Scientists have identified a new molecule that could help distinguish and treat patients with a specific subgroup of medulloblastoma, the most common malignant brain tumor in children. The discovery points to potential targeted therapies using a drug or drugs to block the molecule's activity.
Scientists from USC Stem Cell laboratory discovered a mechanism linking leukemic mutations to varying disease potentials, identifying RNA splicing regulator Rbm25 as a critical factor. The study found that over-contributing clones of blood stem cells produce excessive myeloid cells, leading to potential leukemia development.
A recent court ruling may result in more than 2,000 preventable HIV infections in the coming year due to reduced insurance coverage for PrEP. The study, led by Yale School of Public Health researchers, estimates that a 1% decrease in PrEP coverage could lead to 114 new infections among high-risk populations.
Researchers at Cold Spring Harbor Laboratory have created a method to safely synthesize the cancer-fighting molecule JA, which has shown promise in treating triple-negative breast cancer. The team found that JA inhibits metabolic activity in cancer cells, starves them of energy and building blocks, leading to cell death.
The latest CDC report highlights changing demographics of autism and its impact on early detection. In California, 2.8% of 8-year-old children have been identified with ASD, while the median age of first diagnosis is just over 4 years.
A new study has created a comprehensive map of the human proteome, identifying over 1 million peptides from 17,717 different protein groups. The researchers also found that most alternative splicing detected at the RNA stage is also present in the proteins, validating long-held ideas about this process.
A recent study has uncovered new ways genetic mutations in patients with muscular dystrophies may lead to disease and neurological problems. The research found that certain genes affected in these disorders are crucial for the proper wiring of sensory axons in flies, a discovery that could have implications for humans.
The study found that oral transmission has profound effects on music evolution, shaping vocal music towards structures that are easier to learn and transmit. Human transmission biases also play a significant role in evolving musical systems.
A major conference will discuss the human cost of heritage loss due to climate change and explore how behavioural science can inform choices about what should be saved. International scholars and policy experts will examine how to measure the impact of Loss and Damage on coastal heritage.
A study using a Chinese atmospheric inversion system found that satellite CO2 retrievals underestimate the global net terrestrial carbon sink, but still provide consistent results with other inversions. The system refines our understanding of flux partitioning between northern and tropical regions.
Researchers found that SARS-CoV-2 infection during pregnancy was associated with a nearly two-fold higher odds of neurodevelopmental diagnoses at 12 months of age among male children. The risk was not seen in female children.
Researchers have identified three sets of genes involved in building the fake fly structure on the daisy's petals, which are brought together in a new way to deceive male flies. The plant's use of existing genes for iron movement, root hair growth, and flower control gives it an evolutionary advantage.
Researchers at the Francis Crick Institute have discovered a key role for autophagy in controlling intracellular infections like TB. By boosting this natural process, they hope to create new treatments that can combat antibiotic-resistant bacteria.
A recent study found that U.S. college students have low awareness of wild bee species, with their knowledge focusing primarily on honey bees and pollination services. The researchers suggest that education alone may not be enough to produce attitude and behavior change, and propose a novel approach using semantic network analysis and ...
Exercise training after bariatric surgery alters brain networks associated with food intake and energy regulation. The study found that exercise increased connectivity between the hypothalamus and sensory areas, while decreasing links to the default mode network and salience network.
Genome-wide studies reveal that early European farmers adopted more immune system genes from hunter-gatherers than expected, suggesting natural selection played a key role in adapting to diseases.
Researchers at UChicago develop a more efficient and less toxic method to create MXene material, enabling new applications in electronics and energy storage. The breakthrough allows for the production of large amounts of materials with minimal waste, paving the way for innovative technologies.
A global approach is proposed to integrate natural history museum collections, providing a valuable resource for addressing global issues like invasive species, biodiversity conservation, and climate change. The vast collections held by museums worldwide are becoming increasingly important in policy-relevant research.
A new study using ChatGPT highlights the challenges of AI in academia, including concerns over academic dishonesty. However, researchers believe that AI can also be leveraged to improve education by automating administrative tasks and adapting assessments.
The University of Texas at El Paso has joined a $2.5 million NASA-led project to develop 3D-printed rechargeable batteries using lunar and Martian regolith. Researchers will utilize additive manufacturing processes, such as material extrusion and vat photopolymerization, to produce shape-conformable batteries for space applications.
Researchers developed a new tool to disentangle electronic states in layered quantum materials, revealing surprising results that defy theoretical predictions. By analyzing vibrations and energy measurements, scientists can 'see' how electrons move through the layers.
Researchers attribute unusual radar properties to coherent backscatter opposition effect (CBOE) and ice surface irregularities. The CBOE model, improved by Hofgartner and Hand, can explain all icy satellite radar properties.
A team of researchers has discovered new laws governing fluid flow through experiments on drinking straws, defying previously known resistance laws. The findings have promise for improving fluid handling in medical and engineering applications.
Researchers have overturned the traditional view that oxygen derives from water splitting, instead finding that reactive oxygen species (ROS) produced at mineral-water interfaces are a key source of oxygen. This discovery has significant implications for understanding the evolution of Earth's atmosphere and the habitability of early life.
A cohort study found that nirmatrelvir treatment within five days of a positive COVID-19 test result was associated with reduced post-COVID-19 condition risk, regardless of vaccination status and prior infection history. The study suggests that nirmatrelvir may reduce the risk of long COVID across the risk spectrum.
Scholars developed an AI program using symbolic regression to improve mass inferences of galaxy clusters. The new equations extract jelly at the center and concentrate on doughy outskirts for reliable mass inferences.
A WVU researcher is working on a biopsychosocial intervention to help people with chronic hip pain move and regain mobility. The intervention, called HIPS, combines mindfulness techniques like self-compassion and progressive relaxation with goal-setting and diaphragmatic breathing to reduce pain and increase physical activity.
An international team used AI to analyze old star chemical abundances and found indications that the first stars formed in groups. The study suggests that first-generation stars must have been clustered together rather than isolated, offering a new constraint on the multiplicity of the first stars.
The study found a significant association between the loss of abortion rights and increased mental distress in females of reproductive age. Restricting access to abortion may disproportionately affect lower socioeconomic status individuals, leading to greater economic and mental health burdens.
Researchers at University of Cologne discovered a way to improve DNA repair in body cells, making them resilient towards DNA damage. This can help prevent aging and cancer development, with potential applications for treating human patients.
Scientists at UC Riverside identify microRNA as a key player in plant temperature responses and growth, revealing its essential role in sensing environmental changes. The discovery has significant implications for increasing crop yields in diverse environments and adapting to climate change.
A new national study found that households facing housing insecurity score lower on disaster preparedness scales, highlighting the importance of secure housing for disaster resilience. Housing security is vital for people to be better prepared for disasters, according to researchers.
A 29-year study found that being fit reduces the risk of death from cardiovascular disease in men with high blood pressure. High fitness levels attenuate, but do not eliminate, the increased risk of cardiovascular mortality in individuals with elevated blood pressure.
Recent studies have found improved efficacy against SARS-CoV-2 infection with the third dose of the vaccine, leading to a reduction in hospitalization. Booster vaccinations also resulted in further increases in antibody responses, demonstrating strong and persistent immunity.
Corneal graft rejection can be as high as 10% due to poor patient compliance with medications, which require frequent eyedrop administrations. Researchers at Virginia Commonwealth University developed nanoparticles to encapsulate eye medication, decreasing graft rejection while requiring fewer and smaller doses. The approach reversed s...
A University of Wisconsin-Madison study found that regular mindfulness activities can improve engineering graduate student emotional well-being and resilience. Students who participated in a mindfulness training program reported significant improvements in emotional well-being, stress management, and focus.
A study published in The Lancet Public Health found that women with mental illness are twice as likely to develop cervical cancer due to low screening rates and increased incidence of precancerous lesions. Researchers highlight the need for proactive measures to address inequality in care.
Researchers have discovered a new pathway to produce saponin-based vaccine adjuvants using the genome of the Chilean soapbark tree. This breakthrough could lead to more potent and affordable vaccines, with potential applications in COVID-19, shingles, and malaria prevention.
Researchers at the University of Maryland School of Medicine are using mRNA vaccine technology to combat various infectious diseases. A new clinical trial aims to test an mRNA-based vaccine against malaria, with hopes for a rapid adaptive response to virus evolution and the manufacture of combination vaccines.
A new study reveals oxytocin is essential for social fear contagion in zebrafish, a form of empathy that shares similarities with mammalian behaviors. The hormone's neural activity matches those found in mammals, indicating a conserved role in emotional contagion.
A recent study published in iScience has found that Covid-19 vaccination does not cause concerning changes to periods. Women who have been infected with the Covid-19 virus are at increased risk of menstrual changes such as missed or heavier periods.
A new study by the University of Exeter found that microplastic pollution reduces energy production in microscopic creatures like Paramecium bursaria. The microorganisms rely on algae for energy through photosynthesis, but severe contamination can lead to a 50% decline in net photosynthesis.
A new mathematical model predicts turbulence and heat transport in fusion plasmas with high accuracy, approximately 1,500 times faster than conventional large-scale nonlinear calculations. This breakthrough accelerates fusion research and expands the range of applicability.
Astrophysicists used AI to improve mass estimates of galaxy clusters by adding a simple term to an existing equation. The new equation downplays the importance of complex cores in calculations, providing more reliable mass inferences.
A new point-of-care testing kit will facilitate early diagnosis and monitoring of Alzheimer's Disease in primary clinics or home settings. The kit detects biomarkers in skin samples, enabling early identification of individuals at greatest risk of dementia.
Researchers describe a new approach to constructing a nose in two young patients with congenital arhinia, a rare genetic disorder that causes the absence of the nose. The staged technique involves augmenting the underlying bones of the face and creating an external nose using tissue expansion and grafts.
Researchers at Shinshu University have developed a closed-loop recycling process for polymers using microparticles, resulting in fully recyclable films with high mechanical stability and fracture energy. The strategy enables the reuse of polymer materials, reducing plastic waste and environmental pollution.
Researchers utilize liquid crystal droplets to visualize electric field distribution within microelectrodes, revealing rotational and translational behaviors under applied voltage. The technique provides high spatial resolution and detection accuracy, enabling defect location analysis.
A new study found that droughts and heatwaves exacerbate air pollution inequalities in California, particularly for communities of color. Financial penalties for power plants can significantly reduce people's exposure to pollution, except during severe heat waves.
Researchers have developed a method to produce QS-7, a promising saponin-based vaccine additive, in tobacco plants. This breakthrough paves the way for scalable and sustainable production of important saponin-based vaccine additives.
Researchers discovered that as magma production decreased, volcanoes became increasingly complex, with internal magma pockets and reservoirs forming. The study provides insights into volcanic eruption processes and can inform our understanding of active continental hotspot volcanoes globally.
New research highlights the need for extra support from professionals like teachers, youth workers, and speech therapists for children with disabilities when using the internet. The study found that these professionals often fail to provide adequate guidance on managing online risks, exacerbating existing digital inequalities.
A research team at HKUMed has invented a non-invasive technology to effectively reduce methicillin-resistant Staphylococcus aureus (MRSA) infection in bony tissue. The novel antibacterial nano-sheets can release ROS subject to ultrasound stimulation, eliminating MRSA bacteria deeply seated in bony tissue with 99.72% efficacy.
A new study finds that Black, Latinx, and low-income people are disproportionately exposed to drilling-related pollution near active oil and gas wells in California. This exposure has been linked to various health issues, including asthma, preterm births, and other problems.
Dr. Crystal Mackall, a leader in advancing cell and gene therapies for children's cancers, is the newest recipient of the Edward Netter Leadership Award. She has led numerous clinical trials treating children with sarcomas and brain cancers.
Researchers have identified a protein that enables sorghum to grow in alkaline, salty soils, increasing its productivity in underutilized sodic lands. The findings suggest designing knockouts of AT1 homologs in crops could improve their yields in salty soils.
A new tool, Paper Park Index (PPI), helps identify 55 marine protected areas that fail to protect marine biodiversity. Most 'paper parks' are located in Latin America and the Caribbean, where fishing intensity is high.
A study published in Redox Biology found that decreased expression of mitochondrial aminoacyl-tRNA synthetases leads to downregulation of OXPHOS subunits in type 2 diabetic muscle. Nitric oxide production is also increased, which could be used as a method for diagnosing the disease.
A team of researchers used machine learning to analyze elemental abundances in over 450 extremely metal-poor stars. The study found that 68% of these stars have a chemical fingerprint consistent with enrichment by multiple supernovae, providing the first quantitative constraint on the multiplicity of the first stars. This challenges th...
The new system, built by researchers at the University of Waterloo, uses low-power radar technology to track activities and alert medical experts to potential health issues. It can detect decline in mobility, increased likelihood of falls, and onset of medical conditions without the need for wearable devices.