A new study published in Cell found that TGF-beta and RAS signaling pathways are both required for lung cancer metastasis. Inhibiting RREB1, a transcription factor controlled by RAS, disabled the metastatic process in mouse models, suggesting it could be a potential new drug target.
A team of researchers at ETH Zurich created a method to suppress sound wave propagation in the backward direction without deteriorating forward propagation. They achieved this using self-oscillations and a circulator, which allows sound waves to travel only one way.
A Trinity scientist has won an ERC Starting Grant to investigate the role of microglia in brain disorders. The project aims to create a detailed map of how these immune cells change during brain damage, disease, or repair, with the goal of developing methods to control and rejuvenate neuropathology.
Researchers at Huntsman Cancer Institute have developed a mechanism that accurately forecasts the aggressiveness of triple-negative breast cancer (TNBC). This advancement could allow doctors to identify higher-risk patients and tailor precise treatments.
ISTA's Lisa Bugnet, Alicia Michael, and Marco Mondelli have been awarded ERC Starting Grants to develop new methods for extracting information from data, studying gene regulation, and understanding time-keeping in cells. Their projects aim to simplify data analysis, accelerate personalized medicine, and uncover the secrets of biologica...
Researchers Maria Eichlseder and Fariba Karimi will study keyless encryption and AI's impact on online social networks to promote fair algorithms. Their projects aim to address open problems in cryptographic systems and quantify intersectional inequality.
Researchers from Zhejiang University have developed a hybrid laser direct writing technique that enables the creation of functional copper interconnects and carbon-based sensors within a single integrated system. The process allows for real-time temperature monitoring over extended periods, ensuring optimal performance and reliability.
A recent study published in the Journal of Nutrition Education and Behavior examines the connection between food insecurity and gestational diabetes risk among young American Indian and Alaska Native females. The research highlights how targeted risk reduction methods could significantly improve diabetes health outcomes for this popula...
Researchers found that existing estimates of invasive species in Wisconsin lakes were off by 500%, with some populations present for decades before impacting the ecosystem. Long-term research has provided valuable insights into the effects of invasive species and how to mitigate their impacts.
A novel synthetic biology platform enables rapid and cost-effective transformation of protein binders into high-contrast nanosensors for various applications. The platform uses fluorogenic amino acids to increase fluorescence up to 100-fold, enabling the detection of specific proteins, peptides, and small molecules.
A new study by University of South Florida researchers found that receiving a complimentary healthy food item can influence consumers to purchase indulgent foods. The study, published in the Journal of the Academy of Marketing Science, suggests that free samples may not be as healthy as they seem.
A study published in BMC Global and Public Health found that using an AI-powered conversational agent (ECA) improved knowledge about family planning methods, folic acid use, and healthy eating among young women in Lesotho. The ECA model was adapted to the local culture and used a professional nurse midwife persona to engage users.
A 23-year-old patient with severe systemic lupus erythematosus achieved complete symptom relief after five injections of teclistamab, a cancer medication. The treatment significantly improved kidney function, blood levels, and reduced inflammation in the skin and joints.
Researchers at Mount Sinai developed an AI model that predicts brain blood pressure using noninvasive data, enabling swift detection of critical changes and potentially saving lives. The study showed strong performance in detecting intracranial pressure within seconds.
Researchers at UF are creating a data biorepository to explore pain pathways and create custom treatments. They're collecting and analyzing human tissue samples and using AI to map and understand the complex relationship between neurons and pain.
Researchers at Gladstone Institutes have developed a streamlined way to engineer bacteriophages, viruses that naturally kill bacteria. The new technique uses retrons to edit phage genomes, allowing for the creation of numerous variants and paving the way for alternative treatments for antibiotic-resistant infections.
Researchers developed a gene therapy that restored useful vision to most patients with Leber congenital amaurosis type I, a rare inherited blindness. The treatment showed a 10,000-fold improvement in light sensitivity and improved navigation abilities in patients who received the highest dose.
Researchers have identified key cellular interactions and microenvironments that contribute to the development of chronic kidney disease (CKD) after acute kidney injury (AKI) in mice. The study, published in Nature Communications, provides new insights into how damaged cells interact within disease-promoting microenvironments.
A common skin fungus, Malassezia globosa, may invade deep tissues and cause tumor growth in breast cancer, according to a new study published in mBio. The researchers found that M. globosa colonizes in breast fat pads leading to tumor growth, suggesting a potential link between fungal colonization and cancer progression.
Scientists discover a dynamic paxillin-integrin interaction that enables flexible yet stable cell cohesion. This finding may lead to the development of new medical agents targeting cellular adhesion points.
A study published in Nature Communications reveals a cellular signaling pathway that promotes heart cell survival. The Mst1-FoxO1-C/EBP-β interaction stimulates protective mechanisms in cardiac myocytes, potentially paving the way for new therapies.
Prof. Dr. Hannah Schneider, a young researcher at IPK, has been awarded an ERC Starting Grant for her project on anatomical roots traits relevant to stress tolerance and resource efficiency in crops. Her work aims to engineer crop roots to better forage soil and capture resources, benefiting global agriculture.
Researchers suggest that hematopoietic stem and progenitor cells in the AML niche may retain an inflammatory memory, potentially leading to long-term functional consequences. This finding has significant implications for understanding the biology of acute myeloid leukemia (AML) and developing new cancer therapies.
A new study by Cedars-Sinai Cancer investigators found that most patients with stage 1 and stage 2 pancreatic cancer are upstaged after surgery. Lymph node involvement is often missed in the staging process, leading to inaccurate diagnoses and poorer survival rates.
A new AI tool called CAR-E is being developed to provide personalized coaching conversations for medical students and residents, encouraging reflective practice and enhancing their skills. The web-based tool will use a coaching approach to prompt students to think back on their clinical encounters and knowledge gaps.
A team of scientists used synchrotron light to explore low-valent uranium compounds, accurately identifying the three-valent oxidation state in uranium. The findings shed new light on actinide bonding and demonstrate how uranium's 5f electrons respond to changes in their environment.
A novel approach to overcome limitations of traditional methods, NeuPh uses local conditional neural fields to reconstruct high-resolution phase information from low-resolution measurements. It provides robust resolution enhancement and outperforms existing models in accuracy.
Researchers found that watching others experience harm increases serotonin release in the brain's lateral habenula, promoting resilience against depressive-like states. This breakthrough may inform new treatments for depression, PTSD, and addiction.
A new research model proposes a multi-user task migration strategy that balances migration costs and latency. The model achieves fast and stable convergence, outperforming existing methods in terms of system delay and user experience.
A University of Leicester study has found that certain gut bacteria may influence whether a patient's immune system is successful in fighting mesothelioma, an aggressive form of cancer. Researchers suggest that dietary changes, such as increased fibre intake, could improve the benefits of immunotherapy for these patients.
Drs Johanna Vos aims to better understand weather patterns on extrasolar worlds using the James Webb Space Telescope. Her Exo-PEA project will reveal dominant atmospheric processes governing giant world weather, expanding our understanding of planetary atmospheres.
Researchers have identified the lateral septum as a key region in the brain that regulates feeding behavior, leading to the development of new anti-obesity strategies. The study found that GLP-1R agonists like liraglutide activate neurons in this region to suppress appetite and reduce body weight.
Researchers found that vision impairments contribute significantly to the development of dementia in older adults, with a population attributable fraction ranging from 4.9% to 19.0%. The study highlights the importance of incorporating multiple objective measures of vision impairment into assessments to capture its impact on dementia.
Researchers at Cornell University have discovered an easy-to-reach location on the back of a reptile's head to take their pulse rate, corresponding to heart rate in healthy animals. This technique allows for a more complete cardiovascular examination and can be used to treat animals under anesthesia or when they're feeling defensive.
Two UCD researchers receive ERC Starting Grants to launch projects on microplastic toxicity and TBI biomechanics, promising breakthroughs in toxicology and public health.
Researchers at the Florida Museum of Natural History are studying bagworms' unique life cycle and their potential to inform understanding of modern climate change. They'll also analyze fossils from ancient mammal communities affected by rapid warming, as well as use AI to model future disease outbreaks.
Researchers at the University of Delaware found that flooded rice fields contain higher amounts of arsenic and lower amounts of cadmium. The drier conditions lead to lower arsenic and higher cadmium levels. This study provides potential guidance for reducing toxic metals in foods typically eaten by infants and children.
A recent study published in Molecular Biology and Evolution has discovered the genetic background of head shape variation in snail-eating carabid beetles. The researchers identified the odd-paired (opa) gene as a key factor determining the beetle's body shape, which is linked to its feeding strategy.
A study of 498 participants found that humans disapprove of hidden state deceptions but approve of external state deceptions that protect someone's feelings. The researchers suggest regulation to protect users from harmful deceptions and recommend further experimentation with real-life reactions.
A new study reveals that breeding queen conch populations within a protected marine reserve in The Bahamas sustain populations beyond the borders of the reserve. The research identifies where additional protections could help ensure the survival of future generations.
A recent study has revealed that oral bacteria, specifically Aggregatibacter actinomycetemcomitans, can exacerbate rheumatoid arthritis. The study found that the infection led to increased inflammation and joint damage in animal models.
Researchers at UNIL find that observing others cope with trauma increases resilience and prevents pathological states. Serotonin release in the habenula brain structure is identified as the key mechanism, offering new perspectives for understanding depression and treatment.
Researchers discovered that cyanobacteria can anticipate seasonal changes by sensing photoperiod, promoting cold resistance and altering lipid metabolism. This adaptation may have evolved before circadian clocks, suggesting a new perspective on biological timekeeping.
A new report published in The Lancet Planetary Health highlights the increasing health dangers posed by long-term weather extremes in the UK. The study finds that prolonged exposure to extreme temperatures can lead to various health issues, including reduced physical activity and dementia.
A team of researchers led by Dr. Zihao Ou successfully made the skin on live mice transparent using a mixture of water and tartrazine, a common food coloring. This breakthrough allows for direct observation of organs and tissues beneath the skin, opening up new possibilities for biomedical research.
New research from Hebrew University reveals that parents' understanding of their children's thoughts and feelings is crucial for providing effective emotional support. Parents who are good at mentalization can create a better homework environment, boosting children's independent learning and motivation.
Researchers successfully transform non-volar skin to have volar features, promoting resilience under high-pressure conditions. This breakthrough could lead to a new therapy for treating pressure-caused skin damage in amputees, addressing the painful issue of skin breakdown.
A new study reveals that young patients treated with psychiatric medications receive potentially dangerous combinations at a concerning frequency. Researchers analyzed New York State Medicaid records for over 141,000 patients and found nearly 400 received at least one potentially dangerous combination for one month or longer.
Researchers at Tel Aviv University used modern technologies to challenge the long-held myth that the Roman siege of Masada lasted three years. The study found that the siege actually lasted no more than a few weeks, using precise measurements and 3D digital modeling to calculate the time it took to build the siege system.
A new filtration material developed by MIT researchers uses natural silk and cellulose to remove persistent chemicals, including PFAS and heavy metals. The material's antimicrobial properties help keep filters clean, providing a nature-based solution to water contamination.
Researchers developed an algorithm to analyze peptides in infected wounds, revealing unique biomarkers that enable earlier and more accurate diagnoses. This breakthrough method uses mass spectrometry and machine learning to diagnose infections in just a few minutes.
New analysis of a lunar sample reveals volcanic eruptions on the Moon occurred as recently as 120 million years ago. Researchers found three tiny glass beads with high abundances of KREEP elements, suggesting localized heating and small-scale magma eruption.
Dr. Zewei Xiong has received an ERC Starting Grant to study collective neutrino oscillations in supernovae and neutron-star mergers. His project NeuTrAE aims to clarify lingering puzzles regarding neutrino flavor evolution, a crucial aspect of particle and nuclear astrophysics.
A recent Science study reveals that bat population decline led to a significant increase in pesticide use by farmers, resulting in more than 1,000 infant deaths. The study found a 31% rise in pesticide use and an 8% increase in infant mortality rate, highlighting the potential harm of pesticide misuse on human health.
A new study reveals that mindfulness meditation reduces pain intensity and unpleasantness ratings by directly modifying how we experience pain. Unlike the placebo cream, which only affects brain activity patterns associated with the placebo effect, mindfulness meditation employs a separate neural pathway to alleviate pain.
A recent study by University of Bristol scientists found that the novel pesticide flupyradifurone is lethal to mason bees at field-realistic concentrations. The research also revealed sublethal effects on bees, including reduced nesting behavior and lower survival rates.
Researchers will combine stem cell therapy with brain-computer interfaces to restore function to patients with brain damage. The goal is to create bidirectional connections between cultured brain cells and the living human brain.
Researchers have developed user-friendly tools to analyze spatial proteomics data, enabling biologists to understand how cells communicate with each other. The study sheds light on cellular mechanisms behind synaptic partner matching and immune system coordination, paving the way for new discoveries in biology.
Researchers observed parrotfish behaving more tolerant of neighboring fish but aggressively toward strangers. The 'dear enemy' effect, where territory holders show less aggression towards neighbors than strangers, was also noted. Parrotfish play a critical role in maintaining healthy coral reefs and contributing to white sand beaches.
Researchers at the University of Kansas are analyzing noninfectious mosquito saliva to understand how it affects the immune system and changes at a molecular level. The goal is to identify specific proteins that can serve as candidates for vaccine development.