Research reveals UBE2M's critical regulatory link to inflammation and innate immune pathway in KrasG12D driven non-small cell lung cancer. Simultaneous UBE2M deletion and KrasG12D activation causes severe inflammatory TME, shortening life-span and promoting tumor growth.
Researchers created Eu-doped infinite-layer nickelates using high oxygen pressure, revealing robust high-Tc superconductivity and reentrant superconductivity in both underdoped and overdoped regions. Rare-earth substitution provided an additional control knob, strengthening the superconducting state and enhancing pairing.
Researchers discovered a mitochondrial protein called ROMO1 that protects motor neurons from ALS-like degeneration. ROMO1 helps maintain healthy mitochondria in motor neurons, suggesting that mitochondrial damage may trigger motor neuron degeneration.
Adrian Bird and Huda Zoghbi's groundbreaking work on epigenetics in neurological diseases has reshaped scientists' understanding of brain disease. Their discoveries have inspired international efforts to develop genetic therapies for devastating conditions like Rett syndrome.
A new study reveals that hydrodynamic intensity, not water temperature, is the primary driver of macroinvertebrate biodiversity and community assembly in high-altitude alpine rivers. The study found that taxa richness consistently followed a unimodal pattern to hydrodynamic intensity, peaking under moderate hydrodynamic intensity.
Scientists at MIT have shown that a neutrino laser, proposed to produce a concentrated beam of neutrinos, is impossible due to recoil and fermionic nature. The research demonstrates that the concept, previously thought to be plausible, is fundamentally flawed.
Researchers at Helmholtz Munich developed Synthetic Transfer Vehicles (STVs), an entirely new class of RNA transporters. STV-C8 is the most efficient candidate, transporting RNA far more efficiently than traditional lipid nanoparticles. In animal models, STV-C8 demonstrates effective delivery and expression of RNA in a living organism.
Lumos Labs has launched the Lumosity Research Platform, offering cognitive assessments, digital training interventions, and real-world data for researchers. The platform is designed to support large-scale randomized controlled trials and advance cognitive science.
A new AI framework, Perspective, provides a structured approach to explaining complex patterns in AI predictions, enabling researchers to test hypotheses and improve designs. By revealing the underlying relationships, XAI can support discovery, optimisation, and certification for AI in high-stakes fields.
A new study challenges the idea that plants cannot grow rapidly while tolerating water stress, finding exotic conifers in the Southern Hemisphere grow up to four times faster and are more resistant to drought. Carbon reserves and absence of natural enemies in the Southern Hemisphere may be key factors contributing to this advantage.
Serial ketamine infusions have been found to be well-tolerated and significantly effective in treating treatment-resistant bipolar depression, with antidepressant effects comparable to midazolam. The study's results provide promising hope for patients struggling with this condition, highlighting ketamine as a potential therapeutic option.
Researchers found over 1,200 genetic variants associated with Big Five personality traits, which also predict life outcomes such as health, education, and career paths. The study suggests an interconnected relationship between genetics and the environment, with environmental factors reinforcing and shaping personality traits.
A new study found that men with nonmetastatic prostate cancer who replaced saturated and animal fats with unsaturated and plant-based fats had a lower risk of death. Replacing about 10% of daily calories from animal fat with plant-based fat was associated with a 16% lower rate of death.
A matched case-control study of 29 case and 290 control participants found HLA-A*32:01 strongly associated with lamotrigine-induced DRESS. This association may help identify patients at risk for this severe reaction, which is currently not accounted for in commercial pharmacogenomic panels.
A genetic marker already used to flag risk of vancomycin reaction also identifies patients at risk of lamotrigine reaction, but is missing from gene panels. HLA-A*32:01 is associated with a 16.4-fold higher odds of lamotrigine-induced DRESS, but a negative result does not rule out risk.
Researchers mapped the brain cells in the electrosensory lobe of African weakly electric fish, revealing a balance between fast and slow changes to cell connections. This balance allows the fish to filter out electrical interference and continually learn and adapt, shedding light on how biological brains learn throughout life.
Researchers found that GLP-1 treatment improved muscle and cognitive function, and reduced hallmarks of natural aging in older mice. The treatment also extended lifespan by nearly 100 days, suggesting a potential therapeutic route for slowing physiological aging.
Scientists have discovered chimeric mRNAs that produce previously unknown proteins, expanding the human genome and proteome. These proteins may play important roles in various bodily systems and contribute to disease processes, offering new insights into challenging diseases and potential drug targets.
A team from INRS identified three bacterial strains that delay disease symptoms, reduce disease severity, and promote plant growth. The strains may belong to a previously unrecognized lineage, offering new avenues for research into beneficial plant-associated microorganisms.
A Linköping University study of 58,000 people found that level of education is the strongest socio-economic factor linked to survival rates after acute hip surgery. Higher education was associated with lower mortality rates, while lower education was linked to higher mortality rates.
Female Dotterels travel long distances to secure multiple mates, contradicting the traditional view of birds' migrations. They often visit three to five sites, with the most wide-ranging bird covering 1,343 km, before returning to a final site for an extended stay.
Researchers from Shinshu University discovered that pterostilbene, a natural polyphenol, stabilizes PPARδ, enhancing fatty acid oxidation and promoting lipolysis in skeletal muscle cells. This finding has potential implications for developing functional foods and nutritional supplements to target muscle fat metabolism.
A new study from MIT Sloan School of Management identifies the most effective ways businesses can use and benefit from AI personalization. Researchers found that specific pairings of human and AI personalities can significantly improve ad quality and performance, with text quality increasing click-through rates and decreasing costs per...
Insilico Medicine has released state-of-the-art (SOTA) MMAI specialist models for chemistry and biology, achieving superior performance on over 70 benchmark tasks. These models demonstrate the potential of language models to compete with dedicated scientific methods in drug discovery.
The XENON Collaboration detects low-energy solar neutrinos with unprecedented precision, expanding our understanding of neutrino physics and the search for dark matter. The observation demonstrates the power of advanced technologies in rare event physics, enabling new windows into the universe.
A Murdoch University study found that 56% of cooked shark products sold in Western Australian fish and chip shops are labelled ambiguously or incorrectly. DNA testing identified 16 different species, including 11 shark species, highlighting the need for stronger seafood labelling requirements.
The PACMAN AI framework successfully tested in five real-world experiments, making decisions in milliseconds and surpassing human reaction time. The framework combines multiple machine learning models to monitor and control different aspects of the fusion system, enabling real-time control and safety.
Researchers found that administrative support is beneficial for teachers, but high levels of student violence weaken its impact. Supportive leadership is crucial for teacher well-being, but it's not enough to prevent turnover due to classroom violence.
Researchers have identified three beneficial bacteria that not only delay the onset of tomato bacterial canker but also promote plant growth. These microbes, including Pantoea agglomerans and Pseudomonas marginalis, have shown promise in treating the disease and improving plant health.
Researchers at EMBL Barcelona have developed a method to grow self-organising bovine tissues containing muscle, nerve, and blood vessel cells from bovine embryonic stem cells. This breakthrough provides a powerful model for understanding muscle development and tissue engineering, and lays important groundwork for building more complex ...
A new framework jointly optimizes UAV trajectories and FANET topology to maximize data transmission, outperforming existing methods in field experiments and simulations. The approach enables more efficient and reliable multi-UAV missions for environmental monitoring and other applications.
A new study from the University of Colorado Boulder reveals how the brain's defense mechanism can backfire, forming micro-clots that damage tissue after the original clot is gone. This phenomenon, known as no reflow, affects up to 50% of stroke patients and can lead to long-term disability or death.
Researchers at University of California San Diego have demonstrated that one of biology's most essential enzymes can accurately read and transcribe an expanded, eight-letter genetic alphabet. This breakthrough advances synthetic biology and could allow scientists to create new biological systems and diagnostic tools.
Research suggests that mental health conditions, including PTSD, substance abuse, and depression, can increase the risk of future cardiovascular risks such as heart attacks, strokes, and cardiovascular death. Alcohol abuse was found to be the top psychiatric predictor of serious heart and brain conditions for both men and women.
Experts warn that common narratives about polarisation are overgeneralised and often based on evidence from the US alone. The study calls for a global literature on political polarisation to be a fundamental goal, emphasizing the need for country-dependent solutions to address the growing polarisation challenges of social media and AI.
A new additive, 2-aminobenzothiazole, enhances the efficiency and longevity of tin perovskite solar cells by regulating crystallization, reducing trap formation, and inhibiting tin oxidation. This study shows a substantial increase in solar cell performance and improved device stability.
A research team from Chiba University developed a flexible bio-based plastic that can be chemically converted into fertilizer after use, improving environmental sustainability. The plasticizer improves the flexibility of the plastic, increasing its potential for future applications.
Researchers have developed a human engineered heart tissue model of diastolic heart failure, enabling treatment testing with SGLT2 inhibitors, which partially prevented disease development. The model demonstrated anti-inflammatory effects of SGLT2i, improving ion exchanger function and preventing accumulation of ions in tissues.
Researchers developed a low-cost touch interface that recognizes finger movements and users, using a single-electrode design and triboelectric effects. The interface can be created by printing patterns onto a PVC sheet with a laser printer and can recognize complex inputs, including alphabet characters and user authentication.
A real-world observational study found no significant survival benefit from post-surgery immunotherapy in NSCLC patients with pathological complete response after neoadjuvant chemoimmunotherapy. The study suggests that these patients may already derive the maximum benefit from neoadjuvant therapy alone.
A new species of leafless flowering plant, Thismia daemona, has been discovered in Thong Pha Phum National Park in western Thailand. The species, which belongs to the genus Thismia, is critically endangered due to its limited population size and fragile habitat.
A new study shows that administering cell immunotherapy before surgery to remove a brain tumour is significantly more effective than administering it afterwards. CAR-T cells were able to neutralize tumor cells and immune suppression, leading to unprecedented durable tumour control.
Researchers found that aerobic exercise alters regional brain activity patterns during cognitive tasks, while task repetition influences efficiency. In older adults, a positive correlation was observed between decline in brain activity and task performance, suggesting linked changes in task processing.
A scoping review found that only 77 studies validating 52 medical AI products reported demographic data, highlighting the need for more transparent reporting to confirm safe and unbiased performance. The review also showed that performance reporting for demographic subgroups is inadequate, posing a risk to patient care and outcomes.
Research in Germany found that birdsongs with narrower bandwidths and greater complexity are perceived as more pleasant, with blackbirds' songs considered most attractive. Pleasantness is also influenced by personal taste, but not by knowledge of birds.
A scoping review highlights the inconsistencies in documenting menopause symptoms and status in EHR systems, leading to gaps in quality clinical treatment, research, and positive health outcomes for midlife women. Standardized menopause data elements are crucial to advancing menopause care.
A nationwide study of over 100,000 children found certain fertility treatments, including ovulation induction, IUI, and IVF, are associated with an increased risk of Kawasaki disease before age 5. The study's findings highlight the need for further investigation into the mechanisms underlying Kawasaki disease.
A new study found that the presence of peregrine falcons in the Bay Area dropped by 65% after an outbreak of H5N1 highly pathogenic avian influenza. The decline is synchronous with the outbreak, which has affected millions of birds globally.
Researchers have discovered a new microbe, Caledochytrium aldermaii, that reproduces by growing new cells inside its own body before bursting open to release them. This unique reproductive strategy has the potential to improve the production of omega-3 oils and natural food colours, which are used in food supplements, infant formula, a...
A new platform using liquid-crystal Poincaré-sphere-connected diffractive neural networks enables large-scale photonic in-memory computing with minimal data-movement overheads and ultralow static power. It achieves a 100,000-fold improvement in memory capacity over state-of-the-art platforms.
A new LiDAR system enables simultaneous 3D imaging and multi-parameter sensing for electric vehicle safety. The system accurately measures temperature, gas concentrations, and liquid density, and has potential applications in new energy vehicles and spacecraft.
Researchers have developed a low-iridium heterostructured electrocatalyst that achieves high activity and long-term durability for proton exchange membrane water electrolysis. The catalyst reduces expensive iridium loading while improving oxygen evolution reaction kinetics.
Advanced solid oxide electrolysis cells achieve up to 80% ethane conversion with 85% ethylene selectivity, overcoming traditional trade-offs in alkane upgrading. This technology enables a low-carbon and flexible pathway for sustainable chemical manufacturing.
A new web-based tool, Cog-Free, estimates dementia risk using routine health examination data without cognitive tests. The tool, validated in a prospective cohort study, achieved high accuracy and clinical utility, with variables such as education, grip strength, and age contributing to risk assessment.
Researchers developed a thickness-gradient electrolyte to homogenize current distribution in solid oxide fuel cells, reducing current density deviation by up to 80% and improving durability. The electrolyte's layered structure boosts electrochemical reaction rates while suppressing excessive local current.
Researchers at Barrow Neurological Institute discovered a link between wildfire smoke and neurodegenerative diseases like Parkinson's and Alzheimer's. Wildfire smoke particles activate astrocytes, leading to inflammation and damage to nearby brain cells.
Researchers found that musicians can predict what happens next in movement sequences faster than non-musicians. Visual distractions can disrupt new motor memories, affecting practice sessions and skill learning, the study suggests. The findings have implications for rehabilitation, sports training, and music education.
Researchers at Tohoku University have developed a new method for creating efficient micromixers inside polymer fibers, enabling rapid mixing of minute amounts of liquid. The twisted microchannels fabricated using this method promote mixing even at low Reynolds numbers, making it suitable for various applications.
Rice University bioengineer Michael King joins the Texas Cancer Institute's AI advisory panel to explore AI's potential in cancer research and prevention. The panel aims to ensure responsible and ethical use of AI in biomedical research, with King's expertise in cancer bioengineering playing a key role.
Researchers propose that fireside storytelling was critical to the evolution of sophisticated language, allowing humans to extend social time and create a deep sense of social connection. The unique properties of firelight, including its flickering and infra-red emission, may have played a key role in this process.