Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Longevity clinics have emerged globally, offering advanced diagnostic services and customized lifestyle interventions to extend healthspan. However, concerns arise from lack of scientific validation, high costs, and limited access to populations most at risk for premature aging.
Researchers developed voltage-matrix nanopore profiling to accurately classify proteins in complex mixtures based on their electrical signatures. The method reveals molecular individuality and compositional differences without labeling or modifications, holding promise for disease diagnosis and real-world bioanalytical applications.
Post-traumatic vasospasm (PTV) is a sudden narrowing of brain arteries that can lead to stroke and long-term neurological damage. Early diagnosis using tools like transcranial Doppler ultrasound and S100 protein blood tests is crucial to prevent secondary brain injury.
Researchers developed innovative blood-based biomarkers to predict long-term blood pressure improvements after bariatric surgery. The study analyzed pre-surgery blood tests and identified top 10 molecules linked to improved blood pressure outcomes.
Scientists found that CtBP2 levels decrease with age, but are higher in long-lived individuals. This biomarker may estimate the degree of aging and overall health status.
A study found that higher thymic health is associated with better outcomes in cancer patients treated with immunotherapy, including a 35% lower risk of cancer progression and 44% lower risk of death. Thymic health may serve as a non-invasive biomarker of adaptive immune competence in various cancers.
Researchers have developed a non-invasive blood test that can detect Amyotrophic Lateral Sclerosis (ALS) earlier and with higher accuracy by measuring cell-free DNA. The test distinguishes between ALS patients and healthy individuals, as well as those with other neurological conditions.
A recent study identifies molecular markers in children and adolescents that link childhood maltreatment to long-term brain alterations and mental health outcomes. The researchers found four DNA methylation sites associated with child maltreatment, including the 'master switch' gene FOXP1, which regulates brain development.
A study led by Julie Pilitsis, MD, PhD, found a possible connection between chronic pain and eosinophilia, a white blood cell condition, in patients undergoing spinal cord stimulation or implanted pain medicine pumps. The study suggests that eosinophilia may be an immune biomarker for chronic pain.
The study projects an average increase of up to 68% in respiratory rate for animals in the North compared to those in the South. Small ruminants will be more impacted by climate change, with dairy farming in the South being the most vulnerable to heat stress.
Serum HBV RNA and HBcrAg have emerged as promising biomarkers for chronic hepatitis B, enabling better monitoring of disease progression, treatment response, and risk stratification. These markers provide a window into intrahepatic viral activity, correlating with clinical outcomes such as HCC development and liver fibrosis severity.
Researchers found a significant increase in AMPA receptors across Long COVID patients' brains, correlating with cognitive impairment severity. This discovery provides a direct biological explanation for brain fog symptoms and may lead to novel treatments.
A new study discovers a previously unknown long noncoding RNA, EUDAL, that helps oral cancer cells survive chemotherapy by permanently activating the epidermal growth factor receptor. This RNA molecule blocks the cellular tagging system, allowing EGFR to remain active and promote autophagy in cancer cells.
Researchers used ATR-FTIR spectroscopy to analyze tissue samples from patients with metaplastic breast carcinoma, ductal carcinoma in situ, and invasive ductal carcinoma. The study found that specific spectral features were significantly elevated in carcinomatous tissues and could effectively differentiate between normal tissue and can...
A study has identified KIMA, a genomic signature associated with a poor treatment response in HR+/HER2- breast cancer patients. The signature, composed of nine genes, can predict disease progression and overall survival, enabling personalized therapy selection.
A new research network aims to detect early signs of dementia through open-source digital tools. Penn State will lead a $39 million grant to advance Alzheimer's detection and reduce the financial, interpersonal, and health impacts of Alzheimer's disease.
Leading researchers are advocating for increased diagnostics and treatment of Alzheimer's disease, citing significant advances in research and the availability of new medicines. The European Union has approved two medicines that slow the progression of mild dementia by removing amyloid plaques from the brain.
A study published in Journal of Internal Medicine found that people with moderate to high levels of albumin in their urine have a higher risk of developing dementia. The researchers discovered an association between albuminuria and increased risk of dementia, independent of kidney function.
A deep learning model achieved up to 98% accuracy in distinguishing autistic from neurotypical participants, providing clear insights into brain regions most influential to its decisions. The model could benefit autistic people and clinicians by offering accurate and explainable results to inform assessment and support.
A cohort study reveals oral bacteria and fungi as significant risk factors for pancreatic cancer development. The findings suggest that oral microbiota may serve as biomarkers to identify individuals at high risk of pancreatic cancer, potentially contributing to personalized prevention strategies.
A Japanese study has identified four distinct patterns of immune response after COVID-19 vaccines, with a 'rapid-decliner' group experiencing faster decline in antibody levels. Monitoring changes in antibody levels may help identify individuals at greater risk of infection and inform more effective vaccination strategies.
Researchers at Salk Institute and UC San Diego have identified a unique sugar called HSAT as a potential therapeutic target for slowing tumor progression and metastasis in pancreatic ductal adenocarcinoma. Boosting HSAT levels may slow the formation and spread of pancreatic cancer, leading to improved survival rates among patients.
The VasCog-2-WSO criteria update provide operationalization and guidance on neuroimaging and fluid biomarkers for VCID diagnosis. This new standard aims to facilitate diagnostic consistency among clinicians and researchers worldwide.
A new study published in Clinical Chemistry and Laboratory Medicine has developed a practical tool to support harmonization and quality improvement in vitamin D testing. The multicentre study evaluates the measurement uncertainty of various 25-(OH)D assays and their ability to detect physiologically relevant changes over time.
A recent study identifies C1orf122 as a novel biomarker for hepatocellular carcinoma (HCC) progression and prognosis. C1orf122 promotes HCC via the SRPK1-PI3K/AKT/GSK3β axis, enhancing cell proliferation, suppressing apoptosis, and facilitating cell migration.
Researchers discovered elevated TSPO levels in the brain of genetically engineered mouse models and human patients with familial Alzheimer's disease, indicating a potential biomarker for early detection. The study aims to explore how blocking or enhancing TSPO could halt disease progression.
Researchers at MD Anderson have made significant advancements in treating kidney cancer, including the use of metastasis-directed targeted radiation therapy to delay systemic treatments. Additionally, preliminary data from an ELI-002 vaccine trial showed promise in delaying relapse of KRAS-mutated pancreatic and colorectal cancers.
Researchers have identified two molecular targets, HER2 and CD24, as promising candidates for new nuclear diagnostics and therapeutics for endometrial cancer. These targets may help clinicians identify patients likely to respond to targeted therapies, offering new hope for those with disseminated or recurrent disease.
A recent study identifies four novel proteomic subtypes of GSRCC: Metabolism, Microenvironment Dysregulation, Migration, and Proliferation. Key prognostic biomarkers PRDX2 and DDX27 were also identified, with PRDX2 linked to favorable prognosis and DDX27 associated with poor survival outcomes.
Researchers at Kennedy Krieger Institute have developed biomarkers to help identify children with Sturge-Weber syndrome at risk of developing the condition. These tools can monitor disease progression and guide individualized treatment plans, potentially changing a child's development trajectory.
Researchers developed Vesalius to interpret complex data on cancer cell interactions, leading to potential discoveries in treating hard-to-treat cancers. The tool analyzes whole tissue architecture to identify predictive biomarkers and inform treatment options based on individual disease types.
A team of scientists has unveiled a MoS2-based phototransistor that sets new records in optical gain and sensitivity. The device detects light pulses containing tens of photons and identifies disease biomarkers at attomolar concentrations, outperforming current gold standard assays.
Researchers have developed a self-powered microneedle patch that can monitor biomarkers without drawing blood or relying on external devices. The patch uses dermal interstitial fluid (ISF) as a cleaner sample, which contains similar biomarkers to blood and doesn't require processing before testing.
A new study will investigate whether low levels of the lung protein CC16 in childhood can predict who will develop early chronic obstructive pulmonary disease (COPD) later in life. The five-year study aims to identify children at risk for early COPD and potentially intervene to prevent lung disease.
CISD1 expression linked to poor clinical outcomes, increased stemness levels, and tumor aggressiveness in multiple cancers. The gene's role in cellular bioenergetics also highlights its potential as a prognostic marker.
Researchers at Arizona State University have developed a rapid and accurate diagnostic test called NasRED that can detect diseases like COVID-19 with high sensitivity. The test uses tiny gold nanoparticles to identify disease-related proteins in a sample of bodily fluid, providing lab-quality accuracy without expensive equipment.
Researchers have developed an AI system that can recognize the early warning stages of laryngeal cancer from voice recordings. By analyzing variations in tone, pitch, and volume, the AI can distinguish between voices with benign vocal fold lesions and those with cancer. The study's findings offer a promising breakthrough for non-invasi...
A new study has identified a genetic biomarker that predicts which multiple sclerosis patients will respond well to treatment with glatiramer acetate. This allows for personalized therapy decisions to be made before starting treatment, with those carrying the HLA-A*03:01 gene variant showing significant clinical benefits.
The study identified significant alterations in chromatin accessibility of cis-regulatory elements associated with AML differentiation, linked to mutations in the WT1 transcription factor gene. These changes led to reduced chromatin accessibility and downregulation of target genes, promoting AML proliferation.
Researchers identify key symptom categories and biomarkers for anti-NMDAR encephalitis, a rare autoimmune brain condition. Clinical manifestations suggest the presence of anti-NMDAR encephalitis through NMDA antibody checks, uric acid levels, C-reactive protein, and thyroid-related hormones.
The project aims to develop novel, interpretable biomarkers using advanced artificial intelligence to overcome limitations in current diagnostic tools. The team will integrate multi-modal data and biomechanics for better diagnosis and tracking of chronic obstructive pulmonary disease (COPD).
Researchers have developed a groundbreaking method to observe lysosomes in live suspended cells—quantitatively, in 3D, and without the use of chemical labels. The technology uses holographic tomography in flow cytometry configuration (HTFC) to identify morphological and spatial lysosomal changes in models of lysosomal storage diseases.
A recent study has found that rheumatoid arthritis (RA) is a causal factor for idiopathic pulmonary fibrosis (IPF), while IPF is not causally related to RA. The research also identified shared biomarkers, including CCL2 and CXCL2, which were significantly elevated in RA patients.
A new deep learning model, MSI-SEER, achieves high accuracy in predicting microsatellite instability-high tumors and their responsiveness to immunotherapy. The model combines tumor MSI status with stroma-to-tumor ratio for highly accurate ICI response prediction.
Researchers at Brown University have identified a brain-based biomarker that can predict mild cognitive impairment development into Alzheimer's disease. They used a custom-built tool to analyze electrical activity from neurons and found distinct differences in beta events between patients who developed the disease and those who did not.
The journal is seeking high-quality submissions that explore the potential of voice and speech analysis in diverse medical applications. Submissions focus on acoustic and voice analysis techniques, voice or vocal phenotyping, and vocal biomarkers in health and medicine.
A new study found that two simple blood markers—eGFRdiff and GDF-15 levels—can independently predict kidney disease progression and mortality in people with diabetes. Patients with lower eGFRdiff values faced a higher risk of chronic kidney disease, while those with elevated GDF-15 levels were at increased risk of death.
A groundbreaking study found significant mitochondrial cardiolipin dysregulation in patients with bortezomib-induced peripheral neuropathy. The researchers identified diosmin as a promising candidate for targeting this condition, providing new avenues for therapeutic intervention.
Researchers have identified a novel diagnostic tool that can predict patient outcomes for head and neck squamous cell carcinoma. The LIMA1-alpha protein reliably identifies patients who can be cured with surgery alone, avoiding unnecessary oncological treatments.
Aging and depression are linked to complex brain-body communication, with organs aging at different rates and influencing disease susceptibility. Dr. Hamilton Oh's research reveals how immune cells and metabolic organs amplify or dampen mood symptoms, offering novel therapeutic targets.
Researchers highlight microRNAs as crucial biomarkers for diagnosing and monitoring soft tissue sarcomas, with potential for precision medicine. MicroRNAs could help distinguish between tumor types and guide treatment decisions.
A newly developed AI-based tool uses protein expression to create a stemness index that analyzes tumor similarity to pluripotent stem cells. The model predicts tumor aggressiveness and identifies potential targets for new therapies, offering hope for improved cancer treatment.
The Lundquist Institute has received a $11 million NIH grant to revolutionize the diagnosis and treatment of mucormycosis, a deadly fungal infection. The MUCOR-ADVANCE initiative aims to develop rapid diagnostic tests and immune-based therapies to save lives.
A Finnish population study reveals that middle-aged individuals can have high levels of blood-based biomarkers associated with Alzheimer's disease. The study found a link between kidney disease and higher biomarker levels in middle age, as well as an association between the APOE ε4 gene and older age biomarker concentrations. Further r...
A Phase II study found that 87% of patients with stage III melanoma remained alive and disease-free four years after treatment with nivolumab and relatlimab. Researchers identified unique biomarkers associated with better outcomes, including high TIGIT levels and low B7-H3 levels.
A new review leverages cutting-edge spatial transcriptomics and single-cell omics to identify robust predictive biomarkers for tumor immunotherapy. Representative case studies highlight the potential of spatially resolved markers to guide immunotherapy decisions and predict irAE risk.
The study identified a rare genetic alteration associated with high levels of the ADAM10 protein, which plays a role in breaking down beta-amyloid precursor protein. The researchers aim to develop a panel of prognostic biomarkers to differentiate Alzheimer's disease from other types of dementia.
Researchers at UChicago have developed a more sensitive liquid biopsy test that uses RNA to detect the earliest stages of colorectal cancer with 95% accuracy. The test analyzes RNA modification levels in blood samples, which remain stable regardless of sample preparation.
A new blood biomarker, p-tau217, has been identified as a potential predictor of Alzheimer's disease progression. This marker shows promise in identifying individuals at higher risk of developing the disease, allowing for early intervention and targeted treatment.
Researchers analyzed viral loads during early infection to predict disease progression and developed a method to identify patients at risk of severe symptoms. The study suggests that patients with high viral loads are more likely to experience long-lasting skin lesions and severe symptoms.