New research published in Cell has found that the environment inside our bodies, specifically, the pH level within cells, has a powerful influence on the immune system. The research team identified a key molecular sensor that detects changes in intracellular pH and helps regulate the body’s immune defense. This sensor affects how cells respond to bacterial infections and may also influence susceptibility to inflammatory diseases and cancer. These findings open up a new way of thinking about how our internal environment shapes immune function, and could lead to innovative strategies for disease prevention and treatment.
Cell
Regulation of inflammatory responses by pH-dependent transcriptional condensates
17-Jul-2025