Researchers at Tohoku University used cryo-electron microscopy to determine the high-resolution 3D structure of human SPCA1a, a protein pump involved in calcium and manganese ion transport. The study provided insights into how the protein works and how mutations can cause Hailey-Hailey disease and other neurodegenerative disorders.
Researchers use novel method to map gluons in nuclei by tracking particle interactions, offering insights into proton and neutron structure. The technique has potential applications in harnessing quantum entanglement.
A new digital tool, IWM Tool, has been developed to help farmers design and implement integrated weed management strategies, reducing pesticide use by 50% by 2030. The tool provides a user-friendly approach to diversify weed management strategies, fitting specific needs.
New research from Instituto Gulbenkian de Ciencia finds that zebrafish use oxytocin to recognize and mimic emotions, mirroring the behavior of humans and other mammals. The study suggests that this social behavior is evolutionarily conserved across species.
The Southern Resident killer whale population is spending far less time in the San Juan Islands as their primary food source, Chinook salmon, declines. This decline is likely an effort to find alternative food sources, and research shows a strong relationship between the whales' presence and salmon returns.
Researchers report that RNA vaccination in pregnant rabbits confers benefits to offspring, triggering robust antibody responses that are likely passively transferred. The study supports further development of the LION TM/repRNA vaccine platform for protecting against mother-to-child transmission of pathogens.
A new study found that acquisitions in the biopharmaceutical industry can disrupt trust and knowledge exchange routines between companies, leading to a higher risk of alliance termination. The odds of termination for exposed alliances are 11% greater than for unexposed ones.
Researchers have created a micrometre-size model of atomic graphene to study defects, which are crucial for the material's properties. The model reveals that common defects form in early stages of growth and lead to stable defect configurations.
A new study published at ECCMID 2023 found that antibiotics do not reduce the risk of dying in adults hospitalised with common viral respiratory infections like influenza. The research suggests a restrictive antibiotic strategy for these types of infections may be warranted to reduce unnecessary prescribing and combat antimicrobial res...
The TANGO project seeks to establish a symbiotic relationship between humans and machines, enabling effective and innovative AI systems that expand human reasoning and decision-making capabilities. Real-world use cases will be evaluated to assess the framework's potential impact on individuals and society.
A statewide incentive program in Pennsylvania is associated with a 50% improvement in initiating medication-assisted treatment for opioid use disorder among Medicaid-enrolled patients. The study found that the program increased prescription fills for buprenorphine and substance use disorder treatment within a week of emergency departme...
Scientists at the University of Helsinki have discovered that genetic mutations can significantly impact the accuracy of stem cell-based disease models. The researchers found that somatic mutations in genes like BCOR can affect the differentiation process and gene expression, leading to variations in the model's reliability.
The circadian rhythm governs most cellular functions implicated in cancer progression, making it an opportunity to intervene in the most timely and effective way. Leveraging this information, chronotherapy holds promise as a valuable alternative treatment option.
Researchers found that dieting amplifies neural signals of hunger in the brain, leading to increased food intake and weight gain. This long-term change could be a key target for developing therapies to prevent the yo-yo effect.
Researchers at the University of Helsinki have developed a nasal spray that is effective in preventing coronavirus infection, including the latest variants. The molecule, TriSb92, identifies a region in the spike protein common to all current variants and inhibits its functioning.
Researchers found that select patients with early-stage disease who undergo a less invasive procedure have comparable outcomes to traditional lobectomy. The study adds evidence supporting the preservation of functional lung tissue in cancer patients whenever possible.
Researchers developed smart bandages that can monitor wound conditions and deliver medication to treat inflammation and infection. The bandages have shown promising results in animal models, offering real-time updates and speed healing of chronic infected wounds.
A bacterial molecule, ARBM101, has been found to efficiently lower liver copper levels in a rat model, offering a promising new therapeutic option for Wilson's disease. The treatment approach involves weekly applications followed by month-long breaks, significantly shortening the therapy period.
A recent study published in JAMA Network Open found that food insecurity is associated with a decline in executive function among older adults. The research used data from 3,037 community-dwelling Medicare beneficiaries and suggests that interventions to increase healthy food access may be crucial in mitigating cognitive decline.
Researchers at the University of Texas at Austin are developing a new mining technology that uses CO2 to weaken rock containing critical minerals, reducing energy needed for mining. The goal is to make mining carbon negative by storing more carbon than produced.
A new strategy balances disease control with resistance management by balancing resistance to both fungicides until it increases enough to fail. The approach is robust to variations in parameters and could influence policy recommendations.
A team from KERI-KIT developed a process technology for optimal silicon disulfide (SiS2) production, addressing challenges in processing and material cost. The new technology improves ionic conductivity and moisture stability, making solid-state electrolytes more efficient.
A large-scale population health study found that tobacco users in Canada have higher levels of thiocyanate, a biomarker of cyanide exposure. This may be due to the type of cigarettes smoked in high-income countries, which are engineered to be less harmful but still pose significant health risks.
A recent study of 95,000 U.S. physicians found that female physicians work significantly fewer hours than their male counterparts, resulting in a substantial earnings penalty. This disparity is attributed to societal and institutional barriers that discourage women from working long hours.
MSU researchers have found a specific gene that regulates plant growth in response to low phosphorus levels. This discovery changes the way researchers understand iron toxicity in plants and holds promise for developing crops that can thrive with reduced phosphorus use.
Receiving buprenorphine after a nonfatal opioid overdose significantly lowers the risk of subsequent overdose death. The medication was associated with a 62% reduction in risk, highlighting the need for lifesaving treatment following these events. Current evidence shows low uptake of buprenorphine and other medication-assisted treatments.
A new study published in Ecosphere finds that newly created tidal marshes in Barataria Bay rapidly become indistinguishable from natural marshes, supporting the state's plans to rebuild its coastline. The research reveals similar biodiversity in both created and natural marshes.
A statewide effort in Michigan resulted in a 56% reduction in opioid prescriptions after six common operations and a 26% drop in persistent opioid use. The achievement surpassed national trends, driven by voluntary prescribing guidelines and surgical team involvement.
A new study has deciphered a central regulatory mechanism of fibrin formation, proposing therapeutic approaches. Glycoprotein V controls thrombin activity and limits fibrin formation.
A new study assesses sleep and fatigue risk in emergency physicians over two months using a wearable device, revealing that 50% of their shifts are spent in a high cognitive readiness state. The researchers also found that later shift start times are associated with greater fatigue due to circadian rhythm disruption.
A new report highlights the critical role of corporate investment in advancing climate technology. Corporate investors can accelerate innovation, access global markets, and meet ESG commitments. However, a significant gap remains for governments to incentivize investment in climate-tech that aligns with long-term goals.
A study by Osaka Metropolitan University found that users of heated tobacco products had a higher rate of COVID-19 infections and severe cases requiring hospitalization or oxygen. Researchers analyzed data from 30,130 participants and discovered a significant association between heated tobacco product use and increased risk of SARS-CoV...
Researchers at Dalian Institute of Chemical Physics have developed a new method to synthesize higher alcohols from syngas using synergistic iron carbide catalysts. The catalysts achieve a high oxygenate selectivity and produce a significant amount of higher alcohols, making this process a promising alternative for sustainable production.
Researchers at the University of Adelaide have found that more predictable solar or wind energy generation can save millions of dollars in operating costs and prevent clean energy spillage. By analyzing six existing solar farms, they discovered that optimal locations changed when predictability was considered, leading to significant in...
A recent study by IIASA researchers found that maternal education, especially secondary education, significantly reduces under-five mortality rates in both rural and urban areas of India. The study analyzed data from the Indian National Family Health Survey and discovered a protective effect of maternal education on child mortality.
A retrospective cohort study of hospitalized patients with and without substance use disorders during the early phase of the COVID-19 pandemic found no association between SUD and inpatient COVID-19-related mortality. Patients with and without SUD had similar clinical complications, including mechanical ventilation and ICU admission.
Researchers have found that valosin-containing protein (VCP) is essential for KRAS-mutant pancreatic ductal adenocarcinoma cell growth and survival. Inhibiting VCP, combined with autophagy inhibition, enhances efficacy in preclinical studies.
A new study suggests that age, not weight, should be used to screen for diabetes, capturing the greatest number of people in all racial and ethnic groups. The approach identifies the greatest proportion of adults with prediabetes and diabetes and maximizes equity across racial and ethnic groups.
Researchers developed innovative contrast-enhancing agents to tackle limitations of photoacoustic imaging, including low SNR, image contrast, and targeted delivery. The study suggests promising strategies such as photoswitching agents, near-infrared-II agents, and micromotor agents.
Research using artificial intelligence analyzed nearly 400,000 customer reviews to identify key themes and customer sentiment towards airlines. The study found that customers commonly complained about lost luggage, uncomfortable seating and flight cancellations, but praised in-flight entertainment, ground staff and business-class servi...
Current radiotherapy contouring guidelines often miss lesions in the prostate bed, leading to unnecessary tissue irradiation. PSMA PET mapping reveals that nearly a third of patients experience disease progression within 10 years after radical prostatectomy.
A new tool has been developed to identify adolescent girls in developing countries who are at risk of nutritional deficiency, with a focus on Bangladesh. The tool uses a simple metric and can be applied online, avoiding the need for costly finger prick blood sampling.
Researchers at CABBI designed a new wastewater treatment process that simultaneously treats water and recovers biogas, reducing capital costs and energy usage. The process efficiently converts organic contaminants to biogas, achieving simultaneous energy recovery and wastewater treatment.
Researchers at Wake Forest University School of Medicine will create a data infrastructure support center to assist innovation projects addressing opioid use disorder and pain management. The center will monitor real-time opioid overdose trends and inform prevention and treatment services.
Researchers discovered a way to translate quantum information between different quantum technologies using atoms and lasers. The technology allows the transfer of quantum information from microwave photons to optical photons, enabling long-distance connections between quantum computers.
A team of scientists has characterized chlorophylls in photosystem I using quantum chemical calculations, revealing key elements of its super-efficient energy transfer. The study identifies 'red chlorophylls' that absorb lower energies and overcome energy barriers, enabling the system to constantly open new pathways.
The Indian Institute of Science researchers developed a full-duplex antenna system that cancels out self-interference, enabling faster and more efficient data transfer. The compact design eliminates the need for bulky components, making it suitable for integration into devices.
A new framework developed by a multidisciplinary team provides guidance to local and regional planners to anticipate and prepare for the impacts of climate change on critical civic resources. The C-FEWS framework evaluates options and makes decisions related to specific local conditions, focusing on the nexus of food, energy, and water.
Researchers propose incorporating 'hopamine' into therapeutic mix to personalize care for individuals with Parkinson's disease. By considering each person's unique physical and personal characteristics, healthcare professionals can avoid false hopes and create more effective treatment plans.
A new study published in Cell Reports shows that gut bacteria from the patient's own intestine can cause post-operative infections, which are often fatal. The liver plays a key role in controlling these spreading bacteria through special immune cells called innate lymphoid cells.
Researchers at Chalmers University of Technology have developed a cellulose-based material that can easily remove 80% of toxic dyes from wastewater using sunlight. The method is cost-effective, simple to set up, and could benefit countries with poor water treatment technologies.
Researchers from Beth Israel Deaconess Medical Center found that newer unibody aortic stent grafts failed to meet non-inferiority compared to non-unibody devices. A surveillance program is recommended to monitor safety events related to aortic stent grafts.
Studies suggest that four genetic variants controlling eye pigmentation also regulate retinal health, with imbalances linked to diseases like neurodegenerative conditions. The kynurenine pathway's metabolites play a crucial role in maintaining retinal health.
The giant faba bean genome has been successfully sequenced, providing a wealth of information on its genetic makeup. This breakthrough will facilitate varietal selection for traits related to protein content and yield potential, addressing global demand for plant-based proteins.
Researchers found that chloride ions bind to sweet taste receptors and evoke a taste sensation. The study suggests that low concentrations of Cl- can produce a 'light' sweet taste sensation via the T1r in the taste buds.
A new study warns of a rise in potentially fatal infections caused by bacteria found along parts of the US coast, driven by global warming. The number of Vibrio vulnificus infections has increased from 10 to 80 per year over 30 years, with cases now found further north than ever before.
A new study by Penn State researchers found that ground beetle species will thrive or decline based on their habitats and traits. Habitat conservation can help mitigate the effects of climate change on these insects, which are critical pest control agents in North American agriculture.
The study found a 1.14% incidence rate of moderate and severe OHSS among Chinese women of reproductive age between 2013 and 2017. Women under 35 years old receiving ART are at high risk, accounting for 80% of new cases during this period.
The study found that vaccination significantly reduces the risk of long COVID, while factors such as being overweight, female, smoker, or over 40 increase the likelihood of developing the condition. Vaccination halves people's risk of developing long Covid
Researchers found that a large genetic region responsible for immune responses showed rapid evolution and more Mesolithic hunter-gatherer ancestry, suggesting that genetic variants already present in Europe were passed down preferentially. This suggests that diversity in immune genes may be just as important as adaptation to lifestyle.