Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
Researchers found that targeting MD2 could reduce tumor growth in a mouse model of prostate cancer bone metastasis. High MD2 expression was associated with metastasis, immune suppression, and increased resistance to PARP inhibitor therapy.
Researchers at Charité develop test to determine circadian rhythm using hair roots, revealing genetic and lifestyle factors influencing internal clock. The new method shows promise for tailoring therapies to individual rhythms, potentially improving treatment outcomes.
A new study from the University of Missouri identified over 10 genetic or molecular markers that predict follicular lymphoma relapse early, allowing for targeted surveillance testing. This could improve patient outcomes, reduce unnecessary imaging tests, and lower healthcare costs.
A new genetic 'roadmap' provides a navigational framework for more precise diagnosis and treatment of intrahepatic cholangiocarcinoma. The framework identifies five molecular subtypes, each associated with distinct therapeutic vulnerabilities, enabling targeted treatment strategies.
Researchers have discovered a new biomarker for immunoglobulin A (IgA) nephropathy, which is an autoimmune disease that can lead to kidney failure. Complement pathway proteins, including CFHR1, were found to be overexpressed in patients with IgA nephropathy, suggesting a potential treatment target and diagnostic marker.
Patients with atrial fibrillation have a higher risk of adverse cardiovascular events, including stroke, heart attack, and cardiac arrest. Serum neurofilament light chain levels can serve as a biomarker for cardiovascular risk in these patients.
A post hoc analysis of the Finerenone Trial reveals that sudden death in heart failure was often preceded by modest worsening of symptoms and declining quality of life. The study suggests limited specificity for sudden death among other modes of death, implying a complex trajectory before modes of death.
Researchers have discovered a tumor biomarker that can predict which gastric cancer patients will benefit from immunotherapy before surgery. The biomarker, tsMHC-II expression, showed strong correlation with treatment response and was easily assessable using standard immunohistochemistry techniques.
Researchers at Trinity College Dublin and their colleagues are developing a simple, high-accuracy blood test to detect bowel cancer. The CASPDx CRC test aims to transform cancer outcomes by moving screening away from invasive methods.
A new biomarker in cerebrospinal fluid significantly improves the diagnosis of Parkinson's disease and dementia with Lewy bodies. The test is highly specific, distinguishing between patients with these conditions and Alzheimer's disease.
A recent study found that IGFBP1 levels are significantly higher in elderly IBD patients and negatively correlated with inflammation-related markers. Elevated IGFBP1 levels were associated with lower clinical, endoscopic, and histological disease activity, suggesting a promising non-invasive tool for managing elderly IBD patients.
Researchers are developing a comprehensive diagnostic toolkit to detect lymphatic disorders earlier and as part of routine physical exams. The team, led by Dr. Zhenpeng Qin, is working on identifying biomarkers for lymphatic diseases through blood samples.
A study found that inflammation markers may signal depression in women with type 2 diabetes, but vary based on depression symptoms and measures. The research suggests a path toward precision mental health by identifying specific inflammatory biomarkers linked to different dimensions of mental health.
Researchers at Lund University have developed a new blood marker that significantly improves the accuracy of Alzheimer's diagnosis. The study found that combining two biomarkers, p-tau217 and eMTBR-tau243, can identify people with established Alzheimer's disease with an accuracy rate of around 80%. This breakthrough reduces false posit...
A longitudinal study on individuals with Down syndrome reveals that cerebrovascular lesions do not follow a linear course, fluctuating and even decreasing over time. The analysis shows significant variability in the evolution of these lesions, particularly in regions already affected by Alzheimer's disease.
Researchers develop method using biomarkers to calculate individual biological age, finding significant differences in age-related changes between men and women. The study also identifies clinically relevant biomarkers linked to biological age, opening up new opportunities for preventive medicine.
A novel method for monitoring on-treatment disease burden in high-grade serous ovarian cancer uses tumor-informed breakpoints-spanning ddPCR, detecting superior sensitivity and specificity compared to real-time PCR. The approach may enable sensitive and specific detection of minimal residual disease and early relapse detection.
A new Northwestern University study has discovered a novel biomarker of schizophrenia that could also serve as a new drug candidate to treat the cognitive symptoms of the disorder. The study found that levels of the protein Cacna2d1 signal are reduced in patients with schizophrenia, resulting in overactive brain circuits.
The cf-EpiTracing platform has been developed to detect and trace diseases from as little as 50 μl of human plasma, capturing detailed epigenetic fingerprints. It has delivered impressive results in early diagnosis and screening for colorectal cancer, achieving an accuracy rate of up to 97.6%.
Researchers found elevated pTau levels in individuals with transthyretin amyloidosis and immunoglobulin light-chain amyloidosis, suggesting a new diagnostic approach for systemic amyloidosis. The findings may facilitate earlier detection and help confirm suspected cases.
Researchers develop world's first DNA aptamer that binds to neurofilament light chain, a protein released into the blood with neurodegeneration. The aptamer, MN711, shows high affinity and specificity comparable to commercially available antibodies.
A novel blood-based biomarker, p-tau217, can predict a woman's risk of developing dementia up to 25 years before symptoms appear. Higher levels of p-tau217 were strongly associated with future mild cognitive impairment and dementia among older, cognitively healthy women.
Emerging research across conceptual frameworks, biomarker science, digital phenotyping, and artificial intelligence synthesizes a translational pathway toward a more biologically grounded and clinically useful approach to psychiatric diagnosis. The current system falls short due to standardized clinical language and lack of biological ...
A Chinese Neurosurgical Journal study developed a radiomics-based machine learning model to identify high-risk patients with traumatic brain injury who require emergency decompressive surgery. The model accurately distinguished patients who later required secondary surgery, suggesting its potential to complement clinical judgment.
The Alliance for Clinical Trials in Oncology is spotlighting new trials for colorectal cancer in March, focusing on early detection methods and treatments for treatment delays and loss of appetite. The trials aim to improve patient outcomes, with several enrolling patients with newly diagnosed colon or rectal cancer.
A new PET imaging study reveals that ketamine relieves treatment-resistant depression by altering AMPAR in brain regions, providing potential biomarker for personalized treatment. The study found that ketamine increased AMPAR density in several cortical regions and decreased it in reward-related areas, strongly correlating with reducti...
Cancer cell-derived small extracellular vesicles can be excreted into urine, according to researchers who tracked their journey in mouse models. The study reveals that glomerular cells actively transport sEVs across the filtration barrier, supporting their use in emerging urine-based cancer diagnostics.
A randomized study of 14 young adults found that sparkling water consumption reduced subjective fatigue and improved executive function while playing virtual soccer for three hours. Players who drank sparkling water also committed fewer fouls and had better game enjoyment compared to those drinking plain water.
A network of genes connected to the nervous and immune systems can predict liver cancer risk, fatigue, and depression from viral hepatitis infection. The neuroimmunoma biomarker may monitor disease progression and indicate possible psychiatric complications.
A pilot clinical trial suggests that low-dose oral lithium may help slow the decline of verbal memory in older adults with mild cognitive impairment, particularly those with evidence of amyloid beta. The study found that participants receiving lithium showed a slower rate of decline on a sensitive test of verbal memory.
A recent study found that higher IL6 levels are associated with increased mortality, while genetically higher IL6R levels reduce all-cause mortality through cardiovascular mechanisms. The researchers suggest that IL6R antagonism may be a potential strategy for preventing cardiovascular disease.
A study by Tezpur University and University of Illinois has identified distinct metabolic patterns in blood that can distinguish gallbladder cancer cases from noncancerous conditions. The researchers detected hundreds of altered metabolites and identified markers with high diagnostic accuracy for each condition.
Researchers found NfL levels increase with age in various animals, including mammals, birds, and reptiles. The protein can help assess biological age and predict life expectancy across species.
Researchers found that mice without the ANGPTL4 gene were protected from intestinal inflammation and colon tumors due to altered macrophage behavior. The study suggests that early-life inflammatory events can shape long-term immune programming, providing resistance to future challenges.
A study by RIKEN researchers identifies a MYCN-driven biomarker that predicts the risk of liver cancer. The biomarker, known as the MYCN niche score, uses machine learning to analyze gene expression patterns and indicates whether a tumor-free liver is at high risk for developing tumors.
Researchers developed an AI-based tool called BIOPREVENT to identify patients at higher risk for chronic GVHD and dying from transplant-related causes. The tool combines immune biomarkers, clinical data, and machine learning to create a personalized risk estimate over time.
This review examines cancer-inflammation interplay, translational advances, and clinical strategies. Emerging technologies promise to refine precision therapy, while integrating inflammation-targeting approaches with immunotherapy offers a path to personalized cancer care.
Research finds a specific link between hearing loss and cognitive decline in presbycusis, a neurodegenerative disorder. The Functional-Structural Ratio (FSR) identifies reduced connections between brain areas involved in sound processing and memory, associated with worse hearing thresholds and poorer performance on memory and executive...
Researchers developed blood-based biomarkers that can support accurate dementia diagnosis in diverse populations when integrated with cognitive and neuroimaging measures. The study demonstrated that key plasma biomarkers can reliably distinguish major dementia syndromes even in complex settings.
A study published in Biological Psychiatry identified speech latency as a promising biomarker to enrich clinical trials for patients with schizophrenia. By analyzing speech latency, participants with a high placebo response can be identified and excluded, leading to significant improvements in treatment outcomes.
Researchers have discovered a novel biomarker for fragile X syndrome in both human patients and mouse models, allowing for the comparison of brain wave patterns between species. This breakthrough enables the development of more effective treatments by enabling non-invasive treatment efficacy readouts across species.
A new study highlights the clinical relevance of brain functional connectome uniqueness in identifying biomarkers for major depressive disorder. Researchers found that patients with MDD displayed reduced FC uniqueness, especially in frontoparietal and sensorimotor networks.
Researchers at Boston Children's Hospital have developed a novel mass spectrometry tool called FLEXITau to analyze brain tissue from 203 patients with various tauopathies. The study identified 145 post-translational modifications and 195 cleavage sites across tau, providing a precise molecular roadmap for diagnostics and drug development.
Researchers have developed a four-marker panel that can detect early-stage pancreatic cancer with high accuracy, potentially improving survival rates. The new test distinguishes cancer patients from healthy individuals and those with non-cancerous conditions, such as pancreatitis.
A team at Chalmers University of Technology has discovered biomarkers for Parkinson's disease in the blood, which could lead to early diagnosis via blood tests within five years. The study found distinct gene activities linked to DNA damage repair and stress response in patients in the early phase of the disease.
Researchers identified a targetable driver of brain metastases in inflammatory breast cancer, promoting tumor invasion and triggering brain inflammation via the CXCR2 signaling pathway. Targeting sEcad or the CXCR2 pathway may treat or prevent brain metastasis.
Scientists at the University of Florida and Linköping University discovered protein markers in umbilical cord blood associated with future insulin-dependent diabetes. The study suggests that these markers can be used to predict type 1 diabetes in early childhood, potentially allowing for targeted interventions and lifestyle changes.
Researchers identified statins as a potential booster for cancer immunotherapy by preventing the release of PD-L1-containing sEVs. Statin treatment suppressed UBL3 modification, reduced PD-L1 sorting into sEVs, and improved survival outcomes in lung cancer patients.
A new research project aims to develop an eye drop that can detect the fluorescent signal of a protein associated with Alzheimer's disease. If successful, this low-cost and accessible screening tool could help identify patients in their earliest stages of the disease, enabling them to receive early treatment.
A study found that brief exposure to benzo[a]pyrene disrupted normal development and skeletal health in fish, with effects persisting across multiple generations. The researchers identified specific metabolic signatures that could serve as early warning indicators of long-term toxicity.
Steatotic liver disease can be precisely assessed using three-dimensional ultrafast vascular ultrasound. The technology visualizes subtle microvascular changes, enabling real-time monitoring of disease progression and therapeutic response.
The use of next-generation sequencing in newborn screening can detect a wide range of genetic disorders, some of which are not currently testable through traditional means. This approach enables earlier disease detection and long-term health planning.
A new blood test has identified a protein signature linked to cancer in patients with non-specific symptoms. The test distinguishes cancer from other conditions with high precision and can help prioritize patients for further diagnostics.
The study reveals that low levels of CTDNEP1 drive early and deadly pancreatic tumors, highlighting its role as a tumor suppressor. Tumors with low CTDNEP1 expression showed stronger metabolic activity and immune evasion.
Researchers have identified biological markers that could indicate parental alienation, a form of child manipulation. These markers relate to hormone activation, neurotransmitters, inflammation, and other stress-related processes.
A Japanese research team has developed a biohybrid approach that works inside the body, transforming engineered skin into a visible indicator of internal biological states. The system leverages the body's natural skin regeneration to support long-term biomarker monitoring, providing a visual readout without blood sampling.
Researchers have developed a blood test that can predict Crohn's disease years before symptoms appear. The test measures immune response to flagellin, a protein found on gut bacteria, which is elevated in individuals long before they develop the disease.
A new study from Karolinska Institutet identified seven blood biomarkers that predict the risk and progression of multimorbidity in older adults. These biomarkers reflect biological processes such as metabolism, inflammation, and neurodegeneration.
Researchers developed a unified multimodal framework to analyze joint aging changes in brain function and structure. The study identified two primary aging patterns: synergistic declines in motor control and higher-order cognition, and contradictory adaptations in visual areas.
Researchers found that methylene blue can reverse brain damage caused by cerebral malaria and identified a nine-gene blood signature to diagnose the disease. The study's findings offer new clues on immune processes involved in brain injury and suggest potential for early intervention and clearer treatment decisions.