Dr. Dennis Slamon, a renowned breast cancer researcher, has been elected to the Association of American Physicians (AAP) for his pioneering work in HER2 gene discovery and targeted therapies. His research led to significant improvements in survival rates and established the principle of targeted cancer treatment.
Max Planck researchers have discovered how microscopic dendrites induce fractures in solid-state batteries, leading to short circuits. By understanding the counterintuitive phenomenon of dendrite formation, they've identified potential strategies to prevent or delay cracking.
Researchers found that cinnamic acid effectively inhibits plasmid-mediated conjugation, reducing the global spread of antibiotic resistance genes. The study suggests CA as a broad-spectrum conjugation inhibitor targeting bacterial energy metabolism to limit ARG spread.
A research team presents a general approach to batch verification of arbitrary signatures on blockchain, leveraging IVC to enhance scalability and reduce memory consumption. The proposed scheme supports an arbitrary number of signature verifications and offers significant speedups for both provers and verifiers.
A recent study explores how response timing affects people's use and evaluation of AI systems, challenging the assumption that faster is always better. Participants rated slower responses as more thoughtful and useful, highlighting a subtle but powerful feature of human psychology.
A computational protocol has been established by University of Kent researchers to accurately identify reactions that can result in successful drug candidates for Chagas disease. This approach reduces the need for trial-and-error, prioritizing promising compounds earlier and making the drug discovery process faster and more affordable.
Researchers used LP-TEM to visualize the dynamic processes occurring during early stages of liquid-liquid phase separation (LLPS) in intrinsically disordered proteins/regions. The study provides compelling evidence supporting a non-classical nucleation mechanism and proposes a multi-step process for LLPS, which is common in IDPs/IDRs.
A new framework, Synthegy, combines established search algorithms with artificial intelligence capable of interpreting chemical strategies expressed in natural language. This allows chemists to express their goals in plain language and receive strategically relevant solutions.
Hodgkin lymphoma cells are immune cells stuck in an 'identity crisis,' unable to mature into functional plasma cells. The team discovered that these cells downregulate key B cell features and upregulate proteins to make them more like plasma cells, but not completely functioning as such.
A research team at HHU Düsseldorf has discovered how the transport protein Rrm4 acts as a precision logistics expert in the fungus Ustilago maydis. The protein uses specific 'zip codes' on mRNA to identify and bind to, ensuring stable transport to distant sites within the cell.
The Yōni.Fit device is FDA-cleared for temporary management of stress urinary incontinence and also collects menstrual fluid and/or vaginal discharge. Clinical trials show a 96% clinically significant reduction in SUI bladder leaks.
A protein interaction between iNOS and IRG1 has been identified as a key regulator of the immune response. This discovery could lead to new treatments for conditions such as cardiovascular disease, arthritis, and Crohn's disease.
Young people aged 16-25 are three times more likely to start drinking alcohol than non-alcohol alternatives, according to new research from the University of Sheffield. Despite concerns about a potential 'gateway' effect, no evidence was found that no/lows impact young people's alcohol consumption.
A research team from China has developed a material with high charge-to-spin conversion efficiency, achieving record-breaking performance in spintronic devices. The discovery utilizes nonsymmorphic symmetry to stabilize the material and enables ultra-low power magnetic switching.
A research team developed an innovative method to analyze histone modifications during cell division, revealing three distinct phosphorylation programs that follow a clear temporal sequence. The study refutes the previous assumption that removal of certain chemical groups from histones is crucial for DNA compaction.
The upper-level subtropical westerly jet over East Asia shows a weakened long-term trend under orbital forcing but strengthens under greenhouse gas forcing. This study challenges the simple assumption that warming means weakening and suggests the jet could become stronger under future global warming.
Researchers identified 16 clinical laboratory markers linked to PTSD, including cholesterol and glucose levels, liver indicators, and red and white blood cell counts. These biomarkers may reveal the physical impact of PTSD on the body, supporting timely interventions to mitigate chronic disease risk.
A research team developed an implantable sensor to monitor dynamic H₂O₂ levels in plants, enabling real-time tracking of plant stress responses. The system achieved high time resolution and maintained stable performance under various conditions.
A new study published at the Pediatric Academic Societies Meeting found that adolescents with high social media use had triple the odds of recent alcohol use compared to non-users. The study suggests that digital literacy and safe online navigation are crucial in reducing exposure to alcohol-related content.
A new research study by Australian energy companies and waste management firms has shown how organic waste can be safely turned into clean gas for homes and businesses. The team identified critical specifications for optimal biomethane quality, making it more cost-effective to produce.
New findings suggest that clopidogrel monotherapy is associated with a lower risk of net adverse clinical events compared to aspirin monotherapy, even in patients at high risk of bleeding. This benefit is more pronounced in patients with high bleeding risk and complex procedures.
A cohort study of 6,802 pregnant women found an inverse association between grip strength and the risk of hypertensive disorders of pregnancy. The study suggests that relative grip strength may be a useful tool for risk stratification of HDP.
The study found that outpatient care for youth is driving the growth, with nicotine, cannabis, and opioids being the most common substances. Despite this, alcohol-related visits have declined in all care settings over the past 16 years.
A new study found that electronic provider notifications significantly increased aortic valve replacement rates and improved survival among older patients with severe symptomatic aortic stenosis. The DETECT-AS trial showed that clinicians who received automated email alerts with abnormal heart ultrasound results detected AS were more l...
Researchers reveal how expansion of bone marrow fat promotes immunosuppressive PD-L1 signaling, leading to enhanced osteoclast activity and accelerated bone loss. Reducing bone marrow fat improves bone structure.
A cohort study found that bereavement was associated with increased cardiovascular disease risk both before and during the COVID-19 pandemic. The strongest association was observed for partner or sibling loss during the pandemic, highlighting the importance of targeted clinical monitoring and preventive care for bereaved individuals.
Researchers at Griffith University and Queensland University of Technology have developed a machine-learning model to design efficient urea catalysts using waste gases. The model accurately predicted key co-adsorption energy values, narrowing down over 1,400 candidates to promising ones.
This research explores how vibration can convey emotional qualities like reassurance and encouragement, as well as represent abstract experiences through touch. The findings highlight the potential of vibration as an alternative to sound-based navigation for blind and low vision people.
A novel blood return system has been shown to significantly reduce blood loss during pulmonary embolism procedures, with a median reduction of 97%. The study found that the system improved procedural efficiency and maintained hemodynamic efficacy without added therapies or major complications.
Young scholars explore how to make clinical decisions from biomarkers to immunotherapy. They present innovative approaches for targeted therapy sensitivity and guidelines, shedding light on neoadjuvant care.
A new study found that infants receiving maternal RSV vaccination or Nirsevimab after birth had significantly lower RSV infection rates and fewer severe complications. The study showed a high uptake of the vaccines among pregnant patients and newborns, leading to declining rates of RSV-related illnesses.
A new study found that COVID-19 significantly worsens cardiovascular outcomes, leading to higher one-year mortality rates in patients with severe heart attacks. Patients who survived a heart attack and experienced COVID-19 had a 25% higher one-year mortality rate compared to those without COVID-19.
A pilot study of 100 exclusively breastfeeding women found that maternal dairy intake is associated with decreased concentrations of numerous human milk lipids. The study suggests a link between healthy dairy intake and lower levels of specific milk lipid species, which may have implications for infant health.
New research suggests exposure to fathers' depression in pre-adolescence is associated with poor educational outcomes among males, but not females. Early identification and family-centered support can help promote school success and long-term well-being for affected sons.
Researchers found that obakulactone reduced joint swelling, restored cartilage structure, and improved immune organ function in RA rats. It also suppressed proinflammatory cytokines and shifted macrophage polarization to anti-inflammatory M2.
Researchers developed Plan & Protect, a technology-guided safety planning program for rural youth with suicidality seeking care in emergency departments. The program aims to enhance accessibility and usability of safety planning in resource-limited settings, supporting more effective crisis care for adolescents in rural communities.
Researchers developed a next-generation phototherapeutic agent, NDI-COE, which induces pyroptotic cell death in hypoxic tumor tissues. The agent's superior photochemical mechanism involves strong binding to water molecules and efficient electron transfer to oxygen.
A new study calls for tripling energy efficiency, electrification and action against extreme energy consumption by 2035. This would accelerate the spread of efficient technologies and generate revenue to expand energy access and support low-carbon investment.
A new study examined geographic patterns in autism diagnosis by primary care providers among Medicaid-enrolled children in 29 states, finding significant variation between regions. The study found that 29% of children were diagnosed with ASD by a primary care provider, with rates varying from 20.0% in the Midwest to 36.4% in the West.
Researchers at Goethe University Frankfurt are exploring modern quantum materials, which exhibit fascinating phenomena in response to external stimuli. Olena Fedchenko investigates electronic structure and properties of these materials using various photon sources.
The study found that low influenza vaccination rates among children are associated with increased healthcare visits, hospitalizations, and ICU admissions. Achieving a 70% immunization rate could prevent up to 2.2 million outpatient visits and 123 pediatric deaths during high-incidence flu seasons.
The MitraClip procedure has been shown to be safe and effective for patients with mitral annular calcification, improving symptoms and quality of life. Despite higher mortality rates, patients with MAC experienced significant reductions in mitral regurgitation and improvements in quality of life, indicating a promising treatment option.
A study uncovers the connection mechanism between ketone bodies and the mTORC1 pathway, identifying RagC as a key player. The findings suggest RagC-K349bhb as a potential therapeutic target for BHB-based CRC treatment strategies.
The INSEAD for Impact programme is a three-day immersive executive forum that helps leaders translate emerging trends into practical strategies and prioritized actions. The programme aims to move beyond analysis to execution, supporting leaders in understanding forces reshaping business and building personal and organizational resilience.
The study provides atomic-level templates of GHRHR's active and inactive states, enabling the design of highly selective agonists and potent antagonists. This breakthrough transforms our understanding of GPCR signaling from static snapshots to a dynamic framework for drug development.
Researchers have produced complete genome sequences for six peanut varieties, identifying two candidate genes linked to oil content and seed size. These findings provide a comprehensive blueprint for future peanut breeding and improvement strategies.
Researchers found that elevated Lipoprotein(a) levels are associated with a higher risk of major adverse cardiovascular events, including stroke and death. Patients with high Lp(a) levels should work closely with their healthcare provider to aggressively lower LDL cholesterol and manage other cardiovascular risk factors.
The study found that out-of-state Chicago Abortion Fund callers traveled more than 3 times the distance to Illinois after Dobbs compared to before. These callers were also more likely to have private or no insurance, be from rural areas, and receive hospital-based care during their pregnancy.
A new study reveals that over 75% of older adults have used complementary health approaches, including mindfulness, yoga, tai chi, acupuncture, and more. The study highlights the need for healthcare providers to discuss the risks and benefits of these therapies with their patients.
The CARPOOL study demonstrates radial-to-peripheral access achieves comparable procedural success rates to traditional common femoral artery access for lower extremity peripheral artery disease revascularization. However, the R2P group had higher major adverse limb events at six months due to target vessel revascularization.
A new study found that influenza D viruses can vigorously replicate in human cells and lung tissue samples, suggesting a strong potential to spill over to humans. Researchers also detected antibodies against Influenza D in people who work with cattle, but no active human infection has been discovered to date.
AI models can analyze complex data to predict disease progression and identify early signs of kidney damage. This allows for earlier detection and better treatment planning, making a significant impact on patient outcomes.
A novel study in Biological Diversity reveals the integrated physiological and symbiotic adaptation mechanism underlying P. purpuratum's ex situ conservation. The research demonstrates that ex situ conservation elevates seed-set rates but incurs trade-offs in photosynthetic capacity and oxidative stress.
This eight-year analysis showed that tenofovir alafenamide (TAF) maintained viral suppression, normalized alanine aminotransferase levels, and improved renal and bone safety in patients with CHB. The study's findings support the use of TAF as the preferred long-term treatment option for this population.
The new SCORE2-LAC model aims to improve cardiovascular risk prediction in Latin America and the Caribbean. The model applies region-specific data from 32 countries, incorporating 2.6 million individuals, and will be validated using an additional 37 million people from Brazil.
Researchers have developed SmartDJ, an AI-powered editor that allows users to reshape audio experiences with simple words. The system uses language models and diffusion models to interpret high-level requests and generate edited outputs.
Researchers at Tokyo University of Science demonstrated a method for manipulating metallic chiral nanoparticles using circularly polarized light. By confining light to an evanescent field near the surface of ultra-thin optical fibers, they selectively transported left- and right-handed particles based on their chirality.
A study on elite male football players found that athletes of Black ethnicity, particularly those from West and Central African regions, exhibited more pronounced repolarisation abnormalities and structural remodelling. The findings suggest that treating athletes of Black ethnicity as a single group may oversimplify clinically meaningf...
A study published at ESC Preventive Cardiology 2026 found that climate change is driving extreme weather events, leading to increases in major cardiovascular events. Heatwaves had an immediate impact, while coldwaves produced a delayed and more sustained effect. Air pollution further amplified the effects of extreme temperatures.
A new study reveals that conspicuous markings, including 'eyespots', evolve under specific ecological conditions. Smaller skates and rays, lacking strong physical defences, are more likely to develop bold spots or eyespots in well-lit, shallow waters.