Researchers at La Jolla Institute for Immunology have developed a high-resolution view of the LCMV glycoprotein, revealing its structure and potential vulnerabilities. The breakthrough enables the development of an engineered antibody that can prevent LCMV disease, offering a new route to treatment.
Researchers analyzed autopsies of 14 patients with advanced melanoma, finding that changes to tumor DNA can cause resistance to treatment. The study sheds light on the final stages of cancer and may lead to new treatments for patients with advanced disease.
Scientists have developed a device that can simultaneously detect the presence of COVID-19 and flu viruses at much lower levels and quickly, using graphene nanomaterials. The sensor returns results within 10 seconds, faster than conventional tests.
Research highlights that intensive behavioral weight loss programs significantly reduce cardiovascular disease and Type 2 diabetes risk factors, which persist for at least five years. Participants who lost weight through such programs had lower risk factors compared to those in less intensive or no weight loss programs.
Research outlines actionable steps to address longstanding health disparities in breast cancer screening and treatment options. Surgeons can drive change by maintaining awareness of existing disparities and providing additional resources to patients.
Global efforts to track HIV and HCV incidence among people who inject drugs are necessary to validate targets for ending the epidemics by 2030. The research highlights the importance of prioritizing this population in prevention and elimination work, particularly for vulnerable subgroups like young people and women.
A team of scientists has successfully tested a method to measure biomolecules' precise dimensions and comparability. They used single-molecule FRET analysis to measure distances in proteins with precision, observing structural changes on time scales of less than a millisecond.
A national analysis of pediatric hospitalizations from 2009 to 2019 found a significant increase in mental health diagnoses, with attempted suicide being the leading cause. The study highlights the growing importance of addressing mental health concerns in children and adolescents.
Researchers at the University of Córdoba have developed natural-waste pads that absorb moisture and delay meat oxidation, favoring a more sustainable packaging option. The pads, made from chitosan, nanocellulose, and bay leaf essential oil, show promise in preserving fresh meat for up to 10 days.
A recent study has found a significant link between fibromyalgia and increased odds of exacerbation in pain-related opioid use disorder. Researchers surveyed 125 individuals living with both conditions, revealing that those with fibromyalgia were more likely to report worsening addiction symptoms due to chronic pain.
Researchers debunk rock'n'roll myth, finding narcotics have no effect on inspiration. Instead, complex training programs, meditation, and cultural exposure boost creativity. Training that highlights mental techniques has long-term impacts, while mindfulness activities like meditation also improve imagination in the short term.
Researchers found a modest increased risk of developing heart disease among people exposed to low doses of ionizing radiation. The study suggests that guidelines for protection of workers and patients should be reconsidered to minimize the risks associated with low-dose radiation exposure.
The COVID-19 pandemic significantly declined tobacco assessment rates in community health centers between March and May 2020. Assessments remained 33.5% lower than pre-pandemic levels, highlighting the need for adapted procedures to support tobacco cessation efforts.
Adding pembrolizumab to chemotherapy greatly improves patient outcomes in both MMR-deficient and proficient tumors. Progression-free survival increases by 70% in MMR-deficient tumors and 46% in MMR-proficient tumors.
Research finds COVID-19 vaccine fatigue is driven by confidence in institutions and communication campaigns, with positive incentives boosting willingness among partially vaccinated groups. Effective strategies include adapted vaccines, low-barrier access, and expert consensus.
Astronomers have shed new light on the origin of gamma-ray bursts using the brightest ever recorded event, GRB 221009A. The study reveals a complex jet producing both visible and X-ray light, as well as unexpected excess millimeter and radio emission.
Researchers developed a VR imaging system to measure neural activity in mouse brains during behavior, revealing abnormalities in cortical functional network dynamics associated with autism. The system successfully distinguished between autism model mice and wild-type mice based on their brain network patterns.
A recent study found an unusual peak in RSV hospital admissions in the third quarter of 2021, nearly doubling typical annual numbers. The surge in cases was unexpected, with low hospitalizations reported in 2020 due to the COVID-19 pandemic.
Scientists at Oak Ridge National Laboratory developed an eco-friendly alternative to rigid foam boards, made without harmful blowing agents, using hollow glass spheres and expandable polymer microspheres. The new material offers improved thermal performance and is adoptable by industry, opening avenues for safer composite foams.
The project, STEAM TANKS, aims to measure methane and other volatile organic compounds emitted from liquid storage tanks in West Virginia, Pennsylvania, and Ohio. The researchers will use mobile laboratories, machine learning methods, and partner with industry leaders to develop solutions to mitigate methane emissions.
A new study published in the Journal of Cognition and Development found that preschoolers aged three and five prefer learning from a competent robot over an incompetent human. The research, conducted by Concordia University researchers, used humanoid robots to teach children about unfamiliar objects. Five-year-olds were more likely to ...
A new journal issue explores ADRD care among diverse groups, revealing greater prevalence and incidence among minoritized populations. The study also highlights the importance of cultural complexity in ADRD care, emphasizing the need for precise indicators and culturally relevant research models.
A recent study found that social determinants of health influenced care in 35% of surveyed encounters, with the most common sources being patient conversations and prior knowledge. Integrating this data into EHRs can support personalized care planning.
Researchers have developed a novel photocatalytic hybrid fuel cell that can remove organic pollutants in water while generating electricity. The fuel cell uses BiOCl-NH4PTA as a photocatalyst, which greatly improves electron transfer and charge separation.
The Tibetan Plateau's land surface darkening due to global warming affects regional and remote climates in Asia. The study predicts a 6.9% loss in glacier volume and increased monsoon precipitation over South Asia by the end of the century.
A new study by University of Houston psychologist Adam Fetterman found that neighborhood apps are associated with inaccurate perceptions of higher local crime rates. The frequent use of such services by a large portion of the population suggests important implications for perceptions and behaviors related to people's neighborhoods.
Researchers developed an interpretable machine learning framework to predict and quantify chromosome synthesis difficulties. The model achieved high accuracy and predictive ability, providing a practical tool for chromosome engineering and genome rewriting.
Scientists have developed a new vaccine delivery method using powdered vaccines and a system driven by compressed gas, called MOF-Jet. The device can deliver therapeutics against cancer and other diseases in a relatively painless way, eliminating the need for needles and potentially reducing pain.
A new plant species, Carex quixotiana, has been discovered in the La Mancha region of Spain, specifically known for being the setting of Miguel de Cervantes' classic novel Don Quixote. The species is a type of sedge with unique characteristics and limited distribution.
A study published in Science Translational Medicine has identified immature Natural Killer (NK) cells as a key factor in promoting disease progression in triple-negative breast cancer. The researchers suggest that targeting these rogue NK cells could lead to new and more effective treatments for this aggressive form of breast cancer.
A new study confirms that HIV can persist in myeloid cells for months to several years, even in virally suppressed individuals. The findings suggest that these cells contribute to a long-lived HIV reservoir and may be an important target for cure efforts.
Researchers have described two new species of butterworts (Pinguicula) with striking appearances, found in the high Andes of southern Ecuador. The discovery has tripled the number of Pinguicula species recorded in Ecuador and highlights the region's exceptional biodiversity.
Researchers at University of California San Diego School of Medicine found a significant reduction in disease growth when combining immunotherapy with chemotherapy in patients with advanced endometrial cancer. The study resulted in a 70% risk reduction in the deficient mismatch repair group.
The James Webb Space Telescope detected the thermal emission of TRAPPIST-1 b, indicating a temperature of about 500 kelvins and no substantial atmosphere. This finding marks an important step in determining habitability around small, active stars like TRAPPIST-1.
A new study suggests that acetyl tributyl citrate (ATBC), a leading phthalate alternative, can disrupt neuron-like cells and interfere with the growth and maintenance of neurons. The findings indicate that ATBC could harm brain development and health.
A study by Duke-NUS Medical School researchers analyzed tens of thousands of student data to determine the impact of early class start times on attendance, sleep behavior, and academic performance. The findings suggest that students who attend early morning classes often lose an hour of sleep and experience lower grades.
A new study from the University of Surrey found that Water Safety Plans are not widely used in small drinking supplies in vulnerable rural areas due to a lack of awareness and training. This could put countless lives at risk, as these plans aim to improve the quality of small drinking water supplies.
Researchers have developed a multidisciplinary approach using a new microscope, artificial intelligence algorithm, and voltage indicators to better measure brain activity. The technique enables the imaging of up to 100 neurons at a time, far surpassing previous limits.
A study of global clinical practice guidelines found close alignment in recommending daily intake of fruits, vegetables, legumes, and whole grains for treating and preventing major chronic diseases. The findings aim to increase clinician confidence in providing optimal care.
Researchers propose using a constellation of space interferometers to map the flat and almost perfectly homogeneous background signal, detecting subtle fluctuations known as anisotropies. These fluctuations hold information on the distribution of gravitational wave sources on the largest cosmological scale.
Researchers at King Abdullah University of Science & Technology (KAUST) successfully integrated two-dimensional materials on silicon microchips, achieving high integration density, electronic performance, and yield. The resulting hybrid devices exhibit special electronic properties that enable low-power consumption artificial neural ne...
Researchers developed a new form of omega-3 fatty acid DHA that can cross into the retina, increasing retinal DHA content and preserving function. This approach overcomes previous barriers and shows promise for preventing Alzheimer's-related declines in visual function.
A joint research team from KIST and GIST has developed a new anode material using carbon fiber paper to improve the durability of lithium metal batteries. The technology enhances cycling stability and energy density, leading to potential applications in next-generation secondary batteries for electric vehicles.
Researchers found that thermotolerant methanogens have smaller genomes with a higher fraction of core genes, while psychrotolerant organisms are enriched in uncharged amino acids. This suggests that temperature adaptation is a gradual process involving fine-scale changes rather than large-scale genome modifications.
A new study by Yale University researchers suggests that protecting wildlife can significantly enhance natural carbon capture and storage. By conserving or restoring populations of nine key species, the world can collectively facilitate the additional capture of 6.41 billion tons of carbon dioxide annually.
The study sheds light on the molecular mechanisms of deep-sea adaptation in Ilyophis brunneus. Researchers identified critical genes, including TUGBCP3 and ITGA, that underwent specific mutations related to cytoskeleton maintenance and regulation.
A study of 1,678 participants found that low benefit expectations, negative experiences, and catastrophizing are associated with COVID-19 vaccination adverse effects. Clinician-patient interactions and public vaccine campaigns may be optimized by contextualizing information about vaccines.
Scientists at UvA have created a new, highly improved bright red fluorescent protein called mScarlet3. This variant combines maximum brightness with fast and complete folding, making it an ideal tool for researchers studying cellular processes.
A new finger-prick test for Trichomonas vaginalis has been developed by Washington State University researcher John Alderete. The test detects an antibody specific to the organism and provides rapid, affordable results, making it a potential game-changer in the fight against this prevalent but neglected STI.
Researchers suggest that biochar produced from straw pyrolysis can significantly reduce methane and nitrous oxide emissions from Chinese staple crops. The addition of an integrated energy system also produces biogas and bio-oil, which can replace fossil fuels and further reduce greenhouse gas emissions.
A new photocatalyst, COF-TpHt, is designed to improve the efficiency of hydrogen peroxide production. It exhibits a high production rate and apparent quantum efficiency under visible-light irradiation, outperforming other organic and inorganic counterparts.
Research published in Annals of the Rheumatic Diseases found that people with atopic diseases like asthma or eczema are at a heightened risk of developing osteoarthritis. Drugs used to dampen down allergic reactions may help lessen this risk, suggesting a potential new approach to treating the condition.
The NCATS Platform Vector Gene Therapy (PaVe-GT) program utilizes FDA guidance to prepare applications for Orphan Drug Designation (ODD) and Rare Pediatric Disease Designation (RPDD), stimulating gene therapy development. The PaVe-GT program has already helped receive ODD and RPDD designations for a gene therapy product treating PCCA-r...
Scientists found that oxocarbon-based dyes have intermediate electronic configurations between closed-shell and open-shell forms. The study reveals that longer wavelengths of near-infrared light absorption increase the contribution of open-shell forms in the dye.
A University of Illinois study finds that two human-grade vegan diets provide adequate nutrition for dogs, with benefits including lower blood triglycerides and cholesterol. The research also shows positive changes in the fecal microbiome and reduced stool, indicating a potential shift towards improved gut health.
Researchers found that incubators dampen some sounds but also cause a booming effect at low frequencies, raising noise levels by up to 28 decibels. The study highlights the importance of considering sound in NICU design and use to protect premature infants' hearing.
Researchers from the Earth4All initiative project that global population could peak at 8.5 billion people by mid-century with unprecedented investment in poverty alleviation. The team's analysis also suggests that extreme poverty can be eliminated in a generation, leading to a decline in global population trends.
A new study reveals that lianas play a crucial role in amplifying the effects of lightning strikes, resulting in more severe damage to neighboring trees. High liana density is positively associated with the number of trees killed and damaged by lightning.
An international team of researchers has successfully demonstrated the formation of fullerene and its derivatives in the universe. The reaction involves a corannulene radical and vinyl acetylene, which deposit layers of carbon onto each other to form the desired molecules.
Researchers have identified four distinct patterns of anti-Müllerian hormone (AMH) concentrations in infant girls, including two previously unknown patterns. These patterns may help researchers understand ovarian function and identify potential reproductive conditions earlier.