Articles tagged with Antihistamines
A review of 47 trials involving 6,230 children and adults found that adding oral antihistamines to existing treatments showed small but clinically unimportant reductions in eczema severity. First-generation antihistamines may also increase cognitive impairment and the risk of stopping treatment due to side effects.
Daily aspirin use offers no quick or reliable way to prevent bowel cancer in the general population, increasing risk of serious bleeding. However, it may have potential long-term benefits for people at high genetic risk of colorectal cancer.
Researchers investigated the binding thermodynamics of doxepin geometric isomers to the histamine H1 receptor, revealing differences in enthalpy and entropy contributions. The study highlights the importance of considering conformational constraints in designing ligands with optimized thermodynamic properties.
A study found that first-generation antihistamines may increase delirium risk in older hospital patients. The analysis of 328,140 patients aged 65+ revealed a 41% increased odds of delirium among those prescribed higher amounts of these medications.
A study found that chlorcyclizine, a decades-old allergy medication, could potentially treat erythropoietic protoporphyria (EPP), a condition creating extreme skin light sensitivity and toxic liver buildup. Chlorcyclizine may work by helping the liver clear toxic porphyrin buildup and reducing inflammation.
The number of seizures in US children due to medication or substance exposure has more than doubled between 2009 and 2023. The main culprits are over-the-counter antihistamines, prescription antidepressants, painkillers, and synthetic cannabinoids.
Despite a lack of clinical efficacy evidence, phenylephrine remained the most common oral decongestant in the US from 2012-2021, with hundreds of millions of units sold annually. Most phenylephrine products were co-formulated with antihistamines or antitussives, providing symptom relief for cough and cold symptoms.
The Wilderness Medical Society has published evidence-based guidelines for anaphylaxis treatment in remote areas. The guidelines recommend administering intramuscular epinephrine as the primary prehospital treatment, while also discussing prevention strategies such as extracting additional epinephrine from autoinjectors and using expir...
Researchers found that second-generation antihistamines block histamine binding to HRH1, improving cytotoxic T cell activation and reducing resistance to immunotherapy. High plasma histamine levels in patients were correlated with worse responses to anti-PD-1 immunotherapy.
Researchers found that antihistamines improve responses to immune checkpoint inhibitors in cancer patients, particularly those with pre-existing allergies or high plasma histamine levels. The study suggests targeting the histamine receptor HRH1 may be a useful treatment approach.
A recent study published in the Canadian Medical Association Journal highlights the need to rethink antihistamine use, as millions worldwide take these medications incorrectly. The study emphasizes that newer generation antihistamines are safer and more effective than first-generation antihistamines.
A study from WashU Medicine reveals that allergens in the environment trigger episodes of acute itch in eczema patients, which often don't respond to antihistamines. Researchers found a previously unrecognized pathway carrying itch signals to the brain, opening new avenues for treatment.
Researchers found improved survival among patients with malignant melanoma who used desloratadine and loratadine, particularly in the age group 65 and older. The study suggests these antihistamines may also reduce the risk of new malignant melanoma cases.
Research suggests that administering antihistamines for anaphylaxis symptoms can delay seeking medical care, with a majority of families experiencing delays after using these medications. Experts stress the importance of immediate treatment with epinephrine to prevent fatal outcomes.
Researchers have found a group of antihistamines that can induce differentiation in leukaemic stem cells, leading to cell death. The discovery offers a potential new approach to treating Acute Myeloid Leukaemia (AML), a disease with a high rate of recidivism.
A Rutgers study found a sharp decline in cough and cold medicine recommendations for children under 2 after the FDA's 2008 advisory, with an increase in antihistamine use instead
A study published in Annals of Emergency Medicine found that prednisone did not provide additional relief for emergency patients with hives. Antihistamine levocetirizine alone achieved full itching relief within 2 days for 76% of patients.
Researchers at Michigan State University have discovered that altering pH levels can prevent prion proteins from aggregating and forming deadly diseases. The study used a laser technique to measure the speed at which proteins rearrange before clumping, and found that an antihistamine called astemizole was effective in reducing prion ag...
Researchers at National Jewish Health discover that pre-treating mice with antihistamines reduces gastrointestinal symptoms of peanut allergy. The study provides new insights into food allergy development and suggests potential therapies for prevention and treatment.
Researchers discovered that high doses of antihistamines can blunt nearly 27% of the gene response after vigorous exercise, which could have implications for athletes and exercisers. The study identified 795 genes affected by histamine receptors, highlighting their role in post-exercise recovery.
Adults with eczema are more likely to experience accidental bone fractures and other injuries, according to a new Northwestern University study. The increased risk may be linked to the side effects of steroids and sedating antihistamines commonly prescribed for eczema.
Researchers found that antihistamines can reverse the effects of myeloid derived suppressor cells in mice with tumors and those with allergy symptoms. This suggests a potential link between allergies and cancer prevention.
Researchers at the University of Cincinnati have discovered a treatment for life-threatening ACE inhibitor angioedema, allowing patients to be discharged sooner. The study found that Ecallantide was more effective in reducing swelling and side effects compared to conventional therapy.
A new study from Boston University's Slone Epidemiology Center found no evidence to support suggestions of increased risks of certain birth defects associated with antihistamine use in pregnancy. The study considered over 20,000 new mothers and commonly-used antihistamines available OTC or by prescription.
A UCLA study found that women with hyperemesis gravidarum (HG) who take antihistamines are more likely to experience bad outcomes, including low birth weight babies and premature births. The study also showed that these medications are not effective in treating HG symptoms
Simple insect bites often resolve on their own without treatment, but over-the-counter remedies have limited efficacy. Antihistamines and steroids are not backed by strong evidence for treating itching and inflammation.
A clinical study found that a combination of steroids and antihistamines can alleviate Plavix allergy symptoms in 88% of patients, enabling them to continue treatment. The study's findings have significant implications for cardiac patients with stents, who require long-term Plavix use.
Burn rehabilitation experts at UT Southwestern recommend a hierarchy of treatment strategies to alleviate chronic itching caused by burn scars. Topical creams and ointments are often effective, while oral antihistamines may be necessary for more severe cases. Other non-medicinal treatments like lasers and massage can also provide relief.
Researchers believe immunotherapy could curb the immune response and induce tolerance to peanut allergens, potentially reducing severe reactions. In the next five years, some form of immunotherapy is expected to be available for individuals with peanut allergy.
A study published at the AACR annual meeting found that a history of allergies and asthma significantly reduces the risk of developing brain tumors. Individuals with allergies or asthma had a lower risk of glioblastoma, mid-grade anaplastic astrocytoma, and low-grade gliomas compared to those without these conditions.
A randomised study found that butterbur extract was as effective as conventional antihistamines in treating symptoms of intermittent allergic rhinitis. The extract also did not cause drowsiness, making it a potentially useful treatment option for patients who cannot tolerate other therapies.
A case-control study found associations between CSCR and various systemic conditions, including alcohol, tobacco, and antibiotic use. Eye doctors are advised to discuss these risk factors with patients and take steps to eradicate them.
A recent study using the Environmental Exposure Unit (EEU) technology compared the efficacy of Xyzal and NeoClarityn in controlling seasonal allergic rhinitis symptoms. The results showed that Xyzal was more effective than NeoClarityn in relieving major symptoms, with a faster onset of action and longer duration of relief.
A new study has found that fluticasone steroid nasal spray is more effective in reducing symptoms and inflammation of seasonal allergies compared to a combination of antihistamines. The treatment had minimal side effects, with the researchers preferring it due to its effect on inflammation.
Researchers found intranasal corticosteroids more effective than antihistamines for seasonal allergies, especially in patients with severe disease. The study suggests revising guidelines to recommend regular use of steroids for severe cases and as-needed use for mild cases.
A study found that 24% of elderly individuals experienced recurring dizziness, with factors like anxiety, depression, and taking five or more medications contributing to the issue. Two last-resort options for end-of-life suffering are discussed: terminal sedation and voluntary refusal of food and fluids.
A study published in Annals of Internal Medicine found that diphenhydramine, a commonly used antihistamine, impairs driving performance more significantly than alcohol. Fexofenadine, on the other hand, had minimal impact on driving skills.