Researchers report a method for selectively concentrating proteins and nucleic acids using hierarchical arrays of parallel nanofluidic concentrators; the technique enhanced concentrations by up to a billion-fold within 30 minutes, and enabled detection of nucleic acid and protein biomarkers at attomolar concentrations in human urine and serum samples in less than 1 hour, potentially allowing rapid detection of pathogens and biomarkers for clinical diagnostics, according to the authors.
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Article #19-04513: "Universal amplification-free molecular diagnostics by billion-fold hierarchical nanofluidic concentration," by Wei Ouyang and Jongyoon Han.
MEDIA CONTACT: Jongyoon Han, Massachusetts Institute of Technology, Cambridge, MA; tel: 617-253-2290; e-mail: jyhan@mit.edu
Proceedings of the National Academy of Sciences