About The Study: A plasma-based staging model using eMTBR-tau243 and %p-tau217 demonstrated strong concordance with positron emission tomography-based staging and clinical severity of Alzheimer disease. Plasma-based staging may provide a scalable, minimally invasive approach to biological stratification of Alzheimer disease, with potential value for treatment selection and clinical trial enrichment.
Corresponding Authors: To contact the corresponding authors, email Gemma Salvado, PhD ( gemma.salvado@med.lu.se ) and Oskar Hansson, MD, PhD ( oskar.hansson@med.lu.se ).
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(doi:10.1001/jamaneurol.2026.1405)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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JAMA Neurology