A personalized mRNA-based cancer vaccine, mRNA-4157/V940, improves recurrence-free survival in patients with high-risk melanoma when combined with pembrolizumab. The clinical benefit is observed regardless of tumor mutational burden status.
A recent study found that the COVID-19 pandemic significantly increased mortality rates among people with intellectual disabilities, with a disparity of five times higher than in the general population. This increase was not limited to COVID-19-related deaths but also affected other conditions such as cancer and mental health disorders.
A recent study found that immunotherapy alone resulted in a 89% favorable treatment response rate for patients with desmoplastic melanoma. This suggests that combination therapies may not be necessary for these patients, reducing the risk of toxicity.
Researchers use 3D imaging technology to study Tully monsters and reject vertebrate hypothesis, but uncertainty remains about its exact classification as an invertebrate chordate or protostome. The study sheds light on the challenges of piecing together Earth's evolutionary history and highlights the importance of Mazon Creek fossils.
Researchers found that crowdsourced listeners can accurately assess voice quality for people with Parkinson's disease, supporting the use of crowdsourcing to evaluate speech samples. The study replicated a previous finding that intensive voice and articulation therapies improve voice quality.
A recent Italian study has shed light on how the gut microbiota evolves in infants from birth to three months. The research found that the diversity of gut bacteria increases rapidly in the first few months, with some bacterial families exhibiting marked changes in abundance over time.
Rapid metagenomics can provide accurate results within just 6 hours of knowing bacteria are growing in a blood sample, allowing for effective treatment 18-42 hours earlier than conventional laboratory tests. Metagenomic sequencing has the potential to save lives and better manage the use of antibiotics by rapidly identifying antimicrob...
Researchers developed a new imaging technique that visualizes the interaction between reactive astrocytes and neurons in the brain, revealing a potential breakthrough in Alzheimer's disease diagnosis and treatment. The study found that acetate promotes reactive astrogliosis, leading to dementia, and offers a new target for AD treatment.
A new tool has been developed to measure customer aggression in the retail sector, which can lead to emotional exhaustion and job stress among employees. The scale identifies four types of aggressive behaviors, including being ignored or having fake negative reviews posted online.
A recent clinical trial found that nearly 90% of patients with unresectable desmoplastic melanoma responded to treatment with pembrolizumab. The immunotherapy drug showed impressive results in both treatable and inoperable cases, suggesting a promising treatment option for this rare form of skin cancer.
A novel technique of three-dimensional (3D) slice-to-volume (SVR) MRI allows for precise delineation and measurement of the fetal optic pathway (FOP). The study found that FOP was visualized in 9 cases in unprocessed fetal MRIs, compared to 55 cases in 3D SVR images.
A new target for drug-resistant ovarian cancer has been identified through a preclinical study led by researchers at Penn Medicine. An antibody-drug conjugate targeting B7-H4 showed significant anti-tumor activity and sustained response in treatment-resistant models.
A recent study published in Nature Communications reports finding Poly-Chlorinated Biphenyls (PCBs) at the bottom of the Atacama Trench in the Pacific Ocean. The discovery highlights the persistence of PCBs, a toxic substance banned globally since the 1970s, in deep-sea environments.
A study published in Brain found that disconnecting nerve pathways in the brain can lead to improved seizure freedom in patients with frontal lobe epilepsy. The research, involving 47 patients, revealed that cutting these connections resulted in 88% of patients being seizure-free after three years.
A new CLEM approach uses small gold nanoparticles as single probes visible in both LM and EM with high contrast and photostability. This method detects individual nanoparticles with nanometric precision, enabling accurate correlative microscopy workflows without the need for unstable fluorophores or additional fiducial markers.
A region-wide study of over 50,000 patients with atrial fibrillation found that statin users had a significantly lower risk of stroke and transient ischemic attack compared to non-users. Long-term statin use was associated with greater protection against stroke than short-term use.
A new study found that long COVID's impact on public health systems is likely due to the volume of those infected with SARS-CoV-2, rather than the severity of symptoms. In a highly vaccinated population, adults with Omicron had similar ongoing symptoms and functional limitations as those with influenza.
New research shows that COVID-19 vaccines have directly saved at least 1,004,927 lives across Europe between December 2020 and March 2023. The majority of these lives were saved in people aged 60 years and older, with the first booster accounting for almost two-thirds of lives saved.
A new vaccine type, mRNA-4157/V940, added to immunotherapy significantly reduced melanoma recurrence and death rates. The combination was found to be effective in 22.4% of patients compared to 40% without the vaccine.
Dr. Erik K. Paulson, MD, chair of Duke University's radiology department, has been elected as the 123rd President of ARRS for a one-year term starting April 2023. He succeeds Gary J. Whitman, who served from 2022 to 2023.