Articles tagged with Biomarkers
Researchers have developed a blood test that can detect rare forms of dementia, such as frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP), as well as amyotrophic lateral sclerosis (ALS). The test uses biomarkers, including tau and TDP-43 proteins, to identify underlying pathology.
A new machine-learning model using serum fusion-gene levels predicts HCC with an accuracy of 83-91%, significantly improving upon current biomarkers like serum alpha-fetal protein. This breakthrough tool may help identify patients at risk and monitor cancer recurrence, leading to improved survival rates.
A cohort study found that severe dust exposure increased the risk of dementia in World Trade Center responders under 65. Using personalized protective equipment may prevent this age of onset, according to the research.
Researchers found that nasal microbiota of ICU patients with sepsis is significantly lower in community richness and has distinct compositions compared to non-septic patients. Key bacterial genera such as Corynebacterium, Staphylococcus, Acinetobacter, and Pseudomonas were enriched in the nasal microbiota of septic patients.
The study highlights the potential of omics research and AI tools to disentangle the molecular drivers of Alzheimer’s disease. Key findings include the identification of novel biomarkers for early detection and therapeutic targets, as well as the exploration of genetic factors contributing to AD risk and progression.
Researchers discovered that T-cell aging is not limited by organismal age, and healthy T cells can proliferate indefinitely. The epigenetic clock of T cells shows that death is not the end, and these cells do not plateau with age, defying traditional notions of cellular aging.
A new biomarker database, Space Omics and Medical Atlas (SOMA), has been developed to improve astronaut health, but its findings may also be useful for people on Earth with limited mobility or bedridden conditions. The database provides insights into short and long-term health impacts of spaceflight.
Researchers developed a Single Data Dictionary to predict outcomes for people with TBI, combining factors like social support, health, and biological markers. The dictionary aims to provide personalized care and rehabilitation, improving quality of life for patients and reducing negative impacts on families and society.
Researchers developed a novel radiotracer to detect Claudin18.2 in gastrointestinal cancers, allowing for early diagnosis and targeted therapy optimization. The radiotracer enables whole-body PET imaging within one day, increasing compliance and reducing radiation exposure.
The Association for Molecular Pathology has published guidelines for tumor mutational burden (TMB) testing, aiming to standardize calculation and reporting of TMB as a predictive biomarker for immune checkpoint inhibitor therapies. These recommendations emphasize the importance of comprehensive methodological descriptions in publications.
A study of over 10,000 US adults found a strong association between pro-inflammatory diets and elevated NT-proBNP levels, indicating potential increased cardiovascular risk. The research suggests that dietary inflammatory index may be an important factor in heart failure biomarker levels.
A small study compares healthy brains of young and old, finding normal ageing associated with increased blood-brain barrier permeability in Alzheimer's Disease vulnerable areas. This increased permeability may contribute to disease progression.
The discovery of Helicolocellus fills a 160-million-year gap in the sponge fossil record and suggests non-biomineralizing sponges existed in the Precambrian. The study bridges the Ediacaran and Cambrian fossil assemblages, providing insights into animal evolution.
Researchers discuss Ibrutinib, a BTK inhibitor approved for chronic lymphocytic leukemia treatment, noting 20-25% of patients experience dose-limiting cardiovascular toxicities. A recent study identifies genetic biomarkers, such as KCNQ1 and GATA4, associated with cardiotoxic events, which may improve risk stratification.
A study from Michigan Medicine reveals a connection between neutrophil activation and severe cytokine release syndrome (CRS), a potentially life-threatening reaction to CAR T-Cell therapy. Researchers identified biomarkers of NETosis, a process in which neutrophils create webs that may contribute to CRS.
Researchers have developed a way to classify host immunity in individuals, enabling the early identification of those who won't respond well to regular vaccines. This allows for tailored vaccine regimes to provide long-lasting immunity, reducing influenza-related illness and healthcare costs.
A recent study found that work-life imbalance significantly predicts higher triglycerides and lower HDL levels in midlife and older adults. This suggests that spillover effects of workplace stress on home life can contribute to physiological changes linked to cardiovascular diseases. The research highlights the importance of organizati...
A team of researchers developed an eye-tracking biomarker model that can differentiate children with autism from those with other neurodevelopmental disabilities. The model achieved high sensitivity and specificity, allowing for more accurate diagnoses.
Researchers at the University of Toronto discovered a new RNA virus, Apocryptovirus odysseus, associated with severe inflammation in humans infected with Toxoplasma gondii. The virus is found in two hypervirulent strains of the parasite, exacerbating toxoplasmosis disease and triggering an immune response.
Researchers from Ben-Gurion University of the Negev have discovered a link between proteomic biomarkers and liver fat percentage, which may improve patient monitoring and therapy targeting for NAFLD. The study, conducted over 18 months, found that specific protein changes were independently associated with liver fat relative change.
A groundbreaking study has uncovered a significant breakthrough in the diagnosis and monitoring of kidney diseases associated with nephrotic syndrome. Researchers identified anti-nephrin autoantibodies as a reliable biomarker for tracking disease progression, opening new avenues for personalized treatment approaches.
Research finds insulin levels correlate with triglycerides, ApoB, non-HDL cholesterol, and free cholesterol in women with atherosclerotic coronary disease. The study suggests these laboratory-associated flags indicate early coronary atherosclerosis in both diabetic and non-diabetic women.
Researchers have identified collagen features as valuable biomarkers for evaluating melanoma immunotherapy response. Single-fiber characteristics were found to be more sensitive to treatment-induced changes than bulk collagen features, offering insights into collagen remodeling over time.
Researchers developed a game-changing blood test that can quickly and accurately identify large vessel occlusion strokes, which have the potential to bring life-saving care to patients globally. The test combines biomarkers with a clinical score to detect strokes with 93% specificity and 81% sensitivity.
A new biomarker, miR-519a-3p, has been discovered to detect Alzheimer's disease in its asymptomatic stages. The molecule is linked to the expression of cellular prion protein, which is deregulated in people with neurodegenerative diseases.
Researchers found elevated expression of RPGRIP1L in invasive breast cancer specimens, correlating with shorter survival times and unfavorable clinicopathological features. The study identified 50 genes and 15 proteins related to RPGRIP1L expression, including those involved in immune response and metabolism.
Researchers found cyclin D1 expression in patients with penile cancer (PC) is associated with clinical and histopathological features. Patients with cyclin D1 expression had lower disease-free survival compared to the cyclin D1-negative group.
The IV-Lab project aims to develop a miniaturized, implantable multi-sensors device to monitor blood vessel health. The device will integrate multiple sensors measuring blood pressure, vessel deformation, and cardiovascular biomarkers, enabling timely and personalized treatment for patients with cardiovascular diseases.
A new PET imaging biomarker, Gal-1, has been identified to predict the tumor responses before starting immune checkpoint blockade therapy. This enables targeted interventions and improves patient outcomes by facilitating patient stratification and optimizing immunotherapy.
Researchers have developed a method to use intense ultrasound to extract genetic information from cells, allowing for the detection of cancer biomarkers in blood samples. This approach could enable earlier detection and treatment of cancer, as well as reduce the need for painful biopsies.
Researchers developed a synthetic biomarker technology that can differentiate between prior Zika and dengue virus infections. The technology, using epitope surrogates, correctly identified people previously infected with Zika virus 85.3% of the time.
Cardiovascular biomarkers strongly associated with cardiovascular events and mortality. Adding biomarkers to established risk factors improved heart failure and mortality prediction, but only slightly enhanced atherosclerotic disease risk prediction.
Researchers have developed a new method to detect malignant melanoma using a microneedle patch that measures tyrosinase enzyme levels in the skin. This non-invasive technique has the potential to provide faster and more reliable results compared to traditional biopsies.
Researchers discuss therapeutic opportunities for hypermutated urothelial carcinomas that are resistant to immunotherapy, including the potential of targeted therapies. High TMB is associated with defects in mismatch repair proteins and can lead to increased sensitivity to cancer treatments.
Australian researchers have identified biomarkers that can predict which children are likely to outgrow their peanut allergy. The study found that two-thirds of children with a peanut allergy remain allergic by age 10, but most who naturally outgrew their allergy did so by age six.
Researchers found associations between inflammatory and metabolic biomarkers and accelerated aging, with GlycA and GrimAge showing robust correlations. The study provides insight into the relationship between aging and cardiometabolic health, potentially informing vulnerable populations.
Researchers created a corticolimbic index tool that categorizes Alzheimer's disease into three subtypes based on brain changes. The study found demographic and clinical differences among sex, age at onset, and rate of cognitive decline.
A massive study identifies new biomarkers for renal cell carcinoma subtypes, improving diagnosis and treatment. The researchers' integrative analysis of proteogenomic datasets reveals molecular features shared by clear cell and non-clear cell RCC tumors, as well as unique features to various subtypes.
A new screening algorithm combining maternal history, ultrasound data and several tests for blood markers may predict most preeclampsia cases in the first trimester of pregnancy. The study found that personalized risk-based treatment decisions may improve adherence to preventative measures.
A new study found extensive alternative splicing of messenger RNA in untreated multiple sclerosis patients compared to healthy controls. Interferon-ß therapy corrected dysregulated alternative splicing, linking it to future clinical exacerbations.
Researchers analyzed flour and rice stored in Brazilian homes and found six mycotoxins, including aflatoxin B1 and deoxynivalenol, at high levels, posing significant health risks. The study highlights the importance of proper food storage to prevent contamination.
A recent study led by UC Davis Health researchers provides new insights into the molecular changes linked to 22q11.2 deletion syndrome, a rare genetic condition that can lead to psychosis, ADHD, and other conditions. The study identified two biomarkers, taurine and arachidonic acid, which could predict likelihood of psychosis in patien...
Researchers at UCLA Health have developed a potential biomarker for stroke risk using a network of inflammatory molecules in the blood. The study, published in the journal Stroke, found that patients with higher concentrations of these molecules had an 84% chance of experiencing a stroke during their lifetime.
A new study suggests that proteins detectable in the blood could improve predictions about risk of liver cancer, potentially leading to earlier therapeutic interventions. The researchers used proteomics to develop a prediction model and identified 56 plasma proteins associated with liver cancer.
This study analyzed differentially expressed genes from three datasets to identify hub genes associated with gastric adenocarcinoma. The analysis revealed that genes such as ERBB4 and MAPT were linked to GC progression and had poor overall survival, suggesting potential therapeutic targets.
Researchers at the University of Leipzig Medical Center have identified biomarkers associated with the response to CAR T cell therapy in multiple myeloma. These biomarkers enable patients to predict their likelihood of responding well or less well to treatment before initiating therapy.
Scientists have identified a shared gene module in people with depression and cardiovascular disease, providing new markers for both conditions. The study found that genes involved in inflammation are associated with both diseases, explaining why they often occur together.
The Alzheimer's disease treatment landscape is experiencing a significant shift, with numerous potential drugs making their way through clinical trials. Biomarkers have also emerged as a key area of focus, providing valuable information on the drug's impact and allowing for more precise guidance in future trials.
The project aims to overcome limitations of conventional semen analyses by examining mitochondrial DNA levels in sperm as a novel biomarker of sperm fitness. Researchers will evaluate relationships between mtDNA biomarkers and male reproductive health using large study samples.
Two new Review articles explore AI's application in early cancer detection, highlighting its potential to enhance diagnostic accuracy and improve treatment selection. The articles emphasize the need for a robust, multi-disciplinary approach to integrate AI into medicine.
A new study found a link between midlife racial discrimination and increased levels of Alzheimer's disease markers, including phosphorylated tau181 and neurofilament light, in older age. Researchers analyzed data from 255 Black Americans over 17 years, revealing that chronic stress from racism contributed to dementia risk.
The World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases will showcase new clinical research from over 1507 submitted abstracts. The event will offer valuable knowledge to help clinicians treat patients more effectively in their daily practice.
A new AI-based video biomarker is associated with aortic stenosis development and progression, allowing for opportunistic risk stratification across various imaging modalities. The study's findings suggest potential applications on handheld devices for early detection and intervention.
Researchers have developed a novel sensing platform that boosts the sensitivity of conventional optical sensors using exceptional points (EPs), allowing for improved environmental detection and biomedical imaging. The new EP-enhanced sensing platform enables ultrahigh sensitivity without complex modifications to the sensor.
A new study by VA researchers found biomarkers of intestinal permeability and signs of bacteria in the blood of military breachers exposed to controlled blasts during training. The findings suggest a direct connection between blast exposure and intestinal problems, including cognitive symptoms.
A simple urine test can reduce the number of cystoscopies required to follow up high-risk bladder cancer patients by more than half. The test monitors for recurrence of bladder cancer by measuring levels of five target mRNAs and was found to be effective in picking up cancer recurrence before any disease was visible through a cystoscopy.
A simple blood test every five years is sufficient to screen low-risk men for prostate cancer, according to new research. Researchers found that only 0.13% of men with low PSA levels developed cancer after a decade.
Researchers have identified specific gut microbiota signatures associated with KRAS mutations in colorectal cancer. The study suggests that these microbes may serve as non-invasive biomarkers for identifying subtypes of CRC and inform personalized treatment approaches.
Recent trials have shown that testing for tumour DNA in the blood can identify advanced bladder cancer patients who are less likely to relapse after surgery, allowing doctors to target treatments more effectively.
Researchers from the University of Southern Denmark have identified specific groups of cells driving resistance to chemotherapy in TNBC, offering new biomarkers and alternative treatment options. The studies shed light on the mechanisms behind chemoresistance and its epigenetic control.