Researchers discovered that a topical ABT-263 treatment effectively reduces aged skin senescence markers, priming the skin for improved subsequent wound healing. The treatment also triggered inflammation, which surprisingly helped the healing process by 'waking up' the skin's repair systems.
Teams from HZB and Humboldt University Berlin have developed a new tandem solar cell combining CIGS with perovskite, achieving a world record efficiency of 24.6%. This breakthrough could lead to higher efficiencies of over 30%, making CIGS-perovskite tandem cells a promising technology for sustainable energy solutions.
Researchers discover how an anticancer drug triggers an 'outside in' signal to get sucked into a cancer cell, providing insights into adhesion regulation and potential drug design targets. The study reveals a new mechanism for delivering drugs using P-cadherin protein.
A large observational study found that high levels of 'good' HDL cholesterol are associated with a heightened risk of glaucoma, particularly among those older than 55. In contrast, higher levels of 'bad' LDL cholesterol, total cholesterol, and triglycerides are linked to a lower risk of the condition.
The hospital was ranked highly among healthcare professionals in the US and globally, reflecting its commitment to compassionate care and innovative research. UH Cleveland Medical Center is affiliated with several top medical schools and institutions, further solidifying its reputation as a leading Academic Medical Center.
The Off the Field National Football League Wives Association partnered with the American Heart Association and other organizations to promote water safety skills among children. The event, held in New Orleans, provided Hands-Only CPR and automated external defibrillator education.
Scientists at The Hospital for Sick Children have discovered a way to stop tumour growth before it starts for a subtype of medulloblastoma, the most common childhood malignant brain cancer. By blocking a key protein responsible for waking 'sleeping' stem cells, the study demonstrates a novel strategy to target cancer stem cells.
Researchers found a strong association between asthma and repeated antibiotic use in predicting nasal polyp recurrence after endoscopic sinus surgery. The study suggests that patients with severe chronic rhinosinusitis with nasal polyps may benefit from additional treatments like biologics to manage the disease.
Early-career scientists are vulnerable to deteriorating employment conditions and pressure to meet tight deadlines. FRONTIERS offers immersive experiences at the forefront of knowledge to inspire and nurture the next generation of science journalists.
Researchers at Washington State University have created genetically engineered mice with human-like short telomeres, enabling the study of cellular aging as it occurs in humans. The new mouse model, called HuT mice, has significant implications for anti-aging research and cancer treatment.
Researchers analyzed data from 8,843 women with preeclampsia to evaluate the performance of existing risk prediction models. The study found that these models are most accurate only in the days following diagnosis and deteriorate over time.
Researchers found that a machine learning predictive model leveraging EHR data outperformed screening surveys in identifying patients with health-related social needs. The models demonstrated biases, particularly towards White, non-Hispanic patients.
McGill researchers found that music at an individual's natural tempo significantly reduces pain perceptions. The study discovered the greatest reductions in pain levels occurred when melodies were played at a rate matching the participant's own preferred tempo.
The Primary Prevention Trial aims to determine whether stopping early molecular changes can prevent Alzheimer's disease from taking hold. The study will enroll people as young as 18 with few or no detectable Alzheimer's-related molecular changes in their brains.
A recent UBC study found that there's a 26% annual chance of space rocket junk re-entering the atmosphere and passing through a busy flight area, highlighting the potential for uncontrolled debris to disrupt flights. The researchers emphasize the need for policymakers to take action to address this issue.
A new law in Utah allows minors to revoke their informed consent for gender-affirming care, casting a cloud over the trusted process between doctors and patients. This legislation puts clinicians at risk of litigation and may limit access to necessary medical treatments.
The researchers developed a system that generates electricity and light simultaneously using motion and pressure, stably producing up to 60V and 395nA without degrading performance. This technology has the potential to improve safety in disasters and sports, as well as reduce environmental impact through energy harvesting.
Researchers developed surface-modified apatite coatings using pH control to enhance cell adhesion and improve the biocompatibility of implants. The study found that controlling the nanoscale surface layer of apatite nanoparticles leads to better binding affinity with biological tissues.
A POSTECH research team developed a novel multidimensional sampling theory to overcome limitations of flat optics. Their study identifies constraints of conventional sampling theories and presents an innovative anti-aliasing strategy, significantly enhancing optical performance.
A new study by Stanford University researchers found that coal-fired power stations drag down annual wheat and rice yields by 10% or more due to NO2 emissions. Eliminating these emissions could boost rice output by $420 million per year and wheat output by $400 million per year.
A recent study published in Communications Biology reveals that the Sudan virus binds to human cells through a specific protein called NPC1, which enables it to attach with nine times greater affinity than Ebola. This discovery may contribute to the high fatality rate of the Sudan virus.
A potential new therapy, CT-179, effectively targets tumor cells and disrupts cancer stem cells, leading to improved treatments and increased survival rates. The novel drug, developed by Curtana Pharmaceuticals, may bring new efficacy to brain tumor therapy.
Researchers at FAU's Schmidt College of Medicine will explore the use of genetically engineered cells to treat degenerative diseases, with a focus on understanding how hypoxic conditions drive cellular transformation. The study aims to identify novel pathways controlling this process and develop strategies for engineering more complex ...
Researchers aim to develop room-temperature superconductors using AI and quantum geometry, potentially revolutionizing energy efficiency. The project aims to push boundaries of quantum materials science and superconductivity.
A new Stanford study suggests refining how we assess natural carbon storage strategies to ensure the technology lives up to its potential as a climate change solution. The researchers propose a two-step evaluation process to unlock additional project value and improve data for predictive modeling.
The number of family caregivers supporting older adults living in home and residential-care settings increased to 24.1 million, a 32% rise from 18.2 million in 2011. Caregiving responsibilities continued to fall primarily to women, with those caring for individuals with dementia facing unique challenges.
Researchers at the CNIC have designed a treatment strategy to protect the heart against cardiotoxic effects of anthracyclines, a common class of anticancer drugs. Empagliflozin, an SGLT2 inhibitor, has been shown to preserve cardiac function and metabolism in experimental models.
Researchers at University of California San Diego have discovered the transformation process of healthy stem cells to cancer stem cells in oral cancer. By activating YAP and HPV oncogenes, normal stem cells are reprogrammed into cancer cells, leading to early-stage tumor initiation.
Researchers have created detailed maps of the retina using AI technology to better understand its link to various diseases. The study identified new genetic factors influencing retinal thickness, which may serve as a diagnostic biomarker for disease detection.
The Human Virome Characterization Center at UCLA will investigate the diversity of viruses naturally inhabiting the human body along the oral-gut-brain axis. The center's discovery team will characterize virome richness, diversity, and structure in healthy individuals across different age groups and ethnic backgrounds.
A new study identified USP5 as an enzyme crucial for breaking down unneeded or damaged proteins in the heart. Low levels of USP5 lead to protein buildup, triggering dilated cardiomyopathy in animal models. Increasing USP5 levels helps clear protein 'junk', improving heart function and reducing disease progression.
The Hubble Space Telescope has captured a cosmic bullseye, revealing eight visible rings and confirming a ninth using data from the W. M. Keck Observatory in Hawaii. The galaxy's unique ring structure was formed by a blue dwarf galaxy colliding with its center, creating a new generation of stars.
Researchers discovered that Wnt3 coordinates a two-step process of cell polarity orientation, enabling jellyfish embryos to develop around a central axis. This discovery sheds light on the evolution of body plans in early animals and may provide insights into cellular-level organisation.
A study on painted lady butterfly migrations found that environmental conditions, rather than genetic coding, drive their migratory patterns. The research revealed that butterflies can travel vast distances, crossing the Sahara Desert, without showing significant genomic differences between short and long-distance migrants.
Researchers at the University of Texas at El Paso developed a novel method to measure load demand on the electrical grid for electric vehicles charging while in motion. The model, called modified Toeplitz convolution or mCONV, accounts for varying vehicle sizes, road lengths, and traffic flow.
Researchers at U of T have developed a new platform called smol-seq that uses DNA sequencing to detect metabolites. This method enables the analysis of hundreds of metabolites simultaneously, making it faster and more precise than current methods.
Scientists from DZNE found that preventing brain inflammation may help treat Alzheimer's disease. The study, published in Immunity, suggests that inhibiting the NLRP3 inflammasome can reduce neuroinflammation and help microglia clear harmful amyloid-beta deposits.
A new University of Oklahoma study found that diabetes-linked amputations are rising in Oklahoma, with the statewide rate nearly doubling between 2008 and 2019. The study analyzed over 1.3 million anonymized discharge records and found that rates were highest among males, American Indians, and those with poor health insurance coverage.
Researchers at UCSF used CRISPR gene editing technology to transform ordinary white fat cells into 'beige' fat cells that voraciously consume calories to make heat. Implanted near tumors, these cells outcompeted cancer cells for nutrients, beating back five types of cancer in lab experiments.
A $10.8 million trial will enroll 600 patients aged 60+ to determine whether a hip replacement or internal fixation surgery is better for certain types of hip fractures. The study's patient-focused approach aims to inform clinical guidelines and help patients make informed decisions about their care.
A new genomic toolkit called Sphae has been developed to quickly assess the suitability of phage therapy for treating antibiotic-resistant bacterial strains. The platform can analyze vast datasets in under 10 minutes, prioritizing safety and flagging genes associated with toxins or undesirable traits.
A Northwestern University study found that a fiber-free juice diet can trigger shifts in gut and oral bacteria linked to inflammation and cognitive decline. The study suggests that juicing without fiber may disrupt the microbiome, potentially leading to long-term health consequences.
A research team led by Professor Leslie Wolf aims to increase participation in biomedical studies by empowering participants as co-researchers. The study, funded by PCORI, will investigate the impact of participant involvement on study designs and methods.
Researchers identified a new process leading to formation of low-field magnetars, solving the mystery that puzzled scientists since their discovery in 2010. The team used advanced simulations to model magneto-thermal evolution of neutron stars, finding that a specific dynamo process can generate weaker magnetic fields.
A new study highlights the need for collaboration among recyclers, manufacturers, and policymakers to develop efficient and sustainable lithium-ion battery recycling processes. Advanced techniques like direct recycling and upcycling could reduce costs by up to 40% while minimizing secondary pollution.
A lack of access to early autism diagnosis is causing concern worldwide. New solutions and initiatives are being developed to address this issue, including online diagnostic tools and expanded training for healthcare professionals.
The KAIST research team developed an AI-based technique to accurately predict Hall thruster performance, significantly reducing the time and cost associated with iterative design, fabrication, and testing. The trained neural network ensemble model offers detailed analyses of performance parameters, accounting for key design variables.
The EU-funded ForMovFluid project aims to understand the origin of critical raw materials, essential for renewable technologies and energy transition. By combining laboratory techniques and field work in four countries, researchers will increase knowledge on fluid movement in the Earth's crust.
A 0.5°C rise in global warming will triple the area of Earth that is too hot for humans to survive, with the over 60s facing a 35% increase in heat-related risks. This could lead to millions of deaths, especially in regions like Saharan Africa and South Asia.
A new company launched by Hertz Fellow Ruby Lai is developing a sustainable toilet system that reuses flushwater and requires no sewer system. The system has the potential to save households thousands of gallons of water and hundreds of dollars each year.
Scientists studied painted lady butterflies' migration patterns and found that environmental conditions shape their travel behavior, with some crossing the Sahara Desert. Contrary to previous belief, genetic analysis revealed no difference in DNA sequences between short- and long-trip butterflies.
Physicists have gained valuable insights into false vacuum decay using a quantum machine, which could determine the ultimate fate of the Universe. The simulation reveals complex interactions between bubbles in a false vacuum, offering new possibilities for studying the fundamental physics of the Universe.
A new drug developed by the Centre for Addiction and Mental Health (CAMH) has shown significant promise in reversing memory loss in a mouse model of Alzheimer's disease. The drug, GL-II-73, selectively targets GABA receptors to restore brain function and repair damaged neural connections.
Hannah Dailey, an associate professor of mechanical engineering at Lehigh University, has been recognized with the Presidential Early Career Award (PECASE) for her innovative research on fracture healing. Her virtual mechanical test can identify nonunions early in the healing process, allowing for earlier surgical intervention.
UC Irvine scientists confirm climate change's impact on marine nutrient cycles, revealing a decline in phosphorus levels in southern hemisphere oceans. The research also shows that nitrate concentrations remain steady, but may still decline in the future as the climate continues to change.
The National Comprehensive Cancer Network is joining the global effort to improve awareness and knowledge of cancer risks through its 'United by Unique' campaign. Patient advocates from NCCN guidelines panels are sharing their personal stories to highlight the importance of a people-centered approach in cancer care, which recognizes ev...
A new community-based pickleball program called Project Rally is helping cancer survivors improve their physical and social well-being. The program has shown strong results in terms of participation, enjoyment, and physical improvements.
A new tool named retriever extracts disease-specific drug response signatures to predict cancer treatment combinations, improving personalized treatment strategies. The tool refines predictions using single-cell RNA sequencing data and demonstrates its potential in identifying effective treatments for triple-negative breast cancer.
A new study led by UCL researchers has found that the GLP-1 drug exenatide has no positive impact on movement, symptoms, or brain imaging in people with Parkinson's disease. The trial involved 194 participants and ran for 96 weeks, with no benefits shown in any of these areas.
Eleven scientists will be recognized for their individual exceptional professional achievements and contributions to stroke care and research. Four groundbreaking scientists are devoted to stroke research, while six others will be recognized for their new research findings presented during the meeting.