About The Study: In this large cohort of adults with overweight or obesity without diabetes, fewer than 1 in 4 patients remained on any glucagon-like peptide-1 receptor agonist (GLP-1RA) after 12 months. Switching between GLP-1RA agents was common and may reflect active therapy management rather than nonengagement, particularly as new formulations and weight management agents emerge.
Corresponding Author: To contact the corresponding author, Luyu Xie, PharmD, PhD, email luyu.xie@utsouthwestern.edu .
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(doi:10.1001/jamanetworkopen.2026.1272)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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