Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at the University of Illinois developed cryosoret nanoassemblies that enhance fluorescence signals, reducing detection limits for biomarkers. The new platform offers dual-mode interaction between electric and magnetic components of light, promising highly sensitive and tunable biosensing systems.
A Nagoya University group created a sandwich ELISA technique to accurately measure polysialic acid levels in the blood of patients with psychiatric disorders. The technique uses antibodies that minimize non-specific binding, resulting in increased accuracy.
A unique luminescent probe using terbium has been developed to detect β-glucuronidase, an enzyme that can aid in liver cancer diagnosis. The sensor's sensitivity and accuracy are comparable to conventional methods but at a lower cost, making it suitable for resource-limited settings.
Scientists from Pusan National University discovered a genetic biomarker, FCGBP, that is strongly linked to bronchiolitis obliterans syndrome and poor outcomes following lung transplantation. The finding may help identify high-risk patients and devise timely immunosuppressive treatments.
The Association for Molecular Pathology publishes guidelines for detecting homologous recombination deficiency (HRD) in cancer. The report includes recommendations for clinical laboratories, addressing technical aspects of genomic instability and HRD analysis.
A study by researchers at the University of Gothenburg found that newborn babies and patients with Alzheimer's disease share elevated levels of phosphorylated tau, specifically p-tau217. In newborns, this protein reflects a healthy mechanism for brain development, while in Alzheimer's patients, it indicates disease progression.
The study presents ImmunoCheckDB, a web platform that bridges a critical gap in existing resources by enabling pan-cancer exploration of immune checkpoint inhibitor therapies through combined meta-analytical and multiomic approaches. It curates 173 studies involving 93,234 individuals across 18 cancer types and 30 ICI regimens.
A study found that individuals with short leukocyte telomere lengths are more likely to develop age-related brain diseases such as stroke, dementia, and late-life depression. However, those with healthy lifestyle habits may modify the effects of shorter telomeres.
Researchers developed a blood-based proteomic score to predict healthy aging and age-related diseases. A lower score is associated with higher mortality and disease risk, offering a powerful tool for understanding biological aging.
Researchers developed an improved biological ageing clock, LinAge2, that offers doctors a practical way to assess how quickly a person is ageing and what can be done to slow it down. The new algorithm-powered tool outperforms other clinical models in predicting long-term mortality and health outcomes.
A recent study found that MET mutations are associated with enhanced tumor immunogenicity, increased immune cell infiltration, and improved response rates to immune checkpoint blockade. Certain single base substitutions identified as robust predictive biomarkers for survival in pan-cancer immunotherapy.
Researchers found no significant decline in taurine levels with age across humans, monkeys, and mice, suggesting it may not be a reliable marker of aging. Instead, individual physiological contexts shaped by genetic, nutritional, and environmental factors influence its impact.
The new device, nicknamed ABLE, uses a natural process to condense airborne biomarkers into water droplets, allowing for accurate detection at low concentrations. This technology has immediate applications in hospitals and neonatal units, offering a less invasive alternative to blood draws.
The annual Alzheimer's disease drug development pipeline report, led by Dr. Jeffrey Cummings, highlights an increase in active clinical trials and promising drugs, offering reason for optimism. The report assesses 138 drugs currently being studied and notes the growing importance of biomarkers in clinical trials.
Researchers identified C5aR1 as a novel prognostic biomarker and potential therapeutic target for treating metastatic skin cancer. Elevated C5aR1 presence suggests increased metastasis risk and poor survival in patients with cutaneous squamous cell carcinoma.
Researchers discovered biomarkers in gut bacteria and metabolites that can help diagnose and treat gastrointestinal diseases. The study found that certain biomarkers could predict multiple diseases, including gastric cancer and inflammatory bowel disease.
A team of researchers from CRCHUM has identified a set of biomarkers in blood samples that could help diagnose Parkinson's disease. The study found that immune cells in the blood were activated and overexpressed genes associated with stress responses in patients with Parkinson's, forming a unique genetic signature.
A $2.4 million grant will fund the development of an optical imaging technology to image nerve endings in cancer patients with chemotherapy-induced peripheral neuropathy. The goal is to identify potential biomarkers for the disease, enabling early detection and prevention.
Researchers have developed a machine learning tool that identifies metabolism-related molecular profile differences between colorectal cancer patients and healthy individuals. The tool, called PANDA, shows promise as a noninvasive method of diagnosing colorectal cancer and monitoring disease progression.
A new framework for assessing traumatic brain injuries (TBI) will provide more accurate diagnoses and treatments, leading to better patient outcomes. The framework incorporates clinical symptoms, biomarkers, imaging scans, and modifiers to determine the severity of injury and predict recovery.
Researchers identified metabolite patterns in blood and urine related to ultra-processed food intake. A poly-metabolite score was developed, showing potential to objectively measure diet and reduce reliance on self-reported data.
Researchers have developed a 3D micro-printed sensor that uses whispering-gallery-mode microlasers to detect biomarkers with attogram per milliliter sensitivity. The sensors' unique Limacon-shaped design improves efficiency and enables on-chip integration, making them suitable for high-performance lab-on-a-chip devices.
Researchers from USC Keck School of Medicine have developed a low-cost blood test that detects five biomarkers of Alzheimer's disease, including amyloid and tau proteins. The test uses xMAP technology and has the potential to catch the disease in its earliest stages, when treatment might be able to prevent or delay cognitive decline.
Researchers identified changes in stromal tissue associated with increased aggressive breast cancer risk and poorer survival rates among women with benign breast disease. The study used machine learning to detect subtle changes in breast tissue samples from over 9,000 women.
Researchers identify enlarged salience network as first reliable biomarker for depression risk, predicting symptoms before they appear. The network's expansion could enable early identification and intervention, leading to improved quality of life and treatment outcomes.
Researchers identified platelets, C-reactive protein, and chromogranin A as markers that can predict the failure of hormone-sensitive prostate cancer treatment. The study also found that miR-375 expression and lymphocyte-to-monocyte ratio are negative predictors for therapy failure in castration-resistant prostate cancer patients.
Serum Krebs von den Lungen-6 (KL-6) levels are significantly elevated in patients with interstitial lung disease (ILD), suggesting its potential as a diagnostic biomarker. The study also highlights the relationship between KL-6 levels and pulmonary function, specifically forced vital capacity.
Researchers found that patients taking HIV drugs called NRTIs are substantially less likely to develop Alzheimer's disease. The study, led by Jayakrishna Ambati, analyzed data from two large health insurance databases and determined a significant reduction in Alzheimer's risk among patients on NRTIs.
This study reveals periostin as a superior serum biomarker for diagnosing idiopathic pulmonary fibrosis, with high sensitivity and specificity compared to traditional markers. Periostin levels also correlate with disease severity and predict acute exacerbations in IPF patients.
The American Federation for Aging Research (AFAR) presents the Vincent Cristofalo Rising Star Award to Daniel W. Belsky, PhD, for his contributions to aging research and development of biomarkers in aging. He will present a lecture on quantification of biological aging at the 53rd Annual AGE Meeting.
Scientists at Henry Ford Health + Michigan State University Health Sciences have identified a circulating microRNA called miR-126-3p as a mechanistic biomarker of knee osteoarthritis. This discovery may lead to the development of blood tests for early detection and therapeutics for slowing or stopping disease progression.
Researchers from Université Laval discovered a non-invasive retinal exam can detect Parkinson's disease biomarkers, offering early diagnosis and potential intervention. The study found distinct retinal responses to light stimuli in people with Parkinson's compared to healthy individuals.
The National Multiple Sclerosis Society has committed $18.1 million to support research projects aligned with its Pathways to Cures roadmap, which aims to stop MS, restore function, and end the disease. The funding includes 16 research grants and 28 training fellowships in the US and internationally.
Researchers at Karolinska Institutet have identified biomarkers in the blood associated with long COVID symptoms, particularly severe respiratory disorders. The study found that these biomarkers are also linked to inflammatory signal pathways involved in cell death and lung damage.
Research at the University of Bristol has linked mental health conditions like depression and schizophrenia to immune response, suggesting a fundamental change in understanding causal mechanisms. The study identified 29 potential biomarkers that could be used for novel therapeutics in mental health conditions.
A study published in Neurology found that people with higher biological age than their chronological age are more likely to develop dementia. The researchers discovered an association between advanced biological age and changes in brain structures, including loss of gray matter volume.
A study published in Science Translational Medicine found novel biomarkers for tinnitus that correlate with nervous system's 'fight, flight, or freeze' response. Facial movements and pupil dilation measured while listening to unpleasant sounds can predict tinnitus severity.
Researchers at University of Turku discovered a new biomarker that correlates the thickness of inflammatory cell rim surrounding brain lesions with disease severity and speed. The wider the rim, the more aggressively the disease advances, allowing for earlier treatment identification and evaluating drug candidates.
Researchers developed promising α-synuclein PET tracers that can visualize protein aggregates in living patients, enabling earlier diagnosis and treatment monitoring. Tracers like [18F]C05-05 and [18F]ACI-12589 showed significant results in distinguishing synucleinopathies from healthy controls.
A novel approach to analyzing human blood plasma's low-abundant N-glycoproteome has been developed, enabling the reliable identification of rare and modified glycans. This workflow can detect glycoproteins with concentrations as low as 6.31 pg·mL−1, expanding the range by five orders of magnitude.
Researchers at TUM developed an AI-powered algorithm to predict kidney damage in prostate cancer patients undergoing lutetium-177 PSMA therapy. Early detection could enable personalized treatment adjustments to prevent organ damage.
Researchers at Karolinska Institutet have identified new biomarkers in urine that can indicate the presence and severity of prostate cancer with high precision. The findings surpass current blood biomarker PSA in terms of diagnostic accuracy.
New molecular testing methods are transforming post-transplant care by detecting potential heart injury or rejection earlier than traditional biopsies. This enables physicians to reduce immunosuppressive medicine dosage in low-risk patients, potentially improving patient outcomes beyond the first year post-heart transplant.
A misfolded protein in spinal fluid facilitates reliable Parkinson's diagnosis even in its early stages. The biomarker has a sensitivity and specificity of over 90%, making it a promising tool for disease management and potential therapy development.
Researchers identified five blood proteins that can predict liver disease up to 16 years before symptoms. The combined levels of these proteins achieved high accuracy in predicting disease onset and progression, suggesting potential for early diagnosis and treatment.
The study found that serum-derived hsa_circ_101555 showed excellent diagnostic accuracy in differentiating HCC patients from healthy controls. It also demonstrated a prognostic role in predicting tumor progression and response to therapy, with significant correlations with markers of liver inflammation and tumor features.
Researchers used AI-driven methods to analyze thousands of digital images of melanoma tumor tissue, identifying key immune cell structures that boost immunotherapy effects. The presence of these structures was linked to significantly better overall survival for patients with advanced melanoma.
A new study reveals promising progress toward predicting how patients with major depressive disorder will respond to antidepressant medications. Brain connectivity patterns were found to significantly improve predictions of treatment response across two large, independent clinical trials.
A study on captive olive baboons found that about a quarter exhibited accelerated aging, while another quarter showed signs of slower aging. The researchers investigated physical indicators such as walking speed and fine motor skills, but found that these changes were more closely related to chronological age than epigenetic age.
A new version of Caltech's smart bandage, iCares, has been shown to continually sample fluid from human patients with chronic wounds, providing real-time data on biomarkers present. The bandage can detect molecules such as nitric oxide and hydrogen peroxide, potentially up to three days before symptoms appear.
A team of Singaporean scientists has released a comprehensive long-read RNA sequencing dataset, SG-NEx, to accelerate biomarker discovery and precision medicine. The dataset offers deeper biological insights into RNA complexity, enabling researchers to detect clinically relevant biomarkers and develop better treatments.
A new analysis found that oral hormone therapy can lower levels of lipoprotein(a), a genetic risk factor associated with higher risk of heart attack and stroke. Hormone therapy also improved biomarkers of cardiovascular health, including cholesterol levels.
Liquid biopsy analyzes circulating tumor components in body fluids to detect cancer at early stages, offering a safer and more dynamic alternative to traditional tissue biopsies. This non-invasive approach has shown promise in detecting various types of cancer, including lung, breast, colorectal, prostate, and gastric cancers.
Participants who took the supplement showed improvements in grip strength, lower body mobility, and reductions in body weight. The supplement appeared to reduce stem cell turnover, regulate immune function, and influence gene activity related to stress response.
A new study from Columbia University Mailman School of Public Health found significant associations between cognition and established risk factors for Alzheimer's disease in individuals aged 24-44. The researchers used biomarkers related to cognitive impairment and cardiovascular health to predict long-term trajectories of cognitive de...
Researchers developed a blood test analyzing messenger RNA to detect cancers, track treatment resistance, and monitor tissue injury. The test increased cancer detection by over a factor of 50 and provides useful information for non-cancer applications, such as COVID-19 severity and lung health.
A study has identified an early blood marker for hereditary Alzheimer's disease, beta-synuclein, which can detect neurodegeneration up to 11 years before dementia symptoms. This biomarker could help with early diagnosis and treatment, improving the potential of new medicines for Alzheimer's.
Researchers developed a new method to measure changes in DNA that can help predict a person's age, focusing on how random chemical tags become over time. The study found that methylation entropy predicted age as accurately as traditional methods, with an average error of just five years.
Researchers evaluated different types of Glasgow Outcome Scale Extended (GOSE) scores among US trauma center patients. They found that GOSE-All scores capture the combined effect of brain and extracranial injuries, while GOSE-TBI scores exclude extracranial injury effects.
Dr Ambrish Mithal, an Indian endocrinologist, has been awarded the prestigious IOF CSA Medal of Achievement for his groundbreaking work in advancing the field of osteoporosis. His pioneering efforts have significantly increased understanding and awareness of osteoporosis globally.