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Normal ageing might be associated with increased blood-brain barrier permeability in regions also vulnerable in Alzheimer's Disease, in small study comparing healthy brains of the young and old

06.05.24 | PLOS

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Associations between regional blood-brain barrier permeability, aging, and Alzheimer’s disease biomarkers in cognitively normal older adults
Voxelwise Ktrans maps. Representative voxelwise BBB Ktrans maps in 2 OA (top) and 2 YA (bottom) participants classified as having high and low BBBd. Color bar shows absolute Ktrans values with units of min-1. Credit: Denkinger et al., 2024, PLOS ONE, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)

Normal ageing might be associated with increased blood-brain barrier permeability in regions also vulnerable in Alzheimer's Disease, in small study comparing healthy brains of the young and old

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Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0299764

Article Title: Associations between regional blood-brain barrier permeability, aging, and Alzheimer’s disease biomarkers in cognitively normal older adults

Author Countries: USA

Funding: Research reported in this publication was supported by the National Institute On Aging of the National Institutes of Health under Award Number F31AG072872 and R01 AG080043. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

PLOS ONE

10.1371/journal.pone.0299764

Associations between regional blood-brain barrier permeability, aging, and Alzheimer’s disease biomarkers in cognitively normal older adults

5-Jun-2024

I have read the journal’s policy and the authors of this manuscript have the following competing interests: Dr. Jagust has served as a consultant to Clario, Lilly and Eisai. Dr. Baker consults for Genentech. There are no other disclosures. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Keywords

Alzheimer Disease Biomarkers Blood Brain Barrier Brain Cognitive Neuroscience Cognitive Psychology Public Health

Article Information

Journal
PLOS ONE
DOI
10.1371/journal.pone.0299764
Article Publication Date
2024-06-05
Article Title
Associations between regional blood-brain barrier permeability, aging, and Alzheimer’s disease biomarkers in cognitively normal older adults
COI Statement
I have read the journal’s policy and the authors of this manuscript have the following competing interests: Dr. Jagust has served as a consultant to Clario, Lilly and Eisai. Dr. Baker consults for Genentech. There are no other disclosures. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Contact Information

Hanna Abdallah
PLOS
onepress@plos.org

How to Cite This Article

APA:
PLOS. (2024, June 5). Normal ageing might be associated with increased blood-brain barrier permeability in regions also vulnerable in Alzheimer's Disease, in small study comparing healthy brains of the young and old. Brightsurf News. https://www.brightsurf.com/news/8OMNPK21/normal-ageing-might-be-associated-with-increased-blood-brain-barrier-permeability-in-regions-also-vulnerable-in-alzheimers-disease-in-small-study-comparing-healthy-brains-of-the-young-and-old.html
MLA:
"Normal ageing might be associated with increased blood-brain barrier permeability in regions also vulnerable in Alzheimer's Disease, in small study comparing healthy brains of the young and old." Brightsurf News, Jun. 5 2024, https://www.brightsurf.com/news/8OMNPK21/normal-ageing-might-be-associated-with-increased-blood-brain-barrier-permeability-in-regions-also-vulnerable-in-alzheimers-disease-in-small-study-comparing-healthy-brains-of-the-young-and-old.html.