About The Study: In this longitudinal observational cohort study, gender-affirming hormone therapy was associated with lower rates of moderate-to-severe depressive symptoms, highlighting the importance of gender-affirming primary care models for transgender, nonbinary, and gender diverse patients.
Corresponding Author: To contact the corresponding author, Sari L. Reisner, ScD, MA, email sreisner@umich.edu .
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(doi:10.1001/jamanetworkopen.2025.0955)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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