There is an increasing interest in Parkinson's disease (PD) treatment by increasing dopamine content and reducing dopaminergic metabolites in the brain. Xuming Yang, Shanghai Municipal Hospital of Traditional Chinese Medicine, China and his team detected dopamine content and dopaminergic metabolites in the midbrain of PD rats, which were treated by neural stem cell (NSC) transplantation and Zhichan decoction administration, using high-performance liquid chromatography, and determined global optimization of dihydroxyphenylacetic acid and homovanillic acid levels using genetic algorithm. Results showed that NSC transplantation and Zhichan decoction administration increased dihydroxyphenylacetic acid levels up to 10-fold, while NSC transplantation alone resulted in a 3-fold increment. Homovanillic acid levels showed no apparent change. These findings indicate that after NSC transplantation in PD rats, Zhichan decoction can promote differentiation of NSCs into dopaminergic neurons. Related results were published in Neural Regeneration Research (Vol. 9, No. 9, 2014).
Article: " Zhichan decoction induces differentiation of dopaminergic neurons in Parkinson's disease rats after neural stem cell transplantation," by Huifen Shi1, Jie Song2, Xuming Yang3 (1 Department of Neurology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China; 2 Department of Encephalopathy, Liu'an Hospital of Traditional Chinese Medicine, Liu'an, Anhui Province, China; 3 College of Acupuncture and Massage, Shanghai University of Traditional Chinese Medicine, Shanghai, China) Shi HF, Song J, Yang XM. Zhichan decoction induces differentiation of dopaminergic neurons in Parkinson's disease rats after neural stem cell transplantation. Neural Regen Res. 2014;9(9):931-936.
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