A new study found a protein that regulates macrophage function, clearing residues from regenerating muscle and recovering regenerative capacity in aged mice. The discovery holds promise for regenerative medicine and aging, potentially improving the success of current stem-cell based therapies.
The European Union and European Economic Area will likely fall short of the Sustainable Development Goals target for eliminating tuberculosis by 2030. To meet the goal, an annual decline of 11.7% is needed in TB incidence, whereas the current decline rate of 6.8% is insufficient.
A new method to regulate singlet fission (SF) in chromophores enables the design of SF-based materials with enhanced energy conversion. Pressure-based control strategy opens doors to novel, tunable SF materials.
New research suggests the ancient monument of Stonehenge was not used as a giant calendrical device, but rather served as a symbolic representation of the solar cycle. The 'Stonehenge calendar' theory has been discredited due to forced interpretations and unsupported analogies.
Researchers have discovered a complex network of genes in the resurrection plant Craterostigma plantagineum that enables it to tolerate extreme drought conditions. The study found that this ability is not due to a single 'miracle gene' but rather the result of a whole genome, with many genes present in higher copy numbers than in more ...
A new study by Cedars-Sinai investigators has determined that the pre-supplementary motor area (pre-SMA) plays a primary role in weighing value-based choices, such as choosing which book to read or which slot machine to play. The discovery could help understand neurological disorders like addiction and obsessive-compulsive disorder.
A team of researchers developed a dynamical model that explains how animals learn over time, contradicting previous theories. The multi-dimensional model shows that learned associations are not mediated solely by strength but by multiple nearly independent pathways.
A systematic review and meta-analysis found demographic characteristics, comorbidities, and severe COVID-19 increase the risk of long COVID. Vaccination is protective against developing long COVID sequelae.
Researchers developed an AI-based diagnostic screening system called DeepGlioma to analyze tumor specimens and detect genetic mutations rapidly. The system identified molecular subgroups with high accuracy and has the potential to improve access and speed of diagnosis for patients with deadly brain tumors.
Designing low-carbon multi-storey buildings requires focusing on efficient shapes, structural frames, limited window sizes, and ventilation with heat recovery. The study found that these elements can save up to six gigatonnes of carbon by 2050 and reduce annual heating and cooling costs by 28-44%.
A team of researchers used a genetic algorithm to discover an organic catalyst for the Morita–Baylis–Hillman reaction, which outperformed traditional catalysts. The computational method suggested new molecular structures that were not present in the initial population, leading to a novel discovery.
Researchers developed a platform to study superconducting magnetic detection and phase transitions under high pressure using silicon vacancy defects. They successfully detected pressure-induced magnetic phase transitions in rare-earth magnets and measured the critical temperature-pressure diagram of a superconductor.
Researchers at the Mayo Clinic found that surgical removal of both ovaries in women under 43 increases their risk of developing Parkinson's disease and parkinsonism. The study used health record data from the Rochester Epidemiology Project to analyze over 2,750 women who underwent bilateral oophorectomy.
The National Cooperative Dairy Herd Improvement Program has successfully collected herd production data for 100 years, providing crucial input for cattle breeding and genetics. The program's cooperative structure, data interoperability, and governance model make it a unique example of how data collection benefits producers.
Researchers at the Francis Crick Institute have identified a new cell type, named F-Cell, that plays a crucial role in touch sensing in fruit flies. The study published in Nature Cell Biology reveals that F-Cells are recruited to tactile hairs and participate in sending signals to neighbouring epidermal cells.
A new UK study of 3.6 million surgeries found that operating within 2 weeks of a positive COVID test is safe for recovered patients, with lower mortality rates compared to current guidelines. The study suggests that delaying surgery might cause more harm than good, particularly in patients who have already waited longer for surgery.
A global approach has been developed to survey the vast collections of world's largest natural history museums, estimated to hold over 1.1 billion objects. The initiative aims to inform responses to today's interlocking crises by providing a collective strategy for future conservation and sustainability efforts.
Research found methane emissions from urban areas are underestimated by a factor of three to four, with untreated wastewater contributing to global methane emissions. Improving wastewater treatment could cut up to 6% of total worldwide methane emissions.
The Octapharma USA grant supports the Immunoglobulin National Society's breakfast symposium on PANS/PANDAS, a subset of pediatric acute-onset neuropsychiatric syndrome associated with strep. The program will focus on diagnosis criteria, pathogenic mechanisms, and current treatment options for challenging cases.
Researchers found that cellular growth rate influences gene expression response, leading to unbalanced phenotypic states and a growth-rate-dependent phase transition. The study proposes a mathematical model explaining the bifurcation arising from the relationship between growth rates and gene expression.
Researchers developed a temperature-modulating robotic system to study honeybee behavior in winter, demonstrating its ability to influence movement and prolong colony survival. The system also revealed previously unreported dynamics and shed light on critical periods for bee development.
Chinese scientists have identified a key gene involved in crop alkaline tolerance, which may greatly improve crop yield in sodic environments. The study found that the gene negatively regulates alkaline stress by modulating the efflux of H2O2 under environmental stress.
Researchers at Sylvester Comprehensive Cancer Center found that mesothelioma patients with timely treatment and access to specialized care have better outcomes. However, disparities in access to care are evident, with Black patients being 80% more likely to die than white patients.
A new approach to evaluating carbohydrate quality, the Carbohydrate Food Quality Score (CFQS), acknowledges nutrient and cultural diversity. It supports health equity by recognizing that carbohydrate foods are not homogenous and varying in nutrient profiles and quality.
A comprehensive US state-by-state analysis of COVID-19 impact reveals wide variations in health, education, and economic performance across the country. States with higher poverty, lower educational attainment, and lower healthcare access experienced disproportionately higher rates of SARS-CoV-2 infections and COVID-19 deaths.
UConn researchers have developed simple measurements and equations that better predict fat distribution in individuals based on their sex and ethnicity. The tools account for differences in body composition between ethnic populations and women and men, providing a more accurate assessment of obesity-related health risks.
A study from Karolinska Institutet found that melatonin prescription was associated with a lower risk of self-harm in young people with psychiatric disorders, particularly adolescent girls. The risk of self-harm increased before treatment initiation and decreased afterwards.
A new spectroscopy probe could improve the accuracy of deep brain stimulation procedures for Parkinson's patients by providing real-time information on brain tissue. The probe uses optical fibers to perform spectroscopic measurements, which can help neurosurgeons navigate instruments inside the brain.
The Southern Flying Squirrel has been rediscovered in Honduras after 43 years, with records from 1935 to 1979. The discovery confirms the country's southernmost distribution and highlights the need for conservation efforts due to habitat destruction and climate change.
The study successfully generated functional patient-specific T-cells and thymic epithelial cells from human pluripotent stem cells using thymus organoids. This breakthrough provides a new experimental model system to investigate thymic insufficiency and function, potentially leading to cell-based treatments for thymic defects.
A new analysis of innovative approaches to project economic impacts along climate mitigation pathways reveals near-term emissions reductions are globally economically optimal, with central estimates for 'optimal warming' around 1.8-1.9°C by 2100. The study estimates that one euro invested in climate solutions saves the world about 1.5 ...
A study published in the Journal of Infection found that mNGS was significantly more effective at detecting bloodstream infections than conventional microbiological tests (CMTs), identifying 187 infection cases compared to CMTs' 81. Viral infections were the most common type, with CMV being the leading cause.
The CDC report found a continued rise in autism prevalence among 8-year-olds, with girls now surpassing 1% prevalence rate, while boys remain more likely to be diagnosed. The report also showed shifts in racial and ethnic backgrounds of children identified with ASD, with non-white populations having greater diagnostic access.
A new report reveals that children born into the poorest fifth of families in the UK are 12 times more likely to experience poor health and educational outcomes by age 17. This clustering of adverse outcomes is linked to early childhood disadvantage, with modest reductions seen when lifting families out of poverty.
A new series in The Lancet calls for governments to legislate higher standards for marketing harmful products and businesses to commit to ending lobbying against pro-health policies. The authors also congratulate commercial actors adopting alternative financing models that create social value and promote positive health outcomes.
A major study found that climate change could decline the diet quality of fish by up to 10% as zooplankton communities shift towards more carnivorous groups. This could exacerbate declines in fish biomass, with potential implications for human societies relying on fisheries for food and livelihoods.
A new mouse model of RP58/ZBTB18 haploinsufficiency shows impaired motor learning, working memory, and cognitive flexibility. The study suggests that excitatory synaptic defects underlie intellectual disability caused by RP58/ZBTB18 haploinsufficiency.
A new study from Aarhus University reveals that women with endometriosis can significantly improve their quality of life through psychological therapy, reducing symptoms such as pain and constipation. The trial shows that mindfulness and acceptance-based interventions are equally effective in improving quality of life.
Researchers found that older adults with depression exhibit accelerated biological aging, poor physical and brain health, and worse cardiovascular health. This association suggests opportunities for preventive strategies to reduce disability associated with major depression in older adults.
A new survey found that nearly a third of Americans worry more about obesity due to COVID-19, with 28 million people considering weight loss methods. The survey also showed that nearly 90% with obesity have tried to lose weight at some point in their lives, but many underestimate the effectiveness of treatments like weight-loss surgery.
A robust phase extraction method for overcoming spectrum overlapping in shearography has been proposed, achieving high-quality phase extraction. The method uses a linearly transformed elliptical window to maximize the use of spectrum information and improve phase extraction quality.
A recent study by Cornell University researchers found that lawmakers are only slightly more likely to respond to AI-generated messages than human-generated ones, highlighting the potential risks of emerging technologies on democratic representation. The research used a field experiment to investigate the impact of natural language mod...
A recent study has identified a rare strain of Toxoplasma gondii, COUG, in sea otters that caused fatal steatitis and toxoplasmosis. The strain is virulent and can rapidly kill healthy adult otters, posing a health threat to other marine wildlife and humans.
A new study has uncovered the brain's internal compass, which helps it navigate changing environments. The research found that the brain uses a mechanism called 'network gain' to reorient itself after being disoriented, allowing for rapid recovery of its sense of direction.
Researchers discovered previously unknown details about Margaret Bryan's background and family through a paper published in Notes and Records: The Royal Society Journal of the History of Science. Girolami found that Bryan was born around 1759, married William Bryan in 1783, and had two daughters, Ann Marian and Maria.
A recent study published in Communications Biology used thermal imaging to capture the social dynamics of 'pee-shy' mice, revealing that males adjust their urine marking behavior based on their past interactions. The research provides insight into how animals manage their social signaling, a crucial aspect of their survival and evolution.
Researchers at Texas A&M University have developed the first molecular therapeutic for Angelman syndrome, a devastating neurogenetic disorder. The therapy targets an evolutionarily conserved region in the UBE3A-AS transcript and has shown promising results in clinical trials.
The new 7-Tesla MRI machine will enable researchers to map and measure brain structures with unprecedented precision. The machine, part of the Center for Advanced Medical Engineering, is available for research purposes and will accelerate neuronal research with AI-based algorithms.
A new study from the University of Surrey found that a fun, technology-based climate change education program increased climate change literacy by 9.4% in primary school children and 4.5% in secondary school children. The Heat-Cool program encouraged pupils to use infrared cameras to explore urban heat islands, stimulating interest in ...
A study by Max-Planck-Gesellschaft researchers found that consuming small amounts of high-fat and high-sugar foods regularly rewires the brain, leading to a preference for these types of food.
A new study found that working for a big company or in an HR role does not lower the likelihood of showing unconscious bias against disabled people at work. Despite large firms' efforts to address EDI and unconscious bias through training, levels of implicit bias remain roughly the same across different sized companies.
A study analyzed 25 countries' baseline mercury emission estimates and found that they rarely provide enough information to determine whether changes are due to actual change or data uncertainty. This lack of transparency hinders efforts to draft meaningful mercury reduction targets in national action plans.
A research team has made critical achievements in antiferromagnetic spintronics, revealing emerging frontier distinguished by coherent spin dynamics. Key findings include spin generation and transport, electrically driven spin rotation, and ultrafast spintronic effects.
Researchers Jennifer Bergner and Darryl Seligman suggest that 'Oumuamua's acceleration can be explained by the outgassing of hydrogen gas as the comet warmed up in the sunlight. The comet's small size allowed for a significant effect, with the tiny push from hydrogen spurted out of ice altering its gravitational deflection around the sun.
The new medicine has shown promising results in a Phase 1 clinical trial, with 70% of patients stable after six weeks and one patient remaining stable for over two years. Developed by NTNU researcher Marit Otterlei, ATX-101 targets cancer cells' stress regulation system, leaving healthy cells unaffected.
Researchers from China have identified inosine as a potential broad-spectrum anti-inflammatory agent that improves survival in mice infected with SARS-CoV-2. The study also highlights TBK1 as a promising target for inhibiting cytokine storms and mitigating acute inflammatory lung injury.
A systematic review found considerable uncertainty around analgesic effectiveness and safety for acute non-specific low back pain. Clinicians and patients are advised to use analgesics with caution due to limited high-quality evidence.
Researchers analyzed DNA from Beethoven's hair to shed light on his chronic health problems, including progressive hearing loss. They found genetic risk factors for liver disease and evidence of a hepatitis B virus infection, which likely contributed to his death.
A research team reveals the mechanism behind non-uniform diamond film formation on tools, identifying carbon filaments as a key factor. Inhibiting carbon filament growth is crucial for developing dry processing methods that reduce environmental waste.
A comprehensive roadmap for converting waste energy into clean power has been proposed by global experts. The guide outlines strategies for future research to harness the potential of energy harvesting materials, enabling seamless integration into everyday objects and environments.