Researchers at Virginia Tech found that blocking two enzymes in the malaria parasite prevents it from growing, offering a potential new way to fight the disease. The study, published in Proceedings of the National Academy of Sciences, used an in vitro culture dish and discovered compounds that can inhibit parasitic growth.
Researchers developed a novel assay that integrates data from four fusion callers to identify disease-related gene fusions in pediatric tumors with high accuracy and efficiency. The new bioinformatics platform detected fusions, prioritized them, and custom curated downstream processes for consensus fusion calling.
A new U of M Medical School study reveals that bias-based bullying amplifies emotional distress in youth with multiple marginalized social positions, such as race, ethnicity, and LGBTQ+ status. The research analyzed over 80,000 students and found a significant reduction in emotional distress among those who experienced no bias-based bu...
Researchers have developed a new approach to treating cutaneous neurofibromas, a common skin tumor associated with neurofibromatosis type 1. By targeting the cAMP and Ras/MAPK pathways, this combination therapy may provide an enduring halt in the expansion of these tumors.
According to a new NREL report, millions of US households would see a drop in their energy bills by using heat pumps, with median savings ranging from $300 to $650 per year. However, high installation costs limit the technology's reach, making it only financially feasible for a smaller portion of households.
A new study suggests Mexico can grow its economy by building biorefineries to produce biofuels, chemicals, and pharmaceuticals from abundant organic waste materials. The research promotes the adoption of sustainable practices to achieve UN Sustainable Development Goals 8-12.
A Phase II trial found that neoadjuvant immunotherapy significantly reduced residual tumor and improved overall survival for patients with undifferentiated pleomorphic sarcoma, with 90% having less than 15% viable tumor cells remaining. The treatment approach is a promising option for patients with limited systemic therapy options.
A new study from the University of Delaware and Yale University aims to improve cost estimates for reducing greenhouse gas emissions by understanding the underlying frictions that prevent people from adopting newer, greener technologies. The researchers focus on the social sciences to better understand these negative costs.
A new study from the Icahn School of Medicine of Mount Sinai reveals significant variations in emergency medical service (EMS) performance across the United States. The research found that EMS agencies in rural areas were less likely to provide optimal care, including treating low blood sugar and pain for trauma patients.
Researchers used data from 9,300 miles of Greek roads to develop a machine-learning model predicting crash sites. The model identified key features such as abrupt speed limit changes and incomplete lane markings as predictors of crashes. The study's findings have implications for improving road safety globally.
Researchers at UBC Okanagan have discovered a way to study MUC2, a critical gut protein, from fecal matter, providing a non-invasive method for monitoring gut health. This breakthrough could lead to significant advancements in managing and preventing gut-related diseases.
The new guideline aims to improve diagnosis and treatment of cryptococcosis, a fatal fungal infection that affects mainly the lungs and brain. It provides practical guidance for medical staff to recognize and manage invasive fungal infections, with the goal of improving patient survival rates.
Researchers created an android avatar named Yui with human-like appearance to enable operators to inhabit and improve communication. The system provides a highly immersive experience through advanced head deformation, movement capabilities, and sensory organs.
Scientists investigated the photoluminescence properties of toroidal and randomly coiled supramolecular polymers. The study found that a closed circular structure led to higher energy and more efficient luminescence compared to random coils, which lost excitation energy due to defects.
A new study found that short and simple corrections from ordinary social media users can reduce the perceived accuracy of and engagement with incorrect content. Researchers also discovered that miscorrections can affect social media users, causing further confusion on platforms.
A century of reforestation in the eastern US led to significant cooling effects, with forests lowering land surface temperatures by 1-2 degrees Celsius annually. The study found that forest cover can influence ground surface temperatures and near-surface air temperatures, providing relief from heatwaves.
Research reveals oxytocin neurons in mouse brain modulate object recognition memory, with activation boosting long-term memory and implicating Alzheimer's disease. Oxytocin's role in social memory also highlighted, suggesting a potential link to loneliness or limited social engagement.
A Phase 2b clinical trial published in The Lancet found that abatacept reduces progression to rheumatoid arthritis and can also ease symptoms. After a year-long treatment, patients treated with abatacept showed significant reductions in disease onset and inflammation.
A recent study published in JAMA Network Open found that familiar scents can strengthen memory recall in depressed individuals, potentially aiding recovery. Researchers discovered that odors engage the amygdala, a key component of memory formation, more effectively than words.
Researchers at Cornell University have created a new version of the Vibrio natriegens microbe to speed up biological discovery, enabling cost-effective and scalable synthetic biology experiments. This microbe can be engineered within hours and works effectively without costly equipment, making it ideal for testing protein variants.
Researchers found that honey bees can fly in temperatures ranging from 77 to 104 degrees Fahrenheit without overheating, by lowering their wingbeat frequency and increasing stroke amplitude. This adaptation helps the bees conserve water and improve their heat tolerance.
USC researchers have designed nanoparticles that can target and highlight cancer cells in lymph nodes, allowing for earlier detection of metastasis. The particles work by hitchhiking on immune cells to reach the lymph nodes, where they can amplify the signal detected by MRI scans.
Experts summarize the current state of knowledge and challenges in creating superheavy elements. The 'island of enhanced stability' is confirmed experimentally, but its size and location remain unknown. Breakthrough results have been obtained on production, nuclear structure, and chemical properties.
Researchers at University Hospitals Cleveland Medical Center developed a quality improvement project using routine pain screening, revealing 32.7% of patients reported persistent or chronic pain, with music therapy and art therapy preferred for managing pain.
Researchers at Waseda University studied the behavior of chiral skyrmions in chiral flower-like obstacles and found that they exhibit active matter-like behaviors. The system can be used to develop a topological sorting device, which may create ordered results from disordered motion.
Researchers at University of Limerick in Ireland have discovered a way to efficiently convert low-grade heat into electricity using lignin-derived membranes. The breakthrough technology has significant potential for developing sustainable heat-to-electricity applications, reducing waste heat's environmental impact.
A new study published in eNeuro explores the intricate interplay between brain regions involved in nicotine's effects on the human brain. Researchers discovered that the medial habenula experiences fluctuations in activity based on factors such as dosage and sex, highlighting a nuanced relationship.
A retrospective study found that PRRT was effective in controlling hypoglycemia in 81% of patients with malignant insulinomas, enabling 58% to reduce medication use. The treatment resulted in improved symptom control and reduced potential drug side effects for over 80% of patients.
A recent study found that polar bears, closely observed by scientists, struggled to maintain weight when their preferred seal prey was out of reach during longer ice-free seasons. Despite trying various strategies, including resting and foraging, nearly all the bears lost weight rapidly, highlighting their vulnerability to climate change.
A recent study from the Hebrew University of Jerusalem uncovers notable correlations between the Indian Ocean and precipitation in the Middle East, which may lead to seasonal prediction of Fall precipitation. The research highlights a discernible upward trend in crucial Indian Ocean climate indices over the last four decades, indicatin...
A study published in the Journal of the American College of Surgeons found that gastric bypass surgery results in high rates of Type-2 diabetes remission five years after the operation, even after patients regain a significant amount of weight. In contrast, patients who underwent sleeve gastrectomy and regained their weight were five t...
Researchers found significantly higher levels of IL-18 expression in osteoarthritis patients and cells compared to healthy controls. IL-17 promoted IL-18 production through the MEK/ERK/miR-4492 axis, indicating potential therapeutic targets for OA treatment.
A CHLA research team found that socio-economic factors like family support, employment status, patient age, race, and language spoken can impact clinical outcomes. Children with limited social support systems and working caregivers have worse outcomes.
Research in Journal of Vocational Rehabilitation reveals that companies with inclusive values and committed leadership teams experience improved performance and positive employee perceptions. Disability initiatives also foster a cohesive culture, valuing disabled employees as a vital part of the workforce.
Researchers developed a compact indium phosphide (InP)-based coherent driver modulator that achieved a record-high baud rate and transmission capacity per wavelength, exceeding existing CDMs. The new CDM demonstrated an unprecedented net bit rate of 1.8 Tbps over 80-km standard single mode fiber in the C+L band.
Researchers found that childcare workers in informal creche settings need training to better support non-English speaking migrant and refugee children. The study showed that on-site professional learning improved emotional literacies and strategies for supporting these children, resulting in happier outcomes for families.
A new study has found that anabolic steroid use can increase the risk of atrial fibrillation in individuals with existing genetic predisposition to heart diseases. Researchers discovered that testosterone and other male sex hormones used for muscle building can lead to electrical problems in the heart, particularly in young men.
Pharmacist PDMP use fundamentally changed pharmacy work, interactions with patients and law enforcement, and roles. However, Chiarello argues that PDMPs are enforcement tools rather than healthcare tools, threatening the core of healthcare.
A new clinical trial demonstrates a small reduction in the latent reservoir of HIV-infected cells using a combination of vorinostat and immunotherapy. While the results are promising, further research is needed to create more effective approaches to flush out the virus and attack it when it emerges from latency.
Scientists have pinpointed the group of neurons in the nerve cord that produce and pattern the fly's two major courtship songs. By analyzing neuronal activity and connectivity, researchers found a small number of critical neurons form a highly connected circuit generating the two main types of songs.
A recent study from Argonne National Laboratory has uncovered new insights into the relationship between genetic ancestry and prostate cancer risk. The research, which included large increases in representation among men of African, Hispanic, and Asian ancestries, found 187 new genetic markers that provide more accuracy in calculating ...
A new US-Candidate Risk Score (US-CRS) predicts mortality in adult heart transplant candidates, improving upon the current system. The model combines clinical and laboratory measurements, including molecular markers associated with liver and kidney failure.
A team of researchers from the University of Córdoba has translated and validated a scale to evaluate negative attitudes towards bisexuality, highlighting gender differences and correlations with sexism and social dominance. The scale aims to promote equal treatment and move towards a more egalitarian society.
Researchers developed Subak, a cost-effective method to detect nuclease digestion using fluorescent silver nanoclusters. The tool reduces costs of nucleic acid detection tests, such as those used for COVID-19 identification.
A study from the University of Gothenburg found a significant drop in satisfaction with postnatal care when partners were excluded due to COVID-19 restrictions. Partners of first-time mothers experienced the greatest decline in satisfaction, with a 43% drop compared to labor wards where partners were still allowed.
A new study found that urban environment, road types, and crosswalk access play a major role in determining who gets blamed for crashes. Pedestrians were more likely to be blamed on roads with high traffic speeds and few crosswalks, while drivers were more likely to be faulted in areas with pedestrian-friendly infrastructure.
A new study found that young teenagers who develop a strong distrust of others as a result of childhood bullying are substantially more likely to have significant mental health problems as they enter adulthood. Researchers used data from 10,000 children in the UK and found that adolescents who were bullied at age 11 and developed great...
A new study finds that older adults rely heavily on initial impressions of trustworthiness when making decisions, which can lead to overlooking bad behavior and falling victim to scams. Researchers recommend focusing on a person's actions rather than first impressions to avoid deception.
Scientists at Durham University have found an unexpected way to achieve brighter, more efficient, and stable blue organic light-emitting diodes (OLEDs). The new design strategy uses 'hyperfluorescent' OLEDs, where energy is transferred from a 'sensitiser' molecule to a separate 'emitter' molecule.
A new study finds that Type 2 diabetes causes intervertebral discs to become stiffer and change shape earlier than normal. This leads to a compromised ability to withstand pressure, highlighting the need for preventative and therapeutic strategies.
A study of 11,000 children found that maternal tobacco use during pregnancy is associated with enduring deficits in childhood neurocognition. Continued research on the link between maternal tobacco use and cognitive performance is needed.
A study by the University of Bath and Queensland University of Technology found that non-executive directors who serve beyond recommended tenure limits prioritize their social status over their duty to shareholders. Prolonged tenures can compromise board renewal, financial performance, and governance concerns for boards and shareholders.
A new study has identified a genetic marker that can predict which patients are likely to respond to immunotherapy in various types of cancer. Tumors with high intragenic rearrangement (IGR) burden, which indicates cryptic structural rearrangements of the genetic code, may respond better to immunotherapy.
A cohort study of older adults found that those who followed recommended exercise guidelines before the pandemic had significantly lower odds of being infected or hospitalized from COVID-19. Physical activity was associated with a 10% lower risk of infection and 27% lower risk of hospitalization.
Great apes engage in playful teasing behaviors, including provocative actions and one-sided provocation, similar to human infant teasing. This study suggests that the cognitive prerequisites for humor evolved in the human lineage at least 13 million years ago.
A new study from Norway shows that only a third of fishing ropes can be recycled in a sustainable way. The researchers analyzed 15 types of rope and ranked them according to ease of recycling, highlighting the need for better waste management practices.
Over the last three decades, approximately 11,000 sq miles of Greenland's ice sheet have melted, equivalent to about 1.6% of its total ice cover. This has led to a significant increase in vegetation growth, with dense wetland areas forming in previously icy regions.
A team at Texas A&M University's School of Public Health has received funding to design a mobile app to help older Chinese American and Korean American adults prevent dementia. The app will focus on cognitive function and quality of life, with culturally appropriate content and multiple language options.
A study analyzing 15 exercise apps found limited options for frail older adults, with none adapted to users' cognitive needs. The researchers recommend involving end-users in app creation processes and focusing on simplicity and intuitive design.
Research published in Thorax found a link between age of menarche and increased COPD risk, with early menarche increasing the risk by 17%. Women who experienced infertility or had multiple miscarriages were also at higher risk. Menopause before age 40 was associated with a significant increase in COPD risk.