Articles tagged with Dopaminergic Neurons
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University of Florida researchers have identified a new potential target for treating methamphetamine addiction by modulating the immune system. Using immune-modulating medicines, they were able to mitigate the effects of TNF and dopamine release in mouse brain specimens.
A research team at Max-Planck-Gesellschaft found that pregnant mice exposed to fatty food smells developed more pronounced obesity and insulin resistance in their offspring. The brains of the offspring showed similarities to those of obese adult mice, suggesting a potential link between maternal diet and child health.
Scientists at Gladstone Institutes discovered that overactivated dopamine neurons degenerate and die, leading to Parkinson's disease symptoms. Chronic activation of these cells can cause cell death, potentially triggered by genetic, environmental toxins, and compensating for lost neurons.
Researchers have discovered that microglia, the brain's immune cells, play a key role in how the brain adapts during adolescence. This understanding may transform how neurodevelopmental disorders are treated during this window and possibly into adulthood. The study also found that microglial contact with axons increases dopaminergic ci...
Researchers found that brain's dopamine neurons encode a map of possible future rewards across time and magnitude, guiding adaptive behavior in uncertain environments. This biological insight aligns with recent advances in AI, particularly distributional RL algorithms, which learn from reward distributions rather than averages.
Researchers have discovered a critical link between a cholesterol byproduct and Parkinson's disease development in mice. The study highlights the role of 24-OHC in forming Lewy bodies and killing dopamine neurons, with potential therapeutic targets emerging as drugs that prevent its production.
Researchers at McGill University discovered a novel brain mechanism that explains why bipolar patients alternate between mania and depression. A dopamine-based 'second brain clock' controls mood shifts, operating in tandem with the body's natural sleep-wake cycle.
A new study reveals that patients with Parkinson's disease who exhibit rest tremor have more dopamine preserved in the caudate nucleus, a part of the brain important for movement planning and cognition. This challenges traditional understanding of how dopamine loss relates to PD symptoms.
Researchers at MIT have discovered additional brain pathways that modulate dopamine release, influencing movement and emotional decisions. The newly identified pathways appear to relay emotional information that helps shape motivation to take action.
Researchers identified the external globus pallidus as responsible for impaired decision-making in mice with Parkinson's disease treated with pramipexole. Hyperactivation of this region was linked to poor risk-taking behavior and reduced effectiveness of treatments.
A recent study by FAU researchers links copper regulation to neurodegenerative disorders like Alzheimer's. The team discovered that a specific gene, swip-10, plays a crucial role in maintaining the balance of copper in cells, which can prevent mitochondrial dysfunction and oxidative stress.
Researchers at the University of Birmingham have discovered that male fruit flies ignore physical threats as they pursue a female fly, driven by the neurotransmitter dopamine. As courtship advances, dopamine levels increase, blocking sensory pathways and reducing the ability to respond to threats.
Researchers found that artificial induction of GluCer leads to cellular senescence in DA neurons, highlighting the role of lipid aggregation in PD. The study proposes that lysosomal impairment and lipid accumulation trigger expression of a cellular senescence phenotype in vulnerable DA neurons.
Researchers found that dopamine treatment increased neprilysin levels and reduced beta-amyloid plaques in mouse brains, improving memory function. Long-term L-DOPA treatment also showed improved cognitive performance in mice.
Researchers at Osaka Metropolitan University found that Ecklonia cava polyphenols can protect against neurodegeneration and improve motor function in Parkinson's disease model mice. The antioxidants activate the AMPK enzyme and inhibit reactive oxygen species production, reducing neuronal cell death.
Researchers at the University of Toronto have found a way to better control the preclinical generation of key neurons depleted in Parkinson's disease. They developed an efficient method for stimulating stem cell differentiation to produce neural cells in the midbrain, which closely resemble dopaminergic neurons of natural origin.
Researchers discover dopamine signals affect movement sequence length, shedding light on Parkinson's Disease symptoms and potential therapeutic targets. The study's findings suggest a complex role of dopamine neurons in movement, with distinct effects on movement-related and reward-related dopamine neurons.
A new study finds that SARS-CoV-2 can infect dopamine neurons, causing them to lose their ability to grow and divide, leading to inflammation and potentially severe neurological symptoms. Researchers discovered three drugs that may block or rescue infected dopamine neurons from senescence.
Researchers discovered a previously unreported neuron type with vulnerability in Parkinson's disease, shedding light on the complexity of the disease and potential therapeutic targets. The study identified distinct transcriptomic signatures of this neuron type and found reduced RIT2 expression in Parkinson's disease patients.
A new organoid model replicates the dopaminergic system's structure, connectivity, and functionality, shedding light on its intricate functionality and potential implications for Parkinson’s disease. The model also uncovers the enduring effects of chronic cocaine exposure on the dopaminergic circuit, even after withdrawal.
Researchers at St. Jude Children's Research Hospital have determined the structure of vesicular monoamine transporter 2 (VMAT2), a protein crucial for packaging and releasing neurotransmitters in neurons. The study provides critical information for drug development to treat hyperkinetic disorders like Tourette syndrome.
Researchers found that people with cocaine addiction have weaker signals when receiving rewards, disrupting the brain's ability to learn from experiences. This dysregulation is linked to reduced activity in the ventral striatum and orbitofrontal cortex.
A UNIGE team investigated the destruction of neurons at different times of the day using fruit fly models and found that cellular stress was more deleterious to neurons at night. This suggests that the circadian clock exerts a protective effect on dopaminergic neurons against oxidative stress.
A new Northwestern Medicine study reveals that a dysfunction in the neuron's synapses leads to deficits in dopamine and precedes neurodegeneration in Parkinson's disease. The findings suggest targeting dysfunctional synapses before neurons degenerate may represent a better therapeutic strategy.
Researchers have identified a diverse range of dopamine neurons that control movement, contradicting the long-held assumption that they only respond to rewards. The study sheds new light on Parkinson's disease, which affects motor skills despite the loss of dopamine neurons.
Researchers at Northwestern University discovered that antipsychotic drugs interact with a different neuron type than scientists originally believed, which could lead to better treatments for schizophrenia. The study's findings suggest that the effect of antipsychotics on dopamine receptors has little bearing on their efficacy in humans.
Mass General Brigham researchers have made key improvements to Parkinson's disease cell therapies by using regulatory T cells to supplement neuronal cell therapy. The study shows that co-transplanting regulatory T cells with dopaminergic neurons increases survival and improves behavior recovery in rodent models.
A recent study has identified 53 pesticides linked to an increased risk of Parkinson's disease, with exposure to multiple chemicals combined being more toxic than any single pesticide. The researchers also found that specific pesticides can directly harm dopamine neurons, a key finding for the development of new therapeutic strategies.
Researchers discovered vitamin D's role in regulating dopaminergic neuron differentiation and function. The study found that vitamin D alters developing neurons in the brain's dopamine circuit.
Researchers at UCLA and Harvard have identified 10 pesticides toxic to dopaminergic neurons, which play a key role in voluntary movement. The study used California's pesticide use database and found that co-exposure of certain pesticides increased toxicity, with combinations involving herbicides like trifluralin producing the most harm.
Scientists found that dopamine-containing nerve cells from Parkinson's patients have poorer ability to form extensions, leading to severe dopamine deficiency. Researchers also discovered a medication that makes these cells better at forming nerve extensions.
A recent study has found that sleep is necessary for survival due to its role in regulating the body's homeostasis and preventing diseases. The research also shows that the brain disconnects from the environment during sleep, and that the gut plays a crucial role in this process.
Researchers have discovered that the amygdala uses specialized neurons to learn about threats and rewards, a finding that could lead to more effective treatments for anxiety and drug addiction. By studying how these neurons respond differently to various stimuli, scientists have gained insights into the brain's reward system.
A tiny worm called C. elegans is enabling scientists to explore the emerging theory that Parkinson’s disease starts in the gut, where a sticky protein causes neurons to die. The worms have a digestive tract and neurotransmitters similar to humans, making them a great model for studying cognitive problems associated with Parkinson's.
Researchers at Texas A&M University School of Medicine have identified a specific brain circuit that characterizes how fentanyl affects the brain. Suppressing negative emotional states may increase a person's chance of overcoming opioid use disorder.
Researchers found that dopamine-releasing neurons in the ventral tegmental area of the brain drive maternal instincts through reinforcement learning. This process creates an expectation of future rewards, influencing mothers to pick up their crying children again.
Researchers discovered that krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging. Krill oil increases neuronal resilience, promoting anti-oxidative stress and anti-inflammation, and abrogating multiple aging hallmarks.
The study reveals two neuron subgroups in NAc: NAc BLA and NAc PVT. These neurons regulate reward-seeking behavior and aversion, respectively. The findings provide insight into the brain's reward and aversion processing.
Researchers identified a compound that reverses damage to brain cells caused by Parkinson's disease and breaks a self-sustaining molecular loop between LRRK2 and AICD. The potential drug itanapraced has passed safety tests and could improve quality of life for those afflicted with PD and Alzheimer's disease.
A team of researchers identified a protein kinase substrate downstream of the dopamine signaling pathway regulating brain reward behavior. The study found that phosphorylation of potassium voltage-gated channel subfamily Q member 2 (KCNQ2) decreases its channel activity, increasing neuronal excitability and promoting reward behavior.
Researchers have successfully created dopaminergic neurons directly from the skin of patients with Parkinson's disease, preserving aged characteristics and cellular defects. This breakthrough allows for modeling PD-related neuronal defects in a larger cohort of patients, aiming to identify disease causes and potential therapies.
A new study by UC Berkeley neuroscientists simulated food insecurity in juvenile mice, finding lasting changes in learning, decision-making, and dopamine neurons. The stability of the food supply during young age affects cognitive flexibility in adulthood.
A recent study by the University of Bonn found that neurons born early can develop into all types of dopaminergic neurons in the midbrain, with their career paths determined by the time of emergence. This is contrary to other nerve cells, whose order of birth determines their profession.
Researchers mapped out the brain network responsible for nicotine's negative consequences, opening the door to interventions that boost aversive effects to help people quit smoking. The discovery suggests that manipulating this network could treat nicotine dependence by inducing an acute aversive effect.
A new study found that neuronal cilia play a crucial role in ensuring proper signaling of dopamine receptors, which regulate motivated behavior and movement. Mice lacking functional cilia on dopamine receptor 1-expressing neurons became obese and sedentary, highlighting the importance of cilia in dopamine-dependent neural signaling.
Researchers have developed novel sensors that can precisely measure dopamine levels in nerve cells, providing new insights into the mechanisms of dopamine release. The sensors use modified carbon nanotubes to visualise individual dopamine release events along neuronal structures.
A study published in Nature Communications sheds light on dopamine transporter (DAT) function, which regulates brain reward centre communication. The researchers discovered DAT depends on potassium, not just sodium, rewriting textbooks on its mechanism.
Research found that voluntary wheel running increased dopamine signaling in motor areas of mice. This increase remained even after exercise ended. The study suggests BDNF may catalyze increased dopamine signaling.
Researchers have developed a process to convert non-neuronal cells into functioning neurons that can take up residence in the brain and restore capacities undermined by Parkinson's destruction of dopaminergic cells. In a proof-of-concept study, one group of experimentally engineered cells performs optimally in terms of survival, growth...
Scientists have created a searchable atlas of distinct cell populations in the ventral tegmental area, a key brain region involved in reward-directed behavior and substance use disorders. The study identified 16 cell populations, including classic dopaminergic neurons, glutamatergic neurons, and GABAergic neurons.
A Synapsy study has identified a new neural pathway involved in social interaction, distinct from the traditional reward system. This discovery may hold key to understanding and treating autism spectrum disorders.
Researchers found that a temporary increase in dopamine levels in the basolateral amygdala initiates transitions from non-rapid eye movement (NREM) to rapid eye movement (REM) sleep. This discovery may have important implications for understanding changes in sleep state and treating conditions like cataplexy and narcolepsy.
A new study from the University of Copenhagen has made significant breakthroughs in treating Parkinson's disease by targeting specific neurons in the brainstem. By stimulating excitatory neurons in the caudal area of the pedunculopontine nucleus, researchers were able to restore normal walking function in mice with Parkinson's symptoms.
Researchers identified three KCTD proteins that modulate neurotransmitter activity, enabling fine-tuned movement. Their elimination enhances cAMP production and sensitivity to dopamine in neurons.
A team from UNIGE found that dopaminergic neurons in the reward system are responsible for motivating social interactions. The study used mice to demonstrate how these neurons release dopamine, crucial for motivated behaviors and learning.
Researchers have made significant breakthroughs in understanding Parkinson's disease, revealing that affected neurons don't die but lose properties. This knowledge opens the door to new therapeutic treatments targeting the cell body, rather than just axons.
A new study by Vanessa Ruta and her team found that dopamine neurons in fruit flies correlate strongly with ongoing behavior, reflecting motivation or goal underlying actions. The activity of these neurons not only encode mechanics of movement but also provide moment-to-moment reinforcement, guiding beneficial actions.
Researchers have made significant progress in generating neurons in the lab, a potential therapeutic option for replacing lost neurons in neurodegenerative conditions like Parkinson's disease. A $9 million grant will support further research and development of this novel treatment approach.
A preclinical study found that blocking the Bach1 protein slowed brain cell deterioration in Parkinson's disease. The researchers identified a potent inhibitor of Bach1 called HPPE, which protected cells from inflammation and oxidative stress, and showed promise as a potential therapeutic target.
Researchers from The Stuber Lab discovered that certain neurons in the brain light up in obese mice, preventing signals that indicate satiety. The study found that these neurons communicate with regions involved in depression and motivation, suggesting a link between eating disorders and addiction.