A new class of electrolytes has been developed that overcomes the bottleneck of water activity in traditional aqueous batteries. The electrolytes work with commonly used zinc salts and achieve exceptional electrochemical performance, including a wide stability window and ultra-long cycling life.
A retrospective study evaluates morphological irregularity parameters in Gamma Knife treatment planning for vestibular schwannoma patients. The analysis revealed strong correlations between these parameters and treatment plan outcomes, suggesting potential improvements in planning strategies.
Insilico's unified AI framework combines disease-specific predictive modeling with rigorous benchmarking to improve target identification accuracy and reliability. The validated system generates actionable intelligence, prioritizing targets with strong potential for successful development.
A new study removes bitter-tasting compounds from flaxseed oil, preserving its health-beneficial fatty acids and extending its shelf life. The approach uses bleaching earth to selectively reduce cyclolinopeptides, resulting in a flavor-stable oil that remains milder for longer.
The study found a concerning trend towards trial consolidation at top-performing sites in the US, with more limited access to clinical trials for lower-volume locations. This may be due to factors such as increased complexity of phase I trials and regulatory burdens.
A recent study identified distinct microbial signatures in the oral cavity and gut that serve as robust biomarkers for early gastric cancer detection. These microbial markers can be detected in saliva or stool samples using machine learning models, achieving an AUROC of 0.87 for saliva-based detection.
A new study reveals that strategically located poplar plantations can improve functional connectivity for forest birds in fragmented agricultural landscapes. The findings suggest that managed forests may contribute to both biomass supply and biodiversity conservation, particularly for species with moderate to high dispersal capacity.
A team of scientists has found that applying pressure to the heavy-fermion ferromagnet Ce5CoGe2 reveals superconductivity above a magnetic quantum critical point, defying typical expectations. The unusual phase diagram suggests that other ingredients beyond magnetic fluctuations may drive superconductivity in this material.
Researchers developed an AI model called Path-IO that uses machine learning to predict responses to immunotherapy for patients with metastatic non-small cell lung cancer. The model accurately stratified patients into high-risk and low-risk groups, with patients in the high-risk group having double the risk of death or disease progression.
Researchers have discovered two therapeutic vulnerabilities in LAR triple-negative breast cancer: ERBB2 mutations and senescence. Targeting these weaknesses with next-generation TKIs and immunotherapy could improve patient outcomes.
A digital single-session intervention (SSI) has been shown to meaningfully improve young people's sense of hope and control over their lives. The tool provides short, accessible and evidence-based psychological support and wellbeing activities, increasing feelings of hope and self-agency while reducing feelings of being out of control.
Researchers found that macrophages from CF patients display a pre-activated inflammatory state and exhibit exaggerated activation of NF-κB signaling. The extracellular matrix also acts as a persistent inflammatory stimulus, driving lung inflammation persistence despite CFTR function restoration.
Researchers developed a universal binder system for combining different ceramic materials or ceramics and metals in a single process, enabling new designs and functionalities. This technology has promising applications in power electronics, sensors, and autonomous vehicles, and will be showcased at the Hannover Messe 2026.
Researchers at VUB and La Monnaie/De Munt have created a world-first shoe using pure mycelium as the sole material, achieving load-bearing capacity without reinforcement. The innovative design showcases the potential of fungal materials in traditional crafts.
Researchers have developed graphene-integrated microtube resonators with a unique lobe structure to improve optical modulation and detection. The design enhances axial mode quantization, allowing for efficient light localization and trapping within specific regions of the tube.
A new study by Bournemouth University found that the brain reacts to emojis in a way similar to seeing real human faces, with neural responses occurring within 145-160 milliseconds. This suggests that emojis can be processed by the brain as meaningful emotional signals during online interaction.
Chemokines regulate immune cell infiltration and local immunity in tumors, and targeting their receptor axis has emerged as a promising therapeutic target in cancer immunotherapy. Chemokine-modulating strategies combining with other immunotherapies have demonstrated considerable synergistic potential.
A new biosensor detects active tuberculosis using a protein secreted by the bacterium, providing more accurate information from a clinical perspective. The device achieves high sensitivity and specificity, with promising potential for resource-poor countries.
The University of Hong Kong launches School of Governance and Policy, convening global thought leaders to address regional and transnational challenges. The inaugural week will feature a dynamic platform for ideas to meet action, bridging academic insight, policymaking, and real-world innovation.
A new study finds that water masses from the Southern Hemisphere have been a major contributor to the Indonesian Throughflow for over 800,000 years. The researchers measured nitrogen isotopes in sediment cores and found a remarkable long-term stability of the nitrogen cycle along the equatorial Pacific.
A recent study by researchers at Griffith University and others found that exposure to cocaine contamination altered the movement patterns of Atlantic salmon in Lake Vättern, Sweden. Fish exposed to benzoylecgonine swam up to 1.9 times farther than unexposed fish, with dispersal distances reaching up to 12.3km.
Researchers have discovered a way to prevent the collaboration between two important cancer-related proteins, N-MYC and Aurora A. This breakthrough could lead to new medications to combat childhood cancer. The study, published in Nature Communications, provides insights into how these proteins interact with each other.
Researchers identify specific chemicals that trigger neural activity in nematodes when they detect certain bacteria, leading to changes in feeding behavior and avoiding harmful pathogens. The study sheds light on fundamental mechanisms of how neurons interact with bacteria, paving the way for potential therapeutic interventions.
A phase II clinical trial found that ciltacabtagene autoleucel, a CAR T-cell therapy, achieved a 100% minimal residual disease (MRD)-negativity rate in patients with high-risk smoldering multiple myeloma. The treatment also showed low-grade cytokine release syndrome and transient hematologic toxicities.
A study of 1,338 older adults found that longer, more frequent, and morning naps were associated with higher mortality rates. Excessive daytime napping was linked to increased risk of neurodegeneration, cardiovascular diseases, and greater morbidity.
A cluster-randomized trial found that an adaptive mobile health intervention effectively reduced the rate of gestational weight gain and total gestational weight gain among pregnant patients with overweight or obesity. The study suggests that technology-based interventions can be a valuable tool in managing excess weight during pregnancy.
A video game developed to improve trauma triage decision making in emergency doctors has shown promising results. The game reduced under-triage rates for older patients by 49% compared to those who did not play the game, suggesting improved diagnostic abilities and adherence to guidelines.
The article discusses how emerging digital tools are capturing the biopsychosocial reality of chronic pain. Digital tools such as wearables, AI-driven trackers, and ecological momentary assessments mitigate recall bias by recording data in real-time, providing a more holistic picture of the patient's journey.
Researchers at Gladstone Institutes identified hundreds of human genes influencing HIV infection and two potent antiviral proteins, PI16 and PPID. These proteins block HIV's entry into T cells or limit its ability to replicate within the cell.
A new study reveals that people with Parkinson's disease have a distinct gut microbiome, as do those at genetic risk but without symptoms. This could lead to early detection and potential prevention strategies.
A new study found that cancer types with high lethality receive lower federal research funding, prioritizing these cancers could help direct resources to diseases with greatest potential to reduce suffering. Additionally, certain cancers have a disproportionate impact on underserved populations and quality-of-life burden.
A new study co-led by UT Health San Antonio found that having three or more live births is associated with a reduced risk of stroke and brain damage in women. The research suggests that reproductive factors, such as the number of live births, may be an important predictive factor in assessing stroke risk in women.
The study reconstructs the genetic profile of a small group of Neanderthals from Stajnia Cave, Poland, providing a coherent genetic picture of Neanderthals in this part of Europe. The discovery sheds light on the distribution of a particular Neanderthal maternal lineage in western Eurasia.
A nationally representative study found nearly 1 in 10 U.S. adults with heavy drinking and obesity conditions, highlighting the need for preventive efforts in younger and middle-aged adults without insurance or Medicaid coverage to curb rising rates of alcohol-associated liver disease deaths.
Researchers found that men with a 'country' identity showed distinct vowel patterns in their pronunciations, different from those living in neighboring areas. Country identity was more robustly linked to language patterns than travel patterns.
Researchers discovered how lycophytes, ancient spore-bearing vascular plants, adapted to survive the Permian-Triassic mass extinction by using carbon acid to store CO2 for daytime photosynthesis. This CAM photosynthesis method helped them thrive in extreme heat and dry environments.
Researchers have mapped the first migratory bird brain using high-resolution light microscopy and open-source software tools, creating a valuable resource for neuroscience worldwide. The new Eurasian blackcap atlas enables consistency in brain data interpretation and fosters collaboration among researchers.
Researchers developed a machine learning model using DNA methylation patterns to predict cancer origin in patients with unknown primary. The model correctly identified the cancer type in about 95% of cases, suggesting it could support personalized treatment decisions.
Manchester scientists discovered a new type of aromatic molecule made entirely of metal atoms, with a tiny ring of three bismuth atoms supporting circulating currents like benzene. The finding bridges the gap between organic and all-metal aromaticity, offering insights into chemical bonding.
Primary care-based discussions on reproductive goals, immunizations, and risk-reducing interventions optimize pregnancy outcomes. Prepregnancy counseling reduces maternal morbidity and mortality, while also promoting healthy fetal development.
A study shows how a kea parrot with a missing upper beak uses innovative fighting techniques to dominate his group and gain social status. He achieves this through 'beak jousting,' which proves more effective than other methods, leading to improved health benefits and social recognition.
A team of physicists has discovered that atomic clocks can probe time in a way that reveals its quantum nature. By manipulating the vacuum itself, they created squeezed states that exhibit subtle quantum behavior, allowing a single clock to measure how it ticks both faster and slower simultaneously.
Researchers developed a pathomics framework using a deep learning survival prediction model that analyzes pathology slide images and study patterns to predict patient outcomes. The model correctly stratified patients into high- and low-risk groups with significantly different outcomes.
Researchers at Keck School of Medicine have identified a new potential treatment target for AARS2-related cardiomyopathy, a rare and fatal heart muscle disease in infants. By targeting the PCBP1 gene, they aim to restore healthier AARS2 function in heart cells and prevent damage.
A genetic analysis of 132 individuals buried in a megalithic tomb near Paris found a sharp reduction in the local population followed by the arrival of new groups from southern France and the Iberian Peninsula. The study detected ancient pathogens, including the plague bacterium Yersinia pestis.
Researchers developed a thin plastic film with ultra-fine structures that tear apart viruses on contact, killing them through mechanical force. The film offers a scalable and practical alternative to existing antiviral coatings.
Researchers at NUS CDE have developed biowaste coatings that improve the conversion of carbon dioxide into useful fuels and chemicals, achieving high selectivity rates and reducing reliance on PFAS. The coatings, made from crustacean shells, insect exoskeletons, and plant matter, offer a cost-effective pathway to climate technology.
A study published in Applied and Environmental Microbiology suggests that a fungus strain called Aspergillus calidoustus can survive the harsh conditions of space travel and Martian environments. The fungus was found to tolerate extreme temperatures, radiation, and pressure, making it a strong candidate for surviving the trip to Mars.
Three European countries reach 90% HPV vaccination coverage among girls by age 15, marking progress in cervical cancer prevention. HPV vaccination programmes show significant reductions in infections and precancerous lesions, with early administration increasing full protective potential.
Researchers developed a heat-tolerant cutinase enzyme that combines structural rigidity with flexibility, enabling efficient degradation of PET at high temperatures. This discovery provides new insights into designing enzymes for sustainable plastic recycling and addresses the pressing issue of plastic waste.
A research team developed a two-electrode-based real-time diagnostic technology capable of precisely analyzing the causes of performance degradation in anion exchange membrane water electrolysis (AEMWE) systems under actual operating conditions. The study reveals that voltage increase in water electrolysis systems arises not only from ...
Researchers have identified the Prrx1 gene as a key regulator of metastatic potential in breast cancer tumors. This discovery helps explain why highly invasive cells do not always give rise to metastases, and how cells combine invasiveness and proliferation to become the most dangerous from a clinical perspective.
Research by Taro Yoshimura examines the history and linguistic landscape of biodiversity, finding that ancient Greek dominates molluscan family names, often due to prestige and style. This highlights a human side to naming, where science is shaped by epistemic values and cultural biases.
A recent study reveals that tiny cave shrimps, specifically the Typhlatya genus, play a crucial role in maintaining the unique food web of anchialine caves in the Yucatan Peninsula. The shrimps convert microbial growth into animal biomass, introducing essential nutrients into the ecosystem.
A landmark study found a significant association between prenatal prescription of sterol biosynthesis-inhibiting medications and the risk of autism spectrum disorder (ASD) in children. The research identified commonly prescribed medications as potential contributors to neurodevelopmental vulnerability.
Researchers from CiQUS introduce a prototype thermal memory device capable of switching between high and low thermal conductivity states through electrical stimuli. The device relies on ultra-thin ferroelectric films with precise regulation of thermal conductivity, enabling stable and non-volatile thermal states.
A team of scientists has developed a new method to assemble luminescent molecules into nanotubes with unusual excitonic properties. The nanotubes can be arranged to form luminescent fibers that reach several centimeters in length, and exhibit multidirectional energy transfer within their interiors.
A Phase II trial found that exercise can improve cognitive function in patients receiving chemotherapy, while low-dose ibuprofen may also have some benefits. The study suggests that exercise is more effective in improving cognitive outcomes, but further research is needed to explore the effects of ibuprofen and combination therapy.
A recent survey found that 72% of youth aged 13-17 use AI companions and 52% report regular use, highlighting the need for robust safeguards. Well-designed chatbots can normalize help-seeking, reduce isolation, and offer coping strategies, but poorly designed ones can cause harm.
Researchers have discovered a novel optical material, arsenic trisulfide (As2S3), that can be permanently modified by light and sculpted at the nanoscale level. This material exhibits an unusually large light-induced refractive-index change, enabling the creation of extremely fine optical fingerprints.