In a study that included 31 male participants, 18-35 years of age, researchers report that the administration of ibuprofen resulted in the development of compensated hypogonadism, a clinical condition that affects reproductive health in men; using testis explants and a human steroidogenic cell line, the authors found that ibuprofen modified hormonal profiles through selective transcriptional repression of testicular endocrine cells and induced a state of compensated hypogonadism.
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Article #17-15035: "Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism," by David Møbjerg Kristensen et al.
MEDIA CONTACT: David Møbjerg Kristensen, University of Copenhagen, DENMARK; e-mail: < david@moebjerg.com >; Bernard Jégou, Institut national de la santé et de la recherche médicale, Paris, FRANCE; tel: +33-6-08-78-34-68; e-mail: < Bernard.jegou@inserm.fr >
Proceedings of the National Academy of Sciences