Articles tagged with Biomarkers
Researchers at the University of Toledo have developed a rapid blood screening method to detect elevated bile acids, an early but overlooked marker of liver disease. The test, which has been patented, can accurately identify individuals with high bile acids and has the potential to save lives by catching liver disease early.
Researchers from Hebei Medical University review current evidence on prolonged disorders of consciousness (pDOC) management. They propose a brain communication network model to explain how brain injury leads to long-term unconsciousness, identifying key brain electrical signaling activity measures for diagnosis and treatment.
The PolyU developed AI Virtual Patient Simulation System combines multimodal data from genomic, medical imaging and clinical records to create a digital twin model tracking real-time changes in a patient's condition. It predicts the effectiveness of different cancer treatment options and supports personalized medical solutions.
Researchers identify AGR2 as a prognostic marker for NF-PanNETs, while FOXM1 is found to promote malignancy and proliferation. AGR2-high cells exhibit malignant features, including increased proliferative activity and metastasis-like signatures.
Researchers from USC-led study found that different epigenetic clocks capture distinct aspects of cellular aging, while introducing new gene-expression based clocks with stronger predictive power. These tools can better predict age-related disease and mortality by examining DNA methylation patterns and gene expression.
Researchers developed an AI model that analyzes routine whole histopathology images to predict cancer subtype, genetic mutations, and survival outcomes across 32 solid cancers. The model achieved a strong predictive accuracy score for TP53 mutation detection and demonstrated the ability to infer RNA expression levels and tumor taxonomy.
Pyrogallol's toxicity in aquatic organisms has been linked to oxidative stress and damage across multiple biological systems. The analysis identifies the need for broader environmental surveillance, long-term ecological studies, and improved exposure assessment to determine its effects on human health.
Researchers developed a method to predict how different types of breast cancer will respond to treatment using lab-grown mini tumors. The organoids mimicked a tumor's response to treatment and identified candidate combination therapies for cancers that don't respond to standard treatment.
Researchers identified two immune cell populations present in both initial and recurrent arthritis flares, suggesting an immune-memory disease. These cells may serve as biomarkers for high-risk patients or to guide targeted therapies to reduce side effects.
Researchers identify a combination of classical and emerging viral biomarkers to predict functional cure in chronic hepatitis B. Multimarker models exhibit superior predictive discrimination compared to single viral markers, enabling more accurate treatment decisions.
Researchers developed a multiprotein approach to predict advanced tau pathology among amyloid-positive individuals, outperforming p-tau217 alone. This study suggests a scalable alternative to tau PET staging for clinical or research settings.
A new study identified a previously underappreciated relationship between SUCLA2 and USP10 that strongly correlates with distant metastasis-free survival in breast cancer patients. The interaction between these two genes changes dramatically depending on whether patients receive treatment, highlighting the importance of considering mol...
A new study uses mathematical biomarkers to accurately predict prostate cancer patient outcomes and survival, outperforming traditional PSA monitoring. These metrics can inform personalized treatment protocols, enabling more effective adaptive therapy.
The article proposes a healthspan-focused framework for Italy's National Health Service to promote healthy aging, prevent chronic diseases, and improve functional independence. The framework emphasizes prevention-oriented approaches, personalized healthcare, and multidisciplinary research.
UC San Diego engineers created a smart ring that continuously monitors up to four different chemical biomarkers from finger sweat. The ring provides real-time health insights into individuals with diabetes management and nutrition tracking, closely matching commercial glucose and ketone readings.
Researchers discovered 171 distinct mutations causing MET exon 14 skipping in lung cancer patients. RNA-based testing confirmed these alterations, highlighting the importance of complementary diagnostic approaches.
Researchers discovered specific microRNAs, including miR-16 and miR-140, which may help detect cancer-related muscle wasting in dogs. The study's findings have implications for human medicine, suggesting a potential new approach for earlier diagnosis and monitoring of cancer-related cachexia.
Researchers are exploring innovative technologies to improve disease diagnosis and treatment. AI models have shown promise in speeding up detection and treatment discovery for rare diseases. Meanwhile, electronic noses are being developed for non-invasive cancer screening.
Researchers found that tau buildup in PSP affects brain networks involved in thinking, including the prefrontal cortex and anterior cingulate cortex. The study suggests that symptoms arise from both local tau-related damage and remote disruption of a broader cognitive network.
Dr. Elaine S. Jaffe receives AMP's highest honor for pioneering contributions to lymphoma diagnosis and treatment. Dr. Laura J. Tafe is recognized for her leadership and service to the organization, while Dr. Daniel E. Sabath receives the Meritorious Service Award for his dedication to scientific excellence and organizational service.
Elaine S. Jaffe, a distinguished investigator at the NCI Center for Cancer Research, has transformed our understanding of lymphoid malignancies through her groundbreaking research. Her work has led to significant advancements in disease classifications, diagnosis, and treatment.
A portable, airpod-size fluorescence analytical device has been designed to provide timely home molecular testing. The VPodDuo can measure fluorescent signals generated by various detection chemistry formats and detect quantities of genetic material from several pathogens and human cancer markers.
The ECOG-ACRIN ENDURANCE trial found that indefinite lenalidomide maintenance had no survival benefit and more toxicity compared to stopping treatment after 2 years in patients not undergoing a stem cell transplant. The study suggests that fixed duration treatment can significantly reduce healthcare costs.
The meeting will explore breakthroughs in diabetes prevention and treatment, as well as innovative approaches to monitoring astronauts' health in space. Researchers will also discuss potential targets for slowing or preventing Alzheimer's disease in people with Down syndrome, and advancements in cervical cancer screening.
Researchers developed a new computational approach to identify genes that characterize different cellular states from mRNA-seq data, offering more accurate and interpretable analysis of complex biological data. The Cartesian Distance-Based Gene Expression (CDBGE) algorithm was evaluated using multiple publicly available datasets, demon...
A blood test measuring phosphorylated tau 217 (P-tau217) can estimate an individual's risk of developing cognitive impairment over 2, 5, and 10 years. Higher P-tau217 levels are associated with increased risk of progression to cognitive impairment in cognitively unimpaired older adults.
A new study from UT Health San Antonio found a link between long sleep hours and higher levels of an Alzheimer's-related protein in the blood. The research suggests that long sleep may reflect early neurodegenerative processes, but more sleep is not always better for brain health.
AC004854.2 is significantly upregulated in colorectal cancer tissues and correlates with poor clinical outcomes, increased tumor aggressiveness, and reduced overall survival. It disrupts the PUF60–FUBP1 complex and activates c-MYC transcription, driving CRC malignancy.
Researchers propose using the glucose ketone index (GKI) to track metabolic health in non-communicable diseases, which cause three in four deaths worldwide. The GKI measures blood glucose and ketones and may indicate metabolic state, assess long-term nutritional adherence, and support mitochondrial function improvement.
A new study published in JAMA Network Open found an alarming rise in invasive breast cancer among Asian American women over the last two decades. Breast cancer rates are rising among nearly all ethnic groups much faster than any other U.S. group, with Chinese and Vietnamese women experiencing the highest increases.
Macrophages are critical drivers of chronic allograft failure, with emerging strategies targeting key macrophage signaling pathways providing an important conceptual shift. Targeted therapies, such as inhibiting the purinergic pathway and mTOR/NF-κB pathway, show promise in preventing chronic rejection.
Glial cells play critical roles in determining brain recovery after TBI, and researchers have identified ways to selectively modulate their functions. The study highlights the importance of coordinated cellular behavior and suggests that targeting glial responses could lead to effective therapies.
Researchers have discovered a biomarker that can predict and prevent epileptic seizures by detecting a period of neuronal silence before the seizure occurs. The use of this biomarker in neuromodulation therapy has shown promise in reducing seizure duration by up to 93%.
Researchers developed a low-cost electrochemical sensor to detect dopamine levels in artificial human tears. The technology could support the development of new tools for monitoring Parkinson's disease and other conditions linked to atypical dopamine levels.
Researchers identified why some patients with rare blastic plasmacytoid dendritic cell neoplasm (BPDCN) leukemia don't respond to tagraxofusp. Severe TET2 gene mutations and low TXNRD1 enzyme levels contribute to resistance, suggesting these biomarkers could predict treatment outcomes.
A new study found that BCG vaccines can modify Alzheimer's biomarkers in non-Alzheimer's participants, suggesting a potential biological explanation for the observed link between BCG vaccination and lower disease risk. The vaccine also promoted increased immune responses in healthy participants without Alzheimer's pathology.
A new study has identified molecular tumor characteristics that distinguish between different subtypes of diffuse large B-cell lymphoma (DLBCL). The findings suggest that tumors from high-risk patients, referred to as PG4 proteogenotype, are characterized by specific genetic mutations and protein patterns. These characteristics can hel...
The study identified two proteins, BCL2 and MCL1, as predictive biomarkers for matching patients to specific drug combinations. Combining BRAF-MEK inhibitors with a BCL2 inhibitor induced tumor regression in previously resistant tumors.
A study reveals that Alzheimer's disease biomarkers are associated with rapid cognitive decline and progression to dementia in people over 80. The presence of these biomarkers identifies patients at risk of more significant impairment and loss of independence, even within the context of multiple coexisting conditions.
Researchers at Tufts University School of Medicine discovered biomarkers that could help clinicians better detect and possibly cure early and persistent Borrelia burgdorferi infections. Anti-lipid antibodies, such as anti-phosphatidic acid and anti-phosphatylserine, may indicate new Lyme disease infections or persistent symptoms after ...
A genomic study found two previously unreported truncating germline variants in BRCA2, suggesting inherited alterations may contribute to susceptibility to multiple primary lung cancers. The study also points toward important clinical applications, including the use of PARP inhibitors and molecularly targeted approaches for treatment.
Researchers found PLXNC1 expression is significantly upregulated in CMS4 tumors, serving as an independent risk factor for poor overall survival. Elevated PLXNC1 promotes mesenchymal phenotype, stromal infiltration, and immunosuppressive tumor microenvironment.
Single-cell sequencing resolves responses in various tissues and organs, identifying cells that respond to different exercise modes and doses. This technology enables the development of precision exercise biomarkers for applications in muscle repair, immune regulation, and chronic disease research.
Researchers discovered biomarkers indicating overactivity and dysfunction in the immune system, which can lead to chronic critical illness. Identifying these markers could allow doctors to intervene earlier, leading to shorter ICU stays and improved patient outcomes.
Researchers found frequent silencing of TRAIL-R2 in breast tumors through promoter hypermethylation, associated with invasive ductal carcinoma and advanced tumor stage. Lower TRAIL-R2 expression was linked to more aggressive disease and reduced overall survival.
A team of researchers has identified a distinct blood protein pattern that can accurately diagnose pediatric inflammatory bowel disease and differentiate between its two main forms. The discovery, using proteomics technology, showed high accuracy in identifying IBD and distinguishing ulcerative colitis from Crohn's disease.
Researchers found that patients often wait an average of four weeks for biomarker test results, with the first step taking up to 23 days to order testing. This delay can lead to mismatched therapies, toxic side effects, and reduced treatment options, emphasizing the need for improved testing turnaround times.
A new study by Meike van der Heijden challenges the long-held assumption that activity in easily measured cerebellar cells like Purkinje cells can reliably predict signals in deeper brain regions linked to dystonia, ataxia, and tremor. The research found no significant correlation between Purkinje cell and deep nuclei cell activity.
A new clinical trial, SELECTmeso1, is investigating a personalized treatment for patients with a rare and aggressive form of cancer. The trial aims to improve outcomes for patients with a specific genetic biomarker, and if successful, could lead to future practice-changing trials.
Researchers found that radiation therapy not only targets tumor cells but also activates immune pathways to make tumors more receptive to immunotherapy. The study suggests that radiation-immunotherapy combination strategies could improve patient outcomes by reshaping the surrounding immune landscape and recruiting T cells.
Disturbed sleep impairs BBB integrity through oxidative stress, neuroinflammation, and gut microbiota dysbiosis. Treating underlying sleep disorder is the most direct approach, while mechanism-based interventions show promise for future development.
Klick Labs is launching a series of clinical studies with Mayo Clinic exploring the use of novel vocal biomarkers in connection with Type 2 diabetes, hypertension, ovulation, and blood glucose. The research collaboration aims to leverage the voice's hidden properties to flag critical health issues and enhance patient care.
Researchers at Nagoya University developed an AI tool, DiSPAH, to estimate ALS disease progression speed and identify muscle decline patterns. The study found six distinct patterns of disease progression among patients, with some experiencing rapid deterioration while others declined slowly.
A study by Okayama University researchers revealed that SARS-CoV-2 antibody levels can assess infection history, symptom severity, and cognitive complications in long COVID. The findings suggest that declining S-antibody levels may indicate a greater risk of neurological complications.
Researchers identify CLASS 3G subtype of EGFR mutation associated with limited response to targeted drugs. This structural subtype alters protein shape, reducing treatment efficacy and allowing for more effective combination therapy.
Researchers identified five immunomodulatory proteins in Borrelia recurrentis that prevent activation of the human complement system, allowing the pathogen to survive in the human body. These Chi proteins also convert plasminogen into active plasmin, giving Borrelia recurrentis a significant advantage in spreading after infection.
Researchers developed a simple blood-based assessment to evaluate high-density lipoprotein's (HDL) cholesterol removal capacity from blood vessel walls. The study linked low HDL function to high-risk coronary plaques, supporting the use of this method for predicting cardiovascular risk.
A new study reveals that the KDM3A/METTL16/PDK1 axis drives glycolysis and overcomes tyrosine kinase inhibitor resistance in non-small cell lung cancer. The research suggests that targeting this axis with PDK1 inhibitors could be a promising therapeutic strategy for overcoming acquired drug resistance.
A study characterizes peripheral immune alterations in systemic juvenile idiopathic arthritis, identifying a distinct CD14+CXCL10+ monocyte subpopulation associated with inflammatory network remodeling and disease activity. The monocyte subset is enriched in active sJIA states and exists in a heightened state of immune surveillance.
Cellular senescence has emerged as a key biological process linked to aging and age-related disease. Researchers have identified major features of senescence, including stable proliferative arrest and the senescence-associated secretory phenotype (SASP), which can influence inflammation and tissue dysfunction.