A late University of Virginia School of Medicine scientist's research on the SAS1B protein could lead to new cancer treatments for multiple cancers. The discovery has the potential to selectively target cancer cells while sparing healthy tissue.
Researchers found that cells adapt by packing into unusual geometrical shapes, known as scutoids, in response to pressure changes. This discovery sheds light on how cells cope with physical environment changes and has potential implications for understanding healthy cell adaptation.
Researchers found that herpesvirus infection alters mitochondrial organization and metabolism, shifting balance from healthy to diseased cells. This knowledge can aid in the development of viral treatments.
Researchers developed a system to grow mucus-producing intestinal cells for in vitro testing, allowing for the exploration of mucus behavior under different conditions. The platform simulates infections and tests drug effects on mucus without affecting its properties.
The Healthy Start scheme in England is a vital support for pregnant women and low-income families, but uptake remains suboptimal. A new study recommends reframing the scheme as a child's right to good food and healthy development, improving coordination and resources.
A team of researchers from MIT created a lightweight, compact, and efficient mechanism to reduce noise transmission using a sound-suppressing silk fabric. The fabric uses vibrations to cancel out unwanted sounds in two different ways, one for small spaces and another for larger areas like rooms or cars.
The Academic Payvider model enhances value-based care by fostering improved coordination, reduced insurance hassles, and increased staff attention. This joint approach between payers and providers aims to drive complex care down through innovative reimbursement structures.
A Kinsey Institute study found that female gamers identify only 50.5% of sexual harassment incidents as such, with witnesses labeling even fewer incidents. The study suggests that online sexual harassment causes mental distress and negatively impacts women's gaming experience.
Engineering PhD graduates have a low chance of securing a tenure-track faculty position, with an average annual likelihood of 12.4%. Alternative career tracks in government and industry are recommended to match student expectations with the realities of the job market.
Immediate electronic release of patient results can lead to misinterpretation and negative outcomes, as seen in CU doctor Benjamin Vipler's experience with his mom. The 21st Century Cures Act aims to empower patients with their health information but requires further study on its impact.
A new R&D paradigm is emerging with smart labs that use AI and robots to synthesize nanomaterials. The platform increases material discovery efficiency by over 500 times, reducing the need for human experimentation.
Researchers found that gut bacteria-generated linoleic acid metabolite KetoC markedly reduced inflammation and immune cell expansion. gKetoC also suppressed prolonged T-cell proliferation and dendritic cell activation. The study suggests a potential molecular axis governing the immunomodulatory effects of gKetoC.
Scientists at HKU have studied the volcanism of the Apollo basin and its surroundings, revealing diverse and complex volcanic activities. The study suggests that crustal thickness may be the primary cause of lunar asymmetrical volcanism, which can be tested by returned Chang'e-6 samples.
Researchers have developed a novel photocatalyst that converts greenhouse gases into syngas with high efficiency, paving the way for greening the chemical industry. The breakthrough uses solar energy to achieve a syngas evolution rate of 180.9 mmol g cat-1 h-1 with 96.3% selectivity.
The CUNY-GLOBE partnership will advance six objectives to expand GLOBE's success, including STEM education, Earth system research, and science diplomacy. The team will design and implement initiatives to elevate GLOBE's visibility and scientific relevance.
A team of researchers from the University of Chicago has identified a genetic mutation in a non-coding region of DNA that alters thyroid hormone regulation, leading to a rare form of congenital thyroid abnormality. This discovery sheds light on a previously unexplained phenomenon and may lead to new treatments for individuals with this...
Researchers at the University of Melbourne and Manchester have invented a breakthrough technique for manufacturing highly purified silicon, making it ideal for creating powerful quantum computers. The new technique uses qubits of phosphorous atoms implanted into crystals of pure stable silicon, extending the duration of notoriously fra...
A new study found that experienced firefighters have different epigenetic modifications linked to prostate cancer risk compared to new firefighters. Chemical exposure to PFAS is associated with these changes. The research team investigated fire department data and found a link between PFAS exposure and increased prostate cancer risk.
Researchers have discovered a protein marker to help identify cells able to repopulate in patients with damaged blood vessels. These cells could form new blood vessels and contribute to the repair of heart tissue after a heart attack.
Researchers analyzed over 20,000 college application essays to identify key predictors of academic success. Essays covering more semantic ground and making smaller conceptual jumps were associated with higher grades.
A comprehensive analysis of seized counterfeit pills found that 99.3% contained fentanyl, with 67% also containing para-fluorofentanyl. The study highlights the importance of understanding the contents of counterfeit prescription pills for effective treatment approaches.
A recent study investigated the relationship between RAD51 and FIGNL1, shedding light on the intricacies of homologous recombination. The results reveal that FIGNL1 is essential for proper chromosome separation after replication forks are dismantled, preventing abnormal chromosome bridges that can lead to genetic instability.
A novel investigational PET imaging agent, <sup> 68 </sup> Ga-DPI-4452 (Debio 0328), has been shown to provide rapid and accurate visualization of lesions in clear cell renal cell cancer patients. The agent offers a superior alternative to standard CT imaging and could potentially be used as part of a theranostic pair.
A telehealth program created by Project ECHO has been found to reduce reliance on opioids in pain management. The program connects primary care providers with experts via videoconferencing, leading to lower rates of opioid prescribing and greater adherence to evidence-based recommendations.
A new study by Chalmers University of Technology finds that ship scrubber water discharges caused EUR 680 million in pollution costs between 2014 and 2022. The researchers also found that most shipping companies have already recouped their investments in scrubbers, making cheap heavy fuel oil a more lucrative option.
Researchers developed a new theory that bridges biological vessels and artificial materials, applicable to various functional materials. The Universal Murray's Law can optimize fluid transport in synthetic structures, boosting efficiency in energy storage, catalysis, and sensing.
A new implantable cardiac pump could revolutionize heart transplant care for children, allowing them to wait at home instead of in the hospital. The device performed well in a feasibility trial, with six out of seven children ultimately undergoing transplants and one child's heart recovering on its own.
The 5-year TAF treatment efficacy was high and similar to that of 3-year TDF followed by 2-year TAF in Chinese chronic hepatitis B patients. Favorable effects on bone and renal parameters were sustained with TAF treatment alone and were observed following the switch from TDF to TAF.
A 5:2 diet has been shown to protect against chronic liver inflammation and liver cancer in mice. The study identified two proteins, PPARα and PCK1, that are jointly responsible for the protective effect of fasting.
The article reviews static and dynamic approaches to adjust Schottky barrier height in semiconductor devices. Dynamic techniques include surface modification and external electric fields.
A recent study found that Mozambique's Maniamba Basin has a high total organic carbon content, indicating its potential for generating hydrocarbons. The research identified mixed kerogen types, primarily of terrestrial origin, suggesting the basin's rocks were once lush with vegetation typical of Gondwana ecosystem.
A study by Albert-László Barabási and colleagues used machine learning to identify phrases representing allusions to foundational papers in the physics literature. The findings suggest that hidden citations obscure true impact in science, with influential ideas becoming so familiar that researchers stop citing their sources.
A comprehensive study by University of Technology Sydney researchers confirms CPAP therapy's safety without adverse effects on the respiratory system. The study uses computational modeling to assess airflow velocity and shear stress, providing reassurance for patients.
Scientists discovered that Cu nanoparticles supported on γ-Al2O3 surfaces can redisperse spontaneously at room temperature due to hydroxylation and formation of Cu-OH species. The O2 and H2O led to the transformation of Cu atoms into single atoms, enhancing catalytic activity in RWGS and CO-PROX reactions.
Researchers at UCSF used an AI model to analyze clinical notes and determine patient urgency, achieving an accuracy rate of 89% and surpassing human physician performance in 88% of cases. The study suggests AI could help alleviate ED overcrowding by providing backup decision-making tools for clinicians.
A new study conducted by researchers at Nationwide Children's Hospital found increases in exposures to delta-8 THC, delta-10 THC, and THC-O acetate among young children, teens, and adults. The study highlights the importance of safe storage practices and improved regulation of these products.
The study reveals that cellobiose fragments can bind to the tunnel's back door and block subsequent cellulose molecules, as well as bind to Cel7A near the front door, preventing enzyme binding. New methods could be developed to fine-tune this process, improving biofuel production efficiency.
A study found that adult chimpanzees continue to learn and refine their tool-using skills well into adulthood, suggesting a prolonged learning capacity is key to the evolution of complex tool use in chimps and humans. Chimpanzees developed motor skills for handling sticks by age six, but continued to hone techniques until age 15.
Researchers at Columbia Engineering have developed a technique to modify 2D materials using lasers, creating tiny nanopatterns that can capture quasiparticles called phonon-polaritons. This method uses commercially available tabletop lasers and doesn't require an expensive cleanroom or etching equipment.
Researchers have proposed a new concept called fastest recovery after surgery (FRAS) to expedite recovery in patients undergoing elective major gastrointestinal surgery. The approach has shown zero complications, reduced hospital stay duration, and improved comfort and satisfaction compared to traditional ERAS protocols.
Researchers find that rocks' permeability affects slow slip events, potentially leading to a better model for predicting earthquakes. The study's findings provide new insights into the role of fluid cycling in subduction zones.
A team of researchers from Osaka University used machine learning to identify a highly effective boron-based catalyst for chemical transformations of amino acids and peptides. The new catalyst generates only water as a coproduct and promotes high-yield reactions with minimal environmental impact. By leveraging computational methods, th...
The intersection of digitalization, biotechnology, neurotechnology, and nanotechnology raises concerns about the blurring of boundaries between physical, biological, and digital worlds. Researchers warn that converging technologies can be used to manipulate people's thoughts, feelings, and decisions without their knowledge or consent.
Researchers have identified two types of climate tipping points in Africa, one characterized by a gradual slowdown and the other by flickering between stable humid and dry climates. The study found that transitions with flickering are characteristic of this region, which could help predict future climate change.
LyoWave is commercializing microwave heating technologies developed at Purdue University, improving speed, cost-effectiveness, and product throughput. The company has entered a collaboration with Millrock Technology, applying its technology to boost freeze-drying systems' capacity for pharmaceuticals and diagnostic reagents.
The review emphasizes non-pharmacological approaches as the initial strategy, but acknowledges the need for medical intervention in severe cases. It highlights diphenhydramine as a preferred choice for mild to moderate agitation due to its sedating effects and minimal adverse outcomes.
A new study found that PARP1 is involved in the repair of telomeres, which can lead to genomic instability and cancer. Impairing this process can lead to telomere shortening and increased risk of cancer. The findings challenge existing dogma and open up new possibilities for improving cancer therapies.
A recent Finnish study discovered that high levels of sedentary behavior and low physical activity in children are associated with a higher cardiac workload and increased risk of heart disease in adolescence. Regular moderate to vigorous physical activity from childhood can help prevent these issues.
A new research project showed that mobile vaccination teams are an effective way to increase vaccination uptake in remote areas of Sierra Leone. Immunization rates increased by up to 26% in trial villages, and the cost was about $33 per person, making it a cost-effective intervention.
A study of hand sanitizer sales before, during and after the H1N1 swine flu pandemic found that supply and demand balances quickly, with retailers adapting to stockpiling behaviour. The research suggests there is no need for panic-buying and price gouging.
A smart neckband can differentiate between eating, drinking, and similar movements using machine-learning algorithms and sensors. The device achieved an accuracy rate of 89% for concurrent activities in a study involving six volunteers.
A University of Michigan study shows that as people struggle to distinguish fact from fiction in the US, they are more likely to avoid news and step out of conversations about politics. The researchers found that strong Democrats rely on nonpartisan news media when feeling misinformed, while Republicans use less news media overall.
Researchers have determined the molecular level function of free-forming structures in plant cells that help sense light and temperature, enabling plants to distinguish a range of different light intensities. The formation of these organelles is not random but is linked to specific locations within the cell, particularly near centromeres.
A study outlines critical needs for LEO augmentation of satellite navigation systems, enhancing accuracy and reliability for diverse users. Researchers propose key technologies for construction of LEO constellation to improve PNT services.
A research team at Mass General Brigham developed a foundation model that identified patterns predicting anatomical site, malignancy, and prognosis from radiological images. The approach remained powerful even with limited data, outperforming existing methods in specialized tasks.
New research found that maternal grandmothers' investment in grandchildren who experienced adverse early life experiences can significantly reduce emotional and behavioral problems. The study suggests that supportive caregiving from grandparents can protect children from negative effects of early adversity-induced behavioral issues.
A study published in JAMA found that newly trained internal medicine physicians with top scores on the board certification exam had lower risk of dying within seven days or being readmitted to hospital. The analysis used nearly 7,000 patients and showed a significant link between exam scores and patient outcomes.
Researchers identified a critical interaction between endorepellin and neurexin that triggers neuroepithelial autophagy, maintaining normal neural tube development. This discovery provides a new paradigm for identifying pathogenic mutations for complex genetic disorders like NTDs.
A pioneering research paper demonstrates the effectiveness of using hand images for accurate age prediction, offering a viable alternative to traditional facial photo methods.
A new study published in Stem Cell Reports has identified the key player in coordinating early mouse embryo development, revealing the importance of NKX1-2 protein. The protein ensures that genetic instructions are executed correctly and at the right times, managing cell machinery production and chromosome organization.