Researchers have developed a novel probe, CDg18, to selectively dye M2 macrophages, which are associated with cancer progression. This breakthrough enables real-time monitoring of macrophage reprogramming in cancerous tissues, holding promise for new cancer treatments.
Researchers have found a possible early warning indicator for adverse reactions to childhood cancer treatments. Low levels of vitamin A in the liver and blood may signal an increased risk of pancreatitis, a potentially life-threatening complication of asparaginase treatment. Increasing dietary vitamin A levels may help reduce this risk.
Assistant Professor Reza Ahmadzadeh at UMass Lowell has been awarded a $500,000 NSF CAREER grant to develop new algorithms for robots to learn complex tasks. The project aims to improve robot performance in everyday tasks, enabling them to assist older adults with daily chores and automate difficult duties in the workplace.
A new study from the University of Illinois Chicago found a substantial increase in crash fatalities in four states with legalized recreational cannabis, with an average 10% increase in motor vehicle accident deaths. The study suggests that investing in policies and public health initiatives may mitigate this harm.
Astronomers using JWST discovered that the atmosphere of exoplanet HD149026b, a 'hot Jupiter,' is super-abundant in carbon and oxygen, far above expectations. This finding provides insight into planet formation and suggests that giant planets may have varied atmospheric compositions.
The early stages of the COVID-19 pandemic led to reduced opportunities for sex, with fewer reported unplanned pregnancies and abortions, but higher levels of sexual dissatisfaction and distress. The National Survey found that people were more likely to have multiple partners, but less likely to use condoms with new partners.
A study found that socially vulnerable populations have poorer COVID-19 outcomes despite similar vaccine effectiveness, due to lower vaccination rates. The VISION Network analyzed electronic health record data and immunization records to highlight the need for targeted public health efforts on vaccine coverage.
Researchers used long-read sequencing to identify novel mutational patterns and complex genomic rearrangements in cancer genomes, including those associated with liposarcoma. This approach offers a more comprehensive understanding of DNA mutations and their impact on cell function.
A University of Central Florida professor led a study identifying six challenges humans must overcome to ensure reliable, safe, trustworthy, and compatible AI. The challenges include responsible design, privacy protection, and respectful interaction with human cognitive capacities.
A large observational study found that most patients do not medically benefit from consultation with a medical specialist before their surgery. The study of 359,618 patients in Ontario suggested that preoperative medical consultations were an independent risk factor for death 30 days after surgery.
Researchers at Rutgers University propose a new approach to accurately diagnosing cannabis use disorder, particularly for individuals who use cannabis for therapeutic purposes. The current diagnostic manual may misdiagnose these individuals due to the rapid increase in state-level legalization of medical marijuana.
Researchers investigated the alkenone unsaturation index (U K'37 ) and sea surface temperature (SST) relationship in coastal and continental shelf waters. They proposed a non-linear regression equation to improve SST reconstruction accuracy in marginal seas.
A new study published in Environment International reveals that vehicle exhaust filters have limited impact on reducing ultrafine particles, which are a major contributor to air pollution. The research shows that current filters are not effective at removing smaller liquid particles, highlighting the need for alternative measures to re...
The NRG-GY018 trial found that pembrolizumab significantly improved progression-free survival outcomes in women with stage III-IV or recurrent endometrial cancer, particularly those with mismatch repair deficient tumors. The treatment also demonstrated improved overall survival and quality of life outcomes.
A new protein-based coating developed by Rice University researchers has the potential to extend the shelf life of fruits and vegetables, reducing food waste and spoilage. The coating, made from surplus eggs, was shown to double the shelf life of avocados and bananas in earlier research.
Researchers have identified properties like curl shape, coils, and cuticle layers that can help distinguish between curly, kinky, wavy, and straight hair. These findings aim to provide a more precise and quantitative classification system for haircare products.
A massive supercomplex in mitochondria comprising all four respiratory complexes induces a membrane curvature necessary for proper mitochondrial function. The supercomplex assembly actively contributes to the shaping of the macroscopic architecture of mitochondria.
Researchers developed a hybrid micro-robot that can navigate in physiological environments and capture targeted damaged cells. The micro-robot uses electric and magnetic mechanisms to identify and transport single cells for further study.
Scientists create new 'phase change inks' using nanotechnology to regulate temperature in everyday environments. These innovative materials could transform how we heat and cool buildings, homes, and cars by adjusting radiation absorption based on surroundings, enabling passive climate control.
Scientists have identified distinct mechanisms by which people remove information from their working memory and found that forgetting requires much effort. They also discovered four brain networks that activate when memories are maintained or purged through different mechanisms.
A new study published in Critical Care found that repeated high doses of steroids improve patient outcomes under specific circumstances. The researchers analyzed a large dataset to iron out the specifics of this treatment and identified optimal conditions for pulse methylprednisolone therapy.
Researchers have discovered new targets for developing antibiotics to combat sepsis, a leading cause of death worldwide. The study provides valuable insights into how different bacterial species respond to infection and could lead to more effective treatments.
A researcher has converted elements' visible light into audio, creating complex sounds for each one. The project aims to create an interactive musical periodic table with potential value as an alternative teaching method in chemistry classrooms.
A global analysis of coronavirus protein research found that countries with larger economies generated more 3D structure determinations for the protein components of coronaviruses. However, there were many outliers, with some advanced and prosperous countries publishing few or no structures, while others strongly affected by COVID-19 p...
Researchers have discovered the critical role of linker histone protein H1 in plant immune responses to bacterial and fungal infections. The study found that mutant plants with knocked-out H1 isoforms exhibited higher defense gene expression and resistance to infection, but lacked priming ability.
Researchers have developed a plant-based film that gets cooler when exposed to sunlight and comes in various colors, promoting passive daytime radiative cooling. The material can rival residential air conditioners in cooling power and has potential applications in buildings, cars, and other structures.
Researchers discovered that cancer cells' glycocalyx thickness affects immune cell evasion and engineered immune cells work better with thinner barriers. They also developed special enzymes to overcome the barrier, potentially improving immunotherapies.
A study of 110,780 participants in the UK Biobank found that individuals with a lifetime history of mental illness had metabolite profiles suggesting they were biologically older than their actual age. This may contribute to shorter lifespans and increased age-related diseases among those with mental health problems.
Researchers have found that embryos in pregnancies ending in miscarriage take four days longer to develop in the womb than those in live births. This delay is associated with a higher likelihood of miscarriage and may be used to estimate pregnancy outcomes.
A team of scientists led by Xiulei Ji at Oregon State University has developed a new electrolyte that enables nearly 100% efficiency in zinc metal anode batteries. The breakthrough uses water and inexpensive chloride salts, offering a secure and efficient solution for large-scale energy storage.
Researchers have identified tens of thousands of molecular 'puzzle pieces' in two meteorites, including a larger amount of oxygen atoms than expected. This analysis provides a unique window into the origin of life itself and sheds light on the formation of the universe.
Researchers identified ARID1A and PIK3CA as potential targets for drug development in recurrent and metastatic cervical cancer. The study found that these mutations were associated with improved survival rates, suggesting their potential as new treatment options.
A study by Oregon State University scientists reveals that the black-backed woodpecker can successfully breed in both burned and unburned forests, with better nestling body condition found in green forest. The research has significant implications for conservation and forest management efforts, suggesting that practices promoting pyrod...
A UK study found that virtual wards can safely manage most individuals with mpox, saving an estimated 2,100 hospital bed days. The virtual ward model was widely adopted in the UK to respond to the 2022 global outbreak of mpox.
A team of researchers from POSTECH and Georgia Tech developed a biohybrid 3D printed heart model with integrated sensors to monitor drug-induced cardiotoxicity. The platform enables real-time, continuous monitoring of heart contractions, facilitating the testing of acute and chronic pharmacological effects.
A new study by the University of East Anglia found that large infrastructure projects can create lasting local impact when they offer place-based micro-enterprise training and employment support. The project, INCREASE VS, has helped over 4,500 participants start their own businesses and access work and education opportunities.
Scientists have identified a compound that prevents C. difficile infection caused by multiple strains of the bacterium, including those causing serious illness. Researchers are now developing new drug candidates to prevent serious C. diff infections in people. The research also explores how diet and sex affect C. diff infection severity.
A study analyzed the EAST – AFNET 4 trial, finding early rhythm control therapy improves outcomes in patients with AF and comorbidities. However, a cost-effectiveness analysis revealed that the health benefits come at reasonable additional costs.
A new study found that eating walnuts may alter the mix of gut microbes in a way that increases the body's production of amino acid L-homoarginine, which has been linked to lower cardiovascular risk. Researchers also discovered higher levels of certain bacteria in the gut of participants on the walnut diet.
Researchers found that exposure to human sweat odors, extracted from underarm sweat, reduced social anxiety in patients undergoing mindfulness therapy. The study showed a 39% reduction in anxiety scores compared to a 17% reduction in the control group.
High-entropy metal telluride superconductors exhibit unique properties due to structural disorder and atomic vibrations. The discovery sheds light on the coupling between electrons and lattice vibrations, potentially leading to exotic superconductivity mechanisms.
Research at ESC Acute CardioVascular Care 2023 found that over 40% of women report anxiety four months after a cardiac arrest, compared to 23% of men. Women experienced higher levels of post-traumatic stress disorder (PTSD) and depression, emphasizing the need for long-term mental health support.
Researchers at Max Planck Institute developed an ammonia-based direct reduction process to produce sustainable iron and steel, overcoming logistics and energetic disadvantages of hydrogen. The process yields the same metallization degree as hydrogen-based reduction while forming nitrides that protect the sponge iron from corrosion.
A new study reveals that childhood emotional trauma and sexual abuse are strongly associated with psychiatric symptoms in women, while childhood emotional and physical neglect increase the risk of symptoms in men. The research analyzed data from over 791 volunteers worldwide.
The NRG-GY017 trial found that atezolizumab improved 2-year disease-free survival rates (79% vs. 59%) and pathologically complete or partial responses (69% vs. 40%) for patients with locally advanced cervical cancer. The study also showed a favorable immune response, including positive PD-L1 scoring and T-cell receptor clonal expansion.
Researchers have found that depression and anxiety sufferers who experienced traumatic childhoods tend to grow up as angry adults. The severity of childhood trauma is also correlated with the level of adult anger, with emotional neglect increasing irritability and physical abuse leading to anger attacks or antisocial personality traits.
Women with locally advanced squamous cell carcinoma of the vulva who received gemcitabine concurrently with cisplatin and intensity-modulated radiation therapy exhibited increased rates of pathologic complete responses. The study found improved survival and response outcomes for this population, while minimizing toxicity.
A phase II trial investigating the combination of ribociclib and letrozole showed a response rate of 23%, progression-free survival of 19.1 months, and duration of response of 19.1 months in patients with recurrent low-grade serous ovarian cancer.
The Lp(a) Discovery Project will develop clinical standards for optimal patient care through a new screening measure and quality improvement interventions. The three-year project aims to fill knowledge gaps around Lp(a) and encourage better treatments to reduce cardiovascular risk.
Researchers have created a high-resolution, single-cell model of the human hippocampus CA1 area using data from the BigBrain Atlas. The model replicates the structure and architecture of the neurons, as well as their connectivity. This advancement in neuroscience has potential applications for modeling other brain regions.
A major European study confirms a significant drop in suicides over the last decade, with 15 countries showing a 20% decrease in rates. The study suggests that active measures to prevent suicide may be linked to this decline.
Researchers at Pohang University of Science & Technology have created a high-performance AI semiconductor device using IGZO, achieving over 98% accuracy in handwritten data classification. The new device's design enables efficient linear and symmetric programming, making it suitable for large-scale AI applications.
A study by Karolinska Institutet found that blind individuals have a heightened ability to sense signals from their inner body, with an average accuracy of 0.78 for counting heartbeats. This enhanced sensitivity may also impact emotional processing and perception.
Researchers found that marketing diet or sugar-free versions does not increase overall turnover, but reducing package size leads to an increase in sales figures. Smaller packages also work better when marketed as a fun alternative.
Researchers at Tokyo Medical and Dental University have developed a polymeric nanoparticle gene delivery system that promotes bone formation after traumatic inflammation. The therapy inhibits excessive inflammation and prevents residual ridge resorption, leading to improved tissue healing after tooth extraction.
A new study found that stronger air pollution rules would lower premature death risks for all Americans, but particularly those from marginalized communities. Lowering PM2.5 levels to 8 μg/m3 could reduce mortality rates by 4% for White higher-income adults and up to 7% for Black higher-income and low-income adults.
Researchers at the University of Wisconsin-Madison have identified a specific cell population, called CD4/CD8 double positive T cells, that causes graft-versus-host disease in bone marrow transplants. The team's findings may lead to targeted treatments and improved patient outcomes.
A new study highlights digital divide disparities in rural US communities, citing limited broadband and lower socioeconomic resources. Researchers stress the need for targeted policies to increase access to telemedicine and online health services.
A recent study found that the mitochondrial antioxidant MitoQ can reverse the detrimental effects of HIV and antiretroviral therapy on organs such as the brain, heart, and liver. The researchers used humanized mice infected with HIV and treated them with MitoQ for three months.
A new national study finds that lesbian, gay, and bisexual (LGB) youth are twice as likely to report trouble falling or staying asleep than their straight peers. This is attributed to greater depression, stress, and family conflict among LGB youth, which can make it harder for them to get a good night's sleep.