Articles tagged with Immune Response
Group 2 innate lymphoid cells (ILC2s) form tight anatomical associations with sensory, autonomic, and enteric nerve fibers, receiving neural regulation through activating and inhibitory pathways. ILC2s also secrete cytokines that can act back on neurons, forming positive feedback loops that modulate allergic and anti-infective immunity.
Researchers identified a previously unknown pathway that prostate tumors leverage to suppress the immune system, reshaping the tumor microenvironment to resist treatment. Combining B7-H3-targeted therapy with MEK inhibition improved antitumor responses and prolonged survival in preclinical models of castration-resistant prostate cancer.
The new guidelines, developed by leading experts, focus on improving sepsis care by strengthening systems for diagnosis, treatment, prevention, and quality improvement. Emerging technologies, such as next-generation diagnostics and artificial intelligence, are also being explored to enhance sepsis care.
Researchers identified ANKRD11 as a key regulator that suppresses CD8+ T cell activity during chronic hepatitis B virus infection and cancer. ANKRD11 deficiency reprograms CD8+ T cell differentiation to enhance immunity in chronic infection and cancer, making it a potential therapeutic target.
Salk Institute scientists found that maternal immune activation leads to epigenetic changes in mouse brains, increasing the risk of neurodevelopmental disorders. These changes were particularly significant in areas of the genome associated with autism spectrum disorder.
Researchers have created a high-resolution functional map of human immune cells, revealing intricate circuits that govern health and disease. The dataset provides a powerful framework for designing cancer immunotherapies and treating autoimmune conditions, and serves as a foundation for AI models of biology.
Researchers have mapped how the immune response in people with sepsis changes over time, revealing three distinct immune states. This finding could lead to targeted treatments for sepsis patients, as the immune state doesn't match the clinical stage of sepsis.
Researchers found that longer-lived bats have higher levels of cancer-fighting genes and an immune system that can mount an overwhelming attack against infectious organisms and cancer. This discovery suggests that understanding one will help scientists understand the other.
A new study from Arizona State University finds that past immune encounters can predict future vaccine response, opening a path toward more personalized vaccination strategies. Researchers analyzed blood samples from over 4,000 people, identifying antibody signatures that distinguish strong responders from weak ones.
Researchers at Pusan National University investigated how chronic environmental stress drives immune dysfunction in cold tumors, revealing a key driver of NK-cell maladaptation: the GDF15-AhR axis. This axis sustains activation of stress-sensing receptors, gradually exhausting NK cells and enabling immune escape.
Scientists create a biomimetic zona pellucida coating called BZP to mimic the natural barrier on egg cells, protecting donor islets from the immune system and reducing blood sugar levels in diabetic mice for 100 days. This approach could lead to a promising commercial cell therapy platform for treating various diseases.
A study maps how antibodies target a key region of the SARS-CoV-2 spike protein, neutralizing the virus, and how emerging variants escape. Researchers identified three immune escape strategies: disruption, glycan shielding, and conformational remodeling.
Researchers have identified a naturally occurring gut molecule that strengthens chickens' immune response against bacterial infections. The compound, sodium butyrate, reprograms chicken immune cells to fight diseases without causing inflammation.
Researchers from the University of Rochester's TraCe-bMPS have developed tissue chips that can predict dangerous immune reactions to cancer therapies. The technology, which uses human cells and sensors, has been accepted into the FDA's Innovative Science and Technology Approaches for New Drugs pilot program.
Cancer cells' ability to evade the immune system is linked to changes in their surrounding environment, including nearby nutrients and conditions. Researchers discovered that altering these factors can thin the cancer cell's protective sugar coating, allowing the immune system to recognize and eliminate them.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center are developing drug-based strategies to enhance cancer immunotherapy for melanoma and potentially other cancers. They identified two promising compounds that could strengthen T cell interaction with cancer cells or make tumor cells more susceptible to destruction by T cells.
Researchers found that people with well-controlled HIV have more fibrosis in their fat tissues, leading to insulin resistance and type 2 diabetes. The study also identified a blood marker of scarred fat, which may help predict metabolic future for individuals with HIV.
Researchers at La Jolla Institute for Immunology discovered that immune cells in lung tissue express genes associated with autoimmune disease risk. These tissue-resident immune cells may actively drive the development of autoimmune diseases, particularly in women.
The Alliance QUANTUM trial is testing whether post-transplant consolidation therapy with teclistamab improves survival in patients with primary plasma cell leukemia. Plasma cell leukemia is a rare but aggressive blood cancer with poor long-term survival rates.
Combining cemiplimab, fianlimab, and paclitaxel-based neoadjuvant chemotherapy improved pathologic complete response rates in high-risk -negative breast cancer. Patients with the ImPrint immune signature showed enhanced sensitivity to the combination.
Researchers developed a new treatment strategy using the cancer medicine Teclistamab to reduce antibodies against potential transplants, improving transplant prospects for patients with unfavorable immunological profiles. The study successfully performed a kidney transplant in a patient who had been on the waiting list for over a decade.
Researchers at Tulane University discovered that vesper bats have two distinct copies of genes producing antibodies, which helps them recognize and fight infections. This finding opens up new areas of study on the evolution of immunity and how animals respond to diseases.
A new study reveals that USP22 regulates B-cell activation and differentiation through the CHD4-CD19 axis. Inhibiting USP22 partially reversed B-cell hyperactivation in Kawasaki disease patients.
A recent study found that human lung tissue contains a vast reservoir of tissue-resident memory T cells (T RM cells) capable of targeting a range of viruses, bacteria, and fungi. These cells reside only in the lungs and can live for years, providing a vital line of defense against severe respiratory infections.
Researchers discover how tumors hijack the thymus to evade immune surveillance by transporting tumor antigens there. Disrupting a specific chemokine receptor may enhance anti-tumor immunity and improve cancer treatment outcomes.
A single-group, open-label study found that olorofim, a novel antifungal agent, showed efficacy in patients with disseminated coccidioidomycosis, a rare complication of Valley Fever. By days 42 and 84, about 76% and 73% of patients showed clinical improvement, respectively.
Researchers found that mRNA-based COVID-19 vaccines effectively protected Schistosoma-infected mice against SARS-CoV-2, with strong spike-specific antibody responses and CD4 T-cell immunity. The findings suggest that chronic helminth infection does not necessarily compromise vaccine-induced protection.
Researchers at Tohoku University have discovered a previously unknown pathway for B-cell development in chickens, bypassing the bursa of Fabricius. The discovery reveals that B cells originate in the bone marrow and migrate to the cecal tonsils, establishing an IgA-mediated intestinal barrier.
A new study published in Nature Communications finds that a protein called saxiphilin can neutralize the potent neurotoxin saxitoxin, preventing and even reversing paralytic shellfish poisoning. The discovery could have important public health implications as saxitoxin accumulates in shellfish and causes poisoning when consumed.
A buildup of bile acids caused by an unhealthy gut can drive breast cancer to other parts of the body, researchers reveal. The study found that replenishing beneficial bacteria or treating patients with FDA-approved bile acid sequestrants may reduce breast cancer metastasis.
Scientists at MD Anderson Cancer Center have identified a previously unknown mechanism by which T cells attack and eliminate acute myeloid leukemia (AML) cells. The discovery reveals that AML cells use a CD64-dependent pathway to evade traditional MHC recognition, potentially explaining why AML is sensitive to immune-based treatments.
Researchers found that yeast-based supplements can reprogram early-stage immune cells to produce enhanced anti-tumor responses. The study suggests a potential solution for obesity-related immune dysfunction and cancer, using a food-grade supplement with an excellent safety record.
Scientists at Hackensack Meridian Health's CDI Lab published two companion papers explaining the 'exhaustion' of key immune cells. The first paper identified Id proteins as determinants of exhausted CD8+ T cell fate, while the second paper revealed CTCF's role in dynamic enhancer activation and invariant barriers.
A new method called ATTACH identifies strong interactions between T cells and cancer-specific proteins to isolate effective tumor-reactive T cells. This approach overcomes key challenges in immunotherapy development, offering a rapid and accessible way for isolating rare immune cells.
The new journal features cutting-edge research across basic, clinical, and translational immunology. It is designed to connect researchers across the full breadth of immunology, deepening understanding of the immune system in health and disease.
Scientists at La Jolla Institute for Immunology and Scripps Research have developed an HIV vaccine that trains immune cells to see past HIV's defenses. The vaccine resulted in the best HIV-fighting antibody response ever seen in primates, with human trials now underway.
A new study by Thales Papagiannakopoulos and colleagues found that lung cancer tumors talk directly to the nervous system through sensory neurons in the lungs, promoting cachexia. Silencing these nerves or blocking the production of prostaglandin E2 (PGE2) reduced cachexia, suggesting a potential therapeutic strategy.
A UMD-led study reveals that wild bats balance different types of immune defenses based on sex, age, and competition for mates. The researchers found that male bats rely more on rapid-response immune defenses, while females invest in targeted responses to pathogens.
A modular system designed by Worcester Polytechnic Institute Assistant Professor Jiawei Yang enables the creation of customized hydrogel implants with tailored stiffness and functionality. The system addresses critical challenges in implant design, including adhesion and immune rejection, to improve long-term performance.
Researchers discovered biomarkers indicating overactivity and dysfunction in the immune system, which can lead to chronic critical illness. Identifying these markers could allow doctors to intervene earlier, leading to shorter ICU stays and improved patient outcomes.
A review published in Diabetes Care suggests that physical exercise could play a role in promoting immune regulation, preserving beta-cell function, and reducing inflammation in type 1 diabetes. The evidence highlights the potential benefits of exercise on immune profiles displaying anti-inflammatory characteristics.
Scientists have identified a unique chimeric RNA called UBA1-CDK16 that plays important roles in women's blood cell development and disease severity. The findings suggest the chimeric RNA may serve as a natural brake to protect women from excessive autoimmune activity.
A study by Okayama University researchers revealed that SARS-CoV-2 antibody levels can assess infection history, symptom severity, and cognitive complications in long COVID. The findings suggest that declining S-antibody levels may indicate a greater risk of neurological complications.
Researchers from Kyushu University discovered that the circadian clock protein BMAL1 drives macrophages towards a pro-inflammatory M1 state by activating inflammatory signaling pathways. This mechanism links the body clock to intracellular metabolism and immune function, offering new insights into treating inflammatory diseases.
A University of Minnesota Medical School research team led by Dr. Monica Campo is studying early immune responses in lung cells and their impact on tuberculosis infection outcomes.
Researchers from Florida Atlantic University have identified a key immune pathway that appears to drive damaging inflammation in Huntington disease. Blocking this pathway reduced brain inflammation, protected neurons, and improved movement in a humanized mouse model of the disease.
Research in flies shows that tumor cells with chromosomal instability can become senescent and release signals altering neighboring tissue behavior. This process promotes tumor growth by inducing the death of nearby healthy cells.
Researchers at UT MD Anderson Cancer Center have made significant advances in understanding cancer biology, developing AI-powered atlas of tertiary lymphoid structures as prognostic biomarkers, and uncovering drivers of resistance to KRAS inhibitors. Additionally, they have discovered a molecular pathway that drives stressed cells to b...
Scientists at La Jolla Institute for Immunology have discovered that 'cross-reactive' T cells can recognize multiple species of paramyxovirus, including measles and Nipah viruses. This broad protection is essential in combating emerging diseases with unknown viral strains.
Researchers at Trinity College Dublin found that cells with latent TB remain metabolically flexible, allowing strong antibacterial responses. In contrast, cells from people with active TB disease show impaired metabolism and weaker responses to infection.
A study published in Nature Metabolism has found a crucial link between mitochondrial lipid deficiency and gut inflammation, revealing that cardiolipin plays a key role in maintaining immune homeostasis. The research suggests that targeting the metabolism of immune cells could be a new approach to treating inflammatory bowel diseases.
Researchers at Max Planck Institute for the Science of Light create a 'map' of glycocalyx by mapping individual sugar structures using super-high-resolution microscopy technology. The results show that the spatial arrangement of sugar structures relates to cell physiological state, providing a structured display to the outside world.
Antimicrobial peptides influence amyloid fibrillization through three mechanisms: structural compatibility, directional seeding asymmetry, and surface-mediated catalysis. This review proposes a bidirectional pathogen-amyloid feedback loop, linking infection and neurodegeneration.
A study by UCLA Health researchers linked low immune responses to higher mortality rates in patients, using tuberculosis screening tests as a tool. The results suggest that these tests can predict mortality in various patient groups, including those undergoing organ transplants and cancer patients on immunotherapy.
Researchers found that increases in macrophage cell volume reprogram gene expression and induce inflammation. Cell swelling also triggers an enhanced antiviral response in infected cells.
Researchers at USF Health developed a framework to test AI tools' accuracy in predicting immune responses, aiming to enhance cancer immunotherapies and vaccine development. The study highlights the strengths and weaknesses of current AI approaches, providing guidance for building safe and reliable AI tools for healthcare.
A new study reveals that impaired protein recycling is the key factor in T cell exhaustion, allowing researchers to develop a 'tag and sort' fix to restore normal proteostasis. This approach boosts the potency of cell therapy against cancer.
Researchers at Vanderbilt University Medical Center discovered that enterotoxigenic Bacteroides fragilis reshapes intestinal cell metabolism to support its growth, causing diseases like diarrhea and colorectal cancer. The study provides new possibilities for intervention by targeting metabolic interactions between host and microbes.
A new study found that influenza D viruses can vigorously replicate in human cells and lung tissue samples, suggesting a strong potential to spill over to humans. Researchers also detected antibodies against Influenza D in people who work with cattle, but no active human infection has been discovered to date.
Researchers found that antibiotics disrupt gut microbiota, suppressing protective immune system pathways and increasing severity of A. baumannii pneumonia. The study highlights the gut-lung connection as a potential therapeutic target for hospital-acquired lung infections.