Researchers developed a single-administration vaccine strategy for polio using an injectable microsphere bearing inactivated polio vaccine (IPV) that releases stable antigen over time; the researchers used biocompatible excipients to stabilize IPV, and found that injecting the microspheres into rats elicited a strong immune response against all three IPV antigens.
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Article #17-20970: "Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response," by Stephany Y. Tzeng et al.
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Proceedings of the National Academy of Sciences