Researchers found patients who retreated with docetaxel had longer overall survival and fewer supportive-care needs compared to those switching to cabazitaxel. The study provides evidence-based options for selected patients previously tolerated docetaxel.
A Finnish study found that verifying adolescents' maximal oxygen uptake requires a brief phase to ensure reliable results. The researchers also discovered that different time averaging strategies can significantly affect the final measurement values, highlighting the need for explicit strategy specification.
A new study from Bar-Ilan University identifies the elderly in Iron Age Israel through household artifacts, revealing their social status, influence, and integration within family structures. The research advances beyond traditional methods of identifying the elderly, providing a fresh window into their lived experiences.
The Society for Neuroscience has selected 10 early career policy ambassadors to gain skills in advocating for science funding and issues affecting the field. The 10-month program aims to create an extensive network of neuroscience advocates.
Researchers at NBI developed a real-time adaptive measurement approach that tracks fluctuations in qubit energy-loss rates as they happen. This breakthrough enables faster characterization and calibration of superconducting quantum processors.
A scoping review reveals that bilingual university programs in Europe prioritize academic language use, with EMI approach raising concerns about students' linguistic competence. The CLIL approach is deemed more democratic and inclusive, but challenging to implement.
A global study documents the collective ecological memory of Indigenous Peoples and local communities, revealing a consistent pattern of large-bodied bird species disappearing from local environments replaced by smaller-bodied species, with average bird mass declining from 1500g to 535g over eight decades.
A new method to extract phosphorus from the Baltic Sea could reduce Europe's dependence on imported phosphate mining, revitalizing the ecosystem. Researchers at KTH Royal Institute of Technology have developed a two-step approach using microbes to loosen and bind phosphorus.
The REST-COAST project presented scientific advances, practical tools, and governance insights developed throughout its lifetime. Researchers explored pathways for upscaling from site-specific demonstrations to broadly adaptable frameworks, linking high-resolution modelling with broader decision-support tools.
The QCyber project aims to develop secure quantum-based methods for communication among multiple users, including diplomatic and financial applications. It will be tested in a real fibre-optic network in Stuttgart with up to six nodes and over distances of up to 20 km.
Researchers at the University of Turku discovered that surface cells of lymphatic vessels in oral cancer contain proteins indicating cell division, strongly predicting disease progression and mortality. Early-stage oral cancers can be identified by changes in these vessels, which may lead to death even with small tumors.
The University of East London and STRABAG UK have developed a pioneering low-carbon grout that replaces traditional cement-heavy annulus grout, reducing embodied carbon by over 61%. The innovation uses repurposed construction waste and agricultural by-products to create a sustainable alternative.
Cohort study finds prenatal depression and gestational diabetes independently increase childhood obesity risk, while children exposed to both face the greatest risk, highlighting need for universal screening and targeted interventions.
Researchers at Kogakuin University discovered that adding phosphorus to sodium-yttrium-silicate glasses significantly enhances their performance as solid electrolytes. The study found that P2O5 addition promotes high-ionic conductivity and stability, making sodium-based batteries a promising alternative to lithium-ion technologies.
La Trobe University researchers developed a new way to measure and report farm environmental performance using Farm-scale Natural Capital Accounting. The method combines production data, remote sensing, ecological modeling, and on-ground assessments to deliver transparent and verifiable farm-scale accounts.
Researchers have developed a lightweight antenna that improves signal strength and image sharpness in MRI scans, particularly for deep or delicate tissues like the eye and brain. The technology has the potential to transform diagnostics by reducing scan times and increasing accuracy.
Scientists from the University of Texas at Austin have solved the mystery of how complex life evolved. The discovery suggests that eukaryotes arose when an Asgard archaeon developed a symbiotic relationship with an alphaproteobacterium, which led to the evolution of mitochondria and oxygen-based energy metabolism.
A novel vaccination approach cleared harmful gut bacterium Clostridioides difficile (C. diff) in an animal model of infection. The experimental vaccine protected against illness, death, tissue damage and infection recurrence through mucosal immunization.
Researchers from ISTA developed an algorithm that can extract and analyze information from the world’s most extensive biobank with unprecedented accuracy and speed. The method, dubbed gVAMP, enhances the framework's ability to extract complex information from the dataset at hand, providing a detailed overview of the effects on a trait ...
A meta-analysis of longitudinal studies found that broad spiritual practices, such as attending religious services and meditation, were associated with a 13% reduced risk of hazardous drug and alcohol use. This reduction was greater (18%) among individuals attending religious services at least once per week.
Scientists have developed a technology that reveals which proteins are generated by individual brain cells. They mapped protein production across nearly 20,000 individual cells in the mouse hippocampus, finding surprising patterns and potential links to neurological conditions. The study sheds light on how translation affects memory ci...
Viral transcription in poxviruses is controlled by a unique protein VITF-3 that acts as a molecular clamp. The study reveals the structural details of this process, including the role of the capping enzyme and the specific start signal recognition.
A recent study by HSE University found that the global generative artificial intelligence market is developing at a faster rate than its ability to generate real revenue. The analysis, published in Foresight and STI Governance journal, reveals a nonlinear trend where efficiency increased from 2016 to 2021 but declined thereafter.
Researchers discovered that a plant's internal daily timekeeper coordinates growth by controlling an electrochemical 'language' between different tissues. A key clock component, CCA1, boosts stem elongation while restricting root growth by controlling hormone signaling and proton pump activity.
A new study has mapped the structure and function of healthy children's bone marrow cells, revealing age-dependent differences in blood cell formation. The atlas provides a valuable resource for researchers to better understand childhood leukemia and other blood disorders.
The university has launched a prestigious global scholarly volume to celebrate its School of Advanced Engineering's 10th anniversary. The book aims to address evolving trends in engineering education systems worldwide and provide international references for educators, policymakers, and institutional leaders.
A new monitor tracks the energy transition in Hungary, finding that roughly half of companies increased their share of low-carbon electricity, while others continued to rely on fossil fuels. The study suggests that size, revenue spent on fossil fuels, and initial investments influence a company's willingness to switch to electrification.
A study published in Nature reveals that a protein called lipocalin 2 (LCN2) is produced by stressed cancer cells to shield them from the immune system. Blocking LCN2 with new drugs enables the immune system to target tumor cells, slowing cancer growth in mice.
Researchers argue that mandated reminders about a chatbot's non-human nature may exacerbate mental distress and form stronger attachments. The warnings come after recent deaths by suicide linked to chatbots like ChatGPT and Character.AI, highlighting the need for careful crafting and timing of these reminders.
Researchers have identified the complex shapes of natural oyster reefs are not random, but optimise the establishment and survival of developing oysters. The study provides critical information to guide effective reef restoration using artificial habitats that replicate specific geometric attributes found in natural reefs.
Researchers at Princeton University found a specific brain region and gene, Agouti, linked to caregiving behavior in male African striped mice. Males with lower Agouti levels showed greater interest in caring for pups, while those with higher levels were neglectful or abusive.
Professor Tae-Woo Lee's research team has developed a 'Cold-injection' method to synthesize high-quality perovskite nanocrystals at room temperature, overcoming safety risks and production costs. The technology achieved near-unity photoluminescence quantum yield in a large-scale synthesis of 20 liters.
Researchers have developed a novel polymer alloy material made from commercially available plastics that can handle unprecedented high temperatures and store more energy than traditional polymer capacitors. The new material has a dielectric constant of 13.5, allowing it to maintain its performance level from -148 F to 482 F.
A recent study predicts that nearly 1 in 10 Medicare Advantage beneficiaries will be forced to disenroll from their current plans in 2026. The drivers of these disenrollments include changes to plan payments and risk adjustment, as well as unanticipated increases in healthcare use among Medicare Advantage enrollees.
Researchers propose a new framework to detect chronic diseases earlier by tracking individual biological changes. Advances in technology and AI enable the analysis of complex patterns from wearable devices and biological samples.
A new study has shown that hospital analysers can accurately distinguish genuine liquid medical products from fakes, providing a low-cost screening tool to complement established methods. This breakthrough addresses a global health threat, with an estimated 10.5% of medicines worldwide being substandard or fake.
Ocean researchers call for broadened species categories and improved protections for coral reefs, as narrow definitions allow for military and economic interference. The researchers' letter aims to inform policymakers to address conservation gaps and ensure reef protection.
A new study found that acral melanoma, a rare and aggressive type of skin cancer, varies among individuals with distinct gene expressions linked to different outcomes. The research analyzed the genetic makeup of over 100 tumours from Mexican patients and uncovered three groups showing unique patterns of gene activity.
Researchers developed a compact, low-power FMCW radar signal generator chip for edge and IoT devices, enabling high-speed sensing and precise distance measurement. The chip successfully overcomes the trade-off between chirp speed and signal linearity, bringing us closer to a seamlessly connected 6G society.
A global atlas mapping two key gut bacteria has uncovered a treasure trove of bacterial strains adapted to the infant gut, not found in commercial probiotic products. The study reveals region-specific strains that have naturally evolved to thrive in a baby's microbiome, shaped by regional diets and environments.
A meta-analysis of 55 studies found a significant protective association between spirituality and hazardous alcohol and drug use. The study suggests that spiritual practices may be effective in preventing or reducing the risks associated with these substances.
A groundbreaking study found that frail men have a significantly higher risk of dying within one year after a heart attack, challenging the prevailing narrative that high clinical risk is predominantly a female issue. The research highlights the need for sex-informed care pathways to address this disparity.
Research from UNSW Sydney and ANU found that people with average face-recognition ability performed only slightly better than chance in spotting AI-generated faces. Even super-recognisers, who excel at recognizing real human faces, were not immune to being fooled by highly realistic AI-generated images.
Scientists at the University of Delaware discovered a previously unknown structural role for the HIV integrase protein, which forms gluey filaments that anchor the RNA genome to the capsid. This discovery provides a promising new target for drug development and could lead to the development of next-generation inhibitors.
Prolonged grief disorder (PGD) is characterized by intense emotional pain and longing for the deceased. Research highlights disruptions in reward-related brain networks as key to explaining why grief persists in some individuals.
Researchers found that macrophages retain memories of previous infections due to persistent signaling molecules left behind, which can be reversed by blocking cytokine signaling pathways. This discovery suggests new ways to reduce the activity of misprogrammed macrophages contributing to autoimmune diseases.
A new study published in Acta Obstetricia et Gynecologica Scandinavica has found that the majority of pregnant women in Ireland are not consuming excessive amounts of alcohol during pregnancy. The study used urine tests to detect ethyl glucuronide, a metabolite of alcohol, and found only 0.4% of samples tested positive for the substance.
Researchers at The University of Osaka developed a solid-state analogue that enables the formation of subnanometer pores approaching biological ion-channel dimensions. The team demonstrated the opening and closing process hundreds of times, with spikes in current consistent with biological channels.
A new study by the University of Vienna found that moving in together with a new partner significantly increases life satisfaction in older adults, regardless of whether they marry at the same time. In contrast, relationship breakdowns do not lead to a measurable decline in well-being.
A new study published in BMC Health Services Research reveals that treating patients with lifestyle medicine may improve well-being and job satisfaction among physicians and other health professionals. Participants described higher job satisfaction after lifestyle medicine implementation, citing meaningful patient improvements.
Researchers at RCSI have developed an RNA-activated implant that delivers growth-promoting particles to injured nerve cells, encouraging them to regrow after spinal cord injury. The implant helps overcome molecular barriers by silencing a gene called PTEN.
A study found that ultra-endurance running damages red blood cells, reducing their ability to carry oxygen and nutrients. The damage accelerates the aging and breakdown of these cells, with longer races leading to greater damage.
Southwest Research Institute is developing a comprehensive Product Lifecycle Management system to store and organize decades of scattered records and data for the US Air Force. The system aims to improve aircraft efficiency and safety by using data, modeling, and analytics to perform repairs and maintenance before problems occur.
Researchers developed a framework to predict acoustic streaming in mid-air phased arrays, revealing its influence on tactile perception and object stability. The study validates thermoviscous and atmospheric attenuation models, enabling precise sound-field design for safer ultrasonic interfaces.
Researchers highlight polyploidy-induced senescence as a coordinated biological program that may drive aging, tissue repair, and cancer risk. Polyploidization in healthy tissues could help maintain organ structure and barrier integrity, but its instability can promote chromosomal instability and malignant transformation.
Researchers discovered a short amino acid motif in NIN that confers broader DNA binding specificity, essential for rhizobial infection and nitrogen fixation. This finding suggests NIN evolved by co-opting preexisting molecular features of ancestral NLP transcription factors.
A study by University of Virginia Health System researchers found that Medicare Advantage patients had better access to preventive care and rehabilitation after a stroke, leading to faster recovery times. In contrast, traditional Medicare patients were less likely to receive these services due to prior authorization requirements.
A traditional Chinese mind-body practice called Baduanjin was proven to lower blood pressure as effectively as brisk walking in a large randomized clinical trial. Practiced for centuries, Baduanjin is a low-to-moderate-intensity routine that requires no equipment and can be performed in various settings.
The study identifies SRJ09 as a top candidate for treating beta thalassemia due to its favorable binding affinity to the active site of histone deacetylase 2 (HDAC2). The compound exhibited acceptable drug-likeness properties and stable complex behavior with HDAC2.
A comprehensive review of 280 scientific studies reveals that natural selection can occur on multiple levels of biological organization, including individual and group benefits. This finding challenges the traditional view of natural selection and highlights its complexity in various ecosystems.