Lianhuaqingwen (LHQW) capsule, a herb medicine product, has been clinically proved to be effective in coronavirus disease 2019 (COVID-19) pneumonia treatment. However, human exposure to LHQW components and their pharmacological effects remain largely unknown. The authors of this study aimed to determine human exposure to LHQW components. Based on the human exposure analysis, several ACE2 binding components with good enzyme inhibitory effects were screened out by ACE2 biochromatography. The results obtained by the authors demonstrated chemical and biochemical evidence for exploring molecular mechanisms of therapeutic effects of LHQW capsule for the treatment of COVID-19 patients based on the components exposed to humans.
The research also demonstrated the utility of the human exposure-based approach to identifying pharmaceutically active components in Chinese herb medicines.
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Article reference: Xiaofei Chen, Yunlong Wu, Chun Chen, Yanqiu Gu, Chunyan Zhu, Suping Wang, Jiayun Chen, Lei Zhang, Lei Lv, Guoqing Zhang, Yongfang Yuan, Yifeng Chai, Mingshe Zhu and Caisheng Wu, Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening, Acta Pharmaceutica Sinica B , 2020, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2020.10.002
Keywords: Lianhuaqingwen capsule, PATBS, COVID-19, ACE2, Biochromatography, Comprehensive 2D analysis, In vivo exposure, Surface plasma response, Molecular docking
The Journal of the Institute of Materia Medica , the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
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CiteScore: 10.5
Impact Factor: 7.097
5-Year Impact Factor: 7.865
Source Normalized Impact per Paper (SNIP): 2.210
SCImago Journal Rank (SJR): 1.792
ISSN 2211-3835
Acta Pharmaceutica Sinica B