Researchers use a new method to analyze the structural properties of proteins under extreme pressure, revealing new insights into their native structures. The technique, which applies 3,000 bar of pressure, allows for the observation of protein states that would be invisible under normal conditions.
Researchers developed a non-invasive imaging technique to visualize cardiac micro-vessels in high resolution, enabling better understanding of cardiovascular diseases. The study improves diagnosis and treatment of conditions like microvascular coronary disease and cardiomyopathies.
A massive study identifies new biomarkers for renal cell carcinoma subtypes, improving diagnosis and treatment. The researchers' integrative analysis of proteogenomic datasets reveals molecular features shared by clear cell and non-clear cell RCC tumors, as well as unique features to various subtypes.
Researchers at DGIST and UNIST developed high-performance, skin-attachable perovskite pure red light-emitting devices with enhanced color representation. The team replaced iodine with bromine to improve surface-to-volume ratio and stability, achieving exceptional electrical properties.
Text messaging and bulk ordering can significantly increase mammogram completion rates for breast cancer screening outreach. The study found that these interventions are effective in improving adherence to recommended screening guidelines.
Lysosomes are critical for cellular degradation through endocytosis, phagocytosis, and autophagy, recycling essential components. Research has developed tools to study lysosomes in cultured cells, C. elegans, and mice, with novel assays needed to understand diverse physiological and pathological conditions.
A study by Georgia State University found that people rate AI responses as more virtuous and intelligent than human responses on moral issues. The AI system, ChatGPT, was able to fool participants into believing its responses were better, highlighting the need for a deeper understanding of AI's role in society.
Researchers have discovered a repurposed cancer drug that can convert acinar cells into insulin-producing cells, which could provide a new avenue for treating diabetes. The treatment partially improved hyperglycemia and persisted without additional treatment in diabetic mice and non-human primates.
Researchers at Princeton University and North Carolina State University have combined ancient paperfolding and modern materials science to create a soft robot that can bend and twist through mazes with ease. The new design allows the flexible robot to crawl forward and reverse, pick up cargo and assemble into longer formations.
The VA has launched CIPHER, an online searchable library of EHR-based phenotypes, data mappings, and tools for data visualization. This platform aims to improve the use of complex health data, leading to better care for Veterans and others.
The Multifunctional Ablative Gastrointestinal Imaging Capsule (MAGIC) combines OCT technology with an endoscope camera and ablation laser for superior esophageal imaging. It provides unmatched accuracy in detecting early lesions, enabling potential ablative treatment of esophageal abnormalities.
Researchers found that early neurodevelopmental assessments can predict long-term cerebral palsy outcomes in high-risk infants as young as 3 to 4 months corrected age. However, these tests are limited in identifying cognitive and neurodevelopmental impairments beyond CP diagnosis.
A new study by University of Colorado Boulder primatologist Michelle Sauther found that smaller animals like the lesser galago face extra challenges adapting to climate change. The research highlights the importance of protecting these small and nocturnal species, which are often overlooked in conservation efforts.
A team of researchers characterized electron-hole separation in kesterite thin-film solar cells using scanning probe microscopy. They found that defects at the crystal interface cause electron-hole recombination losses, but suggested creating a light-absorbing layer with higher energy levels to improve efficiency.
Researchers, led by Masako Suzuki, aim to understand the effect of dysregulated vitamin D metabolism on preterm infant kidney development. They will study the genome and transcriptome to gain insights into how vitamin D affects podocyte differentiation during preterm development.
A head-mounted device generating an ultra-low frequency magnetic field has improved symptoms of four male patients with major depressive disorder. The study suggests that future trials may offer a safe and non-invasive way to treat depression.
Researchers from GIST and MIT CSAIL develop a MultiSenseBadmpton dataset to enhance badminton performance analysis and AI-based coaching. The dataset captures joint movements, muscle signals, and gaze movements of badminton players.
Researchers at Iowa State University are developing an AI tool that can identify agricultural pests from photos, including insects and weeds. The project will use a supercomputer to train ensemble models that can analyze images quickly and provide pest-control strategies.
The world's largest study of cerebral palsy genetics found genetic defects are responsible for over a quarter of cases in Chinese children. Researchers identified 81 genes with causation mutations, indicating that improper brain development may be the underlying cause of cerebral palsy rather than lack of oxygen at birth.
Scientists have developed a powerful tool to investigate molecular dynamics in real-time, tracing the evolution of gas-phase furan and uncovering its ring-opening dynamics. The technique, based on attosecond core-level spectroscopy, provides an extremely detailed picture of the relaxation process.
Researchers at USTC create a bioinspired Bouligand structure with hierarchical and reconfigurable interfibrous interface to boost mechanical strength and toughness. The structure, developed through moderate orderliness, exhibits outstanding mechanical properties and dimensional stability, potentially applying in biomedical fields like ...
A study published in The Annals of Internal Medicine found that 7% of patients experienced at least one adverse event and 1.9% experienced a preventable adverse event in outpatient settings, emphasizing the need for evidence-based interventions to improve patient safety.
A new study from the University of Waterloo used software to predict realistic motorcycle riding behaviors, considering human factors and ergonomic trade-offs. It found that shorter and taller riders require joint adjustments to achieve their preferred riding posture.
Researchers at the University of Trento have identified a collection of molecular tools to rewrite DNA, including a compact Cas9 enzyme from the human microbiome. The discovery has potential for gene therapy applications and could speed up the development of therapies for genetic diseases.
A recent study in Saudi Arabia assessed the effectiveness of an educational program improving epilepsy care among caregivers. The intervention showed a significant decrease in knowledge gaps, with 23.2% having sufficient knowledge post-intervention compared to 60% before.
Recent translations of Alhazen's Book of Optics have revealed its profound impact on the development of modern physics. The book, written in the 11th century, laid the foundation for optical sciences and influenced prominent European scientists such as Kepler, Descartes, and Huygens.
Researchers have identified a subset of intestinal epithelial cells that act as both the major target and responder in a mouse model of gut infection by Citrobacter rodentium. These cells, known as distal colonocytes, trigger a unique gene-expression program when infected with the bacteria.
A recent VCU study reveals that Black and Native American youth are dying at significantly higher rates than white youth due to injuries. The gap in pediatric mortality rates is widening, with disparities seen in death rates from diseases like asthma and pneumonia.
A new study conducted by North Carolina State University found that many parents are not taking adequate steps to address security and privacy risks associated with virtual reality (VR) apps. Parents were primarily concerned about physiological development issues, but lacked awareness of data surveillance and collection risks.
Researchers employ a geology tool to analyze hydrogen atoms in cancer cells, finding a distinct ratio compared to healthy tissue. This discovery may lead to new ways to spot cancer early on and inform strategies for studying its growth and spread.
Researchers have pinpointed the location of an internal neural compass in the human brain, which helps orientate itself in space and navigate through the environment. This discovery has implications for understanding diseases such as Parkinson's and Alzheimer's, where navigation and orientation are often impaired.
A team of researchers at Bar-Ilan University has developed a groundbreaking technology that enables direct measurement of the interaction between immune cells and cancer cells from a patient's biopsy. This innovation provides crucial insights into the patient's immune response, enabling tailored cancer treatment decisions.
Researchers used CRISPR/Cas9 DNA editing to insert genetic mutations found in humans with Tourette disorder into mouse embryos, creating a model to study the neurobiology and test new medications. The mice exhibited repetitive motor behaviors and sensorimotor gating deficits, similar to those seen in humans with the disorder.
Researchers at Sylvester Comprehensive Cancer Center have developed a nanoparticle that can penetrate the blood-brain barrier, potentially targeting both primary breast cancer tumors and brain metastases in one treatment. The method shows early promise in preclinical models, where it shrinks breast and brain tumors.
Researchers at Oregon State University have developed a novel device that can improve the delivery of gene therapy for patients with inherited lung diseases such as cystic fibrosis. The device uses aerosolization technology to carry messenger RNA to patients' lungs, reducing shear stress and improving precision.
A new screening algorithm combining maternal history, ultrasound data and several tests for blood markers may predict most preeclampsia cases in the first trimester of pregnancy. The study found that personalized risk-based treatment decisions may improve adherence to preventative measures.
Researchers developed a novel dual-layer coating technique to stabilize lithium metal anodes, addressing issues like dendrite formation and hydrogen evolution reactions. This innovation enables safer and more efficient aqueous zinc batteries.
Desert isopods rigorously regulate their intake of macronutrients and calcium, preferring biological soil crust over plant litter. The research highlights the crucial role of ingested microorganisms in facilitating digestion and growth.
A new study by Tim Grandjean establishes a crucial link between water turbidity and the growth of intertidal areas worldwide. With many coastal waters declining in turbidity over decades, these ecosystems are vulnerable to loss, threatening biodiversity and coastal safety.
Researchers created a corticolimbic index tool that categorizes Alzheimer's disease into three subtypes based on brain changes. The study found demographic and clinical differences among sex, age at onset, and rate of cognitive decline.
Migrasomes are vesicular structures that facilitate information and material exchange between cells and their microenvironments. Researchers have developed protocols for observing migrasomes using optical microscopy, providing insights into essential physiological and pathological processes such as embryonic development and tumorigenesis.
A University of Kansas scholar argues that democratic values have been transgressed in recent years, and proposes seven accountability standards to prevent further erosion. The standards focus on authority, rights, tolerance, truth claims, and professional deference.
Researchers found that SARS-CoV-2 spike protein interrupts p53-MDM2 interaction but does not bind with p53 protein in cancer cells. The study also shows that SARS-CoV-2 spike suppresses p53-dependent gene activation, leading to increased cell viability after chemotherapy exposure.
A self-adaptive temperature control system can improve wound healing by mimicking the skin's thermoregulatory functions. The system, developed by Zhu Meifang at Donghua University, uses an interactive thermoregulatory biomimetic electronic system to regulate temperature and promote dynamic healing processes.
Researchers at UC San Diego developed a machine learning algorithm to simulate chemistry in drug discovery, synthesizing 32 potential multi-target cancer drugs. The new AI platform, POLYGON, can identify molecules with multiple targets, potentially delivering more effective treatments with fewer side effects.
A research team led by Martin Hanczyc is developing artificial cells with specific elements to target cancer cells, aiming to stop their growth and defeat cancer. The team will create bio-hybrid tissues where artificial cells interact with living carcinogenic cells to influence cancer development.
Jeffrey W. Moses, MD, is recognized for advancing the field of interventional cardiovascular medicine through technical excellence and leadership. Dr. Moses has performed over 20,000 interventional procedures and made significant contributions to clinical research and educational activities in interventional vascular therapy.
Black and Hispanic patients with atrial fibrillation were less likely to initiate direct oral anticoagulants at study onset, but these disparities narrowed over time. The study highlights the need to address unequal access to novel therapies for Black and Hispanic populations.
Research suggests that labelling vulnerable patients in hospital as 'socially admitted' can lead to incorrect assumptions about their medical needs and hinder opportunities to identify treatable issues. The study highlights the need for reform of current structures and hierarchies to improve care for these patients.
A Purdue University researcher has received a $2.4 million NIH grant to develop novel inhalation therapeutics for resistant lung infections, which have established resistance to antimicrobial drugs and affect over 2.8 million individuals annually in the US, resulting in more than 35,000 deaths.
A multisite review found that adverse events during outpatient care were relatively common and often serious, with 7% of outpatients experiencing at least one event. Adverse drug events were the most common, and these events occurred more frequently among older adults and were often preventable.
A new study found that sociodemographic variables are the most robust predictors of substance use initiation among adolescents. Factors such as religion, race, and income play a significant role in determining an adolescent's likelihood of initiating substance use.
A large-scale randomized controlled trial found that integrated health interventions, including drinking water, sanitation, handwashing, and nutrition, had measurable effects on children's genetic levels, enhancing their stress-response system and reducing oxidative stress. The study provides comprehensive evidence on the impact of env...
A phase 1/2 trial of CRISPR gene editing has demonstrated safety and efficacy, with measurable improvements in 11 out of 14 participants with a form of inherited blindness. The treatment, EDIT-101, was found to be clinically meaningful for four participants and showed significant improvements in cone-mediated vision.
A team of biologists has discovered that green-rumped parrotlets engage in both infanticide and adoption behaviors, driven by competition for nesting sites. Adoption is found to be a non-violent means of getting genes into the next generation, with males who adopted unrelated offspring going on to nest with widowed females.
Researchers developed a simple and efficient method for diversifying reactive end-groups on poly(2-oxazoline)s, enabling rapid exploration of poly(2-oxazoline)-based nanomedicine platforms. The approach was shown to produce POx-based lipid nanoparticles comparable in transfection capability to their PEGylated counterparts.
Researchers from the University of Bonn are working on a project to make farming more efficient and environmentally friendly using new technologies and artificial intelligence. They aim to tackle key research questions such as monitoring farmland for nutrient deficiency, weed growth, and pest infestations in real-time.
A recent Indonesian study investigates the relationship between coping mechanisms and self-stigma among people living with HIV. The research found that most participants reported low coping strategies and high levels of self-stigma, revealing a moderate correlation.
The RefMap project aims to reduce aviation's environmental impact by optimizing flight paths using data on wind, noise, CO2 emissions. Researchers are developing models to predict drone noise disturbance and improve UAV trajectories, with the goal of creating a digital service for airlines and airports.
A study reviewed 100 US institutions with National Center of Academic Excellence in Cybersecurity designations, finding significant variation in program types, credits, and learning outcomes. The research aims to improve industry-readiness and graduate employability by highlighting areas for improvement in cybersecurity education.