What The Study Did: In this systematic review and meta-analysis of 22 studies, the risk of immediate allergic reactions and severe immediate reactions or anaphylaxis associated with a second dose of a SARS-CoV-2 mRNA vaccine was low among 1,366 patients who experienced an immediate allergic reaction to their first dose.
Authors: Matthew Greenhawt, M.D., M.B.A., M.Sc., of the University of Colorado School of Medicine in Aurora, is the corresponding author.
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(doi:10.1001/jamainternmed.2021.8515)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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JAMA Internal Medicine