Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A recent study published in Frontiers in Immunology highlights the crucial role of tissue-resident memory T cells in non-small cell lung cancer. The research found that these cells can significantly impact patient outcomes and guide personalized treatment strategies, particularly those involving immunotherapy.
Researchers at MedUni Vienna have identified AF1Q as a promising biomarker to predict gastric cancer recurrence risk. The study found that 97.8% of tumour samples had elevated AF1Q levels, associated with higher recurrence risk and lower survival chances.
A head-to-head comparison of six commercial blood tests found that some are accurate enough to replace spinal taps and brain scans in patients with cognitive impairment. The analysis, led by Suzanne Schindler at Washington University School of Medicine, identified reliable tests for diagnosing Alzheimer's disease.
Tumors with mutations in ERCC2, ATM, or RB1 genes were more likely to be eliminated by cisplatin-based chemotherapy. The study found a correlation between these gene mutations and complete pathologic response to neoadjuvant chemotherapy.
Researchers found high diagnostic accuracy for identifying Alzheimer's disease using amyloid probability score 2 blood test and p-tau217 levels. The study suggests blood tests could influence clinical care, warranting further evaluation.
Researchers studied Alzheimer disease blood biomarkers and found a strong association with incident all-cause dementia risk. Biomarker levels increased with age and were linked to dementia starting in midlife.
Researchers found that combining plasma p-tau217 and Aβ42/40 levels could predict early brain Aβ accumulation in people with subthreshold Aβ accumulation. These biomarkers may help screen participants for primary prevention trials.
Researchers found correlations between MIF and DDT levels with patient survival outcomes in melanoma patients. Higher CD74:MIF and CD74:DDT levels were associated with improved survival and enrichment of inflammatory markers.
Researchers identified tissue-resident CD8 T cells and γδ T cells as key drivers of immunotherapy response in Merkel cell carcinoma patients. Patients with tumors containing these immune cells are more likely to respond to treatment, suggesting potential for enhanced outcomes.
Researchers found a blood test to detect alpha-synuclein protein shows promise for diagnosing Parkinson's disease. The study, published in the Journal of Parkinson's Disease, confirmed that the biomarker is highly sensitive and changes over the course of the disease.
Scientists have successfully collected and profiled lung biomarkers from human breath, developing animal models to identify key markers for early detection of metastatic lung tumors. The research establishes a scientific roadmap for an exhaled-breath test, which may revolutionize the diagnosis and surveillance of human lung diseases.
A distinct TNF-α signaling program has been identified as a key driver of epithelial cancer development, contributing to cell proliferation and invasion. The researchers found that this program is active in both normal tissues and tumors, but its level of activity correlates with tumor aggressiveness.
Mayo Clinic scientists have established criteria for a memory-loss syndrome in older adults that specifically impacts the brain's limbic system. The syndrome, called Limbic-predominant Amnestic Neurodegenerative Syndrome (LANS), progresses more slowly and has a better prognosis than Alzheimer's disease.
Researchers from Jilin University provide a comprehensive overview of brain injury biomarkers, including neuron-specific enolase, ubiquitin C-terminal hydrolase-L1, and neurofilament proteins. These biomarkers can help identify brain injuries and predict disease progression.
A Mediterranean diet-based intervention has been shown to optimize cardiometabolic biomarkers in children and adolescents. The study found that this dietary approach can help improve cardiovascular health in young people, potentially reducing the risk of chronic diseases later in life.
Dr. Rissman's research uses plasma Aβ42/Aβ40 ratio to predict brain amyloid PET positivity and identify individuals at risk for Alzheimer's disease. His findings demonstrate the potential of a blood test to screen for amyloid in preclinical AD trials.
A new study has identified specific RNAs that may help identify stage II colon cancer patients who are likely to benefit from chemotherapy following surgery. The researchers found that certain housekeeping RNAs were up-regulated in patients with recurrence, suggesting their potential role in the metastatic process.
The NTU team created a compact and flexible light-based sensing device, like a plaster, to provide highly accurate biomarker readings within minutes. The device detects glucose, lactate, and urea levels in sweat with ultra-high sensitivity and dynamic range.
Researchers developed a novel liquid biopsy technique to monitor disease evolution in metastatic prostate cancer patients. The method analyzes DNA and RNA in circulating extracellular vesicles, capturing tumor genomics and transcriptomic changes.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center have received a $1.8 million grant to advance personalized cancer therapy for prostate cancer patients. They aim to predict and prevent long-term side effects from radiation treatment, improving quality of life for men diagnosed with the disease.
Researchers have discovered a new diagnostic method for PSP by analyzing protein biomarkers in spinal fluid, which could lead to earlier diagnosis and targeted therapies. The high-throughput technology allows for the measurement of thousands of proteins in a tiny drop of fluid, providing a promising solution for identifying the condition.
Researchers at the University of Gothenburg developed an AI model called Candycrunch to automate the analysis of glycan structures in cancer cells. The model can identify abnormal structures and biomarkers in just a few seconds, accelerating the discovery of new treatments.
Researchers found that lower adiponectin levels and higher leptin concentrations in parents during pregnancy may predict offspring mental health disorders. These biomarkers could enable early interventions for children at risk.
Researchers analyzed blood plasma samples from 110 patients infected with Plasmodium vivax to understand how metabolisms were affected during initial episodes versus recurrent cases. The study found that patients with recurrence exhibited modulation in lipid pathways involved in immune system production, while those with first-episode ...
Researchers from University of Helsinki and Stanford University developed more precise methods for transcranial magnetic stimulation (TMS) targeting the brain's electrical responses. The new methods aim to improve treatment outcomes for patients with depression who do not respond to medication or antidepressants.
Xiaohu Xia's research focuses on enhancing diagnostic efficacy of enzyme-linked immunosorbent assay (ELISA) testing using specially tailored nickel-platinum nanoparticles. His goal is to improve disease detection accuracy by more than 300 times, enabling early diagnosis of cancers like prostate and colorectal cancer.
Researchers analyzed three tumor markers for associations with radiographic response and clinical outcomes in NSCLC patients. The study found that CEA, CA-125, and CA-19-9 were associated with progression and radiographic responses in NSCLC.
A wearable health monitor developed by Washington State University researchers can accurately measure levels of important biochemicals in sweat during physical exercise. The device has the potential to track health conditions and diagnose common diseases, including diabetes, gout, kidney disease, and heart disease.
A new, streamlined urine DNA test detects primary bladder cancer more accurately than current methods, potentially reducing the need for invasive cystoscopy. The test shows high sensitivity and specificity, even for detecting high-grade noninvasive papillary carcinoma.
Researchers developed two clinical ageing clocks, PCAge and LinAge, that use blood tests, a urine test, and a health questionnaire to estimate future mortality risk. These clocks show significant predictive efficacy in characterising individual future ageing trajectories.
Researchers found that colder temperature exposure increases oxidative stress in the nasal cavity, leading to worsened asthma symptoms in children. The study used nasal fluid samples and measured malondialdehyde (MDA) levels as a biomarker of oxidative stress.
A team of researchers has developed a simple blood test that uses artificial intelligence (AI) to predict Parkinson's disease up to seven years before the onset of symptoms. The test analyzes a panel of eight blood-based biomarkers with concentrations altered in patients with Parkinson's, providing a diagnosis with 100% accuracy.
Researchers have developed a blood test that can detect rare forms of dementia, such as frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP), as well as amyotrophic lateral sclerosis (ALS). The test uses biomarkers, including tau and TDP-43 proteins, to identify underlying pathology.
A new machine-learning model using serum fusion-gene levels predicts HCC with an accuracy of 83-91%, significantly improving upon current biomarkers like serum alpha-fetal protein. This breakthrough tool may help identify patients at risk and monitor cancer recurrence, leading to improved survival rates.
A cohort study found that severe dust exposure increased the risk of dementia in World Trade Center responders under 65. Using personalized protective equipment may prevent this age of onset, according to the research.
Researchers found that nasal microbiota of ICU patients with sepsis is significantly lower in community richness and has distinct compositions compared to non-septic patients. Key bacterial genera such as Corynebacterium, Staphylococcus, Acinetobacter, and Pseudomonas were enriched in the nasal microbiota of septic patients.
The study highlights the potential of omics research and AI tools to disentangle the molecular drivers of Alzheimer’s disease. Key findings include the identification of novel biomarkers for early detection and therapeutic targets, as well as the exploration of genetic factors contributing to AD risk and progression.
Researchers discovered that T-cell aging is not limited by organismal age, and healthy T cells can proliferate indefinitely. The epigenetic clock of T cells shows that death is not the end, and these cells do not plateau with age, defying traditional notions of cellular aging.
A new biomarker database, Space Omics and Medical Atlas (SOMA), has been developed to improve astronaut health, but its findings may also be useful for people on Earth with limited mobility or bedridden conditions. The database provides insights into short and long-term health impacts of spaceflight.
Researchers developed a Single Data Dictionary to predict outcomes for people with TBI, combining factors like social support, health, and biological markers. The dictionary aims to provide personalized care and rehabilitation, improving quality of life for patients and reducing negative impacts on families and society.
Researchers developed a novel radiotracer to detect Claudin18.2 in gastrointestinal cancers, allowing for early diagnosis and targeted therapy optimization. The radiotracer enables whole-body PET imaging within one day, increasing compliance and reducing radiation exposure.
The Association for Molecular Pathology has published guidelines for tumor mutational burden (TMB) testing, aiming to standardize calculation and reporting of TMB as a predictive biomarker for immune checkpoint inhibitor therapies. These recommendations emphasize the importance of comprehensive methodological descriptions in publications.
A study of over 10,000 US adults found a strong association between pro-inflammatory diets and elevated NT-proBNP levels, indicating potential increased cardiovascular risk. The research suggests that dietary inflammatory index may be an important factor in heart failure biomarker levels.
A small study compares healthy brains of young and old, finding normal ageing associated with increased blood-brain barrier permeability in Alzheimer's Disease vulnerable areas. This increased permeability may contribute to disease progression.
The discovery of Helicolocellus fills a 160-million-year gap in the sponge fossil record and suggests non-biomineralizing sponges existed in the Precambrian. The study bridges the Ediacaran and Cambrian fossil assemblages, providing insights into animal evolution.
Researchers discuss Ibrutinib, a BTK inhibitor approved for chronic lymphocytic leukemia treatment, noting 20-25% of patients experience dose-limiting cardiovascular toxicities. A recent study identifies genetic biomarkers, such as KCNQ1 and GATA4, associated with cardiotoxic events, which may improve risk stratification.
A study from Michigan Medicine reveals a connection between neutrophil activation and severe cytokine release syndrome (CRS), a potentially life-threatening reaction to CAR T-Cell therapy. Researchers identified biomarkers of NETosis, a process in which neutrophils create webs that may contribute to CRS.
Researchers have developed a way to classify host immunity in individuals, enabling the early identification of those who won't respond well to regular vaccines. This allows for tailored vaccine regimes to provide long-lasting immunity, reducing influenza-related illness and healthcare costs.
A recent study found that work-life imbalance significantly predicts higher triglycerides and lower HDL levels in midlife and older adults. This suggests that spillover effects of workplace stress on home life can contribute to physiological changes linked to cardiovascular diseases. The research highlights the importance of organizati...
A team of researchers developed an eye-tracking biomarker model that can differentiate children with autism from those with other neurodevelopmental disabilities. The model achieved high sensitivity and specificity, allowing for more accurate diagnoses.
Researchers at the University of Toronto discovered a new RNA virus, Apocryptovirus odysseus, associated with severe inflammation in humans infected with Toxoplasma gondii. The virus is found in two hypervirulent strains of the parasite, exacerbating toxoplasmosis disease and triggering an immune response.
Researchers from Ben-Gurion University of the Negev have discovered a link between proteomic biomarkers and liver fat percentage, which may improve patient monitoring and therapy targeting for NAFLD. The study, conducted over 18 months, found that specific protein changes were independently associated with liver fat relative change.
A groundbreaking study has uncovered a significant breakthrough in the diagnosis and monitoring of kidney diseases associated with nephrotic syndrome. Researchers identified anti-nephrin autoantibodies as a reliable biomarker for tracking disease progression, opening new avenues for personalized treatment approaches.
Research finds insulin levels correlate with triglycerides, ApoB, non-HDL cholesterol, and free cholesterol in women with atherosclerotic coronary disease. The study suggests these laboratory-associated flags indicate early coronary atherosclerosis in both diabetic and non-diabetic women.
Researchers have identified collagen features as valuable biomarkers for evaluating melanoma immunotherapy response. Single-fiber characteristics were found to be more sensitive to treatment-induced changes than bulk collagen features, offering insights into collagen remodeling over time.
Researchers developed a game-changing blood test that can quickly and accurately identify large vessel occlusion strokes, which have the potential to bring life-saving care to patients globally. The test combines biomarkers with a clinical score to detect strokes with 93% specificity and 81% sensitivity.
A new biomarker, miR-519a-3p, has been discovered to detect Alzheimer's disease in its asymptomatic stages. The molecule is linked to the expression of cellular prion protein, which is deregulated in people with neurodegenerative diseases.
Researchers found elevated expression of RPGRIP1L in invasive breast cancer specimens, correlating with shorter survival times and unfavorable clinicopathological features. The study identified 50 genes and 15 proteins related to RPGRIP1L expression, including those involved in immune response and metabolism.
Researchers found cyclin D1 expression in patients with penile cancer (PC) is associated with clinical and histopathological features. Patients with cyclin D1 expression had lower disease-free survival compared to the cyclin D1-negative group.
The IV-Lab project aims to develop a miniaturized, implantable multi-sensors device to monitor blood vessel health. The device will integrate multiple sensors measuring blood pressure, vessel deformation, and cardiovascular biomarkers, enabling timely and personalized treatment for patients with cardiovascular diseases.