Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Duke University developed an acoustofluidic integrated molecular diagnostics chip, AIMDx, that uses tiny vortexes to detect dangerous viruses. The vortexes trap cells, bacteria, and larger bioparticles, purifying samples for biomedical tests.
Researchers found subtle brain changes in people with Huntington's disease 20 years before symptoms appear, offering hope for earlier interventions. The study identified early markers of neurodegeneration through advanced imaging and biomarkers.
A large UK trial found that adding procalcitonin (PCT) to routine care did not reduce IV antibiotic use in hospitalized children. The study, part of the BATCH trial, enrolled nearly 2,000 children and tested PCT's effectiveness in guiding treatment decisions.
A study found that RAD51 testing can predict which patients with early-stage HER2-negative breast cancer may respond to neoadjuvant therapy. Patients with high RAD51 protein levels showed a higher response rate to PARP inhibitor treatment, suggesting the potential for personalized treatment strategies.
Researchers discovered a brain functional connectome phenotype related to multiple cerebrovascular disease markers that contributes additively to cognitive decline and neurodegeneration alongside Alzheimer's disease. The study highlights the role of cerebrovascular disease in reshaping our understanding of dementia.
A new position paper from the International Osteoporosis Foundation and International Federation of Clinical Chemistry proposes a unified nomenclature for bone status indices to enhance diagnostic consistency and clarity. The guidelines offer a comprehensive framework to unify terminology and improve comparability across studies.
Researchers discovered a key role for neutrophils in cancer cell colonization of abdominal fat through the release of DNA webs called NETs. Additionally, a new biomarker study found that dose-dense chemotherapy improved disease-free survival by 20% and overall survival by 15% for women with early-stage ER-positive breast cancer.
A new study has identified macrophage activity as a key predictor of which skin cancer patients are most likely to respond to immunotherapy. The findings aim to improve personalized medicine for cancer patients and enable clinicians to select effective treatments, reducing side effects and costs.
A systematic literature search identified high-priority clinical actions for post-acute care, including early education, risk assessment, and mental health screening. Implementing these actions can improve the quality of care for non-hospitalized TBI patients.
A new USC study validates a biomarker linked to vascular dementia and suggests that glymphatic damage drives cognitive decline. The findings provide a potential pathway to explain how cognitive impairment arises, offering a target for clinical researchers seeking treatments for vascular dementia.
Researchers at Boston Medical Center have identified six new biomarkers that could detect kidney injury faster and with more sensitivity. These biomarkers can be measured in the urine and may offer a more sensitive approach than existing standards for monitoring kidney health.
A new study by Katherine Alexander and Shelley Berger has found a possible source of variability in cancer treatment response in clear cell renal cell carcinoma (ccRCC). The researchers identified two distinct patterns of nuclear speckles in kidney tumors, which may correlate with patient outcomes.
Scientists develop novel MST detection method using CrAss-like phages (CLPs) to detect human fecal contamination, showing high efficacy and accuracy. The method uses PCR to detect CLP DNA, offering a cost-effective and selective approach to monitoring water quality.
Researchers have identified molecular changes that occur long before symptoms appear, shedding light on the development of Rett syndrome. These findings hold promise for developing safe gene therapies and monitoring biomarkers to track MECP2 gene function.
A new blood-based biomarker, placental growth factor (PlGF), has been identified as a potential tool for detecting early brain changes associated with cognitive impairment and dementia. Elevated PlGF levels were found to be linked to increased vascular permeability, leading to white matter injury and subsequent cognitive decline.
The Davos Alzheimer's Collaborative is partnering with Janssen Research & Development and Beckman Coulter Diagnostics to advance the validation of blood-based biomarkers (BBMs) for Alzheimer's disease. This collaboration aims to develop globally generalizable blood tests that can be used in diverse populations, including those from low...
A new study found that low to moderate wine drinking reduces the risk of serious cardiovascular disease by 50% in people at high risk who follow a Mediterranean diet. The researchers measured tartaric acid in urine to provide an objective measure of wine consumption, showing a greater protective effect than previous studies.
Researchers found that a blunted response to reward feedback in teens predicts the first onset of depression, but not anxiety or suicidal ideation. This study contributes to understanding neural risk factors for mental health disorders and developing new methods to assess mental health risks.
A novel radiotracer has accurately identified a crucial cancer biomarker, Trop2, found in various types of cancer. The radiotracer, <sup>18</sup> F-AlF-RESCA-T4, enables precise visualization of Trop2 expression and can differentiate lung inflammation from cancer.
Researchers at Brigham and Women's Hospital and Wyss Institute receive grant to expand diagnostic biomarker search, shedding light on asthma's unexplained causes. The team aims to develop a test distinguishing different forms of asthma, improving treatment courses.
Researchers discovered a novel combination of plasma-based biomarkers that can predict liver fibrosis in Latino adolescents with obesity. The study found that dihydroxyacetone phosphate (DHAP) and alanine transaminase (ALT) were significantly associated with fibrosis, suggesting a potential low-cost, noninvasive screening tool.
A new study finds that a blood test using phosphatidylethanol (PEth) can detect liver disease caused by excessive drinking, offering a more reliable alternative to self-reported measures. The test has shown strong correlation with Fibrosis 4, an indicator of liver risk, and could be included in routine blood tests.
A new review published in Blood Cancer Discovery outlines how research supported a recent FDA committee decision to allow minimal residual disease as an endpoint for accelerated approval in multiple myeloma. This decision could cut a decade off the drug development process, enabling faster innovation in cancer treatment.
A study published in JAMA found that biomarker-guided antibiotic duration reduced in hospitalized patients with suspected sepsis. However, a daily C-reactive protein-guided protocol did not demonstrate significant benefits. The results suggest that procalcitonin-guided protocols may be a more effective approach.
Researchers uncover the significance of neuroinflammation in Niemann-Pick type C disease, a rare form of childhood dementia. They identify translocator protein (TSPO) as a potential biomarker for disease monitoring and response to therapy.
A study published in Environmental Epigenetics found that pregnant women with preeclampsia had distinct epigenetic modifications, potentially serving as a biomarker. The researchers hope to develop a cheek swab test to detect these risks earlier, allowing for preventative medicine treatments.
Researchers identified plasma extracellular vesicle-derived microRNAs as potential biomarkers for AATD liver disease. They found 39 differentially expressed miRNAs, which were validated in an independent cohort for predicting AATD liver disease.
A recent study develops a physicochemical approach to optical biosensing using 1DZnO nanostructures, enabling rapid CYFRA 21-1 testing within a 5-minute detection window. The developed biosensors have the potential to provide accurate and reliable results in complex matrices like saliva.
A study by St. Jude Children's Research Hospital has identified a serum protein panel test that accurately predicts cardiomyopathy risk in childhood cancer survivors. The test, using a panel of 27 proteins, was tested on 46 survivors and correctly predicted risk in 38 cases.
Researchers have identified a simpler and more accessible alternative to diagnosing kidney fibrosis in transplant patients: measuring vitronectin levels in urine. The study found that vitronectin levels were significantly higher in patients with fibrosis, and combining this measurement with traditional urine tests improved accuracy.
Researchers found a novel link between aortic stenosis and insulin resistance, with certain biomarkers increasing the risk of the disease. The study's findings suggest that managing metabolic health could be a new approach to reduce the risk of AS and improve cardiovascular health in aging populations.
Researchers at the University of Jena have developed a method to functionalise graphene without interference, allowing for ultrasensitive detection of biomarkers. This breakthrough enables rapid, cost-effective diagnostics using graphene-based field-effect transistors.
A global team, including Lehigh University researcher Xuanhong Cheng, is exploring molecular- and cellular-level changes in muscle tissue that could lead to better diagnostic tools and therapeutic options for CFS and long COVID. The team aims to develop noninvasive diagnostic tools using electrical signatures.
This systematic review analyzes 33 biological clocks used for aging and mortality quantification, categorizing them into epigenetic and phenotypic clocks. Epigenetic clocks demonstrate precision in estimating chronological age through DNA methylation, while phenotypic clocks predict mortality using easily measurable clinical variables.
Researchers use AI to predict COPD flare-ups based on daily urine tests, potentially allowing for proactive treatment and prevention. The study identifies biomarkers in urine that can forecast a flare-up seven days prior to symptoms.
The C-Path initiative aims to generate drug development solutions that reflect each person's unique experience, leveraging diverse data and innovative technologies like AI and digital health. GEM-PD seeks to address unmet need in Parkinson's disease therapies by focusing on sex and gender differences.
New treatment combinations and predictive biomarkers hold promise for improving bladder cancer outcomes. The NIAGARA trial showed that combining immune checkpoint inhibitors with chemotherapy can significantly increase two-year survival rates and reduce cancer recurrences.
The VANCE trial demonstrates that Singapore has the expertise and capabilities to run large-scale global cell therapy trials. The study shows promising results for patients with recurrent or metastatic NPC treated with EBV-CTL therapy, with median survival rates of up to 29.9 months.
Researchers have developed microneedle sensors to analyze dermal interstitial fluid, offering a minimally invasive alternative to traditional blood-based diagnostics. These wearable devices show potential to revolutionize personalized healthcare and daily health monitoring.
This review provides a comprehensive overview of CTC detection methods, their association with HCC progression, and their role in prognostication and treatment monitoring. Studies show that the number of CTCs correlates with tumor size, grade, and overall cancer severity.
The University of Washington School of Medicine has released a flagship AI-ready dataset for a type 2 diabetes study, featuring a diverse range of participants and novel measures. The dataset includes environmental sensor data, survey responses, eye-imaging scans, and traditional biologic variables.
Researchers found that HNL Dimer levels decrease rapidly within a day of successful antibiotic treatment, offering a time-saving advantage over traditional biomarkers. This study confirms the previous promising results and provides valuable insights for early diagnosis and treatment of sepsis.
Researchers at Tufts University and Vanderbilt University developed a biomarker to detect inflexible thinking in schizophrenia. The study found that people with schizophrenia generate unique neural patterns when making decisions based on conflicting information.
Research highlights correlation between preeclampsia and COVID-19 in pregnant women, identifying biomarkers for differential diagnosis. The review article emphasizes the pathophysiological similarities between the two conditions, including shared pathways involving the renin-angiotensin system and ACE2.
Researchers have found that combining the VIGex gene expression signature with liquid biopsy analysis improves response prediction to immunotherapy in patients with advanced solid tumors. The study analyzed tumor samples and circulating tumor DNA (ctDNA) by liquid biopsy, showing that the VIGex-Hot subgroup was associated with higher o...
The MEMELAND project will analyze sediments and soil in lakes across Europe to reveal how medieval farming shaped today's landscapes and biodiversity. The study aims to protect northern Europe's essential biodiversity by understanding the environmental changes that occurred during this period.
The International Working Group proposes a new approach to diagnosing Alzheimer's disease, focusing on clinical evaluation supported by biomarkers. This distinction is crucial for identifying those who have the disease and those at risk, paving the way for targeted research and personalized treatments.
A recent revision of Alzheimer Association criteria focuses solely on AD core biomarkers, sparking uncertainty about patient outcomes. The new definition may limit diagnostic flexibility and impact treatment planning.
Researchers have developed a new protocol to exclusively access and quantify proteins carried by extracellular vesicles in the blood. This breakthrough may lead to early diagnosis of Parkinson's disease and other brain disorders, providing treatment opportunities before symptoms appear.
Researchers synthesizing AI with biomarker analysis aim to detect early signs of aging and enable targeted interventions to delay disease. This approach has the potential to slow, prevent or reverse certain effects of aging.
Researchers analyzed steroids from animal dung in lake sediments to determine the dominant large herbivores that lived in northern Yellowstone National Park. The study found bison and elk as primary species for the last 2,300 years, with impacts on local ecosystems.
Researchers developed a method to assess which patients with metastatic triple-negative breast cancer can benefit from immunotherapy. The tool uses predictive biomarkers and machine learning-based approaches to identify patients who are likely to respond to treatment.
Researchers propose a comprehensive biomarker-based approach to assess cardiovascular risk by combining markers of chronic inflammation with cardiac health indicators. This approach reveals the significant impact of aging-related inflammation, or 'inflammaging,' on heart health and opens new avenues for targeted interventions.
Researchers identified three long noncoding RNAs associated with worse outcomes in colorectal cancer patients, potentially serving as prognostic markers. The study's findings could enable doctors to separate high-risk patients from those at low risk of disease recurrence, leading to more effective treatment strategies.
Researchers have identified a genetic signature that can predict neonatal sepsis in newborns before symptoms appear, allowing for earlier recognition and life-saving treatment. The discovery has the potential to improve healthcare outcomes in lower- and middle-income countries where neonatal sepsis is most prevalent.
Researchers have successfully integrated genome sequencing into newborn screening to identify hundreds of rare genetic disorders. This approach allows for earlier diagnosis and treatment, promoting health equity and reducing time to diagnosis.
Researchers developed femtosecond-fieldoscopy, enabling precise measurement of liquid quantities and detecting target molecules in aqueous environments. The technique opens up possibilities for label-free bio-imaging and advanced biomedical applications.
The myeloMATCH program offers a portfolio of biomarker-driven treatment trials to accelerate precision medicine in myeloid malignancies. Patients can enroll in clinical trials throughout their cancer treatment journey, with test results returned quickly to assign them to the most appropriate trial.
A team of researchers, funded by ARPA-H, aims to create an objective quantitative tool to assess pain in patients. They will use biomarkers such as stress hormones and neurotransmitters to generate a composite panel of markers that can be monitored on a portable device.
Researchers found that physically fitter patients with metastatic lung cancer live longer and respond better to chemotherapy. The study identified biomarkers in blood plasma that can indicate which patients are most likely to respond to treatment.