Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
Scientists have identified a shared gene module in people with depression and cardiovascular disease, providing new markers for both conditions. The study found that genes involved in inflammation are associated with both diseases, explaining why they often occur together.
The Alzheimer's disease treatment landscape is experiencing a significant shift, with numerous potential drugs making their way through clinical trials. Biomarkers have also emerged as a key area of focus, providing valuable information on the drug's impact and allowing for more precise guidance in future trials.
The project aims to overcome limitations of conventional semen analyses by examining mitochondrial DNA levels in sperm as a novel biomarker of sperm fitness. Researchers will evaluate relationships between mtDNA biomarkers and male reproductive health using large study samples.
Two new Review articles explore AI's application in early cancer detection, highlighting its potential to enhance diagnostic accuracy and improve treatment selection. The articles emphasize the need for a robust, multi-disciplinary approach to integrate AI into medicine.
A new study found a link between midlife racial discrimination and increased levels of Alzheimer's disease markers, including phosphorylated tau181 and neurofilament light, in older age. Researchers analyzed data from 255 Black Americans over 17 years, revealing that chronic stress from racism contributed to dementia risk.
The World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases will showcase new clinical research from over 1507 submitted abstracts. The event will offer valuable knowledge to help clinicians treat patients more effectively in their daily practice.
A new AI-based video biomarker is associated with aortic stenosis development and progression, allowing for opportunistic risk stratification across various imaging modalities. The study's findings suggest potential applications on handheld devices for early detection and intervention.
A simple blood test every five years is sufficient to screen low-risk men for prostate cancer, according to new research. Researchers found that only 0.13% of men with low PSA levels developed cancer after a decade.
Researchers have developed a novel sensing platform that boosts the sensitivity of conventional optical sensors using exceptional points (EPs), allowing for improved environmental detection and biomedical imaging. The new EP-enhanced sensing platform enables ultrahigh sensitivity without complex modifications to the sensor.
A new study by VA researchers found biomarkers of intestinal permeability and signs of bacteria in the blood of military breachers exposed to controlled blasts during training. The findings suggest a direct connection between blast exposure and intestinal problems, including cognitive symptoms.
A simple urine test can reduce the number of cystoscopies required to follow up high-risk bladder cancer patients by more than half. The test monitors for recurrence of bladder cancer by measuring levels of five target mRNAs and was found to be effective in picking up cancer recurrence before any disease was visible through a cystoscopy.
Researchers have identified specific gut microbiota signatures associated with KRAS mutations in colorectal cancer. The study suggests that these microbes may serve as non-invasive biomarkers for identifying subtypes of CRC and inform personalized treatment approaches.
Recent trials have shown that testing for tumour DNA in the blood can identify advanced bladder cancer patients who are less likely to relapse after surgery, allowing doctors to target treatments more effectively.
Researchers from the University of Southern Denmark have identified specific groups of cells driving resistance to chemotherapy in TNBC, offering new biomarkers and alternative treatment options. The studies shed light on the mechanisms behind chemoresistance and its epigenetic control.
A routine blood test that measures inflammation levels could improve diagnosis and management of debilitating autoimmune diseases. The Systemic Inflammation Index (SII) has shown high accuracy in diagnosing immunological diseases.
Researchers at NIST have developed a method using cellphone magnetometers to rapidly and cheaply measure biomedical properties for monitoring or diagnosing diseases, including glucose levels in saliva. The technique has the potential to detect environmental toxins and measure biomarkers such as histamines with high sensitivity.
Researchers developed a novel assay to study immune checkpoint molecules in blood plasma, finding elevated concentrations in patients with immune-reactive tumors who were nonresponsive to PD-1/PD-L1 blockade therapy. Soluble factors correlated with exhausted antitumor immunity and predicted therapy efficacy.
The US Army has cleared a new whole blood rapid test for traumatic brain injury assessment, allowing clinicians to obtain lab-quality results at the bedside in 15 minutes. This improvement enables faster decision-making and reduces unnecessary medical evacuations.
Newborns can be monitored for potential food allergies using a non-invasive skin tape strip technique, according to researchers at National Jewish Health. The study found abnormal lipids and proteins on the skin could indicate an increased risk of developing atopic dermatitis and food allergies.
A recent study found that eating fortified eggs had no adverse effect on blood cholesterol levels and may even have beneficial effects on cardiovascular health. Subgroup analyses revealed potential benefits among older adults and those with diabetes.
Researchers from Purdue University have discovered a new process by which petunia flowers use volatile organic compounds to communicate with neighboring plants, revealing a key role for a karrikin-like signaling pathway. The study provides insights into the plant's immune system and its ability to respond to threats.
Researchers at Klick Labs developed an algorithm to detect deepfakes with 80% accuracy by analyzing speech pause patterns, offering a solution to the growing problem of AI-generated content. The study's findings suggest that vocal biomarkers can distinguish between real and fake voices, providing a novel approach to flagging deepfakes.
Researchers at NTU Singapore have created a chip that can directly isolate blood plasma from a tube of blood in just 30 minutes, removing over 99.9% of blood cells and platelets. The device, called ExoArc, enables high-quality plasma for disease screening and research, improving diagnosis accuracy and reducing waiting times.
A new genetic test has identified patients with triple negative early-stage breast cancer who are unlikely to respond to immunotherapy drugs. The test, called ImPrintTN, can predict a patient's likelihood of responding to these treatments and help avoid severe side effects.
Researchers argue that middle age marks a shift in brain aging and should be a focus for more research. The study identified changes in the brain's structure, function, and gene expression during this period.
A Johns Hopkins Medicine-led team has developed a fluid biomarker that can detect the early stages of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The biomarker, HDGFL2, is associated with TDP-43 function loss and can be detected in blood or cerebrospinal fluid samples.
Researchers identified six novel protein biomarkers associated with incident coronary heart disease in individuals with and without type 2 diabetes. The study found that these biomarkers may offer potential new approaches to prevention and treatment of CHD.
Research reveals a dynamic pattern of gene expression in liver fibrosis, with persistent effects even during regression. The study identifies key 'hub' genes that could be developed into biomarkers for future therapies.
Researchers discover that certain bacteria can evade the immune system by circumventing antibody coating, leading to severe inflammation. The study identifies IgG2 as a key player in this process, providing potential biomarkers and targets for new treatments.
Researchers at Duke University have developed a new diagnostic platform that uses sound waves to spin an individual drop of water up to 6,000 revolutions per minute. The technique separates tiny biological particles within samples to enable new diagnostics based on exosomes.
Researchers found associations between prenatal vitamin and metal exposures and epigenetic aging biomarkers in early life. A one standard deviation increase in essential metals was associated with lower Horvath EAA at birth, while arsenic was linked to greater EAA at birth and in childhood.
A new biomarker developed by researchers at Monash University and the University of Birmingham can accurately detect when someone has not slept for 24 hours. The test has a 99.2% probability of being correct and could inform future tests to identify sleep-deprived drivers, reducing the risk of accidents and fatalities.
Researchers found associations between proteins involved in fibrinolysis and the development of acute respiratory distress syndrome. Biomarkers, such as PAI-1 and uPA/PAI-1 complex levels, can identify patients at risk of severe COVID-19.
Researchers at the University of Illinois have identified a neural-specific protein, PSD-95, as an early biomarker for Alzheimer's disease. The study found that inhibiting PSD-95 slowed seizure activity in mice with amyloid-beta pathology, suggesting potential therapeutic targets for early-stage Alzheimer's.
A study published by the University of Florida suggests a connection between elevated amyloid blood levels and subtle brain microstructural changes in individuals without dementia. Researchers used diffusion MRI to detect free-water in the brain, revealing associations with structural abnormalities even when PET scans were negative.
A new biomarker, N-methylpyridinium, has been validated for coffee consumption and is considered a reliable qualitative biomarker. The substance is specific to roasted Arabica and Robusta coffee and can be easily detected in various body fluids after coffee consumption.
The study investigates how different genes related to autism spectrum disorders affect the brain's neural circuits, resulting in heightened sensitivity to sounds. The researchers aim to identify a potential biomarker for sensory hypersensitivity and develop treatments using optogenetics and minocycline.
Researchers identified six blood biomarkers associated with increased cardiovascular risk in patients with rheumatoid arthritis. These biomarkers improved the ability to predict arterial inflammation, an indicator of cardiovascular risk, compared to standard clinical indices.
A groundbreaking study has unveiled promising pathways to simplified Alzheimer's diagnosis using blood tests, demonstrating strong correlations with brain amyloid plaques across diverse populations. The Bio-Hermes study shows that blood tests can be used to identify persons with amyloid plaques in the brain, regardless of symptoms or r...
Researchers at UCSF have identified AF1q as a universal biomarker for neuroblastoma, a highly aggressive and fatal form of childhood cancer. High-risk cases have a five-year survival rate of just 50%. The study found that silencing AF1q in neuroblastoma cells induces cell death and weakens tumor progression.
PandaOmics uses advanced AI algorithms to process vast quantities of diverse data, performing gene and pathway analysis and target predictions. The platform has been extensively validated in multiple therapeutic areas, including oncology, inflammation, and immunology.
A recent study from Brigham and Women's Hospital found that a glycan biomarker of IgG is an important predictor for cardiovascular diseases. The research team discovered that the sugar coatings on IgG were directly related to the risk of a CVD event, most likely through inflammatory effects.
Research identifies interferon gamma (IFN-γ) as a potential biomarker for Long COVID fatigue and highlights an immunological mechanism underlying the disease. High levels of IFN-γ persisted in some patients for up to 31 months, coinciding with symptom resolution after vaccination.
A new study from Edith Cowan University found that a blood test using joint cumulative high-sensitivity C-reactive protein and monocyte to high-density lipoprotein ratio can predict type 2 diabetes risk more effectively. Females were most at risk with significant interaction between MHR and CRP observed.
Researchers identified a putative paclitaxel response predictive biomarker for glioblastoma and breast cancer using the whole genome CRISPR knockout screen. The biomarker candidate was validated in two independent breast cancer patient cohorts that received taxane treatment.
A new blood test has been shown to diagnose Alzheimer's disease pathology as accurately as FDA-approved spinal fluid tests, making early diagnosis and treatment accessible to more people. The blood test measures levels of Alzheimer's proteins in the blood, detecting molecular signs of the disease even before symptoms appear.
A new blood test uses the biomarker BD-tau to predict functional outcomes in patients after ischemic stroke. Higher levels of BD-tau are associated with more severe outcomes.
A new hand-held device screens for breast cancer biomarkers from a tiny spit sample, offering quick and efficient results. The portable tool distinguishes between healthy tissue, early cancer, and advanced cancer in a small group of women.
Researchers developed a framework for standardizing biomarker development and validation to improve the prediction of age-related health outcomes. The study highlights the need for expanded focus on functional decline, frailty, chronic disease, and disability, and calls for harmonization of omic data to enhance reliability.
A recent study published in the Journal of Clinical Medicine identifies potential biomarkers for ME/CFS diagnosis and treatment. Researchers found that patients can be divided into subgroups based on immune system function, revealing differences in intestinal barrier function and immune competence.
Researchers identify a promising prognostic biomarker for lung cancer using circulating tumor DNA-based minimal residual disease detection. The study found that this method can effectively guide treatment decisions and predict recurrence risk, potentially modifying the lung cancer treatment paradigm.
A new study proposes a framework for standardizing biomarkers of aging, which could help translate them into clinically actionable tools. The framework suggests using multi-omic approaches and considering associations with other health factors to improve predictive performance and reliability.
Researchers have developed a hand-held biosensor that can detect breast cancer biomarkers from saliva with high accuracy and efficiency. The device is portable, reusable, and cost-effective, making it an excellent choice for communities or hospitals without access to advanced technologies like MRI.
The Redox Medicine Society will host its 26th International Conference on Redox Medicine in Paris, featuring keynotes, sessions, and round-table discussions on advancements and applications in clinical settings. The conference aims to facilitate innovation and excellence in the field of redox medicine.
Researchers identified blood proteomic markers associated with hepatocellular carcinoma (HCC) in patients with cirrhosis. The study found a set of biomarkers, including TGF-β driven mechanistic biomarkers and Myostatin and Pyruvate Kinase M2, which may stratify risk for HCC.
A new blood test developed by Indiana University School of Medicine has identified biomarkers that can objectively measure schizophrenia severity and predict future risk. The test enables personalized treatment matching, reducing uncertainty and improving patient outcomes.
A new nanocomposite porous antifouling coating has been developed, enabling higher numbers of biomarker-detecting probes and up to 17-fold higher sensitivities than previous best-in-class sensors. This breakthrough broadens the diagnostic horizon for multiplexed electrochemical sensors across multiple diseases.
New findings from a study on ketamine's efficacy in treating severe depression reveal that 52% of participants achieved remission after just three infusions. The study also found that half of those who had thought often of suicide before receiving ketamine experienced a dramatic drop in suicidal impulses.
Researchers found elevated PROX1 levels in advanced colon adenocarcinoma, correlating with poor prognosis. PROX1 modulates CRC cell behavior, influencing invasiveness and survival outcomes. The combined PROX1/α-SMA gene set emerges as a potential CRC prognostic marker.
Researchers develop epigenetic clocks based on regional disorder of DNA methylation patterns, identifying common responses and critical differences from canonical clocks. These findings suggest a fundamental decoupling of epigenetic aging processes.