About The Study: Despite a lack of clinical efficacy evidence, phenylephrine was the most common oral decongestant in the U.S. from 2012-2021, with hundreds of millions of units purchased by retail pharmacies annually, and sales remained stable during this time. In contrast to pseudoephedrine, which is often formulated as a stand-alone product, most phenylephrine products were co-formulated with antihistamines or antitussives, which are likely to provide some symptom relief for cough and cold symptoms.
Authors: Timothy S. Anderson, M.D., M.A.S., of the University of Pittsburgh, is the corresponding author.
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(doi:10.1001/jama.2023.27932)
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