Researchers at the CNIO have elucidated a key point about how cohesin attaches to DNA and forms loops. The study suggests that NIPBL is not necessary for cohesin to bind to DNA, but only for it to move and form DNA loops. This finding may be important in understanding Cornelia de Lange syndrome.
Researchers used a new method to analyze temperature records stored in bacteria, revealing surprisingly stable temperatures in the Tanana Valley over 14,000 years. This finding challenges previous assumptions about climate fluctuations and their impact on early human migrations.
Researchers at Zurich University of Applied Sciences identified six compounds contributing to fermented coffee's unique flavor, including 2-methylpropanal, 3-methylbutanal, and ethyl 3-methylbutanoate. The study aims to standardize production methods and increase availability of this distinctive beverage.
Researchers mapped seasonal bird densities across the eastern United States using weather radar stations to identify stopover hotspots. The study found that high-density migrant areas were consistently associated with forest cover and decreased with pasture and cultivated crops.
Researchers used thermal video and image analysis to measure heart and respiration rates in exotic wildlife species in controlled settings. The study validated the accuracy of this technology for future use in wild populations, especially threatened species.
A new analysis shows that the US has substantially higher death rates at all but the oldest ages compared to five high-income European countries. The excess death gap widened during the Covid-19 pandemic, with the number of excess deaths nearly doubling between 2019 and 2021.
Researchers at Nagoya University discovered three new species of bioluminescent polycirrus worms emitting blue-violet light, with names inspired by yokai from Japanese folklore. The findings aim to deepen understanding of bioluminescence mechanisms and potentially lead to new life sciences technologies.
Researchers discover ZBTB12, a molecular barrier that prevents dedifferentiation in human pluripotent stem cells, and shed light on the core differentiation mechanism.
The study found ChatGPT's performance on the USMLE was comparable to a third-year medical student in terms of medical knowledge assessment. ChatGPT outperformed other models due to its dialogic component, providing coherent and justifiable responses. This may create an interactive learning environment for students.
Researchers have discovered a large reservoir of hot gas in the Spiderweb galaxy cluster, which is believed to be on its way to becoming a massive galaxy cluster. The detection was made using ALMA and provides valuable information about the early Universe's structure formation.
Researchers successfully connected human brain to computer for simple computational imaging tasks, using ghost imaging to reconstruct images of an object behind a wall. The use of real-time feedback from the visual cortex improved both imaging speed and image quality.
A new Cornell University study finds that non-white homeowners are more likely to invest in costly flood protection measures than white homeowners. Homeowners with mortgages and those who own their homes outright take the fewest high-cost actions, while renters tend to take none at all.
A study led by University of Houston researchers found that the Texas Gulf Coast is polluted with high concentrations of sulfate, a major component of particulate matter. The pollution originates from anthropogenic shipping emissions and chemical processing, making it particularly hazardous to human health.
A study found that regular exercise increases mitochondrial fusion, benefiting muscle cells and maintaining physical fitness even in old age. Daily sessions of exercise throughout life delay the accumulation of dysfunctional mitochondria and decline in physical fitness.
The new dataset provides a 'ranking' of countries contributing most to global warming, with CO2 emissions driving the most warming. Countries like Brazil and Indonesia are rising in their contribution, while industrialised nations see slight declines.
A 50-year study on Great Sippewissett Marsh found that more than 90% of the world's salt marshes will be underwater by 2100 due to sea-level rise. Despite attempts to adapt, low-lying wetlands are unlikely to migrate landward, and human development may exacerbate the problem.
Researchers at Sanford Burnham Prebys have identified a group of proteins called AJSZ that help solve a known problem in cellular reprogramming. By blocking the activity of these proteins, they were able to reduce scarring on the heart and induce a 50% improvement in overall heart function in mice that have undergone a heart attack.
Scientists developed an injectable biomaterial with improved adhesion, stretchability, and toughness, making it ideal for surgical wound sealing. The material showed superior adhesive strength, stability, and biocompatibility in physiological conditions.
Researchers have found lab-made antibodies that can strengthen the body's fight against yellow fever, a disease with no current treatment. The monoclonal antibody infusions were able to remove all signs of infection from research animals, offering potential hope for a cure.
Researchers led by Nicolas Ajzenman found that immigrants don't increase crime rates, but people's perception of crime does. In Chile, migrants' presence sparked concerns among citizens, with those exposed to immigration inflows more likely to rank crime as a top concern.
A novel drug, AF-130, has been shown to improve heart function and prevent sleep apnoea in heart failure patients. This breakthrough could lead to improved life expectancy and wellness for nearly 200,000 people in New Zealand affected by heart disease.
A new platform has been established to improve the analysis of dynamic metabolic features in cells. The Raman-based flow cytometry tool allows for the profiling of cell populations without labeling or destroying them, providing a non-invasive big-data type for culture-independent phenomes.
A pilot study uses drones to accurately map how and why pedestrians use city streets in Santiago de Chile. The study finds that drones can reliably collect data on pedestrian behavior, providing valuable insights for urban planning and infrastructure development.
Researchers developed a programmable bacterial injection system that can deliver a range of proteins, including those for gene editing, to different cell types. The system has shown promising results in targeting cancer cells and delivering proteins to the brain in live mice without provoking an immune response.
A team of researchers from South Africa has discovered exceptional trace fossils that provide insight into the locomotion of ancient giant amphibians. The fossils, found on a rock surface once part of a tidal flat or lagoon, suggest these animals propelled themselves through water with continuous side-to-side tail motions.
The University of Texas at Austin is helping the Port of Corpus Christi determine if it can permanently store greenhouse gas emissions from industrial operations beneath the seafloor of the Gulf of Mexico. The project aims to store carbon dioxide emissions in geological formations deep beneath the seafloor, reducing atmospheric emissions.
Researchers have developed nanodiscs based on the cell membranes of human red blood cells, which can effectively neutralize bacterial toxins. These nanodiscs, called RBC-NDs, are biocompatible and non-toxic, making them potentially useful as nanovaccines.
Researchers from the Smidt Heart Institute found that individuals with spherical hearts are 31% more likely to develop atrial fibrillation and 24% more likely to develop cardiomyopathy. The study identified four genes associated with cardiomyopathy and a greater risk of developing atrial fibrillation.
Researchers found that dexamethasone prevents cytokine storms in severe COVID-19 patients by inhibiting ion channels and reducing immune cell inflammation. This led to improved lung function and reduced mortality rates. The study's findings provide new insights into the mechanisms of steroid treatment in severe COVID-19.
A new study found that 20% of households have too little allocated parking and 13.4% of surveyed households do not own a car but are still allocated a parking space. Experts are calling for planning policy to 'unbundle' parking spaces from apartments to reduce housing costs and alleviate street parking woes.
A phase 3 randomised controlled trial found monthly injections of fitusiran effective in reducing bleeds in patients with severe haemophilia A or B. The study included 56 male patients with inhibitors, who experienced no bleeds after nine months on prophylactic treatment.
A new subspecies of rainbow trout, O. mykiss calisulat, has been identified after genetic analysis revealed its distinctiveness. This discovery is significant as it marks the first newly identified Pacific trout subspecies since 2008 and the youngest rainbow trout subspecies by more than 100 years.
Research analysis reveals gaps and uncertainties in evidence base for cancer drugs, including lack of relevance and inconsistent reporting. Findings emphasize the importance of improving communication of benefits and harms to support informed decision-making by patients and clinicians.
The Energy Circulation Theory (ECT) simulates the formation of galaxies with different shapes, such as disc, spiral, and elliptical ones. The study demonstrates that various galactic distributions result from stellar seed releases and galactic seed interactions.
A new study reveals a surprising exception to the rule of uniformity across the Indo-West Pacific coral reef ecosystem. Chlorodielline crabs with overlapping ranges have uniquely shaped gonopods, but otherwise appear identical, suggesting genetic divergence in different geographic areas.
A new study from the University of Exeter finds that a vegan diet rich in mycoprotein can support muscle growth during resistance training to the same extent as an omnivorous diet. The study shows comparable increases in muscle mass and strength in response to both diets.
Research by Whitehead et al. reveals that cellular senescence triggers amyloidosis through changes in small extracellular vesicles and extracellular matrix composition. The study provides novel insights into the formation of aortic medial amyloid and offers potential therapeutic targets for mitigating its effects.
Researchers found that syntactic surprise, a measure of unexpected word arrangement, significantly improves marketing message efficacy. The optimal level of syntactic surprise falls within the middle range, with messages being most effective at a medium level.
A new study by University of Copenhagen researchers found that stereotypes about senior employees influence their retirement decisions, leading to premature retirements. Senior employees often feel uncertain about their status and worry about being perceived as inflexible or unproductive.
Researchers developed a robust multiagent trajectory-planner that enables drones to generate collision-free trajectories even with delayed communications. The system achieved a 100% success rate in simulations and flight experiments, guaranteeing safe group operations.
Researchers at KTH Royal Institute of Technology developed a thermal wood composite using coconuts and lemons that can store both heat and cold. The material, which is transparent and energy-saving, can regulate temperatures around 24C, reducing energy consumption for heating and cooling.
Seer researchers identified four structurally distinct protein isoforms that were differentially expressed in non-small cell lung cancer patients. These findings suggest that these protein isoforms may play a role in NSCLC disease pathogenesis, potentially leading to the development of new diagnostic markers or therapeutic targets.
A new initiative has shown that holistic, team-based care that bridges clinic treatment to community resources can improve diabetes care and management. Healthcare organizations partnering with community groups to address social factors such as food insecurity also shows promise in empowering patients to better manage their own symptoms.
Researchers modeled how elements move across star-forming regions, finding that galactic winds influence temperature and metal distribution. The study's findings suggest a non-spherical wind pattern, contrary to previous spherical models.
A new study predicts that Antarctic deep ocean currents will slow by over 40% in the next 30 years and may collapse, with significant impacts on climate and marine ecosystems. The decline of this circulation could stagnate the bottom of the oceans and trap nutrients, affecting marine life for centuries to come.
Researchers Paul Byrne and Rebecca Hahn have compiled a global catalog of 85,000 volcanoes on Venus, providing the most comprehensive understanding of the planet's volcanic properties. The dataset includes detailed analyses of volcano distribution, size, and clustering, which will aid in locating future active lava flows.
A recent study from Brigham Young University proves that artificial intelligence can respond to complex survey questions just like a real human. The researchers found high correspondence between how AI and humans voted in 2012, 2016, and 2020 U.S. presidential elections.
A team from the National Eye Institute identified Reserpine as a compound that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10, an inherited retinal ciliopathy disease. The study suggests a potential treatment strategy for addressing retinal ciliopathies caused by multiple genes.
A machine learning model developed by Colorado State University researchers has been tested with forecasters at the Storm Prediction Center to improve medium-range severe weather forecasts. The tool provides a probabilistic measure of hazardous weather events, such as tornadoes and hail, four to eight days in advance.
Researchers at UC San Diego and UC Merced developed a high-throughput method to study the circadian clock in real time, shedding light on its internal functions. The study found that kinases play a crucial role in relaying the circadian rhythm from the core oscillator to gene expression.
A recent study published in the European Journal of Preventive Cardiology found that regular physical activity can help offset the detrimental effects of inadequate or excessive sleep on mortality risk. The research included over 90,000 adults and used accelerometry to track physical activity and sleep duration.
A large case-control study identified nine genes associated with stomach cancer risk and found that pathogenic genetic variations exacerbate the damage caused by H. pylori infection, significantly increasing the risk of gastric cancer. The study suggests that screening for pathogenic variants can help prioritize interventions.
A study published in Science Advances reveals that viral SARS-CoV-2 variants are developing resistance to protease inhibitors, including Paxlovid. Researchers warn that this could undermine the effectiveness of antiviral treatments and highlight the need for next-generation compounds with different resistance profiles.
A study found that as alcohol consumption increased, the probability of a firearm-involved suicide also rose until a certain blood alcohol concentration was reached. Interventions focusing on heavy alcohol use may help reduce suicide mortality rates, particularly those involving firearms.
Fruit fly gut remodels itself to accommodate beneficial microbiome species, maintaining long-term stability of the gut environment. The research team identified physical conditions and substances that facilitate colonization by desirable species.
Researchers at USC have developed a new type of chip with the best memory of any chip thus far for edge AI. The chip uses metal oxide memristors to store information in a compact and stable way, eliminating the von Neumann bottleneck in current computing systems.
Researchers at Heidelberg University developed new methods to detect biogenic carbon in zircon minerals, which can preserve traces of life hundreds of millions of years old. The study's findings open up new possibilities for research into the Earth's early period, where fossils and sediments are scarce.
Scientists at US national laboratories are developing new chemical recycling methods to make sustainable, high-quality plastic materials. They aim to transform plastic waste into valuable chemicals and reduce plastic pollution, paving the way for a circular economy.
Research found increased trust in scientists during COVID-19 pandemic, with polarized attitudes emerging, influencing behavior and vaccine adoption. Those with initial positive views became even more positive, while those with negative views became more entrenched.
A new method using brain signal processing has been developed to categorize different types of depression. The study achieved a 91% accuracy rate in detecting anxious and non-anxious depression, showing promise for improved diagnosis and treatment.