Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Boston Children's Hospital have developed a novel mass spectrometry tool called FLEXITau to analyze brain tissue from 203 patients with various tauopathies. The study identified 145 post-translational modifications and 195 cleavage sites across tau, providing a precise molecular roadmap for diagnostics and drug development.
A team at Chalmers University of Technology has discovered biomarkers for Parkinson's disease in the blood, which could lead to early diagnosis via blood tests within five years. The study found distinct gene activities linked to DNA damage repair and stress response in patients in the early phase of the disease.
Researchers have developed a four-marker panel that can detect early-stage pancreatic cancer with high accuracy, potentially improving survival rates. The new test distinguishes cancer patients from healthy individuals and those with non-cancerous conditions, such as pancreatitis.
Researchers identified statins as a potential booster for cancer immunotherapy by preventing the release of PD-L1-containing sEVs. Statin treatment suppressed UBL3 modification, reduced PD-L1 sorting into sEVs, and improved survival outcomes in lung cancer patients.
Researchers identified a targetable driver of brain metastases in inflammatory breast cancer, promoting tumor invasion and triggering brain inflammation via the CXCR2 signaling pathway. Targeting sEcad or the CXCR2 pathway may treat or prevent brain metastasis.
Scientists at the University of Florida and Linköping University discovered protein markers in umbilical cord blood associated with future insulin-dependent diabetes. The study suggests that these markers can be used to predict type 1 diabetes in early childhood, potentially allowing for targeted interventions and lifestyle changes.
A new research project aims to develop an eye drop that can detect the fluorescent signal of a protein associated with Alzheimer's disease. If successful, this low-cost and accessible screening tool could help identify patients in their earliest stages of the disease, enabling them to receive early treatment.
A study found that brief exposure to benzo[a]pyrene disrupted normal development and skeletal health in fish, with effects persisting across multiple generations. The researchers identified specific metabolic signatures that could serve as early warning indicators of long-term toxicity.
The use of next-generation sequencing in newborn screening can detect a wide range of genetic disorders, some of which are not currently testable through traditional means. This approach enables earlier disease detection and long-term health planning.
A new blood test has identified a protein signature linked to cancer in patients with non-specific symptoms. The test distinguishes cancer from other conditions with high precision and can help prioritize patients for further diagnostics.
Steatotic liver disease can be precisely assessed using three-dimensional ultrafast vascular ultrasound. The technology visualizes subtle microvascular changes, enabling real-time monitoring of disease progression and therapeutic response.
The study reveals that low levels of CTDNEP1 drive early and deadly pancreatic tumors, highlighting its role as a tumor suppressor. Tumors with low CTDNEP1 expression showed stronger metabolic activity and immune evasion.
Researchers have identified biological markers that could indicate parental alienation, a form of child manipulation. These markers relate to hormone activation, neurotransmitters, inflammation, and other stress-related processes.
Researchers have developed a blood test that can predict Crohn's disease years before symptoms appear. The test measures immune response to flagellin, a protein found on gut bacteria, which is elevated in individuals long before they develop the disease.
A Japanese research team has developed a biohybrid approach that works inside the body, transforming engineered skin into a visible indicator of internal biological states. The system leverages the body's natural skin regeneration to support long-term biomarker monitoring, providing a visual readout without blood sampling.
A new study from Karolinska Institutet identified seven blood biomarkers that predict the risk and progression of multimorbidity in older adults. These biomarkers reflect biological processes such as metabolism, inflammation, and neurodegeneration.
Researchers developed a unified multimodal framework to analyze joint aging changes in brain function and structure. The study identified two primary aging patterns: synergistic declines in motor control and higher-order cognition, and contradictory adaptations in visual areas.
Researchers found that methylene blue can reverse brain damage caused by cerebral malaria and identified a nine-gene blood signature to diagnose the disease. The study's findings offer new clues on immune processes involved in brain injury and suggest potential for early intervention and clearer treatment decisions.
A study among WTC responders with chronic PTSD found measurable physical changes in their brain structure, including cortical changes and imbalance of myelinated to unmyelinated neurons. These changes were most strongly associated with re-experiencing symptoms in individuals with PTSD.
A new study found that lysophosphatidylcholines (LPCs) promote or protect against Alzheimer's disease depending on a person's genetics. LPCs transport healthy fatty acids to the brain, and their impact is critical in early detection and personalized treatments for those carrying the APOE ε4 gene.
Researchers developed G2PDeep, a web-based platform integrating six molecular data types to predict complex health outcomes. The platform enables better identification of omics-based molecular markers and improves personalized treatment strategies.
A new rapid blood test for ALS has been developed by Brain Chemistry Labs, providing 97% accuracy in diagnosing the disease from a single blood draw. The test is based on microRNA analysis and can also rule out patients without ALS, offering hope to those struggling with this debilitating condition.
A comprehensive review reveals tau protein plays essential roles in brain functions while driving neurodegeneration and psychopathology. Tau deficiency enhances insulin secretion, normalizing glucose levels in diabetic mouse models.
A study at Macquarie University identified simultaneous abnormalities in energy metabolism, immune cells, and blood vessel function in people with ME/CFS. The researchers found 'energy stress' in white blood cells, altered T-lymphocyte subsets, and disruptions to vascular homeostasis.
Chromatin accessibility maps reveal that MDS stem cells gradually lose their normal identity and acquire characteristics typical of myeloid progenitors. A 'progenitor score' developed by the team tracks cell movement toward a progenitor-like state, correlating with disease severity and prognosis.
A new blood biomarker, neurofilament light (NFL), has been shown to accurately predict the extent of brain damage after a cardiac arrest. This breakthrough discovery may transform care for patients in intensive care units, allowing for more informed decisions about their treatment.
A study published in Biological Psychiatry identifies a distinct immuno-inflammatory biomarker in the brain linked to immune system dysfunction and poorer response to standard treatments. The findings provide potential value for clinical prediction and precision therapies.
A subset of depressed individuals with chronic, low-grade inflammation may benefit from anti-inflammatory treatment, according to a systematic review and meta-analysis. The study found that anti-inflammatory medications significantly reduced depressive symptom severity and anhedonia in these patients.
A targeted treatment approach significantly reduces moderate and severe acute kidney injury after major surgery in high-risk patients identified by biomarkers. The study shows that a closely monitored set of clinical measures provides effective protection in the first hours after surgery.
Researchers have developed a simple urine test that can effectively diagnose and stage bladder cancer using cell-free DNA fragmentation analysis. The study found that specific patterns of cfDNA fragmentation can identify muscle-invasive bladder cancer with excellent specificity and predictive value.
Researchers argue that widely used proxies for aging may conflate genuine modifications with simpler effects on physiology. Targeting specific pathologies can extend lifespan without slowing aging process. Historically, increased human lifespan was primarily driven by reduced infectious disease mortality, not a fundamental slowing of a...
Researchers at Rice University have developed a way to make serum markers more sensitive by editing them inside the bloodstream, enabling clearer observation of gene-expression changes in the brain. This approach could lead to more precise diagnostic capabilities using simple blood tests.
A new study suggests that sweat can reveal information about a person's health, including hormone levels, medication doses, and early detection of diseases like diabetes and cancer. Wearable sensors using artificial intelligence can detect specific metabolites in sweat, providing personalized health insights.
The USC Epstein Family Alzheimer’s Therapeutic Research Institute is leading the charge against Alzheimer’s with advances in blood tests and treatments. Researchers aim to develop effective preventive therapies within the next decade.
Serum markers such as NLR, PLR, ESR, LDH, ALP, creatine kinase-BB, SUA, CRP, and CA 15-3/27.29 have been linked to breast cancer diagnosis, prognosis, and therapeutic monitoring. These biomarkers offer affordable, non-invasive, and accessible diagnostic strategies for bridging the diagnostic gap in low-resource settings.
Researchers developed a deep learning model to measure adrenal gland volume on existing CT scans, identifying the first imaging biomarker of chronic stress. The AI-derived biomarker correlates with validated stress questionnaires, cortisol levels, and future cardiovascular outcomes.
A recent study found that TDP-43 protein levels in blood may indicate presence of LATE dementia, a cause often linked to Alzheimer's disease. Researchers hope this discovery could lead to development of simple blood test to diagnose LATE during life.
A study by NTU Singapore researchers found that enlarged perivascular spaces, or 'clogged drains', in the brain are a likely early-warning sign of Alzheimer's disease. The condition can be visually identified on routine MRI scans, complementing existing methods to detect Alzheimer's earlier.
The study reveals that mutated and unmutated CLL subtypes originate from distinct stages of B cell development. New molecular biomarkers, including genes LPL, ZNF667, and ZNF667-AS1, have been identified for more precise patient stratification.
A new study found that individuals with a history of major depression showed higher MRI markers associated with neuroinflammation in the VTA, suggesting increased extracellular inflammatory processes. Current depressive symptom severity was associated with distinct microstructural changes indicating different underlying pathophysiologi...
A new urine test can detect SORD deficiency, a common cause of inherited nerve disease, earlier and more cheaply than genetic tests. The test has brought understanding and access to care for affected families, particularly in the Old Order Amish community.
Researchers are presenting groundbreaking findings at the Association for Molecular Pathology's annual meeting, including a novel technique to study ancient DNA and rapid detection of serious fungal pathogens. The Association for Molecular Pathology is providing press materials and resources for media coverage.
Researchers aim to identify biological biomarkers that can enable earlier diagnosis and intervention for schizophrenia. Progress in biomarker development is crucial for improving patients' quality of life and reducing the societal burden of the disorder.
A novel methylation analysis method, called UMBS-seq, achieves both accuracy and gentleness, unlocking more reliable cancer biomarker detection. The method outperforms existing methods for 5-methylcytosine detection with low input DNA, preserving DNA integrity.
Australian scientists have developed a new blood test that can identify women with ovarian cancer more likely to benefit from PARP inhibitor therapy, offering hope for more effective treatment. The test measures immune biomarkers and predicts which patients will respond to treatment.
Researchers have identified three distinct immunotypes in EPTB patients, revealing new insights into disease mechanisms. Additionally, gene expression-based biomarkers have been developed to reliably diagnose both pulmonary and extrapulmonary tuberculosis.
Researchers found that the leptin-SCD pathway fuels breast cancer growth and motility, leading to poorer recurrence-free survival. Selectively blocking SCD activity can counteract pro-tumorigenic effects driven by leptin, revealing a potential therapeutic target for obese patients.
Researchers at UMC Utrecht are developing a predictive model to accurately predict disease progress in juvenile dermatomyositis. The Interferon Score aims to identify which children can safely reduce medication and which require intensified treatment.
A new study reveals that a large gap between two common kidney function tests may indicate future disease, particularly among older adults. The research found that over a third of hospitalized participants had a significant difference in their creatinine and cystatin C readings, which can predict serious health problems.
A study published in Chinese Medical Journal identified tumor-promoting keratinocytes linked to HPV infection and poor prognosis. These cells were found to interact with immune cells, promoting tumor proliferation and differentiation.
Researchers found that combining three biomarkers – lipoprotein(a), remnant cholesterol, and high-sensitivity C-reactive protein – can reveal a nearly three-fold increase in heart attack risk. This combination approach may aid health care professionals in identifying individuals with high-risk profiles earlier.
The BrainHealthy competition offers real-world experience to talented young brain health researchers. The contest aims to advance new studies on age-related brain changes, brain health biomarkers, and Alzheimer's disease.
Researchers developed a prognostic model using machine learning to predict suicide risk in depression patients. The study found that clinical features and biochemical biomarkers, such as TSH levels, contributed significantly to the model's accuracy, achieving an 82% success rate.
Researchers used lipid biomarker analyses to study survival strategies of microorganisms in extreme deep-sea ecosystems. They found that methane- and sulfate-metabolizing microbes can thrive in environments with high pH values and low organic carbon concentrations.
A new study suggests that collecting and testing cancer cells in patients' blood could help doctors choose the right breast cancer treatment. The 'labyrinth chip' technology separates cancer cells from other blood cells, allowing researchers to identify biomarkers that distinguish aggressive treatments from less invasive ones.
Researchers have discovered a previously unknown group of cells that produce adrenaline, which may help the fetal heart adapt to stress. The study provides a detailed map of the developing human heart, revealing over 70 distinct cell types and their interactions.
Researchers have developed a blood test that detects Parkinson's disease by analyzing the activity of immune cells. The study found 22 genes whose expression was altered in patients with Parkinson's, suggesting potential diagnostic markers and insights into the disease's mechanisms.
The review highlights how T cells specifically recognize and eliminate malignant cells through antigen recognition mechanisms. It also explores how tumors evade immune surveillance through various mechanisms and discusses potential therapeutic strategies, including combination therapies to improve response rates for cancer patients.
The Association for Molecular Pathology recognized Dr. Laposata's contributions to clinical laboratory practice and his role in challenging the FDA's rule on laboratory-developed test regulation. The award preserves diagnostic innovation, ensures patient access, and avoids escalating healthcare costs.
Tear-derived extracellular vesicles show promise as non-invasive biomarkers for ocular and neurodegenerative diseases. The study highlights their potential to provide valuable information about the eye's health, including processes related to neurodegenerative diseases.