Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new blood test has been shown to diagnose Alzheimer's disease pathology as accurately as FDA-approved spinal fluid tests, making early diagnosis and treatment accessible to more people. The blood test measures levels of Alzheimer's proteins in the blood, detecting molecular signs of the disease even before symptoms appear.
Research identifies interferon gamma (IFN-γ) as a potential biomarker for Long COVID fatigue and highlights an immunological mechanism underlying the disease. High levels of IFN-γ persisted in some patients for up to 31 months, coinciding with symptom resolution after vaccination.
A new study from Edith Cowan University found that a blood test using joint cumulative high-sensitivity C-reactive protein and monocyte to high-density lipoprotein ratio can predict type 2 diabetes risk more effectively. Females were most at risk with significant interaction between MHR and CRP observed.
Researchers identified a putative paclitaxel response predictive biomarker for glioblastoma and breast cancer using the whole genome CRISPR knockout screen. The biomarker candidate was validated in two independent breast cancer patient cohorts that received taxane treatment.
A new blood test uses the biomarker BD-tau to predict functional outcomes in patients after ischemic stroke. Higher levels of BD-tau are associated with more severe outcomes.
A new hand-held device screens for breast cancer biomarkers from a tiny spit sample, offering quick and efficient results. The portable tool distinguishes between healthy tissue, early cancer, and advanced cancer in a small group of women.
Researchers developed a framework for standardizing biomarker development and validation to improve the prediction of age-related health outcomes. The study highlights the need for expanded focus on functional decline, frailty, chronic disease, and disability, and calls for harmonization of omic data to enhance reliability.
A recent study published in the Journal of Clinical Medicine identifies potential biomarkers for ME/CFS diagnosis and treatment. Researchers found that patients can be divided into subgroups based on immune system function, revealing differences in intestinal barrier function and immune competence.
Researchers identify a promising prognostic biomarker for lung cancer using circulating tumor DNA-based minimal residual disease detection. The study found that this method can effectively guide treatment decisions and predict recurrence risk, potentially modifying the lung cancer treatment paradigm.
A new study proposes a framework for standardizing biomarkers of aging, which could help translate them into clinically actionable tools. The framework suggests using multi-omic approaches and considering associations with other health factors to improve predictive performance and reliability.
Researchers have developed a hand-held biosensor that can detect breast cancer biomarkers from saliva with high accuracy and efficiency. The device is portable, reusable, and cost-effective, making it an excellent choice for communities or hospitals without access to advanced technologies like MRI.
The Redox Medicine Society will host its 26th International Conference on Redox Medicine in Paris, featuring keynotes, sessions, and round-table discussions on advancements and applications in clinical settings. The conference aims to facilitate innovation and excellence in the field of redox medicine.
Researchers identified blood proteomic markers associated with hepatocellular carcinoma (HCC) in patients with cirrhosis. The study found a set of biomarkers, including TGF-β driven mechanistic biomarkers and Myostatin and Pyruvate Kinase M2, which may stratify risk for HCC.
A new nanocomposite porous antifouling coating has been developed, enabling higher numbers of biomarker-detecting probes and up to 17-fold higher sensitivities than previous best-in-class sensors. This breakthrough broadens the diagnostic horizon for multiplexed electrochemical sensors across multiple diseases.
New findings from a study on ketamine's efficacy in treating severe depression reveal that 52% of participants achieved remission after just three infusions. The study also found that half of those who had thought often of suicide before receiving ketamine experienced a dramatic drop in suicidal impulses.
A new blood test developed by Indiana University School of Medicine has identified biomarkers that can objectively measure schizophrenia severity and predict future risk. The test enables personalized treatment matching, reducing uncertainty and improving patient outcomes.
Researchers found elevated PROX1 levels in advanced colon adenocarcinoma, correlating with poor prognosis. PROX1 modulates CRC cell behavior, influencing invasiveness and survival outcomes. The combined PROX1/α-SMA gene set emerges as a potential CRC prognostic marker.
Researchers investigate biomarkers from genome, transcriptome, proteins, and metabolites to help tackle the high mortality rate of pediatric sepsis. The review highlights potential biomarkers, including genomics, transcriptomics, proteomics, and metabolomics.
Researchers develop epigenetic clocks based on regional disorder of DNA methylation patterns, identifying common responses and critical differences from canonical clocks. These findings suggest a fundamental decoupling of epigenetic aging processes.
Researchers mapped changes in tumor-related bacteria to uncover potential strategies to combat the rise of young-onset colorectal cancer. Unique bacterial signatures were found in tumors from younger patients, including Akkermansia and Bacteroides, which are more likely to have left-sided, rectal, and advanced stage tumors.
Researchers developed a molecular predictor of radiation response using cell line data and machine learning-based approaches, capturing a wider range of biological processes. The new gene signature has the potential to aid decision-making, personalize treatments, and improve outcomes for various types of cancers.
A phase II clinical trial found Muse cell-based product CL2020 to be highly tolerated and improved ALS symptoms, but may not halt disease progression. The treatment's efficacy depends on combining it with other drugs for future treatments.
Researchers identified kynurenine as a key biomarker affecting RBC storage quality and efficacy. High levels of kynurenine indicate fragile blood, prone to rupture, while lower levels suggest better storage stability.
Researchers developed a method to track changes in maternal heart rate variability using non-invasive wearable devices. These changes can potentially predict preterm birth, providing a new digital biomarker for early detection.
A multicenter study confirms that up to 50% of ALS patients develop cognitive symptoms, with 35.5% also presenting pathological features of frontotemporal dementia. The study highlights the marked heterogeneity of neuropathological characteristics, suggesting possible different pathophysiological mechanisms.
Researchers found XRCC1 to have both positive and negative correlations with prognosis across different tumors. The study also revealed associations between XRCC1 expression and DNA methylation patterns, TMB, MSI, immune cell infiltration levels, and immune checkpoint gene expression.
A study of over 1.6 million ED visits found that nearly two-thirds of low-risk pulmonary embolism patients were hospitalized, despite evidence suggesting safety in outpatient management. Researchers suggest further investigation into ED triage decisions to improve appropriate use of outpatient care.
Researchers have identified UCHL1, a protein found in highly aggressive neuroendocrine carcinomas and neuroblastoma, as a potential molecular biomarker for diagnosing these cancers and predicting responses to therapy. Targeting UCHL1 with inhibitors has been shown to delay the growth and spread of these tumors in pre-clinical models.
A international academic consortium has identified 13 biomarkers that significantly improve the ability to accurately predict cardiovascular disease risk in people with type 2 diabetes. The standout biomarker was N-terminal pro b-type natriuretic peptide (NT-proBNP), which is currently used to monitor heart failure status in patients.
New biomarkers have been discovered to improve the diagnosis and monitoring of lupus nephritis, a severe manifestation of systemic lupus erythematosus. The study identified six novel urine biomarkers that can detect even low concentrations of proteins in the urine.
Researchers found that the complement system remains activated in Long Covid patients, causing cell damage and tissue destruction. This abnormal activity can lead to thromboinflammation and other symptoms of the condition.
A new study reveals that RNA binding motif protein X-linked (RBMX) plays a crucial role in predicting cancer prognosis and response to immunotherapy. Abnormal expression of RBMX is associated with immune regulation, tumor microenvironment, and therapeutic effects of immune checkpoint inhibitors.
A new study found that stress drives up inflammation in the body, which is linked to metabolic syndrome. Stress management techniques may be a way to improve biological health outcomes. The research suggests that reducing inflammation can help mitigate the connection between stress and metabolic syndrome.
Researchers found that two common biomarkers, global longitudinal strain and N-terminal-pro-B-type natriuretic peptide, can identify asymptomatic childhood cancer survivors at elevated risk of declining heart muscle function. These biomarkers may lead to earlier treatment to prevent further heart damage.
Researchers at UC Davis found that men with FMR1 premutation who experienced reduced executive function were at higher likelihood of developing fragile X-associated tremor/ataxia syndrome. Executive function challenges, particularly working memory and organization issues, were strongly associated with the development of FXTAS.
Researchers unveiled a previously unknown effect of PG545 in ovarian cancer cells, inducing DNA damage and promoting autophagic degradation of RAD51. This breakthrough could aid in selecting the most appropriate treatments for ovarian cancer patients with PARPi resistance.
A combination of 11 proteins can predict long-term disability outcomes in multiple sclerosis, making it possible to tailor treatments to individual patients. The study identified a specific protein, neurofilament light chain, as a reliable biomarker for disease activity.
Researchers developed a novel test that detects single ⍺-synuclein fibrils in patient samples to identify patients with Parkinson's disease earlier. This breakthrough has the potential to create early applicable molecular diagnostics, improve clinical trials, and facilitate drug screening for neurodegenerative diseases.
The £30M ADVANCE study aims to accelerate the development of new therapies for people with liver cirrhosis by identifying translational biomarkers. Researchers will enroll 200 patients with cirrhosis and use advanced techniques to analyze gene expression, blood tests, and MRI scans.
Researchers used OCTA to visualize retinal blood vessel changes in migraine patients during and between attacks. Blood flow decreases were found, with asymmetrical flow correlated to headache pain side.
A new consortium, co-led by Florian Rieder, MD, and Vipul Jairath, MD, will create clinical care pathways toward drug development and improve disease management for patients with Crohn's disease and permanent ileostomy. The EndO-trial Consortium aims to develop effective drugs and measure treatment outcomes using patient-reported outco...
A new study found that COVID-19 infection can lead to persistent brain injury markers in the blood even months after recovery from hospitalization. Patients with neurological complications during the acute phase of the illness showed robust biomarker evidence of ongoing neuroglial injury.
Researchers found that baseline amyloid burden and brain health are stronger predictors of Alzheimer's progression than age alone. The study also showed that individuals with higher amyloid levels developed dementia two years earlier than those without.
Scientists at the University of Washington School of Medicine developed a novel protein design approach using AI, creating proteins that bind to challenging biomarkers with exceptionally high affinity and specificity. The breakthrough has implications for drug development, disease diagnosis, and environmental monitoring.
Zarbio and Georgia State University scientists propose a framework for understanding Alzheimer's disease, linking molecular mechanisms, beta-amyloid biomarkers, and diagnosis. The Amyloid Degradation Toxicity Hypothesis resolves long-standing paradoxes in AD research.
A new study by UCL researchers suggests that a vest mapping the heart's electrical activity could help identify people at high risk of sudden cardiac death. The electrocardiographic imaging (ECGI) vest combines signals with MRI images to generate 3D models, potentially predicting risk factors for life-threatening heart rhythms.
Researchers have identified sST2 and suPAR in the blood of dengue patients, which could accurately predict patients at risk of severe dengue. The test kits would improve patient outcomes by distinguishing between non-life-threatening cases and severe dengue, requiring hospitalization.
A study found that the common drug Entresto (sacubitril/valsartan) increases plasma Aβ42 and Aβ40 levels in patients with cardiac failure, making them falsely positive on a debated Alzheimer's blood test. This could lead to misclassification of patients as having Alzheimer's disease.
Researchers have identified promising treatment candidates for morphine tolerance and cancer, as well as a biomarker for kidney injury. A monoclonal antibody targeting the mu-opioid receptor has been shown to alleviate morphine tolerance and physical dependence, while inducing excessive mitochondrial fission in tumor cells. Additionall...
Researchers at the University of Gothenburg have developed a way to distinguish different types of structural changes in glycan molecules linked to various cancers. The AI-enhanced method uses mass spectrometry to identify patterns in data sets, providing a precise answer to what will change for a specific disease.
Researchers at UVA Health System created an 'atlas of atherosclerosis' revealing critical processes that form harmful plaque buildup. The study provides unprecedented insights into atherosclerosis and its impact on coronary artery disease, heart attacks, and strokes.
A study found that saliva biomarkers sTNFR2 and sIgA can effectively detect pain in people with dementia, providing an alternative to invasive methods. The researchers discovered a decrease in sTNFR2 levels and an increase in sIgA in patients with dementia compared to a control group.
Multiple sclerosis affects over 2.8 million worldwide, and EU funding will investigate viral infections like EBV as potential causes and co-factors. The BEHIND-MS consortium aims to develop new cell models to test hypotheses on the disease's development.
Researchers at the Center for Development of Functional Materials created a sensor to monitor metronidazole levels in organisms and the environment. The sensor, combining magnetic fluorescent nanoparticles, showed good sensitivity and practical advantages, enabling real-time analysis and ease of handling.
Researchers use AI to develop dynamic modeling of brain graphs, capturing dynamics in continuous time for more accurate predictions and personalized treatment of brain diseases. The project aims to track disease development in individual patients and identify biomarkers associated with brain disorders.
Researchers used brain imaging and machine learning to identify distinct patterns of brain connectivity in people with autism spectrum disorder (ASD), taking into account individual differences. The study reveals that certain brain features are shared across subtypes, while others are unique to specific individuals.
Researchers developed a machine learning model that accurately predicted improvements in brain health using neural biomarkers. The study achieved 90% accuracy and confirmed a functional relationship between the BrainHealth Index and neural markers.
A deep learning AI model developed using mammographic images alone accurately predicted both ductal carcinoma in situ (DCIS) and invasive carcinoma, showing no bias across multiple races. The model outperformed traditional risk models in predicting breast cancer risk, providing a more accurate and equitable assessment.
Researchers have developed a device that detects glucose and adenosine monophosphate biomarkers in saliva with high sensitivity, enabling easy at-home health monitoring. The electrochemical aptamer-based biosensor is simple, accurate, and stable, making it suitable for use without laboratory equipment.
A new study identified 60 alcohol-associated circulating metabolites that appear to produce counteractive effects on the risk of heart disease. The findings suggest that moderate alcohol consumption may trigger changes in metabolomic profiles, yielding both beneficial and harmful outcomes.