Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers uncover intricate interplay between enhancers and silencers influenced by DNA methylation, providing crucial insights into dynamic gene control. High-resolution mapping reveals how genes are controlled and modified, paving the way for precision medicine tailored to individual patients.
Researchers identified a correlation between the HSD3B1 biomarker and resistance to combined hormone therapy and radiotherapy in men with prostate cancer. The study found that high levels of the enzyme led to increased testosterone production, promoting resistance to treatment.
The American Gastroenterological Association released a new guideline recommending the use of biomarkers to help manage Crohn’s disease. Biomarkers such as C-reactive protein and fecal calprotectin can measure levels of inflammation, helping doctors assess disease activity and guide treatment decisions.
Researchers found a modest improvement in predicting pathologic response to chemotherapy using molecular subtypes, but no association with overall survival and progression-free survival. The study suggests the need for subtype-directed therapy trials to test targeted treatments.
Scientists developed a high-throughput method to study oxidized lipids in ALS. Analysis of blood plasma from rats with ALS revealed 17 oxylipin alterations associated with oxidative stress and inflammation. Oxylipins may serve as biomarkers for monitoring disease progression.
Researchers at UMass Lowell found that anti-inflammatory bacteria were less abundant in people with Parkinson's disease, suggesting a potential biomarker for early diagnosis. A new study on Latinos may also uncover novel biomarkers for Alzheimer's disease.
Researchers found overactive inflammation and loss of protective mechanisms in the brains of individuals who died by suicide, supporting further exploration of anti-inflammatory medications. The study suggests that targeting these biological changes could reduce suicide risk.
A study published in The Lancet Neurology found that monitoring brain injury biomarkers and glucose variation over the first week of hospitalization can provide a more accurate picture of the pathological process. This allows for division into different groups with distinct disease trajectories and prognoses, enabling personalized trea...
A comprehensive review study identifies emerging biomarkers that mirror efforts to halt beta-cell autoimmunity, offering potential applications in clinical practice. The study's findings may improve the management of type 1 diabetes during its partial remission phase.
Researchers at Uppsala University have developed an instrument to measure 21 biomarkers for cardiovascular disease, improving prediction and treatment. The CVD-21 panel reflects functional disturbances influencing cardiovascular development and treatment outcomes.
Researchers developed a handheld, wireless biosensor to detect Alzheimer's and Parkinson's biomarkers from saliva and urine samples. The device has shown high accuracy comparable to existing state-of-the-art methods.
Researchers created a blood-based test to detect both diseases, measure viral and bacterial loads, and track treatment progress. The test aims to improve patient outcomes by catching immune reconstitution inflammatory syndrome (IRIS) earlier.
A new study has identified a brain connectivity variate that predicts psychiatric disorders in adolescents. The finding provides evidence for a transdiagnostic brain-based measure underlying individual differences in developing psychiatric disorders in early adolescence.
A new study suggests that analyzing genetic material from nearby healthy tissue may help predict lung cancer's return after treatment. The study analyzed RNA from tumor cells and adjacent, seemingly normal lung tissue and found that the expression of genes associated with inflammation was especially useful for making predictions.
Researchers at UCLA have developed a new method to engineer more powerful immune cells that can potentially be used for 'off-the-shelf' cell therapy to treat challenging cancers. Gamma delta T cells with high expressions of CD16 surface marker exhibited increased ability to recognize and kill cancer cells.
A study of 144 Covid survivors found that women with elevated inflammatory biomarkers during the acute phase were more likely to experience lingering symptoms like fatigue, breathlessness, and sleep disturbance. This research sheds light on a potential link between inflammation and persistent Long Covid symptoms in women.
Researchers found that patients with elevated NfL levels had a 91% higher risk of worsening disability with relapse within a year, and a 49% higher risk without relapse nearly two years later. The study suggests that interventions may prevent worsening symptoms by targeting nerve cell death.
A recent study published in Nature Communications validates MSIntuit CRC, an AI-driven digital pathology diagnostic, as a reliable pre-screening tool for colorectal cancer. The diagnostic accurately rules out nearly 50% of MSS patients while correctly classifying over 96% of MSI patients.
A study of 185 women found that high neighborhood deprivation was associated with changes in DNA methylation and gene expression in Black women with breast cancer. This suggests a potential link between environmental factors and biological susceptibility to chronic diseases.
Researchers found an epigenetic signature in cheek cells of obese twins that differs from their thinner siblings, suggesting a susceptibility to obesity may be written into molecular processes. The discovery could lead to a simple cheek swab test for an obesity biomarker and enable earlier prevention methods.
A new blood test has been developed to detect common deadly cancers, such as ovarian and gastroesophageal cancers, earlier with ultra-sensitive technology. The test can pick up the presence of a protein produced by cancer cells in a tiny amount of blood in less than two hours.
Researchers deciphered when genes responsible for producing 2-methylhopanes were acquired by certain groups of organisms. They found that these genes were likely present in the last common ancestor of Cyanobacteria over two billion years ago.
Researchers have discovered a novel biomarker that enables the evaluation of near-infrared photoimmunotherapy (NIR-PIT) treatment success. The biomarker uses microbubbles to track tumor vessels and measure the effectiveness of NIR-PIT, which combines antibodies and near-infrared light to destroy cancer cells.
Researchers developed a new way to diagnose bipolar disorder using a simple blood test that can identify up to 30% of patients. The test, combined with digital mental health assessments, can differentiate between major depressive disorder and bipolar disorder.
A recent study by the University of Gothenburg found no correlation between post-COVID condition and ongoing viral infection or active brain damage. The study analyzed 25 participants with confirmed post-COVID condition, six without residual symptoms, and 17 control subjects, revealing undetectable SARS-CoV-2 antigens in all samples.
Brazilian researchers found that Zika-infected mice with microcephaly have lower Ndel1 enzyme activity, which plays a key role in neuron differentiation and migration. The study suggests that Ndel1 may be a biomarker for early diagnosis of microcephaly and offers hope for treatment options.
Researchers identify cytotoxic CD4+ tissue-resident memory T cells as potential asthma triggers, particularly in older male patients. These cells can cause severe inflammatory responses and make treatment challenging.
A new study by Klick Labs reveals that AI technology can screen for Type 2 diabetes using six to 10 seconds of a person's voice, with high accuracy rates. The research used acoustic features to analyze recordings from over 18,000 participants and identified significant vocal variations between individuals with and without the condition.
A new blood test has been developed to measure the levels of critical omega-3 fatty acids in the bloodstream, providing a convenient way to assess cardiovascular and cognitive health. The Omega-3 Index (O3I) is derived from two key fatty acids, EPA and DHA, which can be obtained only from certain dietary sources.
A new study has identified two main pathways involved in Alzheimer's disease, with one acting through amyloid and tau proteins and the other based on immune system reactions. The research also found that certain genes have opposite effects in men and women, suggesting a need for further investigation.
A recent study by UTHealth Houston found that the offspring of adolescent and young adult women with a history of cancer face a higher risk of birth defects. The study examined 6,882 offspring ages 12 months and younger and found an increased risk of specific types of defects in the offspring of women with a history of cancer.
Researchers developed a wearable device to track bipolar disorder patients' skin electrical activity, detecting manic and depressed phases. The study aims to improve diagnosis and treatment with personalized, rapid interventions.
Post-Acute Sequelae of COVID-19 research aims to track long-term health symptoms in survivors. A $3.7 million grant will support the development of self-supervised deep learning technologies to recognize post-COVID lung progression phenotypes.
A recent human study found that grape consumption improved key markers of eye health in older adults, including increased Macular Pigment Optical Density (MPOD) and reduced AGEs. Regular grape intake was also shown to increase plasma antioxidant capacity and total phenolic content.
Researchers developed a low-cost, ultrasensitive blood test to detect a highly specific biomarker for multiple common cancers. The test showed promise for early cancer detection and disease monitoring, detecting levels of the biomarker in the blood of patients with many types of cancers.
Researchers identified a circulating tumor DNA (ctDNA) biomarker that can predict disease recurrence and response to treatment in patients with BRAF-negative melanoma. The study found that measuring ctDNA levels and variants can help tailor therapy and improve patient outcomes.
Researchers developed a novel approach to predict therapeutic targets for aging and age-related diseases. They trained a domain-specific BioGPT model on biomedical literature, which improved its performance in identifying prospective targets.
A VHIO-led study has identified DPPA3 as a regulator of dormant cancer cells and chemoresistance in colorectal cancer. High levels of DPPA3 are found to predict disease relapse, while HIF1 is proposed as a potential therapeutic target to sensitize CRC cells to chemotherapy.
A significant breakthrough sheds light on Parkinson's disease mechanisms, revealing that mitochondrial DNA damage triggers the spread of debilitating symptoms. The researchers' findings offer promising potential for innovative treatments and diagnostics.
Dr. Wang's research aims to extract effective disease biomarkers from large-scale brain imaging studies using advanced statistical learning approaches and scalable computing tools. The goal is to improve diagnosis, prognosis, and treatment accuracy for Alzheimer's Disease and related dementias.
Researchers identified specific blood biomarkers that can accurately identify patients with long COVID, revealing distinct immune and hormone function differences. The study also found abnormal T cell activity, reactivation of latent viruses, and reduced cortisol levels in patients with long COVID.
A study published in eBioMedicine identified 9 sets of biomarkers, both metagenomic and transcriptomic, associated with 30-day mortality in patients with severe community-acquired pneumonia. The biomarkers were validated with an accuracy of 85%, significantly higher than existing clinical prediction models.
Researchers at the University of Alabama at Birmingham found that BNP levels are high in end-stage heart failure patients with cardiogenic shock, but no longer a reliable predictor of clinical outcomes after ventricular assist device (VAD) implantation. This study suggests reevaluating routine use of BNP testing for these patients.
A new study uses AI to predict mortality rates in patients with hip fractures, identifying key biomarkers for poor outcomes. The model achieved accurate predictions using basic blood and lab test data as well as demographic information.
A team of researchers has identified a unique pattern in brain activity that reflects the recovery process in patients with treatment-resistant depression. After six months of deep-brain stimulation therapy, 90% of patients exhibited significant improvement in their symptoms and 70% no longer met the criteria for depression.
Scientists have identified a DNA methylation pattern that can accurately diagnose pancreatic cancer, distinguishing it from chronic pancreatitis. The marker, which involves six specific methylation positions in the PRKCB gene, has been validated on tissue and blood samples, offering hope for improved diagnosis and treatment.
A recent study published in the American Journal of Kidney Diseases found that lower uromodulin levels are associated with a higher risk of developing end-stage kidney disease. Participants who experienced steeper declines in uromodulin also showed an increased risk of kidney failure.
Researchers at Ann & Robert H. Lurie Children's Hospital of Chicago found a genetic biomarker that correlates with increased prevalence of anaphylaxis or severe reaction to food in patients with food allergies. The presence of α-tryptase, encoded by the TPSAB1 gene, is associated with more severe symptoms.
Researchers have identified a pattern of brain activity, or biomarker, related to clinical signs of recovery from treatment-resistant depression. The study found that 90% of patients showed significant improvement in depression symptoms after six months of DBS therapy.
A new study introduces the concept of a 'noise barometer,' measuring biological age based on epigenetic changes. The researchers found that specific cytosines show increased variability with age, indicating a biomarker for aging and disease. This approach provides a novel perspective on aging research.
A study at the Technical University of Munich found that people with long Covid experience altered blood vessels in the eye, which could be used to diagnose the condition. Persistent inflammatory responses were also linked to symptom severity and chronic inflammation.
Researchers at Lund University discovered a blood biomarker called DOPA decarboxylase (DCC) that can identify Parkinsonian diseases by measuring elevated levels in the blood, regardless of disease progression
A study at the University of Tsukuba has found that changes in brainwave activity can objectively measure depression, enabling early detection and treatment. The research used electroencephalogram (EEG) tests to track brain wave patterns over a two-to-four week period.
Researchers created a machine-learning algorithm using the largest data set of digital biomarkers for hot flashes. The predictive system delivers cooling to mitigate or fully alleviate hot flashes using Embr Wave's wearable device.
A study of nearly 20,000 patients found that the color of their phlegm can indicate the degree of inflammation in their lungs and predict future outcomes. Patients with darker green or brown-colored sputum were at a higher risk of exacerbations, hospitalizations, and death.
Researchers have demonstrated the effectiveness of five noninvasive tests for liver disease, which could revolutionize diagnosis and treatment. These tests use disease biomarkers and may enable breakthrough discoveries in developing new treatments for patients with liver disease.
Researchers found that pregnant mice experiencing copy number variation (CNV) showed similarities to aging, with biomarkers and genetic effects appearing during pregnancy and reversing after delivery. This study aims to revolutionize aging treatment by investigating the mechanisms behind post-labor rejuvenation.
Researchers have developed a new tool that measures children's looking behavior to predict expert clinical diagnosis of autism in children between 16-30 months. The tool provides objective measurements of social disability, verbal ability, and non-verbal learning skills.
The EarliPoint device is a first-of-its-kind FDA-authorized tool for early diagnosis of autism spectrum disorder. Early detection can help jumpstart targeted treatment plans, improving outcomes for individuals with autism.
Researchers have created a new method to investigate the sugars coating immune cells, which could lead to the identification of novel disease biomarkers and improved cancer detection. This technique allows for the isolation of distinct cell populations and analysis of glycosylation patterns in healthy versus diseased patients.