About The Study: In this single-center cohort study, both bariatric surgery and semaglutide or tirzepatide treatment were associated with substantial fat mass loss, moderate fat-free mass (FFM) loss, and improved FFM to fat mass ratio. These findings provide evidence to guide interventions aimed at preserving FFM while promoting fat loss.
Corresponding Authors: To contact the corresponding authors, email Jason M. Samuels, MD, ( jason.m.samuels@vumc.org ) and Danxia Yu, PhD, ( danxia.yu@vumc.org ).
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(doi:10.1001/jamanetworkopen.2025.53323)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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