A recent study has investigated how cells divide in fibrous environments, revealing the impact of extracellular matrix shape and fiber number on mitotic errors. By re-creating and studying lattice structures, researchers have gained a deeper understanding of cellular dynamics and its connection to disease biology.
Research using mice models of Alzheimer's disease found that deep brain stimulation activated only a small population of new neurons, restoring cognitive and non-cognitive functions. The study also identified protein pathways involved in improved memory performance and plaque clearance.
A new study finds significant variation in life-threatening maternal complications among Medicaid enrollees, with rates differing by state and race-ethnicity. The five states with the highest rates of severe maternal morbidity included D.C., California, Nevada, New Jersey, and New York.
Researchers at the University of Washington School Medicine have engineered stem cells that do not generate dangerous arrhythmias. These 'MEDUSA' cardiomyocytes can engraft in the heart, mature into adult cells and beat in sync with natural pacemaking without generating dangerous heart rates.
A study of high school students in Brazil found that excessive smartphone use is associated with thoracic spine pain (TSP), affecting girls more than boys. The research highlights the importance of health education programs to combat this issue and promote physical activity and good posture.
A decade-long study suggests Indigenous-managed forests can absorb up to 26,000 metric tons of dangerous pollutants from wildfires each year, preventing an estimated 15 million cases of respiratory and cardiovascular disease. This absorption saves Amazon cities US$2 billion a year in healthcare costs.
A fasting diet that focuses on early eating has been shown to reduce the risk markers of type 2 diabetes. Researchers found that participants who followed a time-restricted, intermittent fasting diet experienced greater tolerance to glucose and reduced blood lipids compared to those on a daily, low-calorie diet.
New research suggests the Marinoan Ice Age, which created glaciers from pole to pole 635 million years ago, had patches of open water in mid-latitude seas. This finding provides evidence that life could have persisted during this period, potentially influencing the carbon cycle and climate.
Researchers have identified new ways to treat antibiotic-resistant TB by targeting unique weaknesses in the bacteria. The study found that certain drug-resistant strains are more sensitive to antibiotics targeting unrelated pathways, paving the way for faster treatment and reduced resistance.
A new pesticide exposure test has been developed to help protect the health and safety of agricultural workers, particularly those in the emerging cannabis industry. The test uses a bio solid-phase microextraction method that can detect ultra-trace levels of pesticide residues in human blood plasma.
New research suggests a way to ward off age-related weight gain by stimulating beige fat cells. Beige fat has thermogenic properties that can reduce blood sugar and fatty acids causing heart disease. The study identifies a specific signaling pathway responsible for suppressing beige fat formation in older mice.
Researchers from the University of Cambridge have built a super-sized nanocage that could deliver larger drug cargoes, outperforming existing nanocages in terms of internal volume and stability.
The SWELL project focuses on recovering non-metallic components, including electrolytes, from spent lithium-ion batteries. This can lead to a significant increase in battery material sustainability.
Researchers at Penn State found that broccoli's aryl hydrocarbon receptor ligands bind to a protein in mice, promoting gut health and reducing disease. This interaction activates various activities that affect intestinal cell functions, leading to improved gut barrier function and resilience.
Research explores the complex relationship between droughts, food security, and conflict in Central America. The study finds that decreases in water availability play a major role in conflict insurgences, while stable conditions of peace are more influenced by favorable socio-economic conditions.
A new study reveals how ferroelectric coatings improve all-solid-state lithium batteries by reducing space charge layers and enhancing lithium transportation. The coatings made from guanidinium perchlorate increase battery capacities to near-liquid lithium-ion levels.
Researchers at Hokkaido University and Kyushu University have developed a technique to synthesize potential molecular switches from anthraquinodimethanes (AQDs), a group of overcrowded organic molecules. The synthesized derivatives can stably form twisted and folded isomers, as well as other isomeric forms, in different solvents.
Researchers tracked female bushcrickets' movement and found they tend to fly more frequently and longer distances than males, making them more vulnerable to bats. This contradicts the assumption that males take higher risks in search of mates.
Enoblituzumab, a monoclonal antibody, is safe in men with aggressive prostate cancer and may induce clinical activity against cancer throughout the body. The drug targets B7-H3 protein overexpressed on prostate cancer cells, blocking immune system inhibition and triggering tumor cell destruction by activating immune cells.
A study of California's high-elevation Sierra Nevada squirrels reveals that climate is just one factor influencing their niche. Squirrel species use different spaces due to variations in climate, topography, and land cover, such as meadows or forests.
Researchers investigated the impact of COVID-19 on oocyte quality and embryo development in a prospective cohort study. The study found that SARS-CoV-2 infection did not have a clear negative effect on oocyte quality or embryo development, with some women experiencing improved outcomes after infection.
Researchers found that underutilized asset building programs could be a solution to help low income families build wealth. The study showed that incorporating these programs into healthcare may make them more accessible to families in need.
A new study found that despite awareness of COVID-19 risks, bushmeat consumption remained unchanged in rural communities along the Kenya-Tanzania border. Education levels played a critical role in understanding disease transmission. Increased food costs caused by regulations led to increased bushmeat consumption.
Researchers at Carnegie Mellon University developed Pix2pix3d, a machine learning tool that generates realistic 3D representations of 2D sketches. The tool allows users to create customized 3D models for various applications, including video games and consumer products.
Researchers have identified a biomarker signature that can predict which patients with kidney cancer will respond well to immunotherapy. The signature is based on the number of immune cells in and around tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1.
The MSU facility will provide several thousand additional hours of chip testing capacity annually, addressing the US national shortfall in advanced microelectronics testing. The K500 cyclotron will be used to test electronic components for space-based applications where levels of ionizing radiation are higher than at Earth's surface.
Researchers discovered that viruses that infect bacteria and archaea in deep-sea hydrothermal vents share a common immunological memory, allowing symbiotic microbes to defend against the same virus. This challenges conventional wisdom on virus-host interactions, revealing a more nuanced relationship between these microorganisms.
Researchers at Osaka Metropolitan University analyzed the collection of leptons to demonstrate that the lepton flavor mixings are large in the random mass matrix model. The study found that the measure of the matrix should obey the Gaussian distribution, which supports the experimental results for the seesaw model.
A Brown-led research team found that four dementia-care interventions saved between $2,800 and $13,000 in societal costs and reduced nursing home admissions while improving quality of life. Non-drug interventions have been shown to be effective in clinical trials and can help people with dementia stay safely at home longer.
A team of researchers has developed a highly sensitive imaging method to detect heavy metals like cadmium in cocoa beans. The study found that cadmium accumulates primarily in the outer shell of the bean and can be reduced through improved processing steps, which could minimize exposure.
Partners of colorectal cancer survivors experience long-term financial toxicity leading to worse health-related quality of life. Multilevel interventions are needed to address individual and systemic factors affecting both patients and their partners.
Researchers have developed a new method called Nano-tRNAseq to measure both the abundance and modification of tRNA molecules in a single step. This technology has significant advantages over conventional techniques, offering rapid, cost-effective, and high-throughput analysis with single-molecule resolution.
Researchers at the University of Bath have successfully created antimicrobial ferroelectric composite materials using a novel 3D printing process. These materials can eradicate E coli bacteria within 15 minutes, with potential applications in heart valves, stents, and bone implants.
Researchers at the University of Tokyo have discovered the 3D structure of TnpB, a protein involved in genome editing and a probable precursor to the CRISPR-Cas12 enzyme. The study reveals how TnpB recognizes and cuts DNA using a unique pseudoknot shape similar to that found in guide RNAs of Cas12 enzymes.
A study published by the University of Washington found that a community-based prevention system called Communities That Care (CTC) reduced handgun carrying among adolescents growing up in rural areas. By the 12th grade, adolescents in CTC communities were 24% less likely to report carrying a handgun than those in control communities.
A new study found that SARS-CoV-2 presence on people's hands and frequently touched household surfaces significantly contributes to the spread of COVID-19. The research suggests that frequent handwashing, regular surface disinfection, and physical distancing can curb the virus's transmission.
Researchers have discovered that a characteristic nucleosome structure is essential for replication initiation at certain genome locations. This regular chromatin arrangement allows the replication machinery to access the DNA, enabling cells to divide correctly.
Researchers analyzed 30 healthy pancreata from diverse donors and found PanIN lesions in 18 cases, which had distinct microenvironments compared to normal pancreatic tissue. The study suggests that PanINs may already possess features of malignant cells and challenges the long-held assumption that they always progress to cancer.
Researchers from Japan have synthesized two di-superatomic molecules composed of Ag and evaluated the factors involved in their formation. The study found that a twist between the two icosahedral structures stabilizes the nanocluster by shortening the distance between them. Additionally, the presence of Pd and Pt central atoms was foun...
A new study led by Brigham investigators found that people produce shared antibody responses to certain regions of the virus, leading to selective pressure and new variants. The team's findings have implications for our understanding of immunity and public health, particularly in terms of re-infection during the COVID-19 pandemic.
Researchers found evidence of ancient drug use in Europe using human hair analysis, revealing the presence of scopolamine, ephedrine and atropine in Bronze Age containers from Menorca. The substances may have been derived from nightshade plants used in shamanic rituals.
The study provides molecular data and computational models to understand the complex interactions affecting inflorescence architecture in strawberry. Researchers identified gene functions that affect branching iterations, final flower number, and berry yield.
A novel Cu-based catalyst with improved catalytic performance for CO2 reduction has been developed by leveraging strong metal-support interactions and defect sites cooperativity. The DFNS/TiO2-Cu catalyst showed excellent activity and stability, outperforming other copper-based thermal catalysts.
A recent study published in Environment International found that the mutation rate in trees growing in contaminated areas did not increase significantly due to ambient radiation. The researchers used a new bioinformatics pipeline to evaluate de novo mutations in two widely cultivated tree species, Japanese cedar and flowering cherry.
A team of Lithuanian scientists created a VR-based rehabilitation system to help patients recover from stroke. The system uses sensors to track the patient's movements and provides real-time feedback to improve motor function, balance, and coordination.
Researchers used ancestral sequence reconstruction to study protein interactions in cyanobacteria, finding that they can evolve independently of direct selection pressure. The discovery challenges classical evolutionary theory and suggests that fortuitous compatibility may be the basis for a significant fraction of cellular interactions.
A new study predicts US forests may lose significant carbon storage due to climate change, compromising their role as a climate solution. The researchers used multi-perspective modeling approaches to forecast changes in aboveground carbon storage in different regions.
A two-year grant from the Craig H. Neilsen Foundation will support a pilot project implementing Vocational Resource Facilitation to investigate participant and stakeholder experiences. The goal is to enhance return-to-work rates and employment outcomes for individuals with spinal cord injury.
A long-term study reveals that the risk of fatal collisions between vehicles and spotted hyenas in the Serengeti is influenced by road characteristics and the annual migration of large ungulate herds. Adult females are most frequently run over, likely due to their regular travel distances between dens and migrating prey herds.
Researchers found that single-atomic state of Pd enhances CO2 reduction and boosts CH4 production in a novel Pd/CN-SA catalyst. Comprehensive analysis reveals superior activation of CO2, negative conduction band potentials, and excellent hydrogen utilization efficiency.
Researchers analyzed 1.5 million patients with 53 million electronic notes to identify 9,477 distinct phenotypes and demonstrated a high degree of agreement with expert judgment in various clinical fields.
Research reveals connection between star brightness and dust concentrations, paving way for study of dust's role in planetary formation. The University of Tokyo's latest findings may help unravel the secrets of life's creation.
A study published by the University of Texas Health Science Center at Houston found a historic increase in group A strep infections among young children in Houston. The researchers identified three main types of group A strep diseases and found that emm12 strains were disproportionately represented, compared to emm1 strains.
Researchers at Drexel University have developed a new method that combines UV-visible spectroscopy with cyclic voltammetry to track ion movement in batteries and supercapacitors. This breakthrough could lead to the design of higher performing energy storage devices.
Researchers developed an implant that delivers electrical stimulation to specific spinal neurons to treat dangerously low blood pressure in people with spinal cord injuries. The treatment, called the neuroprosthetic baroreflex, has shown promise in clinical trials and could be used in hospitals and at home to monitor blood pressure.
The World Health Organization (WHO) is urging countries to share data on the origins of SARS-CoV-2 immediately. Scientists argue that early data from China could help prevent future pandemics by providing insights into the virus's transmission and potential animal sources.
A new study reveals that male yellow crazy ants are composed of haploid cells with two distinct genetic compositions, producing chimeric males. This unique reproductive mode deviates from the typical single-cell zygote development and may be associated with a genetic conflict between co-occurring genetic lineages.
Researchers used DNA methylation data alongside traditional risk factors to improve prediction accuracy for type 2 diabetes. The study, involving over 14,600 participants, found that the new approach correctly predicted an extra 449 individuals, leading to potential preventative measures and reduced health burden.
Researchers discovered multiple virus types persisting within organs such as kidneys and brain, challenging our understanding of the human microbiome. The findings suggest viruses may contribute to chronic diseases like cancer or autoimmune disorders, while also playing a role in immune system regulation.
Astronomers have discovered a massive, runaway black hole that has left behind a never-before-seen trail of newborn stars. The black hole, weighing as much as 20 million Suns, is plowing into gas to trigger new star formation along a narrow corridor.