Articles tagged with Biomarkers
A study from Michigan Medicine reveals a connection between neutrophil activation and severe cytokine release syndrome (CRS), a potentially life-threatening reaction to CAR T-Cell therapy. Researchers identified biomarkers of NETosis, a process in which neutrophils create webs that may contribute to CRS.
Researchers have developed a way to classify host immunity in individuals, enabling the early identification of those who won't respond well to regular vaccines. This allows for tailored vaccine regimes to provide long-lasting immunity, reducing influenza-related illness and healthcare costs.
A recent study found that work-life imbalance significantly predicts higher triglycerides and lower HDL levels in midlife and older adults. This suggests that spillover effects of workplace stress on home life can contribute to physiological changes linked to cardiovascular diseases. The research highlights the importance of organizati...
A team of researchers developed an eye-tracking biomarker model that can differentiate children with autism from those with other neurodevelopmental disabilities. The model achieved high sensitivity and specificity, allowing for more accurate diagnoses.
Researchers at the University of Toronto discovered a new RNA virus, Apocryptovirus odysseus, associated with severe inflammation in humans infected with Toxoplasma gondii. The virus is found in two hypervirulent strains of the parasite, exacerbating toxoplasmosis disease and triggering an immune response.
Researchers from Ben-Gurion University of the Negev have discovered a link between proteomic biomarkers and liver fat percentage, which may improve patient monitoring and therapy targeting for NAFLD. The study, conducted over 18 months, found that specific protein changes were independently associated with liver fat relative change.
A groundbreaking study has uncovered a significant breakthrough in the diagnosis and monitoring of kidney diseases associated with nephrotic syndrome. Researchers identified anti-nephrin autoantibodies as a reliable biomarker for tracking disease progression, opening new avenues for personalized treatment approaches.
Research finds insulin levels correlate with triglycerides, ApoB, non-HDL cholesterol, and free cholesterol in women with atherosclerotic coronary disease. The study suggests these laboratory-associated flags indicate early coronary atherosclerosis in both diabetic and non-diabetic women.
Researchers have identified collagen features as valuable biomarkers for evaluating melanoma immunotherapy response. Single-fiber characteristics were found to be more sensitive to treatment-induced changes than bulk collagen features, offering insights into collagen remodeling over time.
Researchers developed a game-changing blood test that can quickly and accurately identify large vessel occlusion strokes, which have the potential to bring life-saving care to patients globally. The test combines biomarkers with a clinical score to detect strokes with 93% specificity and 81% sensitivity.
Researchers found elevated expression of RPGRIP1L in invasive breast cancer specimens, correlating with shorter survival times and unfavorable clinicopathological features. The study identified 50 genes and 15 proteins related to RPGRIP1L expression, including those involved in immune response and metabolism.
Researchers found cyclin D1 expression in patients with penile cancer (PC) is associated with clinical and histopathological features. Patients with cyclin D1 expression had lower disease-free survival compared to the cyclin D1-negative group.
The IV-Lab project aims to develop a miniaturized, implantable multi-sensors device to monitor blood vessel health. The device will integrate multiple sensors measuring blood pressure, vessel deformation, and cardiovascular biomarkers, enabling timely and personalized treatment for patients with cardiovascular diseases.
A new biomarker, miR-519a-3p, has been discovered to detect Alzheimer's disease in its asymptomatic stages. The molecule is linked to the expression of cellular prion protein, which is deregulated in people with neurodegenerative diseases.
A new PET imaging biomarker, Gal-1, has been identified to predict the tumor responses before starting immune checkpoint blockade therapy. This enables targeted interventions and improves patient outcomes by facilitating patient stratification and optimizing immunotherapy.
Researchers developed a synthetic biomarker technology that can differentiate between prior Zika and dengue virus infections. The technology, using epitope surrogates, correctly identified people previously infected with Zika virus 85.3% of the time.
Cardiovascular biomarkers strongly associated with cardiovascular events and mortality. Adding biomarkers to established risk factors improved heart failure and mortality prediction, but only slightly enhanced atherosclerotic disease risk prediction.
Researchers have developed a method to use intense ultrasound to extract genetic information from cells, allowing for the detection of cancer biomarkers in blood samples. This approach could enable earlier detection and treatment of cancer, as well as reduce the need for painful biopsies.
Researchers have developed a new method to detect malignant melanoma using a microneedle patch that measures tyrosinase enzyme levels in the skin. This non-invasive technique has the potential to provide faster and more reliable results compared to traditional biopsies.
Researchers discuss therapeutic opportunities for hypermutated urothelial carcinomas that are resistant to immunotherapy, including the potential of targeted therapies. High TMB is associated with defects in mismatch repair proteins and can lead to increased sensitivity to cancer treatments.
Australian researchers have identified biomarkers that can predict which children are likely to outgrow their peanut allergy. The study found that two-thirds of children with a peanut allergy remain allergic by age 10, but most who naturally outgrew their allergy did so by age six.
Researchers found associations between inflammatory and metabolic biomarkers and accelerated aging, with GlycA and GrimAge showing robust correlations. The study provides insight into the relationship between aging and cardiometabolic health, potentially informing vulnerable populations.
Researchers created a corticolimbic index tool that categorizes Alzheimer's disease into three subtypes based on brain changes. The study found demographic and clinical differences among sex, age at onset, and rate of cognitive decline.
A massive study identifies new biomarkers for renal cell carcinoma subtypes, improving diagnosis and treatment. The researchers' integrative analysis of proteogenomic datasets reveals molecular features shared by clear cell and non-clear cell RCC tumors, as well as unique features to various subtypes.
A new screening algorithm combining maternal history, ultrasound data and several tests for blood markers may predict most preeclampsia cases in the first trimester of pregnancy. The study found that personalized risk-based treatment decisions may improve adherence to preventative measures.
A new study found extensive alternative splicing of messenger RNA in untreated multiple sclerosis patients compared to healthy controls. Interferon-ß therapy corrected dysregulated alternative splicing, linking it to future clinical exacerbations.
Researchers analyzed flour and rice stored in Brazilian homes and found six mycotoxins, including aflatoxin B1 and deoxynivalenol, at high levels, posing significant health risks. The study highlights the importance of proper food storage to prevent contamination.
A recent study led by UC Davis Health researchers provides new insights into the molecular changes linked to 22q11.2 deletion syndrome, a rare genetic condition that can lead to psychosis, ADHD, and other conditions. The study identified two biomarkers, taurine and arachidonic acid, which could predict likelihood of psychosis in patien...
Researchers at UCLA Health have developed a potential biomarker for stroke risk using a network of inflammatory molecules in the blood. The study, published in the journal Stroke, found that patients with higher concentrations of these molecules had an 84% chance of experiencing a stroke during their lifetime.
A new study suggests that proteins detectable in the blood could improve predictions about risk of liver cancer, potentially leading to earlier therapeutic interventions. The researchers used proteomics to develop a prediction model and identified 56 plasma proteins associated with liver cancer.
This study analyzed differentially expressed genes from three datasets to identify hub genes associated with gastric adenocarcinoma. The analysis revealed that genes such as ERBB4 and MAPT were linked to GC progression and had poor overall survival, suggesting potential therapeutic targets.
Researchers at the University of Leipzig Medical Center have identified biomarkers associated with the response to CAR T cell therapy in multiple myeloma. These biomarkers enable patients to predict their likelihood of responding well or less well to treatment before initiating therapy.
Scientists have identified a shared gene module in people with depression and cardiovascular disease, providing new markers for both conditions. The study found that genes involved in inflammation are associated with both diseases, explaining why they often occur together.
The Alzheimer's disease treatment landscape is experiencing a significant shift, with numerous potential drugs making their way through clinical trials. Biomarkers have also emerged as a key area of focus, providing valuable information on the drug's impact and allowing for more precise guidance in future trials.
The project aims to overcome limitations of conventional semen analyses by examining mitochondrial DNA levels in sperm as a novel biomarker of sperm fitness. Researchers will evaluate relationships between mtDNA biomarkers and male reproductive health using large study samples.
Two new Review articles explore AI's application in early cancer detection, highlighting its potential to enhance diagnostic accuracy and improve treatment selection. The articles emphasize the need for a robust, multi-disciplinary approach to integrate AI into medicine.
A new study found a link between midlife racial discrimination and increased levels of Alzheimer's disease markers, including phosphorylated tau181 and neurofilament light, in older age. Researchers analyzed data from 255 Black Americans over 17 years, revealing that chronic stress from racism contributed to dementia risk.
The World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases will showcase new clinical research from over 1507 submitted abstracts. The event will offer valuable knowledge to help clinicians treat patients more effectively in their daily practice.
A new AI-based video biomarker is associated with aortic stenosis development and progression, allowing for opportunistic risk stratification across various imaging modalities. The study's findings suggest potential applications on handheld devices for early detection and intervention.
Researchers have developed a novel sensing platform that boosts the sensitivity of conventional optical sensors using exceptional points (EPs), allowing for improved environmental detection and biomedical imaging. The new EP-enhanced sensing platform enables ultrahigh sensitivity without complex modifications to the sensor.
A new study by VA researchers found biomarkers of intestinal permeability and signs of bacteria in the blood of military breachers exposed to controlled blasts during training. The findings suggest a direct connection between blast exposure and intestinal problems, including cognitive symptoms.
A simple urine test can reduce the number of cystoscopies required to follow up high-risk bladder cancer patients by more than half. The test monitors for recurrence of bladder cancer by measuring levels of five target mRNAs and was found to be effective in picking up cancer recurrence before any disease was visible through a cystoscopy.
A simple blood test every five years is sufficient to screen low-risk men for prostate cancer, according to new research. Researchers found that only 0.13% of men with low PSA levels developed cancer after a decade.
Recent trials have shown that testing for tumour DNA in the blood can identify advanced bladder cancer patients who are less likely to relapse after surgery, allowing doctors to target treatments more effectively.
Researchers have identified specific gut microbiota signatures associated with KRAS mutations in colorectal cancer. The study suggests that these microbes may serve as non-invasive biomarkers for identifying subtypes of CRC and inform personalized treatment approaches.
Researchers from the University of Southern Denmark have identified specific groups of cells driving resistance to chemotherapy in TNBC, offering new biomarkers and alternative treatment options. The studies shed light on the mechanisms behind chemoresistance and its epigenetic control.
A routine blood test that measures inflammation levels could improve diagnosis and management of debilitating autoimmune diseases. The Systemic Inflammation Index (SII) has shown high accuracy in diagnosing immunological diseases.
Researchers developed a novel assay to study immune checkpoint molecules in blood plasma, finding elevated concentrations in patients with immune-reactive tumors who were nonresponsive to PD-1/PD-L1 blockade therapy. Soluble factors correlated with exhausted antitumor immunity and predicted therapy efficacy.
The US Army has cleared a new whole blood rapid test for traumatic brain injury assessment, allowing clinicians to obtain lab-quality results at the bedside in 15 minutes. This improvement enables faster decision-making and reduces unnecessary medical evacuations.
Researchers at NIST have developed a method using cellphone magnetometers to rapidly and cheaply measure biomedical properties for monitoring or diagnosing diseases, including glucose levels in saliva. The technique has the potential to detect environmental toxins and measure biomarkers such as histamines with high sensitivity.
Newborns can be monitored for potential food allergies using a non-invasive skin tape strip technique, according to researchers at National Jewish Health. The study found abnormal lipids and proteins on the skin could indicate an increased risk of developing atopic dermatitis and food allergies.
A recent study found that eating fortified eggs had no adverse effect on blood cholesterol levels and may even have beneficial effects on cardiovascular health. Subgroup analyses revealed potential benefits among older adults and those with diabetes.
Researchers at Klick Labs developed an algorithm to detect deepfakes with 80% accuracy by analyzing speech pause patterns, offering a solution to the growing problem of AI-generated content. The study's findings suggest that vocal biomarkers can distinguish between real and fake voices, providing a novel approach to flagging deepfakes.
Researchers at NTU Singapore have created a chip that can directly isolate blood plasma from a tube of blood in just 30 minutes, removing over 99.9% of blood cells and platelets. The device, called ExoArc, enables high-quality plasma for disease screening and research, improving diagnosis accuracy and reducing waiting times.
Researchers from Purdue University have discovered a new process by which petunia flowers use volatile organic compounds to communicate with neighboring plants, revealing a key role for a karrikin-like signaling pathway. The study provides insights into the plant's immune system and its ability to respond to threats.
A new genetic test has identified patients with triple negative early-stage breast cancer who are unlikely to respond to immunotherapy drugs. The test, called ImPrintTN, can predict a patient's likelihood of responding to these treatments and help avoid severe side effects.
Researchers argue that middle age marks a shift in brain aging and should be a focus for more research. The study identified changes in the brain's structure, function, and gene expression during this period.
A Johns Hopkins Medicine-led team has developed a fluid biomarker that can detect the early stages of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The biomarker, HDGFL2, is associated with TDP-43 function loss and can be detected in blood or cerebrospinal fluid samples.
Researchers identified six novel protein biomarkers associated with incident coronary heart disease in individuals with and without type 2 diabetes. The study found that these biomarkers may offer potential new approaches to prevention and treatment of CHD.
Research reveals a dynamic pattern of gene expression in liver fibrosis, with persistent effects even during regression. The study identifies key 'hub' genes that could be developed into biomarkers for future therapies.