A randomized trial found that continuing oral anticoagulants after transcatheter aortic valve implantation did not reduce thromboembolic events but increased bleeding risk. The study suggests interrupting OACs may be beneficial for patients undergoing TAVI.
The MATTERHORN trial shows that transcatheter edge-to-edge repair is non-inferior to surgery in patients with secondary mitral regurgitation, with some safety benefits favouring TEER. The study found no significant difference in efficacy between the two techniques.
Researchers found that supplementing potassium only when levels fell below 3.6 mEq/L was noninferior to the current practice of maintaining higher levels, with no increase in adverse outcomes. Lower thresholds did not worsen clinical outcomes or dysrhythmias.
A blood test that measures three modifiable factors together can better predict cardiovascular risk than any marker used alone. The study found that inflammation is at least as important as cholesterol in predicting cardiovascular events.
The NOTION-3 trial demonstrates that PCI plus TAVI is beneficial for patients with CAD, reducing MI and urgent revascularisation. The study suggests that performing PCI should be recommended for patients undergoing TAVI with CAD.
Researchers found that digital consultations significantly improved medication adherence among heart failure patients, with 28% receiving optimal medication combinations after 12 weeks. The study also showed no negative impact on patient satisfaction or quality of life.
A recent study suggests that synaptic plasticity is a collective action, where the behavior of one synapse influences others. The researchers found that strong competition among neighboring spines affects their dynamics and influences the direction and extent of plasticity. Understanding how neurons manage synaptic resources may contri...
Researchers found that measuring two types of fat in the bloodstream along with C-reactive protein can predict a woman's risk for cardiovascular disease decades later. Women with high levels of LDL cholesterol, Lp(a) and CRP had increased associated risks for heart disease, stroke and coronary heart disease.
A low-dose triple-pill protocol demonstrated improved blood pressure lowering and control, with good tolerability, compared to standard-care protocols for Black African adults with uncontrolled hypertension. The study results have significant implications for hypertension treatment in Nigeria.
Researchers used artificial networks as teachers and students to investigate how language-like communication enhances learning. The results showed that both roles developed a language that enables the student to learn from the teacher, influenced by task and learner performance.
Researchers identified 25 ferroptosis-related genes in keloids, including ALOX12 and CYP4F8, which show reduced activity. Understanding how specific miRNAs regulate ferroptosis may lead to new therapies that target these molecules to control keloid growth.
A randomized controlled trial found that transcatheter edge-to-edge repair (M-TEER) significantly reduced cardiovascular death and hospitalizations for heart failure, compared to medical therapy alone. The study also showed improved health status in patients with moderate to severe functional mitral regurgitation.
A novel low-dose 3-in-1 blood pressure pill (GMRx2) significantly reduces blood pressure in patients with uncontrolled hypertension. After six months treatment, the GMRx2 group achieved a 5.8mmHg lower systolic blood pressure compared to standard care.
A novel method for the selective chemical recycling of PET has been developed, allowing for the recovery of polyester from textile waste. The method uses alcohols and an inexpensive iron trichloride catalyst to yield diethyl terephthalate and ethylene glycol with high selectivity.