVID, new technologies such as robotic imaging, fusion imaging, and AI.
A new study from Boston Medical Center found that offering medications for opioid addiction in jails leads to a significant decrease in overdose deaths. Treating opioid addiction during incarceration is also cost-effective and saves lives.
The American College of Medical Genetics and Genomics (ACMG) has published a statement addressing factors that contribute to bias in clinical genetic testing. The statement highlights three main areas: environmental, clinical, and technical biases, which affect health equity for individuals from historically marginalized populations.
Researchers at Tohoku University developed a method for creating molecular robots using artificial multicellular-like bodies made of phospholipids and synthetic surfactants. The technique allows for the assembly of micron-sized compartments that can combine to form heterogeneous structures with multiple functionalities.
A novel robotic bronchoscope system is developed to diagnose and biopsy pulmonary lesions, enabling early detection of lung cancer. The system features a flexible end effector and navigation system for accurate positioning and visualization.
Tumors with low PD-L1 levels use genetic strategies like MYC activation to avoid immune attack, but this can be predicted by monitoring for MYC status. The study's findings could lead to new clinical trials assessing MYC status as a marker for selecting patients for immunotherapy.
A study of 1,618 US counties found that greater representation of Black primary care physicians is associated with improved survival-related outcomes for Black individuals. The findings suggest investments to build a more representative PCP workforce nationally may improve population health and reduce disparities.
Researchers developed a novel approach that promotes bone regeneration in mice without implantation of bone tissue or biomaterials. By carefully stretching the skull along its sutures, they activated skeletal stem cells that reside in these wiggly seams, repairing damage to the skull that would not have healed on its own.
A new study from Johns Hopkins Bloomberg School of Public Health suggests that chronic health conditions such as type 2 diabetes and asthma are greatly undertreated in the US jail and prison population. The researchers found significant disparities in treatment rates compared to the general US population, with incarcerated individuals ...
Researchers found that senescent cells promote regeneration by secreting factors that stimulate nearby muscle tissue to produce new muscle cells. The presence of these cells enhances the regeneration process, allowing salamanders to grow lost limbs in a matter of weeks.
A study found that savanna species in Cerrado biome produce significantly more bark than forest species to protect against frequent fires. This adaptation enables them to survive and regenerate after burning, highlighting the importance of controlled fire management in these ecosystems.
Researchers at the University of Arizona developed an algorithm to measure wind by analyzing water vapor movements, providing a novel solution for forecasting extreme weather events. The method uses data from two operational satellites of NOAA and achieves higher resolution than traditional methods.